Record No:1
| ACCESS NO | D109773 |
| GENE_NAME | SLC6A4 |
| DESCRIPTION | Solute carrier family 6 member 4 |
| ALIASES | 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, |
| NCBI_ENTREZ_NO | 6532 |
| UNIPROT_ACCESS_NO | P31645 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma (AS), Asthma with Depression (AD) |
| SAMPLE | CD4 T cells |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Participants with AS and AD had lower expression level of SLC6A4 than the healthy controls. Decreased expression of SLC6A4 gene may be one of the possible comorbidity mechanisms of asthma and depression. |
| REFERENCE | 27263299 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Neurotransmitter:sodium symporter activity, serotonin:sodium symporter activity, protein binding, monoamine transmembrane transporter activity, symporter activity, myosin binding, syntaxin-1 binding, Rab GTPase binding, cocaine binding, protein homodimerization activity, metal ion binding, nitric-oxide synthase binding, actin filament binding, serotonin binding. |
| GO_BIOLOGICAL_PROCESS | Response to hypoxia, neurotransmitter transport, serotonin transport, brain development, response to nutrient, memory, circadian rhythm, response to toxic substance, response to organic substance, positive regulation of gene expression, positive regulation of serotonin secretion, monoamine transport, negative regulation of cerebellar granule cell precursor proliferation, negative regulation of synaptic transmission ( dopaminergic), response to estradiol, social behavior, neurotransmitter biosynthetic process, vasoconstriction, response to drug, sperm ejaculation, negative regulation of neuron differentiation, positive regulation of cell cycle, negative regulation of organ growth, brain morphogenesis, protein complex oligomerization, protein homooligomerization, serotonin uptake, transmembrane transport, cellular response to retinoic acid, cellular response to organic substance, cellular response to cGMP, regulation of thalamus size. |
| BIOGRID_INTERACTION_ID | 112423 |
| SNP_ID | 300336 |
| DRUG_ID | - |
| STRUCTURE_ID | 203000 |
| MONOCLONAL_ANTIBODY | Anti-Serotonin transporter antibody for Mouse, Rat, Human. |