Record No:1
| ACCESS NO | D109596 |
| GENE_NAME | PAK3 |
| DESCRIPTION | p21 (RAC1) activated kinase 3 |
| ALIASES | ARA, MRX30, MRX47, OPHN3, PAK-3, PAK3beta, bPAK, beta-PAK. |
| NCBI_ENTREZ_NO | 5063 |
| UNIPROT_ACCESS_NO | O75914 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | PAK3 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Nucleotide binding, catalytic activity, protein kinase activity, protein serine/threonine kinase activity, MAP kinase kinase activity, protein binding, ATP binding, kinase activity, transferase activity, Rho GTPase binding, SH3 domain binding, metal ion binding, GTPase binding. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, activation of MAPK activity, stimulatory C-type lectin receptor signaling pathway, protein phosphorylation, multicellular organism development, axonogenesis, metabolic process, positive regulation of fibroblast migration, regulation of neuron projection development, phosphorylation, dendrite development, signal transduction by protein phosphorylation, regulation of actin filament polymerization, T cell costimulation, activation of protein kinase activity, regulation of actin cytoskeleton organization, positive regulation of neuron apoptotic process, ephrin receptor signaling pathway, regulation of axonogenesis, synapse organization, T cell receptor signaling pathway, dendritic spine development, dendritic spine morphogenesis, positive regulation of dendritic spine morphogenesis, cellular response to organic cyclic compound, positive regulation of DNA biosynthetic process. |
| BIOGRID_INTERACTION_ID | 111099 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204444 |
| MONOCLONAL_ANTIBODY | Anti-PAK3 antibody for Human, Mouse, Rat; Anti-PAK1+PAK2+PAK3 (phospho S144 + S154 + S144 + S141) antibody for Human, Mouse, Rat; Anti-PAK1+PAK2+PAK3 (phospho S141 + S144 + S154) antibody for Human, Mouse, Rat. |