Record No:1
| ACCESS NO | D110347 |
| GENE_NAME | GATA3 |
| DESCRIPTION | GATA binding protein 3 |
| ALIASES | HDR, HDRS. |
| NCBI_ENTREZ_NO | 2625 |
| UNIPROT_ACCESS_NO | P23771 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Dermatitis |
| SAMPLE | Skin, T cells |
| TECHNIQUES | Microarray |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE124700, GSE124701 |
| COMMENTS | GATA3 was down regulated in skin and T cells of Atopic Dermatitis patients as compared to healthy controls. |
| REFERENCE | 30738053 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Transcription regulatory region sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), proximal promoter sequence-specific DNA binding, enhancer sequence-specific DNA binding, DNA-binding transcription repressor activity (RNA polymerase II-specific), DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, DNA-binding transcription factor activity, transcription coregulator activity, transcription coactivator activity, interleukin-2 receptor binding, protein binding, transcription factor binding, zinc ion binding, sequence-specific DNA binding, transcription regulatory region DNA binding, metal ion binding, protein dimerization activity, E-box binding, MG box domain binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, cell morphogenesis, in utero embryonic development, cell fate determination, neuron migration, cell activation, type IV hypersensitivity, positive regulation of cytokine production, kidney development, mesonephros development, lens development in camera-type eye, immune system process, immune system development, pro-T cell differentiation, aortic valve morphogenesis, cardiac right ventricle morphogenesis, ventricular septum development, chromatin remodeling, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, defense response, humoral immune response, signal transduction, nervous system development, axon guidance, blood coagulation, negative regulation of cell proliferation, male gonad development, response to virus, anatomical structure morphogenesis, post-embryonic development, positive regulation of signal transduction, response to gamma radiation, positive regulation of endothelial cell migration, positive regulation of gene expression, negative regulation of gene expression, regulation of neuron projection development, phosphatidylinositol 3-kinase signaling, protein deubiquitination, cytokine-mediated signaling pathway, neuron differentiation, T cell differentiation, erythrocyte differentiation, regulation of epithelial cell differentiation, TOR signaling, negative regulation of interferon-gamma production, negative regulation of interleukin-2 production, positive regulation of interleukin-13 production, positive regulation of interleukin-4 production, positive regulation of interleukin-5 production, T cell differentiation in thymus, negative regulation of mammary gland epithelial cell proliferation, embryonic hemopoiesis, cellular response to interferon-alpha, ureter maturation, parathyroid hormone secretion, regulation of cytokine biosynthetic process, norepinephrine biosynthetic process, inner ear morphogenesis, response to drug, regulation of CD4-positive, alpha-beta T cell differentiation, regulation of neuron apoptotic process, ear development, response to estrogen, thymic T cell selection, T-helper 2 cell differentiation, innate immune response, response to ethanol, positive regulation of T cell differentiation, positive regulation of cell differentiation, negative regulation of fat cell differentiation, negative regulation of cell cycle, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, cell maturation, sympathetic nervous system development, thymus development, embryonic organ development, developmental growth, anatomical structure formation involved in morphogenesis, homeostasis of number of cells, negative regulation of inflammatory response, T cell receptor signaling pathway, regulation of histone H3-K4 methylation, positive regulation of protein kinase B signaling, parathyroid gland development, pharyngeal system development, uterus development, mesenchymal to epithelial transition, mast cell differentiation, ureteric bud formation, regulation of histone H3-K27 methylation, canonical Wnt signaling pathway involved in metanephric kidney development, cellular response to cytokine stimulus, cellular response to interleukin-4, cellular response to tumor necrosis factor, positive regulation of histone H3-K14 acetylation, otic vesicle development, cellular response to BMP stimulus, positive regulation of ureteric bud formation, nephric duct morphogenesis, nephric duct formation, regulation of nephron tubule epithelial cell differentiation, ureter morphogenesis, interleukin-4 secretion, interferon-gamma secretion, lymphocyte migration, cochlea development, negative regulation of DNA demethylation, regulation of hematopoietic stem cell differentiation, regulation of establishment of cell polarity, negative regulation of cell motility, negative regulation of endothelial cell apoptotic process, positive regulation of T-helper 2 cell cytokine production, negative regulation of cell proliferation involved in mesonephros development, positive regulation of thyroid hormone generation, positive regulation of histone H3-K9 acetylation, positive regulation of interleukin-5 secretion, positive regulation of interleukin-13 secretion, positive regulation of transcription regulatory region DNA binding, regulation of cellular response to X-ray, negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation, negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation. |
| BIOGRID_INTERACTION_ID | 108895 |
| SNP_ID | 300774 300965 301037 301038 300966 300967 |
| DRUG_ID | - |
| STRUCTURE_ID | 203822 203823 203824 |
| MONOCLONAL_ANTIBODY | Anti-GATA2 + GATA3 antibody for Mouse, Rat, Human; Anti-GATA3 antibody for Human, Mouse; Anti-GATA3 (phospho S308) antibody for Human. |