Record No:1
| ACCESS NO | D113748 |
| GENE_NAME | TLR2 |
| DESCRIPTION | Toll-like receptor 2 |
| ALIASES | CD282, TIL4. |
| NCBI_ENTREZ_NO | 7097 |
| UNIPROT_ACCESS_NO | O60603 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Airway Epithelial Cell Brushings |
| TECHNIQUES | Microarray |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE113185 |
| COMMENTS | TLR2 expression was increased in IL-6TS High asthma patients characterized by frequent exacerbations, eosinophilic airway inflammation and increased numbers of T cells and macrophages infiltrating the airway submucosa. |
| REFERENCE | 29902480 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Lipopolysaccharide binding, lipopolysaccharide receptor activity, protein binding, signaling pattern recognition receptor activity, Toll-like receptor binding, signaling receptor activity, triacyl lipopeptide binding, peptidoglycan binding, protein-containing complex binding, protein heterodimerization activity, lipopeptide binding. |
| GO_BIOLOGICAL_PROCESS | Response to hypoxia, microglial cell activation, cell activation, toll-like receptor signaling pathway, response to molecule of bacterial origin, cytokine secretion involved in immune response, immune system process, MyD88-dependent toll-like receptor signaling pathway, leukotriene metabolic process, apoptotic process, inflammatory response, immune response, signal transduction, I-kappaB phosphorylation, learning, negative regulation of cell proliferation, response to toxic substance, positive regulation of gene expression, microglia development, positive regulation of Wnt signaling pathway, lipopolysaccharide-mediated signaling pathway, central nervous system myelin formation, response to bacterial lipoprotein, response to lipopolysaccharide, response to progesterone, interleukin-10 production, tumor necrosis factor production, positive regulation of chemokine production, positive regulation of interferon-beta production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-18 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of tumor necrosis factor production, response to insulin, positive regulation of toll-like receptor signaling pathway, toll-like receptor 2 signaling pathway, toll-like receptor TLR1:TLR2 signaling pathway, toll-like receptor TLR6:TLR2 signaling pathway, detection of triacyl bacterial lipopeptide, detection of diacyl bacterial lipopeptide, neutrophil degranulation, innate immune response, positive regulation of transcription by RNA polymerase II, nitric oxide metabolic process, positive regulation of oligodendrocyte differentiation, regulation of cytokine secretion, positive regulation of inflammatory response, negative regulation of phagocytosis, defense response to Gram-positive bacterium, positive regulation of NF-kappaB transcription factor activity, positive regulation of nitric-oxide synthase biosynthetic process, negative regulation of synapse assembly, response to fatty acid, cellular response to bacterial lipopeptide, cellular response to lipoteichoic acid, cellular response to diacyl bacterial lipopeptide, cellular response to triacyl bacterial lipopeptide, positive regulation of NIK/NF-kappaB signaling, positive regulation of interleukin-8 secretion. |
| BIOGRID_INTERACTION_ID | 112952 |
| SNP_ID | 300141 300226 300988 301030 300533 300589 |
| DRUG_ID | 4177 |
| STRUCTURE_ID | 200189 |
| MONOCLONAL_ANTIBODY | Anti-TLR2 antibody for Mouse, Rat, Human, Dog, Cynomolgus monkey, Rhesus monkey, Common marmoset. |