Record No:1
| ACCESS NO | D109717 |
| GENE_NAME | YES1 |
| DESCRIPTION | YES proto-oncogene 1, Src family tyrosine kinase |
| ALIASES | HsT441, P61-YES, Yes, c-yes. |
| NCBI_ENTREZ_NO | 7525 |
| UNIPROT_ACCESS_NO | P07947 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | CD4 T cells |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE75011 |
| COMMENTS | YES1 was significantly decreased in asthmatics as compared to allergic rhinitis patients. |
| REFERENCE | 27271570 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Phosphotyrosine residue binding, protein kinase activity, protein tyrosine kinase activity, non-membrane spanning protein tyrosine kinase activity, signaling receptor binding, epidermal growth factor receptor binding, protein binding, ATP binding, kinase activity, transferase activity, enzyme binding, ion channel binding. |
| GO_BIOLOGICAL_PROCESS | Cellular protein modification process, protein phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, regulation of glucose transmembrane transport, phosphorylation, peptidyl-tyrosine phosphorylation, cell differentiation, T cell costimulation, cellular response to platelet-derived growth factor stimulus, peptidyl-tyrosine autophosphorylation, Fc-gamma receptor signaling pathway involved in phagocytosis, regulation of cell proliferation, regulation of vascular permeability, positive regulation of transcription by RNA polymerase II, protein autophosphorylation, ephrin receptor signaling pathway, positive regulation of peptidyl-tyrosine phosphorylation, leukocyte migration, cellular response to retinoic acid, cellular response to transforming growth factor beta stimulus. |
| BIOGRID_INTERACTION_ID | 113357 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 207447 |
| MONOCLONAL_ANTIBODY | Anti-Yes1 antibody for Human, Mouse, Rat; Anti-Fyn (phospho Y530) + Yes (phospho Y537) antibody for Human. |