Record No:1
| ACCESS NO | D114112 |
| GENE_NAME | PLAU |
| DESCRIPTION | Plasminogen activator, urokinase |
| ALIASES | ATF, BDPLT5, QPD, UPA, URK, u-PA. |
| NCBI_ENTREZ_NO | 5328 |
| UNIPROT_ACCESS_NO | P00749 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Bronchial Epithelial Cells (BECs) |
| TECHNIQUES | RNA Sequencing, qRT-PCR |
| OMICS | Transcriptomics, Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | GSE85216, GSE85215, GSE85214 |
| COMMENTS | PLAU was significantly increased in severe asthmatics as compared to control subjects. |
| REFERENCE | 29769273 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Serine-type endopeptidase activity, protein binding, peptidase activity, serine-type peptidase activity, hydrolase activity. |
| GO_BIOLOGICAL_PROCESS | Response to hypoxia, proteolysis, chemotaxis, signal transduction, blood coagulation, hemostasis, regulation of signaling receptor activity, smooth muscle cell migration, regulation of smooth muscle cell migration, positive regulation of cell migration, plasminogen activation, regulation of cell adhesion mediated by integrin, regulation of cell proliferation, fibrinolysis, neutrophil degranulation, regulation of wound healing, regulation of smooth muscle cell-matrix adhesion. |
| BIOGRID_INTERACTION_ID | 111344 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 202267 202268 202269 202270 202271 202272 202273 202274 202275 |
| MONOCLONAL_ANTIBODY | Anti-uPA antibody for Human; Anti-Urokinase antibody for Mouse, Human, Rat. |