Record No:1
| ACCESS NO | D109619 |
| GENE_NAME | HMGB2 |
| DESCRIPTION | High mobility group protein B2 |
| ALIASES | HMG2. |
| NCBI_ENTREZ_NO | 3148 |
| UNIPROT_ACCESS_NO | P26583 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | HMGB2 was significantly decreased in asthmatics as compared to healthy subjects. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Four-way junction DNA binding, enhancer sequence-specific DNA binding, DNA binding, damaged DNA binding, double-stranded DNA binding, single-stranded DNA binding, DNA-binding transcription factor activity, RNA binding, protein binding, transcription factor binding, drug binding, DNA binding ( bending), protein domain specific binding, chemoattractant activity, transcription regulatory region DNA binding, non-sequence-specific DNA binding ( bending), RAGE receptor binding, supercoiled DNA binding. |
| GO_BIOLOGICAL_PROCESS | Positive regulation of endothelial cell proliferation, immune system process, inflammatory response to antigenic stimulus, DNA topological change, apoptotic DNA fragmentation, DNA recombination, chromatin organization, nucleosome assembly, chromatin remodeling, regulation of transcription by RNA polymerase II, chemotaxis, inflammatory response, spermatogenesis, spermatid nucleus differentiation, male gonad development, positive regulation of gene expression, negative regulation of gene expression, positive regulation of nuclease activity, DNA geometric change, response to lipopolysaccharide, positive regulation of interferon-beta production, V(D)J recombination, response to drug, positive regulation of DNA binding, innate immune response, positive regulation of innate immune response, positive regulation of erythrocyte differentiation, positive regulation of megakaryocyte differentiation, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, response to steroid hormone, regulation of neurogenesis, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, positive chemotaxis, DNA ligation involved in DNA repair, cell chemotaxis, cellular response to lipopolysaccharide, regulation of stem cell proliferation, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. |
| BIOGRID_INTERACTION_ID | 109391 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 203044 |
| MONOCLONAL_ANTIBODY | Anti-HMGB2 antibody for Mouse, Human, Rat. |