Record No:1
| ACCESS NO | D114266 |
| GENE_NAME | STAT1 |
| DESCRIPTION | Signal transducer and activator of transcription 1 |
| ALIASES | CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91. |
| NCBI_ENTREZ_NO | 6772 |
| UNIPROT_ACCESS_NO | P42224 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Rhinitis |
| SAMPLE | Nasal Epithelial Tissues |
| TECHNIQUES | Microarray Data Analysis |
| OMICS | Genomics, Bioinformatics |
| STUDY | High Throughput |
| GEO_PRIDE_ACCESS_NO | GSE51392, GSE19187, GSE44037 |
| COMMENTS | STAT1 was down-regulated in allergic rhinitis. STAT1 may be involved in the pathogenesis of Allergic Rhinitis. |
| REFERENCE | 30368403 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity ( sequence-specific DNA binding), transcription factor activity ( RNA polymerase II proximal promoter sequence-specific DNA binding), transcription factor activity ( RNA polymerase II core promoter sequence-specific DNA binding), core promoter binding, DNA binding, double-stranded DNA binding, DNA binding transcription factor activity, obsolete signal transducer activity, tumor necrosis factor receptor binding, protein binding, enzyme binding, CCR5 chemokine receptor binding, histone acetyltransferase binding, nuclear hormone receptor binding, histone binding, identical protein binding, protein homodimerization activity, sequence-specific DNA binding, ubiquitin-like protein ligase binding, cadherin binding, protein phosphatase 2A binding, repressing transcription factor binding, promoter-specific chromatin binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, negative regulation of endothelial cell proliferation, positive regulation of mesenchymal cell proliferation, positive regulation of defense response to virus by host, negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, DNA-templated transcription, regulation of DNA-templated transcription, signal transduction, positive regulation of transcription of Notch receptor target, JAK-STAT cascade, response to nutrient, blood circulation, positive regulation of cell proliferation, response to mechanical stimulus, macrophage derived foam cell differentiation, response to organic cyclic compound, viral process, negative regulation of angiogenesis, cytokine-mediated signaling pathway, positive regulation of interferon-alpha production, cellular response to insulin stimulus, tumor necrosis factor-mediated signaling pathway, response to cytokine, response to interferon-beta, cellular response to interferon-beta, interleukin-21-mediated signaling pathway, response to drug, response to hydrogen peroxide, regulation of apoptotic process, negative regulation of I-kappaB kinase/NF-kappaB signaling, response to peptide hormone, NOTÂ endothelial cell migration, positive regulation of erythrocyte differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, negative regulation by virus of viral protein levels in host cell, positive regulation of smooth muscle cell proliferation, response to cAMP, defense response to virus, positive regulation of nitric-oxide synthase biosynthetic process, interferon-gamma-mediated signaling pathway, regulation of interferon-gamma-mediated signaling pathway, type I interferon signaling pathway, regulation of type I interferon-mediated signaling pathway, renal tubule development, interleukin-6-mediated signaling pathway, interleukin-27-mediated signaling pathway, interleukin-35-mediated signaling pathway, cellular response to cytokine stimulus, cellular response to interferon-gamma, cellular response to organic cyclic compound, metanephric mesenchymal cell proliferation involved in metanephros development, metanephric mesenchymal cell differentiation, negative regulation of metanephric nephron tubule epithelial cell differentiation. |
| BIOGRID_INTERACTION_ID | 112649 |
| SNP_ID | 300855 |
| DRUG_ID | - |
| STRUCTURE_ID | 202207 202208 |
| MONOCLONAL_ANTIBODY | Anti-STAT1 (phospho S727) antibody for Mouse, Rat, Human; Anti-STAT1 (phospho Y701) antibody for Mouse, Human; Anti-STAT1 antibody for Mouse, Human, Non human primates, Dog, Monkey. |