Record No:1
| ACCESS NO | D110052 |
| GENE_NAME | RAC1 |
| DESCRIPTION | Rac family small GTPase 1 |
| ALIASES | MIG5, MRD48, Rac-1, TC-25, p21-Rac1. |
| NCBI_ENTREZ_NO | 5879 |
| UNIPROT_ACCESS_NO | P63000 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Severe Asthma |
| SAMPLE | Blood |
| TECHNIQUES | RNA Sequencing |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | RAC1 was decreased in severe asthmatics as compared to control. |
| REFERENCE | 30426778 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Nucleotide binding, GTPase activity, protein serine/threonine kinase activity, protein binding, GTP binding, Rab GTPase binding, enzyme binding, protein kinase binding, thioesterase binding, histone deacetylase binding, Rho GDP-dissociation inhibitor binding, ATPase binding. |
| GO_BIOLOGICAL_PROCESS | Cell morphogenesis, positive regulation of protein phosphorylation, mast cell chemotaxis, protein phosphorylation, endocytosis, chemotaxis, inflammatory response, actin filament organization, cell adhesion, cell-matrix adhesion, G-protein coupled receptor signaling pathway, small GTPase mediated signal transduction, Rho protein signal transduction, blood coagulation, cell proliferation, regulation of cell size, response to wounding, anatomical structure morphogenesis, regulation of hydrogen peroxide metabolic process, regulation of lamellipodium assembly, positive regulation of lamellipodium assembly, positive regulation of cell-substrate adhesion, cell migration, Rac protein signal transduction, cell projection assembly, lamellipodium assembly, actin cytoskeleton organization, actin filament polymerization, platelet activation, regulation of cell migration, positive regulation of actin filament polymerization, positive regulation of microtubule polymerization, T cell costimulation, ruffle organization, actin cytoskeleton reorganization, negative regulation of interleukin-23 production, substrate adhesion-dependent cell spreading, positive regulation of Rho protein signal transduction, intracellular signal transduction, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, positive regulation of apoptotic process, neutrophil degranulation, engulfment of apoptotic cell, bone resorption, positive regulation of DNA replication, vascular endothelial growth factor receptor signaling pathway, hepatocyte growth factor receptor signaling pathway, ephrin receptor signaling pathway, negative regulation of receptor-mediated endocytosis, neuron projection morphogenesis, cell motility, regulation of defense response to virus by virus, regulation of small GTPase mediated signal transduction, regulation of stress fiber assembly, positive regulation of stress fiber assembly, localization within membrane, positive regulation of focal adhesion assembly, Wnt signaling pathway, planar cell polarity pathway, regulation of respiratory burst, cellular response to mechanical stimulus, semaphorin-plexin signaling pathway, positive regulation of neutrophil chemotaxis, ruffle assembly, positive regulation of substrate adhesion-dependent cell spreading. |
| BIOGRID_INTERACTION_ID | 111817 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 202259 202260 202261 202262 |
| MONOCLONAL_ANTIBODY | Anti-Rac1 antibody for Mouse, Rat, Rabbit, Human; Anti-RAC1 + Cdc42 (phospho S71) antibody for Human; Anti-Rac1 + Rac2 + Rac3 antibody for Human, Mouse, Rat. |