Record No:1
| ACCESS NO | D114555 |
| GENE_NAME | TLR4 |
| DESCRIPTION | Toll-like receptor 4 |
| ALIASES | ARMD10, CD284, TLR-4, TOLL. |
| NCBI_ENTREZ_NO | 7099 |
| UNIPROT_ACCESS_NO | O00206 |
| ORGANISM | Human |
| DISEASE_PHENOTYPE | Pollen Induced Allergic Rhinitis |
| SAMPLE | Nasal Lavage (NAL), Peripheral Blood, Bone marrow |
| TECHNIQUES | Flow Cytometry |
| OMICS | Others |
| STUDY | Low Throughput |
| GEO_PRIDE_ACCESS_NO | NA |
| COMMENTS | TLR4 expression was increased in leukocytes in nasal lavage, peripheral blood and bone marrow during symptomatic allergic rhinitis. |
| REFERENCE | 22555057 |
| IMMUNITY_TERM | Yes |
| GO_MOLECULAR_FUNCTION | Lipopolysaccharide binding, lipopolysaccharide receptor activity, transmembrane signaling receptor activity, signaling receptor binding, protein binding, signaling receptor activity, protein heterodimerization activity. |
| GO_BIOLOGICAL_PROCESS | Activation of MAPK activity, activation of innate immune response, toll-like receptor signaling pathway, B cell proliferation involved in immune response, immune system process, nitric oxide production involved in inflammatory response, regulation of dendritic cell cytokine production, MyD88-dependent toll-like receptor signaling pathway, MyD88-independent toll-like receptor signaling pathway, inflammatory response, immune response, signal transduction, I-kappaB kinase/NF-kappaB signaling, I-kappaB phosphorylation, response to bacterium, positive regulation of platelet activation, positive regulation of gene expression, astrocyte development, detection of fungus, positive regulation of B cell proliferation, lipopolysaccharide-mediated signaling pathway, response to lipopolysaccharide, detection of lipopolysaccharide, interferon-gamma production, negative regulation of interferon-gamma production, negative regulation of interleukin-17 production, negative regulation of interleukin-23 production, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production, positive regulation of chemokine production, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interferon-gamma production, positive regulation of interleukin-1 production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of tumor necrosis factor production, positive regulation of stress-activated MAPK cascade, negative regulation of MyD88-independent toll-like receptor signaling pathway, toll-like receptor 4 signaling pathway, TRIF-dependent toll-like receptor signaling pathway, T-helper 1 type immune response, macrophage activation, positive regulation of tumor necrosis factor biosynthetic process, defense response to bacterium, positive regulation of macrophage activation, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of interleukin-12 biosynthetic process, innate immune response, positive regulation of MHC class II biosynthetic process, positive regulation of interferon-beta biosynthetic process, positive regulation of interleukin-8 biosynthetic process, positive regulation of nitric oxide biosynthetic process, negative regulation of osteoclast differentiation, positive regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, positive regulation of lymphocyte proliferation, interleukin-1 beta secretion, regulation of cytokine secretion, positive regulation of interleukin-1 beta secretion, regulation of inflammatory response, positive regulation of inflammatory response, defense response to Gram-negative bacterium, positive regulation of NF-kappaB transcription factor activity, positive regulation of nitric-oxide synthase biosynthetic process, intestinal epithelial structure maintenance, positive regulation of macrophage cytokine production, necroptotic process, negative regulation of ERK1 and ERK2 cascade, positive regulation of ERK1 and ERK2 cascade, positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to mechanical stimulus, apoptotic signaling pathway, cellular response to oxidised low-density lipoprotein particle stimulus, positive regulation of cytokine production involved in inflammatory response, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of NIK/NF-kappaB signaling, positive regulation of oxidative stress-induced neuron death, positive regulation of reactive oxygen species biosynthetic process, cellular response to amyloid-beta. |
| BIOGRID_INTERACTION_ID | 112954 |
| SNP_ID | 300227 300836 300917 300918 300919 300837 301029 300590 |
| DRUG_ID | 4177 |
| STRUCTURE_ID | 200190 200191 200192 |
| MONOCLONAL_ANTIBODY | Anti-TLR4 antibody for Guinea Pig, Human, Mouse, Rhesus Monkey, Rat, Pig; Anti-TLR4/MD2 Complex antibody for Mouse, Rat; Anti-TLR4/MD2 antibody for Mouse. |