Record No:1
| ACCESS NO | D113739 |
| GENE_NAME | SPP1 |
| DESCRIPTION | Secreted phosphoprotein 1 |
| ALIASES | BNSP, BSPI, ETA-1, OPN. |
| NCBI_ENTREZ_NO | 6696 |
| UNIPROT_ACCESS_NO | P10451 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Airway Epithelial Cell Brushings |
| TECHNIQUES | Microarray |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE113185 |
| COMMENTS | SPP1 was increased in IL-6TS High asthma patients characterized by frequent exacerbations, eosinophilic airway inflammation and increased numbers of T cells and macrophages infiltrating the airway submucosa. |
| REFERENCE | 29902480 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, protein binding, extracellular matrix binding. |
| GO_BIOLOGICAL_PROCESS | Osteoblast differentiation, androgen catabolic process, inflammatory response, cell adhesion, embryo implantation, response to organic substance, regulation of signaling receptor activity, extracellular matrix disassembly, cell differentiation, extracellular matrix organization, biomineral tissue development, response to vitamin D, post-translational protein modification, cellular protein metabolic process, positive regulation of bone resorption, positive regulation of DNA-templated transcription, decidualization, response to steroid hormone, negative regulation of collateral sprouting of intact axon in response to injury, cellular response to testosterone stimulus, positive regulation of estradiol secretion. |
| BIOGRID_INTERACTION_ID | 112574 |
| SNP_ID | 300984 300985 300986 |
| DRUG_ID | - |
| STRUCTURE_ID | 201042 |
| MONOCLONAL_ANTIBODY | Anti-Osteopontin antibody for Human, Mouse. |