Record No:1
| ACCESS NO | D111889 |
| GENE_NAME | EZH2 |
| DESCRIPTION | Enhancer of zeste 2 polycomb repressive complex 2 subunit |
| ALIASES | ENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS, WVS2. |
| NCBI_ENTREZ_NO | 2146 |
| UNIPROT_ACCESS_NO | Q15910 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Peripheral Blood |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | EZH2 expression was significantly elevated in asthmatics as compared to healthy controls. |
| REFERENCE | 30282734 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), DNA binding, chromatin binding, transcription corepressor activity, RNA binding, protein binding, methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity, histone-lysine N-methyltransferase activity, chromatin DNA binding, histone methyltransferase activity, ribonucleoprotein complex binding, sequence-specific DNA binding, transcription regulatory region DNA binding, histone methyltransferase activity (H3-K27 specific), primary miRNA binding, promoter-specific chromatin binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, regulation of protein phosphorylation, DNA methylation, chromatin organization, chromatin silencing at telomere, regulation of DNA-templated transcription,, regulation of transcription by RNA polymerase II, positive regulation of cell proliferation, regulation of gene expression, negative regulation of gene expression, positive regulation of epithelial to mesenchymal transition, regulation of gliogenesis, skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration, cardiac muscle hypertrophy in response to stress, histone methylation, cerebellar cortex development, hippocampus development, methylation, response to estradiol, negative regulation of transcription elongation from RNA polymerase II promoter, histone lysine methylation, cellular response to trichostatin A, hepatocyte homeostasis, regulation of cell proliferation, regulation of circadian rhythm, positive regulation of MAP kinase activity, negative regulation of DNA-binding transcription factor activity, positive regulation of GTPase activity, negative regulation of epidermal cell differentiation, negative regulation of gene expression, epigenetic, negative regulation of transcription, DNA-templated, negative regulation of retinoic acid receptor signaling pathway, rhythmic process, regulation of neurogenesis, negative regulation of striated muscle cell differentiation, cellular response to hydrogen peroxide, G1 to G0 transition, negative regulation of G0 to G1 transition, histone H3-K27 methylation, protein localization to chromatin, positive regulation of protein serine/threonine kinase activity, liver regeneration, histone H3-K27 trimethylation, positive regulation of dendrite development, positive regulation of cell cycle G1/S phase transition, response to tetrachloromethane, negative regulation of G1/S transition of mitotic cell cycle. |
| BIOGRID_INTERACTION_ID | 108446 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 204240 204241 |
| MONOCLONAL_ANTIBODY | Anti-KMT6 / EZH2 antibody for Human, Rat, Mouse; Anti-KMT6 / EZH2 - N terminal antibody for Human, Rat, Mouse; Anti-KMT6 / EZH2 - C terminal antibody for Human, Mouse. |