Record No:1
| ACCESS NO | D113741 |
| GENE_NAME | SOCS3 |
| DESCRIPTION | Suppressor of cytokine signaling 3 |
| ALIASES | ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3. |
| NCBI_ENTREZ_NO | 9021 |
| UNIPROT_ACCESS_NO | O14543 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Airway Epithelial Cell Brushings |
| TECHNIQUES | Microarray |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE113185 |
| COMMENTS | The IL-6TS High subset (characterized by frequent exacerbations, eosinophilic airway inflammation and increased numbers of T cells and macrophages infiltrating the airway submucosa) did show a robust increase in the expression of SOCS3 as compared to IL-6TS Low and healthy controls. |
| REFERENCE | 29902480 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Phosphotyrosine residue binding, protein kinase inhibitor activity, protein binding. |
| GO_BIOLOGICAL_PROCESS | Regulation of protein phosphorylation, negative regulation of protein kinase activity, JAK-STAT cascade, negative regulation of signal transduction, protein ubiquitination, cytokine-mediated signaling pathway, intracellular signal transduction, regulation of growth, positive regulation of tyrosine phosphorylation of STAT protein, negative regulation of tyrosine phosphorylation of STAT protein, negative regulation of apoptotic process, post-translational protein modification, regulation of cell differentiation, positive regulation of cell differentiation, negative regulation of JAK-STAT cascade, negative regulation of insulin receptor signaling pathway, negative regulation of inflammatory response, regulation of interferon-gamma-mediated signaling pathway, branching involved in labyrinthine layer morphogenesis, placenta blood vessel development, trophoblast giant cell differentiation, spongiotrophoblast differentiation, interleukin-6-mediated signaling pathway, cellular response to leukemia inhibitory factor. |
| BIOGRID_INTERACTION_ID | 114488 |
| SNP_ID | 300969 300970 300971 |
| DRUG_ID | - |
| STRUCTURE_ID | 200519 |
| MONOCLONAL_ANTIBODY | Anti-SOCS3 antibody for Rat, Human. |