Record No:1
| ACCESS NO | D114442 |
| GENE_NAME | MMP9 |
| DESCRIPTION | Matrix metalloproteinase 9 |
| ALIASES | CLG4B, GELB, MANDP2, MMP-9. |
| NCBI_ENTREZ_NO | 4318 |
| UNIPROT_ACCESS_NO | P14780 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Rhinitis |
| SAMPLE | Nasal Mucosa (of middle turbinate tissues) |
| TECHNIQUES | ELISA |
| OMICS | Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | The expressions of MMP9 in Allergic Rhinitis tissues were significant increased as compared to that of healthy subjects. |
| REFERENCE | 22667130 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Endopeptidase activity, metalloendopeptidase activity, serine-type endopeptidase activity, protein binding, collagen binding, peptidase activity, metallopeptidase activity, zinc ion binding, hydrolase activity, identical protein binding, metal ion binding. |
| GO_BIOLOGICAL_PROCESS | Skeletal system development, ossification, positive regulation of protein phosphorylation, proteolysis, embryo implantation, cytokine-mediated signaling pathway, extracellular matrix disassembly, extracellular matrix organization, macrophage differentiation, positive regulation of cell migration, collagen catabolic process, cellular response to reactive oxygen species, endodermal cell differentiation, positive regulation of apoptotic process, negative regulation of apoptotic process, neutrophil degranulation, positive regulation of DNA binding, positive regulation of epidermal growth factor receptor signaling pathway, ephrin receptor signaling pathway, leukocyte migration, positive regulation of keratinocyte migration, cellular response to cadmium ion, positive regulation of release of cytochrome c from mitochondria, positive regulation of receptor binding, positive regulation of vascular smooth muscle cell proliferation, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of cation channel activity, negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. |
| BIOGRID_INTERACTION_ID | 110461 |
| SNP_ID | 300250 300353 300354 300251 300659 300660 |
| DRUG_ID | 4182 4184 4185 4186 4187 |
| STRUCTURE_ID | 200731 200732 200733 200734 |
| MONOCLONAL_ANTIBODY | Anti-MMP9 antibody for Mouse, Rat, Rabbit, Guinea pig, Human, Dog, Monkey, Common marmoset. |