Record No:1
| ACCESS NO | D114160 |
| GENE_NAME | TNF |
| DESCRIPTION | Tumor necrosis factor |
| ALIASES | DIF-alpha, TNFA, TNFSF2, TNLG1F, TNFα . |
| NCBI_ENTREZ_NO | 7124 |
| UNIPROT_ACCESS_NO | P01375 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Bronchial Epithelial Cells (BECs) |
| TECHNIQUES | RNA Sequencing, qRT-PCR |
| OMICS | Transcriptomics, Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | GSE85216, GSE85215, GSE85214 |
| COMMENTS | TNF was significantly increased in severe asthmatics as compared to control subjects. |
| REFERENCE | 29769273 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Protease binding, cytokine activity, tumor necrosis factor receptor binding, protein binding, identical protein binding, transcription regulatory region DNA binding. |
| GO_BIOLOGICAL_PROCESS | Protein import into nucleus, translocation, negative regulation of transcription by RNA polymerase II, MAPK cascade, activation of MAPKKK activity, activation of MAPK activity, positive regulation of cytokine production, regulation of protein phosphorylation, positive regulation of protein phosphorylation, negative regulation of endothelial cell proliferation, chronic inflammatory response to antigenic stimulus, negative regulation of cytokine secretion involved in immune response, positive regulation of chronic inflammatory response to antigenic stimulus, positive regulation of humoral immune response mediated by circulating immunoglobulin, glucose metabolic process, activation of cysteine-type endopeptidase activity involved in apoptotic process, defense response, inflammatory response, immune response, humoral immune response, I-kappaB kinase/NF-kappaB signaling, JNK cascade, multicellular organism development, extrinsic apoptotic signaling pathway via death domain receptors, intrinsic apoptotic signaling pathway in response to DNA damage, response to virus, response to salt stress, animal organ morphogenesis, response to organic substance, regulation of signaling receptor activity, positive regulation of gene expression, negative regulation of gene expression, negative regulation of alkaline phosphatase activity, regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of lipid storage, cytokine-mediated signaling pathway, extracellular matrix organization, osteoclast differentiation, sequestering of triglyceride, cortical actin cytoskeleton organization, positive regulation of protein complex assembly, positive regulation of fever generation, lipopolysaccharide-mediated signaling pathway, negative regulation of interleukin-6 production, positive regulation of chemokine production, positive regulation of interferon-gamma production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, receptor biosynthetic process, positive regulation of peptidyl-serine phosphorylation, tumor necrosis factor-mediated signaling pathway, positive regulation of heterotypic cell-cell adhesion, negative regulation of myosin-light-chain-phosphatase activity, regulation of cell proliferation, defense response to bacterium, positive regulation of apoptotic process, positive regulation of programmed cell death, regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of I-kappaB kinase/NF-kappaB signaling, negative regulation of protein complex disassembly, positive regulation of protein complex disassembly, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of MAP kinase activity, protein kinase B signaling, positive regulation of JUN kinase activity, negative regulation of growth of symbiont in host, negative regulation of viral genome replication, positive regulation of chemokine biosynthetic process, cellular extravasation, positive regulation of interleukin-8 biosynthetic process, positive regulation of nitric oxide biosynthetic process, negative regulation of fat cell differentiation, negative regulation of myoblast differentiation, negative regulation of osteoblast differentiation, regulation of osteoclast differentiation, positive regulation of osteoclast differentiation, positive regulation of protein catabolic process, positive regulation of cell adhesion, positive regulation of protein kinase activity, negative regulation of transcription, DNA-templated, positive regulation of transcription, DNA-templated, negative regulation of mitotic cell cycle, positive regulation of transcription by RNA polymerase II, positive regulation of translational initiation by iron, negative regulation of glucose import, positive regulation of JNK cascade, embryonic digestive tract development, positive regulation of smooth muscle cell proliferation, regulation of protein secretion, positive regulation of cytokine secretion, regulation of inflammatory response, positive regulation of phagocytosis, regulation of insulin secretion, defense response to Gram-positive bacterium, leukocyte migration, leukocyte tethering or rolling, negative regulation of lipid catabolic process, regulation of immunoglobulin secretion, positive regulation of membrane protein ectodomain proteolysis, positive regulation of DNA binding transcription factor activity, positive regulation of NF-kappaB transcription factor activity, positive regulation of protein transport, response to glucocorticoid, positive regulation of hair follicle development, positive regulation of protein kinase B signaling, positive regulation of vitamin D biosynthetic process, positive regulation of calcidiol 1-monooxygenase activity, epithelial cell proliferation involved in salivary gland morphogenesis, regulation of branching involved in salivary gland morphogenesis, negative regulation of branching involved in lung morphogenesis, positive regulation of ERK1 and ERK2 cascade, positive regulation of calcineurin-NFAT signaling cascade, cellular response to lipopolysaccharide, cellular response to amino acid stimulus, cellular response to nicotine, cellular response to organic cyclic compound, death-inducing signaling complex assembly, positive regulation of mononuclear cell migration, positive regulation of podosome assembly, endothelial cell apoptotic process, protein localization to plasma membrane, apoptotic signaling pathway, extrinsic apoptotic signaling pathway, necroptotic signaling pathway, positive regulation of NIK/NF-kappaB signaling, positive regulation of superoxide dismutase activity, regulation of establishment of endothelial barrier, negative regulation of bicellular tight junction assembly, positive regulation of vascular smooth muscle cell proliferation, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of leukocyte adhesion to arterial endothelial cell, positive regulation of protein localization to cell surface, positive regulation of ceramide biosynthetic process, positive regulation of blood microparticle formation, positive regulation of chemokine (C-X-C motif) ligand 2 production, regulation of reactive oxygen species metabolic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. |
| BIOGRID_INTERACTION_ID | 204240 |
| SNP_ID | 300071 300082 300083 300084 300085 300640 300641 300838 300538 300086 300932 300991 300994 300995 300996 300997 301005 301008 301014 301028 301053 301178 301179 300094 |
| DRUG_ID | 4070 4071 4072 4073 4074 4075 4076 |
| STRUCTURE_ID | 201647 201648 |
| MONOCLONAL_ANTIBODY | Anti-TNF alpha antibody for Mouse, Rat, Cat, Dog, Guinea pig, Human, Chimpanzee, Zebrafish, Cynomolgus monkey, Rhesus monkey, Apteronotus leptorhynchus. |