Record No:1
| ACCESS NO | D112787 |
| GENE_NAME | NOTCH2 |
| DESCRIPTION | Neurogenic locus notch homolog protein 2 |
| ALIASES | AGS2, HJCYS, hN2. |
| NCBI_ENTREZ_NO | 4853 |
| UNIPROT_ACCESS_NO | Q04721 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Severe Asthma |
| SAMPLE | Epithelial Brushings |
| TECHNIQUES | Microarray |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE64913 |
| COMMENTS | NOTCH2 was significantly down regulated in peripheral airways of severe asthmatics as compared to healthy subjects. |
| REFERENCE | 28045928 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Calcium ion binding, protein binding, signaling receptor activity. |
| GO_BIOLOGICAL_PROCESS | Cell fate determination, marginal zone B cell differentiation, pulmonary valve morphogenesis, regulation of DNA-templated transcription, transcription initiation from RNA polymerase II promoter, apoptotic process, cell cycle arrest, Notch signaling pathway, multicellular organism development, nervous system development, animal organ morphogenesis, negative regulation of gene expression, positive regulation of keratinocyte proliferation, stem cell population maintenance, hemopoiesis, cell differentiation, negative regulation of apoptotic process, negative regulation of growth rate, positive regulation of Ras protein signal transduction, bone remodeling, regulation of developmental process, atrial septum morphogenesis, Notch signaling involved in heart development, positive regulation of ERK1 and ERK2 cascade, regulation of actin cytoskeleton reorganization, regulation of osteoclast development. |
| BIOGRID_INTERACTION_ID | 110915 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 203849 203850 |
| MONOCLONAL_ANTIBODY | Anti-Notch2 antibody for Human. |