Record No:1
| ACCESS NO | D110693 |
| GENE_NAME | IL13 |
| DESCRIPTION | Interleukin 13 |
| ALIASES | IL-13, P600. |
| NCBI_ENTREZ_NO | 3596 |
| UNIPROT_ACCESS_NO | P35225 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Dermatitis |
| SAMPLE | Skin Biopsy |
| TECHNIQUES | RNA Sequencing, qRT-PCR |
| OMICS | Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | IL13 mRNA was significantly upregulated in African American and European American Atopic Dermatitis lesional skin. |
| REFERENCE | 30223113 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, cytokine receptor binding, interleukin-13 receptor binding, protein binding. |
| GO_BIOLOGICAL_PROCESS | Microglial cell activation, positive regulation of immunoglobulin production, inflammatory response, immune response, response to mechanical stimulus, regulation of proton transport, regulation of signaling receptor activity, cytokine-mediated signaling pathway, positive regulation of B cell proliferation, response to lipopolysaccharide, positive regulation of connective tissue growth factor production, negative regulation of NAD(P)H oxidase activity, response to nicotine, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of macrophage activation, positive regulation of ion transport, positive regulation of mast cell degranulation, response to ethanol, positive regulation of smooth muscle cell proliferation, positive regulation of protein secretion, positive regulation of release of sequestered calcium ion into cytosol, cellular response to mechanical stimulus, cellular response to cytokine stimulus, negative regulation of transforming growth factor beta production, negative regulation of neuron death, negative regulation of lung ciliated cell differentiation, positive regulation of lung goblet cell differentiation, negative regulation of complement-dependent cytotoxicity, positive regulation of pancreatic stellate cell proliferation, negative regulation of endothelial cell apoptotic process. |
| BIOGRID_INTERACTION_ID | 109810 |
| SNP_ID | 300008 300009 300034 300055 300056 300113 300450 300605 300606 300274 300275 300510 300567 300617 300463 300783 300788 300618 300122 300937 300938 300939 300941 300949 300951 |
| DRUG_ID | 4026 |
| STRUCTURE_ID | 201045 201046 201047 |
| MONOCLONAL_ANTIBODY | Anti-IL-13 antibody for Human, Rat, Mouse. |