Record No:1
| ACCESS NO | D109544 |
| GENE_NAME | HIF1A |
| DESCRIPTION | Hypoxia inducible factor 1 subunit alpha |
| ALIASES | HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78. |
| NCBI_ENTREZ_NO | 3091 |
| UNIPROT_ACCESS_NO | Q16665 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | HIF1A was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), p53 binding, DNA binding, DNA-binding transcription factor activity, protein binding, transcription factor binding, enzyme binding, protein kinase binding, protein domain specific binding, ubiquitin protein ligase binding, histone acetyltransferase binding, nuclear hormone receptor binding, histone deacetylase binding, contributes_to sequence-specific DNA binding, protein heterodimerization activity, protein dimerization activity, Hsp90 protein binding, E-box binding. |
| GO_BIOLOGICAL_PROCESS | Angiogenesis, blood vessel development, response to hypoxia, neural crest cell migration, epithelial to mesenchymal transition, embryonic placenta development, B-1 B cell homeostasis, positive regulation of endothelial cell proliferation, vasculature development, heart looping, positive regulation of neuroblast proliferation, connective tissue replacement involved in inflammatory response wound healing, outflow tract morphogenesis, cardiac ventricle morphogenesis, lactate metabolic process, regulation of glycolytic process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, cellular iron ion homeostasis, signal transduction, lactation, visual learning, response to iron ion, regulation of gene expression, positive regulation of autophagy, vascular endothelial growth factor production, positive regulation of vascular endothelial growth factor production, positive regulation of gene expression, negative regulation of gene expression, positive regulation of epithelial cell migration, positive regulation of receptor biosynthetic process, response to muscle activity, positive regulation of macroautophagy, protein ubiquitination, protein deubiquitination, cytokine-mediated signaling pathway, axonal transport of mitochondrion, neural fold elevation formation, cerebral cortex development, cell differentiation, negative regulation of ossification, negative regulation of bone mineralization, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of TOR signaling, oxygen homeostasis, positive regulation of chemokine production, regulation of transforming growth factor beta2 production, collagen metabolic process, embryonic hemopoiesis, positive regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of cell proliferation, hemoglobin biosynthetic process, glucose homeostasis, mRNA transcription by RNA polymerase II, negative regulation of apoptotic process, negative regulation of neuron apoptotic process, positive regulation of blood vessel endothelial cell migration, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, post-translational protein modification, positive regulation of erythrocyte differentiation, positive regulation of angiogenesis, positive regulation of glycolytic process, positive regulation of transcription, DNA-templated, negative regulation of growth, positive regulation of transcription by RNA polymerase II, muscle cell cellular homeostasis, positive regulation of hormone biosynthetic process, blood vessel morphogenesis, digestive tract morphogenesis, camera-type eye morphogenesis, regulation of catalytic activity, positive regulation of nitric-oxide synthase activity, cartilage development, elastin metabolic process, intestinal epithelial cell maturation, epithelial cell differentiation involved in mammary gland alveolus development, iris morphogenesis, retina vasculature development in camera-type eye, regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of chemokine-mediated signaling pathway, regulation of thymocyte apoptotic process, negative regulation of thymocyte apoptotic process, cellular response to interleukin-1, cellular response to hypoxia, dopaminergic neuron differentiation, hypoxia-inducible factor-1alpha signaling pathway, positive regulation of pri-miRNA transcription by RNA polymerase II, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of autophagy of mitochondrion, regulation of aerobic respiration, negative regulation of reactive oxygen species metabolic process, negative regulation of mesenchymal cell apoptotic process. |
| BIOGRID_INTERACTION_ID | 109338 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204174 204175 204176 204177 |
| MONOCLONAL_ANTIBODY | Anti-HIF-1 alpha antibody for Human, Mouse, Rat, Cow, Pig, Chicken, Non human primates. |