Record No:1
| ACCESS NO | D112410 |
| GENE_NAME | miR-146a |
| DESCRIPTION | MicroRNA 146a |
| ALIASES | MIRN146, MIRN146A, MIR146A, miRNA146A. |
| NCBI_ENTREZ_NO | 406938 |
| UNIPROT_ACCESS_NO | - |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Serum |
| TECHNIQUES | qRT-PCR |
| OMICS | Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Circulating plasma concentrations of miR-146a were significantly elevated in asthmatic individuals compared to healthy controls. miR-146a levels were higher in asthmatics with worse disease control. Elevated blood miR-146a levels in asthmatics were associated with need for higher doses of ICS. |
| REFERENCE | 30300399 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | mRNA binding involved in posttranscriptional gene silencing. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of endothelial cell proliferation, positive regulation of gene expression, negative regulation of angiogenesis, gene silencing by miRNA, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of cell migration involved in sprouting angiogenesis, negative regulation of cell migration involved in sprouting angiogenesis, positive regulation of apoptotic process in bone marrow, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, positive regulation of cellular senescence. |
| BIOGRID_INTERACTION_ID | 135787 |
| SNP_ID | 300143 300839 |
| DRUG_ID | - |
| STRUCTURE_ID | - |
| MONOCLONAL_ANTIBODY | - |