Record No:1
| ACCESS NO | D114466 |
| GENE_NAME | STAT3 |
| DESCRIPTION | Signal transducer and activator of transcription 3 |
| ALIASES | ADMIO, ADMIO1, APRF, HIES. |
| NCBI_ENTREZ_NO | 6774 |
| UNIPROT_ACCESS_NO | P40763 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Atopic Dermatitis |
| SAMPLE | Skin Biopsies |
| TECHNIQUES | Immunohistochemistry |
| OMICS | Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | pSTAT3 was highly expressed in atopic lesional skin compared with normal control. |
| REFERENCE | 27498343 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | RNA polymerase II proximal promoter sequence-specific DNA binding, DNA-binding transcription factor activity (RNA polymerase II-specific), RNA polymerase II repressing transcription factor binding, DNA-binding transcription activator activity (RNA polymerase II-specific), DNA binding, DNA-binding transcription factor activity, nuclear receptor activity, protein binding, transc, iption factor binding, protein kinase binding, protein phosphatase binding, chromatin DNA binding, CCR5 chemokine receptor binding, glucocorticoid receptor binding, identical protein binding, protein homodimerization activity, sequence-specific DNA binding, transcription regulatory region DNA binding, protein dimerization activity. |
| GO_BIOLOGICAL_PROCESS | Negative regulation of transcription by RNA polymerase II, temperature homeostasis, eye photoreceptor cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, protein import into nucleus, defense response, acute-phase response, inflammatory response, signal transduction, JAK-STAT cascade, nervous system development, aging, cell proliferation, positive regulation of cell proliferation, negative regulation of cell proliferation, response to organic substance, negative regulation of autophagy, positive regulation of gene expression, negative regulation of hydrogen peroxide biosynthetic process, response to organic cyclic compound, viral process, phosphorylation, cytokine-mediated signaling pathway, stem cell population maintenance, sexual reproduction, positive regulation of cell migration, intracellular receptor signaling pathway, response to estradiol, cellular response to hormone stimulus, leptin-mediated signaling pathway, response to cytokine, somatic stem cell population maintenance, miRNA mediated inhibition of translation, interleukin-15-mediated signaling pathway, interleukin-7-mediated signaling pathway, interleukin-9-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-23-mediated signaling pathway, regulation of multicellular organism growth, regulation of cell proliferation, response to drug, positive regulation of tyrosine phosphorylation of STAT protein, glucose homeostasis, eating behavior, mRNA transcription by RNA polymerase II, negative regulation of apoptotic process, response to peptide hormone, cellular response to leptin stimulus, response to leptin, positive regulation of interleukin-6 biosynthetic process, response to ethanol, positive regulation of erythrocyte differentiation, positive regulation of Notch signaling pathway, positive regulation of angiogenesis, negative regulation of glycolytic process, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of mitochondrial membrane permeability, astrocyte differentiation, modulation of chemical synaptic transmission, positive regulation of NF-kappaB transcription factor activity, regulation of cell cycle, radial glial cell differentiation, regulation of feeding behavior, growth hormone receptor signaling pathway, JAK-STAT cascade involved in growth hormone signaling pathway, negative regulation of cell death, interleukin-6-mediated signaling pathway, interleukin-27-mediated signaling pathway, interleukin-35-mediated signaling pathway, cellular response to cytokine stimulus, cellular response to organic cyclic compound, T-helper 17 cell lineage commitment, energy homeostasis, postsynapse to nucleus signaling pathway, negative regulation of neuron death, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of pri-miRNA transcription by RNA polymerase II, positive regulation of metalloendopeptidase activity, positive regulation of vascular endothelial cell proliferation, positive regulation of gene silencing by miRNA, negative regulation of stem cell differentiation, positive regulation of ATP biosynthetic process, negative regulation of neuron migration. |
| BIOGRID_INTERACTION_ID | 112651 |
| SNP_ID | 300856 300857 300858 300974 300859 |
| DRUG_ID | 4256 |
| STRUCTURE_ID | 204008 |
| MONOCLONAL_ANTIBODY | Anti-STAT3 antibody for Human, Rat, Mouse, Non human primates; Anti-STAT3 (phospho Y705) antibody for Human, Rat, Mouse; Anti-STAT3 (phospho S727) antibody for Human, Rat, Macaque Monkey. |