Record No:1
| ACCESS NO | D110732 |
| GENE_NAME | IL10 |
| DESCRIPTION | Interleukin 10 |
| ALIASES | CSIF, GVHDS, IL-10A, TGIF. |
| NCBI_ENTREZ_NO | 3586 |
| UNIPROT_ACCESS_NO | P22301 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Dermatitis, Psoriasis |
| SAMPLE | Skin Biopsy |
| TECHNIQUES | RNA Sequencing |
| OMICS | Genomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE121212 |
| COMMENTS | IL10 was increased in atopic dermatitis lesions as compared to psoriasis lesions and healthy skin of control subjects. |
| REFERENCE | 30641038 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, interleukin-10 receptor binding, protein binding, growth factor activity. |
| GO_BIOLOGICAL_PROCESS | Positive regulation of endothelial cell proliferation, response to molecule of bacterial origin, negative regulation of cytokine secretion involved in immune response, negative regulation of chronic inflammatory response to antigenic stimulus, positive regulation of B cell apoptotic process, inflammatory response, immune response, cytoplasmic sequestering of NF-kappaB, aging, negative regulation of cell proliferation, response to organic substance, regulation of gene expression, regulation of signaling receptor activity, response to activity, response to inactivity, cytokine-mediated signaling pathway, hemopoiesis, B cell differentiation, leukocyte chemotaxis, negative regulation of myeloid dendritic cell activation, negative regulation of B cell proliferation, response to lipopolysaccharide, negative regulation of interferon-gamma production, negative regulation of interleukin-1 production, negative regulation of interleukin-12 production, negative regulation of interleukin-18 production, negative regulation of interleukin-6 production, negative regulation of interleukin-8 production, negative regulation of tumor necrosis factor production, receptor biosynthetic process, response to insulin, negative regulation of heterotypic cell-cell adhesion, positive regulation of heterotypic cell-cell adhesion, response to carbon monoxide, interleukin-12-mediated signaling pathway, cellular response to hepatocyte growth factor stimulus, type 2 immune response, B cell proliferation, negative regulation of T cell proliferation, response to drug, negative regulation of tumor necrosis factor biosynthetic process, defense response to bacterium, defense response to protozoan, positive regulation of macrophage activation, negative regulation of apoptotic process, negative regulation of growth of symbiont in host, negative regulation of nitric oxide biosynthetic process, regulation of isotype switching, negative regulation of MHC class II biosynthetic process, positive regulation of MHC class II biosynthetic process, negative regulation of interferon-alpha biosynthetic process, positive regulation of cell cycle, positive regulation of DNA-templated transcription, negative regulation of mitotic cell cycle, positive regulation of transcription by RNA polymerase II, positive regulation of cytokine secretion, negative regulation of inflammatory response, regulation of synapse organization, negative regulation of membrane protein ectodomain proteolysis, positive regulation of DNA binding transcription factor activity, response to glucocorticoid, regulation of sensory perception of pain, negative regulation of cytokine activity, branching involved in labyrinthine layer morphogenesis, cellular response to lipopolysaccharide, cellular response to estradiol stimulus, negative regulation of chemokine (C-C motif) ligand 5 production, endothelial cell apoptotic process, liver regeneration, regulation of response to wounding, negative regulation of hydrogen peroxide-induced neuron death, NOT regulation of complement-dependent cytotoxicity, positive regulation of sprouting angiogenesis, negative regulation of sensory perception of pain, negative regulation of vascular smooth muscle cell proliferation, positive regulation of vascular smooth muscle cell proliferation, NOT negative regulation of endothelial cell apoptotic process. |
| BIOGRID_INTERACTION_ID | 109800 |
| SNP_ID | 300457 300076 300454 300601 300860 300602 300931 300934 300935 300936 300945 300946 300947 300948 300973 300976 300977 300978 300455 301153 301155 301160 301161 301162 301164 |
| DRUG_ID | - |
| STRUCTURE_ID | 200231 200232 200233 200234 200235 |
| MONOCLONAL_ANTIBODY | Anti-IL-10 antibody for Human, Rat, Mouse. |