Record No:1
| ACCESS NO | D114326 |
| GENE_NAME | HMGB1 |
| DESCRIPTION | High mobility group box 1 |
| ALIASES | HMG-1, HMG1, HMG3, SBP-1. |
| NCBI_ENTREZ_NO | 3146 |
| UNIPROT_ACCESS_NO | P09429 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Rhinitis |
| SAMPLE | Nasal Lavage Fluid |
| TECHNIQUES | ELISA |
| OMICS | Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | The level of HMGB1 was significantly increased in nasal fluids of patients with allergic rhinitis, patients with NARES (nonallergic rhinitis with eosinophiliac syndrome), as well as patients with polyps as compared to healthy subjects. |
| REFERENCE | 26045910 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Four-way junction DNA binding, bubble DNA binding, lipopolysaccharide binding, phosphatidylserine binding, DNA binding, chromatin binding, damaged DNA binding, double-stranded DNA binding, single-stranded DNA binding, DNA binding transcription factor activity, RNA binding, double-stranded RNA binding, single-stranded RNA binding, cytokine activity, integrin binding, protein binding, transcription factor binding, DNA binding ( bending), calcium-dependent protein kinase regulator activity, lyase activity, C-X-C chemokine binding, protein kinase activator activity, chemoattractant activity, RAGE receptor binding, DNA polymerase binding, repressing transcription factor binding, supercoiled DNA binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, eye development, myeloid dendritic cell activation, positive regulation of protein phosphorylation, endothelial cell proliferation, activation of innate immune response, toll-like receptor signaling pathway, adaptive immune response, plasmacytoid dendritic cell activation, macrophage activation involved in immune response, immune system process, dendritic cell chemotaxis, inflammatory response to antigenic stimulus, regulation of tolerance induction, regulation of T cell mediated immune response to tumor cell, DNA topological change, DNA repair, base-excision repair, apoptotic DNA fragmentation, DNA recombination, chromatin remodeling, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, autophagy, chemotaxis, inflammatory response, cellular response to DNA damage stimulus, positive regulation of cytosolic calcium ion concentration, regulation of signaling receptor activity, regulation of autophagy, negative regulation of RNA polymerase II transcriptional preinitiation complex assembly, lung development, neuron projection development, chromatin assembly, regulation of restriction endodeoxyribonuclease activity, activation of protein kinase activity, DNA geometric change, positive regulation of mismatch repair, negative regulation of interferon-gamma production, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, V(D)J recombination, positive regulation of toll-like receptor 2 signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of toll-like receptor 9 signaling pathway, T-helper 1 cell activation, endothelial cell chemotaxis, positive regulation of activated T cell proliferation, positive regulation of apoptotic process, apoptotic cell clearance, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, neutrophil degranulation, negative regulation of CD4-positive, alpha-beta T cell differentiation, positive regulation of DNA binding, positive regulation of MAPK cascade, positive regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell migration, T-helper 1 cell differentiation, innate immune response, positive regulation of innate immune response, positive regulation of myeloid cell differentiation, positive regulation of glycogen catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, positive regulation of interleukin-1 secretion, positive regulation of interleukin-1 beta secretion, positive chemotaxis, DNA ligation involved in DNA repair, positive regulation of DNA ligation, response to glucocorticoid, positive regulation of ERK1 and ERK2 cascade, positive regulation of monocyte chemotactic protein-1 production, positive regulation of monocyte chemotaxis, positive regulation of wound healing, neutrophil clearance, positive regulation of NIK/NF-kappaB signaling, positive regulation of sprouting angiogenesis, positive regulation of vascular endothelial cell proliferation, tumor necrosis factor secretion, negative regulation of apoptotic cell clearance, positive regulation of interleukin-6 secretion, regulation of nucleotide-excision repair, positive regulation of dendritic cell differentiation. |
| BIOGRID_INTERACTION_ID | 109389 |
| SNP_ID | - |
| DRUG_ID | - |
| STRUCTURE_ID | 201977 201978 |
| MONOCLONAL_ANTIBODY | Anti-HMGB1 antibody for Mouse, Rat, Human, Hamster, Cow, Pig, Dog, Chicken. |