Record No:1
| ACCESS NO | D109553 |
| GENE_NAME | DUSP6 |
| DESCRIPTION | Dual specificity phosphatase 6 |
| ALIASES | HH19, MKP3, PYST1. |
| NCBI_ENTREZ_NO | 1848 |
| UNIPROT_ACCESS_NO | Q16828 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | DUSP6 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Phosphoprotein phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, hydrolase activity, phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, activation of MAPK activity, inactivation of MAPK activity, negative regulation of protein phosphorylation, protein dephosphorylation, dorsal/ventral pattern formation, response to organic substance, positive regulation of cell death, response to organic cyclic compound, dephosphorylation, cell differentiation, peptidyl-tyrosine dephosphorylation, regulation of fibroblast growth factor receptor signaling pathway, response to drug, regulation of endodermal cell fate specification, positive regulation of apoptotic process, response to nitrosative stress, regulation of heart growth, negative regulation of ERK1 and ERK2 cascade, response to growth factor. |
| BIOGRID_INTERACTION_ID | 108181 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200332 200333 |
| MONOCLONAL_ANTIBODY | Anti-DUSP6 antibody for Mouse, Rat, Human. |