Record No:1
| ACCESS NO | D114485 |
| GENE_NAME | TSLP |
| DESCRIPTION | Thymic stromal lymphopoietin |
| ALIASES | - |
| NCBI_ENTREZ_NO | 85480 |
| UNIPROT_ACCESS_NO | Q969D9 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Rhinitis (AR), Chronic Rhinosinusitis with nasal polyps (CRSwNPs) |
| SAMPLE | Nasal Epithelial Cells |
| TECHNIQUES | ELISA |
| OMICS | Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | AR and CRSwNPs showed significant up-regulation in the release of TSLP in comparison with normal controls. |
| REFERENCE | 25910474 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, interleukin-7 receptor binding. |
| GO_BIOLOGICAL_PROCESS | Positive regulation of cytokine-mediated signaling pathway, positive regulation of cell proliferation, regulation of signaling receptor activity, positive regulation of chemokine production, positive regulation of interleukin-10 production, positive regulation of interleukin-13 production, positive regulation of interleukin-5 production, positive regulation of interleukin-6 production, positive regulation of mast cell activation, interleukin-7-mediated signaling pathway, positive regulation of tyrosine phosphorylation of STAT protein, negative regulation of apoptotic process, positive regulation of inflammatory response, positive regulation of chemokine (C-C motif) ligand 1 production, positive regulation of granulocyte colony-stimulating factor production, positive regulation of STAT cascade, positive regulation of interleukin-5 secretion. |
| BIOGRID_INTERACTION_ID | 124555 |
| SNP_ID | 300087 300088 300213 300927 300802 300877 301048 301049 300751 300689 |
| DRUG_ID | 4124 |
| STRUCTURE_ID | 202588 |
| MONOCLONAL_ANTIBODY | - |