Record No:1
| ACCESS NO | D114174 |
| GENE_NAME | ATF6B |
| DESCRIPTION | Activating transcription factor 6 beta |
| ALIASES | CREB-RP, CREBL1, G13. |
| NCBI_ENTREZ_NO | 1388 |
| UNIPROT_ACCESS_NO | Q99941 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Asthma |
| SAMPLE | Bronchial Epithelial Cells (BECs) |
| TECHNIQUES | RNA Sequencing, qRT-PCR |
| OMICS | Transcriptomics, Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | GSE85216, GSE85215, GSE85214 |
| COMMENTS | ATF6B was significantly decreased in severe asthmatics as compared to control subjects. |
| REFERENCE | 29769273 |
| IMMUNITY_TERM | No |
| GO_MOLECULAR_FUNCTION | Contributes to RNA polymerase II distal enhancer sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), contributes to DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, DNA-binding transcription factor activity, protein binding, cAMP response element binding, transcription regulatory region DNA binding. |
| GO_BIOLOGICAL_PROCESS | DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to unfolded protein, signal transduction, endoplasmic reticulum unfolded protein response, ATF6-mediated unfolded protein response, positive regulation of transcription by RNA polymerase II, negative regulation of ATF6-mediated unfolded protein response, positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. |
| BIOGRID_INTERACTION_ID | 107778 |
| SNP_ID | 300863 300864 |
| DRUG_ID | - |
| STRUCTURE_ID | 204792 |
| MONOCLONAL_ANTIBODY | - |