Record No:1
| ACCESS NO | D114280 |
| GENE_NAME | hsa-miR-21 |
| DESCRIPTION | MicroRNA 21 |
| ALIASES | MIRN21, hsa-mir-21, MIR21, miR-21, miRNA21. |
| NCBI_ENTREZ_NO | 406991 |
| UNIPROT_ACCESS_NO | - |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Contact Dermatitis (Diphenylcyclopropenone (DPCP)-sensitized subjects) |
| SAMPLE | Skin Biopsies |
| TECHNIQUES | Microarray, qRT-PCR |
| OMICS | Genomics |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | hsa-miR-21 was significantly upregulated in patients with allergic contact dermatitis as compared to healthy subjects. |
| REFERENCE | 22594804 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | mRNA 3-UTR binding, mRNA binding involved in posttranscriptional gene silencing. |
| GO_BIOLOGICAL_PROCESS | Positive regulation of protein phosphorylation, negative regulation of endothelial cell proliferation, transforming growth factor beta receptor signaling pathway, embryo implantation, positive regulation of cell proliferation, negative regulation of cell proliferation, regulation of cell shape, positive regulation of endothelial cell migration, negative regulation of endothelial cell migration, positive regulation of cardiac muscle hypertrophy, negative regulation of cardiac muscle hypertrophy, positive regulation of gene expression, negative regulation of gene expression, negative regulation of cardiac muscle cell apoptotic process, positive regulation of epithelial to mesenchymal transition, positive regulation of keratinocyte proliferation, positive regulation of phosphatidylinositol 3-kinase signaling, negative regulation of angiogenesis, regulation of cell migration, positive regulation of cell migration, negative regulation of cell migration, BMP signaling pathway, positive regulation of cell projection organization, activation of protein kinase B activity, negative regulation of type I interferon production, collagen metabolic process, negative regulation of GTPase activity, negative regulation of smooth muscle cell apoptotic process, gene silencing by miRNA, miRNA mediated inhibition of translation, phenotypic switching, regulation of epidermal growth factor receptor signaling pathway, positive regulation of activated T cell proliferation, positive regulation of apoptotic process, negative regulation of apoptotic process, negative regulation of regulatory T cell differentiation, positive regulation of fat cell differentiation, positive regulation of endothelial cell differentiation, positive regulation of osteoblast differentiation, positive regulation of angiogenesis, negative regulation of innate immune response, positive regulation of inflammatory response, negative regulation of stress fiber assembly, regulation of protein kinase B signaling, positive regulation of protein kinase B signaling, negative regulation of type I interferon-mediated signaling pathway, epithelial to mesenchymal transition involved in cardiac fibroblast development, negative regulation of cartilage development, endothelial tube morphogenesis, negative regulation of ERK1 and ERK2 cascade, positive regulation of ERK1 and ERK2 cascade, cellular response to lipopolysaccharide, positive regulation of inflammatory response to wounding, positive regulation of cytokine production involved in inflammatory response, positive regulation of cellular response to hypoxia, negative regulation of arginine catabolic process, negative regulation of NIK/NF-kappaB signaling, negative regulation of hydrogen peroxide-mediated programmed cell death, negative regulation of superoxide dismutase activity, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of potassium ion export, regulation of signal transduction involved in mitotic G2 DNA damage checkpoint, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, negative regulation of chondrocyte proliferation, negative regulation of reactive oxygen species biosynthetic process, cellular response to resveratrol, positive regulation of metalloendopeptidase activity, positive regulation of vascular smooth muscle contraction, positive regulation of vascular smooth muscle cell proliferation, positive regulation of replicative senescence, negative regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell migration, positive regulation of myofibroblast differentiation, negative regulation of hydrogen sulfide biosynthetic process, negative regulation of aortic smooth muscle cell differentiation, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of vascular smooth muscle cell differentiation, negative regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular endothelial cell proliferation, negative regulation of endothelial tube morphogenesis, negative regulation of G1/S transition of mitotic cell cycle, positive regulation of T-helper 17 type immune response, positive regulation of T-helper 17 cell differentiation, regulation of reactive oxygen species metabolic process. |
| BIOGRID_INTERACTION_ID | 135840 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | - |
| MONOCLONAL_ANTIBODY | - |