Record No:1
| ACCESS NO | D109516 |
| GENE_NAME | FURIN |
| DESCRIPTION | Furin, paired basic amino acid cleaving enzyme |
| ALIASES | FUR, PACE, PCSK3, SPC1. |
| NCBI_ENTREZ_NO | 5045 |
| UNIPROT_ACCESS_NO | P09958 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | FURIN was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Protease binding, endopeptidase activity, serine-type endopeptidase activity, serine-type endopeptidase inhibitor activity, protein binding, peptidase activity, serine-type peptidase activity, hydrolase activity, peptide binding, metal ion binding, nerve growth factor binding. |
| GO_BIOLOGICAL_PROCESS | Signal peptide processing, proteolysis, transforming growth factor beta receptor signaling pathway, regulation of signal transduction, negative regulation of endopeptidase activity, protein processing, peptide hormone processing, viral life cycle, viral protein processing, extracellular matrix disassembly, extracellular matrix organization, collagen catabolic process, zymogen activation, nerve growth factor processing, negative regulation of low-density lipoprotein particle receptor catabolic process, nerve growth factor production, NOT negative regulation of nerve growth factor production, negative regulation of transforming growth factor beta 1 production, secretion by cell, regulation of protein catabolic process, peptide biosynthetic process, cellular protein metabolic process, regulation of low-density lipoprotein particle receptor biosynthetic process, regulation of lipoprotein lipase activity, positive regulation of membrane protein ectodomain proteolysis, regulation of endopeptidase activity, cornification, dibasic protein processing, positive regulation of transforming growth factor beta1 activation. |
| BIOGRID_INTERACTION_ID | 111082 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 207583 207584 |
| MONOCLONAL_ANTIBODY | Anti-Furin antibody for Human, Mouse, Rat. |