Record No:1
| ACCESS NO | D110544 |
| GENE_NAME | TNFAIP3 |
| DESCRIPTION | Tumour necrosis factor alpha-induced protein 3 |
| ALIASES | A20, AISBL, OTUD7C, TNFA1P2. |
| NCBI_ENTREZ_NO | 7128 |
| UNIPROT_ACCESS_NO | P21580 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Dermatitis |
| SAMPLE | Skin Biopsy |
| TECHNIQUES | Microarray |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | A20 was down regulated in Atopic Dermatitis patients and psoriasis patients as compared to healthy controls. A20 expression was the lowest in Atopic Dermatitis patients. |
| REFERENCE | 30118730 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Protease binding, DNA binding, catalytic activity, ubiquitin-protein transferase activity, thiol-dependent ubiquitin-specific protease activity, protein binding, peptidase activity, cysteine-type peptidase activity, zinc ion binding, transferase activity, hydrolase activity, kinase binding, thiol-dependent ubiquitinyl hydrolase activity, identical protein binding, ubiquitin binding, protein self-association, metal ion binding, Lys63-specific deubiquitinase activity, K63-linked polyubiquitin modification-dependent protein binding. |
| GO_BIOLOGICAL_PROCESS | B-1 B cell homeostasis, response to molecule of bacterial origin, regulation of germinal center formation, negative regulation of chronic inflammatory response, proteolysis, apoptotic process, inflammatory response, immune response, metabolic process, regulation of tumor necrosis factor-mediated signaling pathway, protein ubiquitination, protein deubiquitination, negative regulation of protein ubiquitination, negative regulation of NF-kappaB transcription factor activity, negative regulation of type I interferon production, response to muramyl dipeptide, negative regulation of interleukin-1 beta production, negative regulation of interleukin-2 production, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production, negative regulation of toll-like receptor 2 signaling pathway, negative regulation of toll-like receptor 3 signaling pathway, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of toll-like receptor 5 signaling pathway, protein K11-linked deubiquitination, negative regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of protein catabolic process, negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of bone resorption, negative regulation of innate immune response, negative regulation of smooth muscle cell proliferation, regulation of defense response to virus by host, regulation of inflammatory response, negative regulation of inflammatory response, negative regulation of B cell activation protein, complex oligomerization, negative regulation of cell death, regulation of vascular wound healing, cellular response to hydrogen peroxide, nucleotide-binding oligomerization domain containing signaling pathway, negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, protein K63-linked deubiquitination, protein K48-linked ubiquitination, protein K48-linked deubiquitination, cellular response to lipopolysaccharide, protein deubiquitination involved in ubiquitin-dependent protein catabolic process, tolerance induction to lipopolysaccharide, establishment of protein localization to vacuole, negative regulation of osteoclast proliferation, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of cellular protein catabolic process, positive regulation of hepatocyte proliferation, negative regulation of CD40 signaling pathway, negative regulation of endothelial cell apoptotic process. |
| BIOGRID_INTERACTION_ID | 112983 |
| SNP_ID | 300885 300886 |
| DRUG_ID | - |
| STRUCTURE_ID | 200427 200429 200430 200431 400432 200433 200434 |
| MONOCLONAL_ANTIBODY | Anti-TNFAIP3 antibody for Mouse, Rat, Human. |