Record No:1
| ACCESS NO | D111222 |
| GENE_NAME | CREBBP |
| DESCRIPTION | CREB binding protein |
| ALIASES | CBP, KAT3A, MKHK1, RSTS, RSTS1. |
| NCBI_ENTREZ_NO | 1387 |
| UNIPROT_ACCESS_NO | Q92793 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Airway Epithelial Cells (AECs) |
| TECHNIQUES | qRT-PCR, Immunohistochemistry |
| OMICS | Genomics, Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | CREBBP expression was down regulated in asthmatics as compared to healthy controls. |
| REFERENCE | 28137284 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Proximal promoter sequence-specific DNA binding, RNA polymerase II transcription factor binding, RNA polymerase II activating transcription factor binding, p53 binding, chromatin binding, damaged DNA binding, transcription coregulator activity, transcription coactivator activity, transcription corepressor activity, histone acetyltransferase activity, protein binding, transcription factor binding, zinc ion binding, acetyltransferase activity, transferase activity, transferase activity transferring acyl groups, MRF binding, metal ion binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, response to hypoxia, stimulatory C-type lectin receptor signaling pathway, regulation of transcription, DNA-templated, transcription initiation from RNA polymerase II promoter, protein acetylation, signal transduction, Notch signaling pathway, positive regulation of transcription of Notch receptor target, regulation of smoothened signaling pathway, viral process, histone acetylation, N-terminal peptidyl-lysine acetylation, regulation of lipid metabolic process, positive regulation of transforming growth factor beta receptor signaling pathway, protein destabilization, positive regulation of type I interferon production, cellular response to UV, homeostatic process, embryonic digit morphogenesis, regulation of apoptotic process, regulation of myeloid cell differentiation, positive regulation of Notch signaling pathway, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, rhythmic process, regulation of transcription from RNA polymerase II promoter in response to hypoxia, protein-containing complex assembly, regulation of cellular response to heat, beta-catenin-TCF complex assembly. |
| BIOGRID_INTERACTION_ID | 107777 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204405 204406 204407 204408 204409 |
| MONOCLONAL_ANTIBODY | Anti-CREBBP antibody for Human, Mouse. |