Record No:1
| ACCESS NO | D113844 |
| GENE_NAME | HPN |
| DESCRIPTION | Hepsin |
| ALIASES | TMPRSS1. |
| NCBI_ENTREZ_NO | 3249 |
| UNIPROT_ACCESS_NO | P05981 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Severe Asthma |
| SAMPLE | Airway Epithelial Cells (AECs) |
| TECHNIQUES | Microarray |
| OMICS | Transcriptomics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE63142, GSE67472 |
| COMMENTS | HPN was down regulated in severe asthma. HPN had the highest positive correlation with Asthma Quality of Life Questionnaire (AQLQ) scores (a lower AQLQ relates to increased symptoms), FEV1% predicted and the highest negative association with CRS, use of Inhaled Corticosteroid and Oral Corticosteroid. |
| REFERENCE | 27984699 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Serine-type endopeptidase activity, protein binding, peptidase activity, serine-type peptidase activity, calcium-activated potassium channel activity, hydrolase activity, serine-type exopeptidase activity. |
| GO_BIOLOGICAL_PROCESS | Proteolysis, regulation of cell shape, positive regulation of gene expression, negative regulation of epithelial to mesenchymal transition, positive regulation of plasminogen activation, positive regulation of cell growth, basement membrane disassembly, negative regulation of apoptotic process, positive regulation by host of viral transcription, hepatocyte growth factor receptor signaling pathway, negative regulation of epithelial cell proliferation, detection of mechanical stimulus involved in sensory perception of sound, potassium ion transmembrane transport, cochlea morphogenesis, response to thyroid hormone, pilomotor reflex, positive regulation of hepatocyte proliferation, positive regulation of thyroid hormone generation. |
| BIOGRID_INTERACTION_ID | 109486 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 205157 205158 205159 205160 |
| MONOCLONAL_ANTIBODY | Anti-Hepsin/HPN antibody for Human, Mouse, Rat. |