Record No:1
| ACCESS NO | D114048 |
| GENE_NAME | SPARC |
| DESCRIPTION | Secreted protein cysteine-rich (osteonectin) |
| ALIASES | BM-40, OI17, ON. |
| NCBI_ENTREZ_NO | 6678 |
| UNIPROT_ACCESS_NO | P09486 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Bronchial Epithelial Cells (BECs) |
| TECHNIQUES | RNA Sequencing, qRT-PCR |
| OMICS | Transcriptomics, Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | GSE85216, GSE85215, GSE85214 |
| COMMENTS | SPARC was significantly increased in severe asthmatics as compared to control subjects. |
| REFERENCE | 29769273 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Calcium ion binding, protein binding, collagen binding, metal ion binding, extracellular matrix binding. |
| GO_BIOLOGICAL_PROCESS | Ossification, negative regulation of endothelial cell proliferation, platelet degranulation, receptor-mediated endocytosis, signal transduction, heart development, response to gravity, response to lead ion, positive regulation of endothelial cell migration, negative regulation of angiogenesis, regulation of cell morphogenesis, extracellular matrix organization, lung development, response to lipopolysaccharide, response to L-ascorbic acid, response to cytokine, wound healing, regulation of cell proliferation, response to peptide hormone, pigmentation, response to ethanol, response to cadmium ion, inner ear development, anatomical structure development, response to glucocorticoid, response to cAMP, response to calcium ion, bone development, cellular response to growth factor stimulus. |
| BIOGRID_INTERACTION_ID | 112560 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 200222 200223 200224 |
| MONOCLONAL_ANTIBODY | Anti-SPARC antibody for Human, Mouse. |