Record No:1
| ACCESS NO | D114044 |
| GENE_NAME | PSMD2 |
| DESCRIPTION | Proteasome 26S subunit, non-ATPase 2 |
| ALIASES | P97, RPN1, S2, TRAP2. |
| NCBI_ENTREZ_NO | 5708 |
| UNIPROT_ACCESS_NO | Q13200 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Bronchial Epithelial Cells (BECs) |
| TECHNIQUES | RNA Sequencing, qRT-PCR |
| OMICS | Transcriptomics, Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | GSE85216, GSE85215, GSE85214 |
| COMMENTS | PSMD2 was significantly increased in severe asthmatics as compared to control subjects. |
| REFERENCE | 29769273 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Contributes to endopeptidase activity, protein binding, enzyme regulator activity. |
| GO_BIOLOGICAL_PROCESS | MAPK cascade, protein polyubiquitination, stimulatory C-type lectin receptor signaling pathway, antigen processing and presentation of exogenous peptide antigen via MHC class I (TAP-dependent), regulation of cellular amino acid metabolic process, negative regulation of G2/M transition of mitotic cell cycle, protein deubiquitination, anaphase-promoting complex-dependent catabolic process, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, tumor necrosis factor-mediated signaling pathway, NIK/NF-kappaB signaling, Fc-epsilon receptor signaling pathway, regulation of protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, neutrophil degranulation, regulation of mRNA stability, post-translational protein modification, regulation of catalytic activity, T cell receptor signaling pathway, transmembrane transport, Wnt signaling pathway (planar cell polarity pathway), regulation of transcription from RNA polymerase II promoter in response to hypoxia, interleukin-1-mediated signaling pathway, negative regulation of canonical Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, regulation of mitotic cell cycle phase transition, regulation of hematopoietic stem cell differentiation. |
| BIOGRID_INTERACTION_ID | 111681 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 205020 205021 205022 205023 205024 205025 205026 205027 205028 205029 205030 205031 205032 205033 |
| MONOCLONAL_ANTIBODY | - |