Browse Result
Total number of records for Asthma in Airway Smooth Muscle Cells of Human in DAAB (Version-2) database: 55
| Record no | Disease | Organism | Sample | Gene Name | Techniques | Omics | Study | Comments | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Asthma | Human | Airway Smooth Muscle Cells | CCL15 | Real time PCR | Genomics | Low Throughput | Chemoattractant for eosinophils, monocytes, neutrophils and lymphocytes and recruits them in the airways | 22092970 |
| 2 | Allergic Asthma after challenge with Aspergillus fumigatus | Human | Airway Smooth Muscle Cells | PTX3 | RT PCR and ELISA | Genomics, Others | Low Throughput | Activates and regulates complements and bind to pathogens. Overexpressed in Airway Smooth Muscle Cells of asthmatic patientsasthma. | 22529962 |
| 3 | Asthma | Human | Airway Smooth Muscle Cells (ASM) | ATP2A2 | Immunochemistry and reat time PCR and cell biology | Others, Genomics | Low Throughput | SERCA2 mRNA and protein expression is reduced in ASM cells from subjects with moderately severe asthma. Rises in intracellular calcium following cell surface receptor-induced SR activation or inhibition of SERCA-mediated Calcium re-uptake were attenuated in ASM cells from asthmatics. | 19541629 |
| 4 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | LPHN1 | Microarray, qRT-PCR | Genomics | High Throughput, Low Throughput | LPHN1 level was significantly increased in asthmatic ASMCs as compared with healthy ASMCs. | 27325752 |
| 5 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | LPHN3 | Microarray, qRT-PCR | Genomics | High Throughput, Low Throughput | LPHN3 level was significantly increased in asthmatic ASMCs as compared with healthy ASMCs. | 27325752 |
| 6 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | PLEKHG1 | Microarray | Genomics | High Throughput | PLEKHG1 was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 7 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | PSG4 | Microarray | Genomics | High Throughput | PSG4 was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 8 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | TCN2 | Microarray | Genomics | High Throughput | TCN2 was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 9 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | PTDSS1 | Microarray | Genomics | High Throughput | PTDSS1 was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 10 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | EYA1 | Microarray | Genomics | High Throughput | EYA1 was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 11 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | MLPH | Microarray | Genomics | High Throughput | MLPH was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 12 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | GALNT5 | Microarray | Genomics | High Throughput | GALNT5 was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 13 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | IGDCC4 | Microarray | Genomics | High Throughput | IGDCC4 was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 14 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | PARD6G | Microarray | Genomics | High Throughput | PARD6G was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 15 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | PTPRU | Microarray | Genomics | High Throughput | PTPRU was significantly down regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 16 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | PDE1C | Microarray | Genomics | High Throughput | PDE1C was significantly up regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 17 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | TPM1 | Microarray | Genomics | High Throughput | TPM1 was significantly up regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 18 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | KIAA1324L | Microarray | Genomics | High Throughput | KIAA1324L was significantly up regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 19 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | PRUNE2 | Microarray | Genomics | High Throughput | PRUNE2 was significantly up regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 20 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | CYR61 | Microarray | Genomics | High Throughput | CYR61 was significantly up regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 21 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | ID4 | Microarray | Genomics | High Throughput | ID4 was significantly up regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 22 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | CSRP1 | Microarray | Genomics | High Throughput | CSRP1 was significantly up regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 23 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | FAT3 | Microarray | Genomics | High Throughput | FAT3 was significantly up regulated in asthmatic ASMCs as compared to healthy ASMCs. | 27325752 |
| 24 | Bronchial Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | LET7A | qRT-PCR | Genomics | Low Throughput | The relative expression levels of Let7a in ASMCs from asthmatic subjects were significantly decreased compared with those in the ASMCs from non-asthmatic subjects. | 30988708 |
| 25 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | TIMMDC1 | qRT-PCR, Western Blotting | Genomics, Proteomics | Low Throughput | TIMMDC1 was upregulated in asthma groups as compared to control group. | 30528236 |
| 26 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | lncTCF7 | qRT-PCR | Genomics | Low Throughput | lncTCF7 was upregulated in asthma groups as compared to control group. lncTCF7 facilitated human ASMCs growth and migration via targeting TIMMDC1 thus activating AKT signaling, providing a novel possible target for asthma therapy. | 30528236 |
| 27 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | BDNF | ELISA | Others | Low Throughput | Secreted BDNF was significantly elevated in asthmatics as compared to non asthmatic subjects. | 27317689 |
| 28 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) (cocultured with eosinophils from asthmatics) | WNT5A | qRT-PCR | Genomics | Low Throughput | After 24 hrs of co-culture with eosinophils from asthmatic subjects, WNT5A gene expression in ASMC was significantly increased as compared with control ASMC cultured without eosinophils. No significant effect on WNT5A gene expression was detected after incubation of ASMC with eosinophils from healthy subjects. | 27297409 |
| 29 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) (cocultured with eosinophils from asthmatics) | TGFB1 | qRT-PCR | Genomics | Low Throughput | Eosinophils from both asthmatic and healthy subjects induced overexpression of the TGFB1 gene in ASMC, but the effect of eosinophils from asthmatic subjects was significantly greater. | 27297409 |
