Record No:1
| ACCESS NO | D111223 |
| GENE_NAME | EP300 |
| DESCRIPTION | E1A binding protein p300 |
| ALIASES | KAT3B, MKHK2, RSTS2, p300. |
| NCBI_ENTREZ_NO | 2033 |
| UNIPROT_ACCESS_NO | Q09472 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Airway Epithelial Cells (AECs) |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | EP300 expression was down regulated in asthmatics as compared to healthy controls. |
| REFERENCE | 28137284 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II proximal promoter sequence-specific DNA binding, RNA polymerase II transcription factor binding, RNA polymerase II activating transcription factor binding, p53 binding, DNA binding, chromatin binding, damaged DNA binding, transcription coregulator activity, transcription coactivator activity, histone acetyltransferase activity, lysine N-acetyltransferase activity acting on acetyl phosphate as donor, protein binding, beta-catenin binding, protein C-terminus binding, transcription factor binding, zinc ion binding, acetyltransferase activity, transferase activity, transferase activity, transferring acyl groups, chromatin DNA binding, activating transcription factor binding, nuclear hormone receptor binding, metal ion binding, tau protein binding, androgen receptor binding, NF-kappaB binding, peptide-lysine-N-acetyltransferase activity, protein propionyltransferase activity, pre-mRNA intronic binding, STAT family protein binding, peptide butyryltransferase activity, histone crotonyltransferase activity, histone butyryltransferase activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, response to hypoxia, somitogenesis, thigmotaxis, behavioral defense response, stimulatory C-type lectin receptor signaling pathway, transcription-coupled nucleotide-excision repair, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, protein acetylation, internal protein amino acid acetylation, apoptotic process, DNA damage response (signal transduction by p53 class mediator resulting in cell cycle arrest), positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response, cell cycle, Notch signaling pathway, positive regulation of transcription of Notch receptor target, nervous system development, heart development, skeletal muscle tissue development, learning or memory, circadian rhythm, animal organ morphogenesis, regulation of autophagy, positive regulation of gene expression, macrophage derived foam cell differentiation, positive regulation of neuron projection development, viral process, histone acetylation, protein deubiquitination, N-terminal peptidyl-lysine acetylation, internal peptidyl-lysine acetylation, peptidyl-lysine acetylation, B cell differentiation, platelet formation, lung development, positive regulation of transforming growth factor beta receptor signaling pathway, negative regulation of protein complex assembly, protein destabilization, positive regulation of protein binding, positive regulation of type I interferon production, cellular response to UV, multicellular organism growth, megakaryocyte development, swimming, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, response to estrogen, positive regulation by host of viral transcription, histone H4 acetylation, histone H2B acetylation, fat cell differentiation, regulation of megakaryocyte differentiation, negative regulation of gluconeogenesis, positive regulation of Notch signaling pathway, positive regulation of gene expression (epigenetic), positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, rhythmic process, protein stabilization, positive regulation of DNA-binding transcription factor activity, regulation of cell cycle, face morphogenesis, regulation of androgen receptor signaling pathway, regulation of transcription from RNA polymerase II promoter in response to hypoxia, peptidyl-lysine propionylation, regulation of tubulin deacetylation, peptidyl-lysine crotonylation, peptidyl-lysine butyrylation, regulation of cellular response to heat, positive regulation of NIK/NF-kappaB signaling, regulation of signal transduction by p53 class mediator, beta-catenin-TCF complex assembly, positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding. |
| BIOGRID_INTERACTION_ID | 108347 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 206943 206944 206945 206946 206947 206948 206949 206950 206951 206952 |
| MONOCLONAL_ANTIBODY | Anti-KAT3B / p300 antibody for Human, Mouse, Rat. |