Record No:1
| ACCESS NO | D114367 |
| GENE_NAME | VEGFA |
| DESCRIPTION | Vascular endothelial growth factor A |
| ALIASES | MVCD1, VEGF, VPF. |
| NCBI_ENTREZ_NO | 7422 |
| UNIPROT_ACCESS_NO | P15692 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Seasonal Allergic Rhinitis |
| SAMPLE | Nasal Biopsy, Nasal Fluid |
| TECHNIQUES | Microarray, ELISA |
| OMICS | Genomics, Others |
| STUDY | High Throughput, Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | VEGFA was up regulated in allergic rhinitis patients as compared to healthy controls. VEGFA level in nasal fluid was found to increase upon allergen challenge. Oligonucleotide microarray analysis of nasal biopsies and protein analyses of nasal fluids indicate that VEGFA may be an important mediator in Seasonal Allergic Rhinitis. |
| REFERENCE | 12633568 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Fibronectin binding, cytokine activity, platelet-derived growth factor receptor binding, vascular endothelial growth factor receptor binding, protein binding, growth factor activity, heparin binding, chemoattractant activity, identical protein binding, protein homodimerization activity, vascular endothelial growth factor receptor 1 binding, vascular endothelial growth factor receptor 2 binding, protein heterodimerization activity, receptor ligand activity, extracellular matrix binding. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, angiogenesis, ovarian follicle development, branching involved in blood vessel morphogenesis, vasculogenesis, response to hypoxia, in utero embryonic development, kidney development, positive regulation of protein phosphorylation, positive regulation of endothelial cell proliferation, cell migration involved in sprouting angiogenesis, positive regulation of neuroblast proliferation, positive regulation of mesenchymal cell proliferation, positive regulation of receptor internalization, platelet degranulation, positive regulation of leukocyte migration, heart morphogenesis, outflow tract morphogenesis, coronary vein morphogenesis, regulation of transcription by RNA polymerase II, multicellular organism development, nervous system development, mesoderm development, lactation, positive regulation of cell proliferation, regulation of cell shape, regulation of signaling receptor activity, positive regulation of endothelial cell migration, positive regulation of gene expression, negative regulation of gene expression, cytokine-mediated signaling pathway, cell differentiation, monocyte differentiation, macrophage differentiation, lung development, positive regulation of cell migration, regulation of cGMP metabolic process, epithelial cell differentiation, positive regulation of vascular endothelial growth factor receptor signaling pathway, post-embryonic camera-type eye development, positive regulation of protein complex assembly, positive regulation of protein autophosphorylation, activation of protein kinase activity, positive regulation of CREB transcription factor activity, positive regulation of peptidyl-serine phosphorylation, tube formation, endothelial cell chemotaxis, cellular response to vascular endothelial growth factor stimulus, lymph vessel morphogenesis, positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway, positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway, VEGF-activated neuropilin signaling pathway, growth, eye photoreceptor cell development, NOT positive regulation of tyrosine phosphorylation of STAT protein, negative regulation of apoptotic process, surfactant homeostasis, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, positive regulation of MAP kinase activity, positive regulation of blood vessel endothelial cell migration, positive regulation of angiogenesis, positive regulation of cell adhesion, positive regulation of transcription by RNA polymerase II, vascular endothelial growth factor receptor signaling pathway, cell maturation, camera-type eye morphogenesis, cardiac muscle fiber development, branching morphogenesis of an epithelial tube, positive regulation of axon extension involved in axon guidance, artery morphogenesis, positive regulation of epithelial cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive chemotaxis, positive regulation of positive chemotaxis, induction of positive chemotaxis, positive regulation of cellular component movement, positive regulation of cell division, positive regulation of focal adhesion assembly, primitive erythrocyte differentiation, mammary gland alveolus development, positive regulation of mast cell chemotaxis, cardiac vascular smooth muscle cell development, coronary artery morphogenesis, regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, cellular response to hypoxia, dopaminergic neuron differentiation, commissural neuron axon guidance, positive regulation of protein kinase C signaling, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of branching involved in ureteric bud morphogenesis, regulation of retinal ganglion cell axon guidance, motor neuron migration, cellular stress response to acid chemical, positive regulation of peptidyl-tyrosine autophosphorylation, positive regulation of p38MAPK cascade, positive regulation of histone deacetylase activity, positive regulation of retinal ganglion cell axon guidance, positive regulation of protein kinase D signaling, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, positive regulation of sprouting angiogenesis. |
| BIOGRID_INTERACTION_ID | 113265 |
| SNP_ID | 300064 300851 300852 300853 300926 300854 300887 300065 |
| DRUG_ID | 4087 4088 4048 |
| STRUCTURE_ID | 200905 200906 200907 200908 200909 200910 |
| MONOCLONAL_ANTIBODY | Anti-VEGFA antibody for Mouse, Rat, Rabbit, Dog, Human, Sheep, Guinea pig. |