Record No:1
| ACCESS NO | D112635 |
| GENE_NAME | IFNG |
| DESCRIPTION | Interferon gamma |
| ALIASES | IFG, IFI. |
| NCBI_ENTREZ_NO | 3458 |
| UNIPROT_ACCESS_NO | P01579 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | CD4 T cells from Broncho Alveolar Lavage Fluid (BALF) |
| TECHNIQUES | Flow Cytometry, ELISA, qRT-PCR |
| OMICS | Others, Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | IFNG expression was significantly decreased in asthmatic patients as compared to healthy subjects. |
| REFERENCE | 30227178 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, interferon-gamma receptor binding, protein binding. |
| GO_BIOLOGICAL_PROCESS | Protein import into nucleus ( translocation), negative regulation of transcription by RNA polymerase II, positive regulation of protein phosphorylation, adaptive immune response, apoptotic process, immune response, humoral immune response, cell cycle arrest, cell surface receptor signaling pathway, positive regulation of cell proliferation, response to virus, regulation of signaling receptor activity, positive regulation of autophagy, positive regulation of gene expression, negative regulation of gene expression, positive regulation of epithelial cell migration, regulation of protein ADP-ribosylation, negative regulation of epithelial cell differentiation, positive regulation of protein complex assembly, negative regulation of interleukin-17 production, positive regulation of interleukin-12 production, positive regulation of interleukin-23 production, positive regulation of CD4-positive and CD25-positive ( alpha-beta regulatory T cell differentiation involved in immune response), positive regulation of peptidyl-serine phosphorylation of STAT protein, positive regulation of protein import into nucleus ( translocation), positive regulation of smooth muscle cell apoptotic process, interleukin-12-mediated signaling pathway, regulation of growth, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of nitric oxide biosynthetic process, regulation of regulatory T cell differentiation, positive regulation of osteoclast differentiation, negative regulation of transcription, DNA-templated, negative regulation of smooth muscle cell proliferation, regulation of insulin secretion, positive regulation of membrane protein ectodomain proteolysis, defense response to virus, positive regulation of killing of cells of other organism, interferon-gamma-mediated signaling pathway, regulation of interferon-gamma-mediated signaling pathway, positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity, positive regulation of fructose 1,6-bisphosphate metabolic process, positive regulation of vitamin D biosynthetic process, positive regulation of calcidiol 1-monooxygenase activity, positive regulation of protein serine/threonine kinase activity, positive regulation of protein deacetylation, extrinsic apoptotic signaling pathway, positive regulation of protein localization to plasma membrane, positive regulation of exosomal secretion, positive regulation of core promoter binding, positive regulation of tumor necrosis factor (ligand) superfamily member 11 production. |
| BIOGRID_INTERACTION_ID | 109680 |
| SNP_ID | 300998 301006 301011 301007 |
| DRUG_ID | 4160 |
| STRUCTURE_ID | 201182 201183 201184 |
| MONOCLONAL_ANTIBODY | Anti-Interferon gamma antibody for Human, Rat, Mouse, Monkey, Cow, Macaque Monkey, Baboon, Sheep, Goat, Horse, Dog, Ferret, Pig, Zebrafish, Non human primates. |