Record No:1
| ACCESS NO | D109821 |
| GENE_NAME | NOTCH1 |
| DESCRIPTION | Neurogenic locus notch homolog protein 1 |
| ALIASES | AOS5, AOVD1, TAN1, hN1. |
| NCBI_ENTREZ_NO | 4851 |
| UNIPROT_ACCESS_NO | P46531 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Childhood Allergic Asthma |
| SAMPLE | Peripheral Blood Mononuclear Cells (PBMC) |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | mRNA level of NOTCH1 was elevated in children with Allergic Asthma comparing to healthy controls. The mRNA expression of NOTCH1 was positively correlated with the percentage of Th17 cells and Th17/Treg ratio. |
| REFERENCE | 28463581 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription activator activity (RNA polymerase II-specific), chromatin binding, DNA-binding transcription factor activity, enzyme inhibitor activity, transmembrane signaling receptor activity, Notch binding, calcium ion binding, protein binding, enzyme binding, chromatin DNA binding, signaling receptor activity, sequence-specific DNA binding, metal ion binding, protein heterodimerization activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, angiogenesis, in utero embryonic development, cell fate specification, epithelial to mesenchymal transition, liver development, heart looping, sprouting angiogenesis, positive regulation of neuroblast proliferation, inflammatory response to antigenic stimulus, outflow tract morphogenesis, endocardium development, endocardium morphogenesis, atrioventricular node development, coronary vein morphogenesis, aortic valve morphogenesis, atrioventricular valve morphogenesis, coronary sinus valve morphogenesis, pulmonary valve morphogenesis, mitral valve formation, endocardial cushion development, epithelial to mesenchymal transition involved in endocardial cushion formation, endocardial cushion morphogenesis, cardiac chamber formation, cardiac ventricle morphogenesis, cardiac atrium morphogenesis, cardiac right atrium morphogenesis, cardiac left ventricle morphogenesis, cardiac right ventricle formation, ventricular trabecula myocardium morphogenesis, growth involved in heart morphogenesis, negative regulation of cell proliferation involved in heart valve morphogenesis, regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation, regulation of cardioblast proliferation, Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation, cell migration involved in endocardial cushion formation, negative regulation of extracellular matrix constituent secretion, pericardium morphogenesis, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription initiation from RNA polymerase II promoter, immune response, humoral immune response, cell cycle arrest, Notch signaling pathway, positive regulation of transcription of Notch receptor target, multicellular organism development, spermatogenesis, determination of left/right symmetry, compartment pattern specification, |
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