Record No:1
| ACCESS NO | D111131 |
| GENE_NAME | BCL6 |
| DESCRIPTION | B-cell lymphoma 6 protein |
| ALIASES | BCL5A, LAZ3, ZBTB27, ZNF51 |
| NCBI_ENTREZ_NO | 604 |
| UNIPROT_ACCESS_NO | P41182 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Childhood Asthma |
| SAMPLE | CD4 T cells |
| TECHNIQUES | qRT-PCR, Western Blotting |
| OMICS | Genomics, Proteomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | BCL6 expression was significantly increased in asthmatics as compared to healthy controls. |
| REFERENCE | 29490514 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, DNA-binding transcription factor activity ( RNA polymerase II-specific), intronic transcription regulatory region sequence-specific DNA binding, DNA-binding transcription repressor activity ( RNA polymerase II-specific), nucleic acid binding, DNA binding, chromatin binding, DNA-binding transcription factor activity, protein binding, chromatin DNA binding, identical protein binding, sequence-specific DNA binding, metal ion binding. |
| GO_BIOLOGICAL_PROCESS | Protein import into nucleus ( translocation), negative regulation of transcription by RNA polymerase II, cell morphogenesis, negative regulation of cell-matrix adhesion, immune system process, germinal center formation, regulation of germinal center formation, negative regulation of type 2 immune response, negative regulation of B cell apoptotic process, regulation of transcription by RNA polymerase II, inflammatory response, cellular response to DNA damage stimulus, Rho protein signal transduction, spermatogenesis, protein localization, negative regulation of cell proliferation, cytokine-mediated signaling pathway, actin cytoskeleton organization, B cell differentiation, negative regulation of cell growth, positive regulation of B cell proliferation, positive regulation of histone deacetylation, negative regulation of mast cell cytokine production, negative regulation of Rho protein signal transduction, type 2 immune response, regulation of cell proliferation, regulation of apoptotic process, positive regulation of apoptotic process, negative regulation of apoptotic process, regulation of GTPase activity, regulation of memory T cell differentiation, positive regulation of regulatory T cell differentiation, negative regulation of cell differentiation, negative regulation of T-helper 2 cell differentiation, positive regulation of neuron differentiation, negative regulation of Notch signaling pathway, negative regulation of DNA-templated transcription, negative regulation of isotype switching to IgE isotypes, erythrocyte development, regulation of inflammatory response, regulation of immune response, positive regulation of cellular component movement, negative regulation of mitotic cell cycle DNA replication, negative regulation of cellular senescence. |
| BIOGRID_INTERACTION_ID | 107076 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200064 200065 200066 200067 202980 202981 |
| MONOCLONAL_ANTIBODY | Anti-Bcl6 antibody - C- termini for Human; Anti-bcl-6 antibody for Human; Anti-Bcl6 antibody for Human; Anti-Bcl-6 antibody for Human. |