Record No:1
| ACCESS NO | D112881 |
| GENE_NAME | TSLP |
| DESCRIPTION | Thymic stromal lymphopoietin |
| ALIASES | - |
| NCBI_ENTREZ_NO | 85480 |
| UNIPROT_ACCESS_NO | Q969D9 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma, Allergic Rhinitis |
| SAMPLE | Serum |
| TECHNIQUES | ELISA, qRT-PCR |
| OMICS | Others, Genomics |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | Level of TSLP in asthma and rhinitis patients and in those complicated with allergic rhinitis was significantly increased as compared with the control group. TSLP may be involved in the pathogenesis of asthma and rhinitis. Dust mite and mugwort allergy could increase its level significantly. |
| REFERENCE | 28303765 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, interleukin-7 receptor binding. |
| GO_BIOLOGICAL_PROCESS | Positive regulation of cytokine-mediated signaling pathway, positive regulation of cell proliferation, regulation of signaling receptor activity, positive regulation of chemokine production, positive regulation of interleukin-10 production, positive regulation of interleukin-13 production, positive regulation of interleukin-5 production, positive regulation of interleukin-6 production, positive regulation of mast cell activation, interleukin-7-mediated signaling pathway, positive regulation of tyrosine phosphorylation of STAT protein, negative regulation of apoptotic process, positive regulation of inflammatory response, positive regulation of chemokine (C-C motif) ligand 1 production, positive regulation of granulocyte colony-stimulating factor production, positive regulation of STAT cascade, positive regulation of interleukin-5 secretion. |
| BIOGRID_INTERACTION_ID | 124555 |
| SNP_ID | 300087 300088 300213 300927 300802 300877 301048 301049 300751 300689 |
| DRUG_ID | 4124 |
| STRUCTURE_ID | 202588 |
| MONOCLONAL_ANTIBODY | - |