Record No:1
| ACCESS NO | D114486 |
| GENE_NAME | IL6 |
| DESCRIPTION | Interleukin 6 |
| ALIASES | BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6. |
| NCBI_ENTREZ_NO | 3569 |
| UNIPROT_ACCESS_NO | P05231 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Allergic Rhinitis (AR), Chronic Rhinosinusitis with nasal polyps (CRSwNPs) |
| SAMPLE | Nasal Epithelial Cells |
| TECHNIQUES | ELISA |
| OMICS | Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | AR and CRSwNPs showed significant up-regulation in the release of IL6 in comparison with normal controls. |
| REFERENCE | 25910474 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Cytokine activity, interleukin-6 receptor binding, protein binding, growth factor activity. |
| GO_BIOLOGICAL_PROCESS | Neutrophil apoptotic process, hepatic immune response, neutrophil mediated immunity, monocyte chemotaxis, positive regulation of acute inflammatory response, positive regulation of leukocyte chemotaxis, acute-phase response, inflammatory response, immune response, humoral immune response, positive regulation of cell proliferation, negative regulation of cell proliferation, regulation of signaling receptor activity, regulation of vascular endothelial growth factor production, positive regulation of gene expression, negative regulation of lipid storage, cytokine-mediated signaling pathway, platelet activation, endocrine pancreas development, neuron projection development, response to peptidoglycan, positive regulation of chemokine production, positive regulation of interleukin-6 production, negative regulation of collagen biosynthetic process, positive regulation of peptidyl-serine phosphorylation, positive regulation of T cell proliferation, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of apoptotic process, negative regulation of apoptotic process, positive regulation of MAPK cascade, post-translational protein modification, cellular protein metabolic process, negative regulation of chemokine biosynthetic process, negative regulation of fat cell differentiation, positive regulation of osteoblast differentiation, positive regulation of translation, regulation of angiogenesis, negative regulation of bone resorption, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, positive regulation of JAK-STAT cascade, positive regulation of smooth muscle cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, positive regulation of B cell activation, positive regulation of immunoglobulin secretion, positive regulation of DNA binding transcription factor activity, NOT positive regulation of NF-kappaB transcription factor activity, response to glucocorticoid, defense response to virus, glucagon secretion, interleukin-6-mediated signaling pathway, cellular response to hydrogen peroxide, cellular response to lipopolysaccharide, T-helper 17 cell lineage commitment, positive regulation of T-helper 2 cell cytokine production, negative regulation of interleukin-1-mediated signaling pathway, positive regulation of type B pancreatic cell apoptotic process. |
| BIOGRID_INTERACTION_ID | 109783 |
| SNP_ID | 300237 300458 300592 300921 300922 300923 300924 300380 301069 300238 |
| DRUG_ID | 4039 4040 |
| STRUCTURE_ID | 200317 200318 200319 200320 |
| MONOCLONAL_ANTIBODY | Anti-IL-6 antibody for Rat, Human, Mouse. |