Record No:1
| ACCESS NO | D109689 |
| GENE_NAME | S1PR3 |
| DESCRIPTION | Sphingosine-1-phosphate receptor 3 |
| ALIASES | EDG-3, EDG3, LPB3, S1P3. |
| NCBI_ENTREZ_NO | 1903 |
| UNIPROT_ACCESS_NO | Q99500 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | S1PR3 was significantly decreased in asthmatics as compared to allergic rhinitis patients. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | G protein-coupled receptor activity, integrin binding, protein binding, lipid binding, sphingosine-1-phosphate receptor activity. |
| GO_BIOLOGICAL_PROCESS | Cytokine production, sphingosine-1-phosphate receptor signaling pathway, inflammatory response, signal transduction, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, Notch signaling pathway, positive regulation of cell proliferation, anatomical structure morphogenesis, regulation of interleukin-1 beta production, negative regulation of establishment of endothelial barrier. |
| BIOGRID_INTERACTION_ID | 108227 |
| SNP_ID | - |
| DRUG_ID | 4112 4113 |
| STRUCTURE_ID | 207548 |
| MONOCLONAL_ANTIBODY | Anti-EDG3/S1P3 antibody for Human, Mouse, Rat. |