Record No:1
| ACCESS NO | D109559 |
| GENE_NAME | SREBF1 |
| DESCRIPTION | Sterol regulatory element binding transcription factor 1 |
| ALIASES | SREBP1, bHLHd1. |
| NCBI_ENTREZ_NO | 6720 |
| UNIPROT_ACCESS_NO | P36956 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | SREBF1 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, chromatin binding, DNA-binding transcription factor activity, nuclear receptor activity, protein binding, protein kinase binding, sterol response element binding, sequence-specific DNA binding, protein-containing complex binding, protein dimerization activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, regulation of heart rate by chemical signal, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, lipid metabolic process, aging, circadian rhythm, steroid metabolic process, cholesterol metabolic process, insulin receptor signaling pathway, lipid biosynthetic process, cellular response to starvation, response to glucose, positive regulation of triglyceride biosynthetic process, response to organic cyclic compound, regulation of fatty acid metabolic process, lung development, intracellular receptor signaling pathway, positive regulation of histone deacetylation, regulation of protein stability, response to food, response to retinoic acid, response to progesterone, cellular response to insulin stimulus, response to glucagon, response to lipid, response to drug, mRNA transcription by RNA polymerase II, response to peptide hormone, fat cell differentiation, regulation of cholesterol biosynthetic process, positive regulation of cholesterol biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, negative regulation of insulin secretion, regulation of insulin secretion, response to cAMP, response to fatty acid, cellular response to fatty acid, positive regulation of pri-miRNA transcription by RNA polymerase II, regulation of autophagy of mitochondrion, regulation of protein targeting to mitochondrion. |
| BIOGRID_INTERACTION_ID | 112598 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 207678 |
| MONOCLONAL_ANTIBODY | Anti-SREBP1 antibody for Human. |