| 30 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) (cocultured with eosinophils from asthmatics) | COL1A1 | qRT-PCR | Genomics | Low Throughput | After 24 hrs of co-culture with eosinophils from asthma patients, collagen gene expression in ASMC was increased significantly compared with control ASMC cultured without eosinophils. No significant effect on collagen gene expression was detected after incubation of ASMC with eosinophils from healthy subjects. | 27297409 |
| 31 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-216a | qRT-PCR | Genomics | Low Throughput | miR-216a levels were considerably lower in the ASM cells of asthmatic patients than in those of non-asthmatic individuals. miR-216a may function as a key regulator of airway remodeling by targeting JAK2, thus suggesting the potential role of miR-216a in the pathogenesis of asthma. | 30299194 |
| 32 | Asthma | Human | Lung Tissues, Airway Smooth Muscle Cells (ASMCs) | P-Rex1 | Immunohistochemistry, Western Blotting | Others, Proteomics | Low Throughput | P-Rex1 expression was significantly increased in asthmatics as compared to healthy controls. P-Rex1 may represent a key target for treating both Airway Smooth Muscle hyperplasia and Airway Hyperresponsiveness, providing a novel approach to reverse airway remodeling and restore airway function in severe asthma. | 30312708 |
| 33 | Severe Asthma | Human | Airway Smooth Muscle Cells (ASMs) | PP5 | qRT-PCR, Flow Cytometry | Genomics, Others | Low Throughput | Increased expression of PP5 in ASM cells from subjects with severe asthma was observed as compared to that from healthy controls. Protein Phosphatase 5 mediates corticosteroid insensitivity in Airway Smooth Muscle in patients With Severe Asthma. | 27501780 |
| 34 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | DBX2 | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The study confirmed DBX2 as hub DMPs (differentially methylated positions) involved in asthma. | 29449426 |
| 35 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | ACP6 | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The study confirmed ACP6 as hub DMPs (differentially methylated positions) involved in asthma. | 29449426 |
| 36 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | KCNJ11 | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The study confirmed KCNJ11 as hub DMPs (differentially methylated positions) involved in asthma. | 29449426 |
| 37 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | PDE4D | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | This study confirmed the decrease in baseline PDE4D ( phosphodiesterase 4D) promoter region methylation in asthma that modulated asthmatic ASMC proliferation. | 29449426 |
| 38 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-1265 | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The miRNAs associated with the highest and lowest methylated CpGs are miR-1265 and miR-1266 in ASMCs from Severe asthmatics. miR-1265 is overexpressed in ASMCs from severe asthmatics. | 29449426 |
| 39 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-1266 | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The miRNAs associated with the highest and lowest methylated CpGs are miR-1265 and miR-1266 in ASMCs from Severe asthmatics. miR-1266 is overexpressed in ASMCs from severe asthmatics. | 29449426 |
| 40 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-137 | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The miRNAs associated with the highest and lowest methylated CpGs are miR-137 and miR-372 in the healthy subjects ASMCs. | 29449426 |
| 41 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-372 | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The miRNAs associated with the highest and lowest methylated CpGs are miR-137 and miR-372 in the healthy subjects ASMCs. | 29449426 |
| 42 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-575 | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The miRNAs associated with the highest and lowest methylated CpGs are miR-548Q and miR-575 in the Non severe asthma samples. | 29449426 |
| 43 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-548Q | Illumina 450K array (Infinium Methylation 450K array) | Epigenetics | High Throughput | The miRNAs associated with the highest and lowest methylated CpGs are miR-548Q and miR-575 in the Non severe asthma samples. | 29449426 |
| 44 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | CTGF | Immunohistochemistry | Others | Low Throughput | Immunohistochemistry revealed that ASM cells from patients with severe asthma exhibited high expression of CTGF as compared to mild and non-asthmatic tissues. In patients, higher CTGF gene expression in bronchial biopsies was correlated with increased basement membrane thickness indicating that the enhanced CTGF expression in ASMCs may contribute to airway remodelling in asthma. | 29516637 |
| 45 | Asthma | Human | Lung Tissues, Airway Smooth Muscle Cells (ASMCs) | PRMT1 | Immunohistochemistry, qRT-PCR, Western Blotting | Others, Genomics, Proteomics | Low Throughput | PRMT1 expression was significantly increased in asthmatics as compared to healthy controls. | 28081849 |
| 46 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-101-3p | qRT-PCR | Genomics | Low Throughput | miR-101-3p expression was significantly decreased in asthmatics as compared to healthy controls. | 28081849 |
| 47 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | miR-19-3p | qRT-PCR | Genomics | Low Throughput | miR-19-3p expression was significantly decreased in asthmatics as compared to healthy controls. | 28081849 |
| 48 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | α-SMA | Western Blotting, Immunofluorescence Staining | Proteomics, Others | Low Throughput | α-SMA expression was significantly increased in ASMCs of asthmatics as compared to that of healthy controls. | 28081849 |
| 49 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | COL1A1 | Western Blotting, Immunofluorescence Staining | Proteomics, Others | Low Throughput | COL1A1 expression was significantly increased in ASMCs of asthmatics as compared to that of healthy controls. | 28081849 |
| 50 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | FN1 | Western Blotting, Immunofluorescence Staining | Proteomics, Others | Low Throughput | FN1 expression was significantly increased in ASMCs of asthmatics as compared to that of healthy controls. | 28081849 |
| 51 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | STAT1 | Western Blotting | Proteomics | Low Throughput | p-STAT1 expression was significantly increased in ASMCs of asthmatics as compared to that of healthy controls. | 28081849 |
| 52 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs) | ERK | Western Blotting | Proteomics | Low Throughput | Total ERK expression was significantly increased in ASMCs of asthmatics as compared to that of healthy controls. | 28081849 |
| 53 | Asthma | Human | Airway Smooth Muscle Cells (ASMCs), Bronchial Tissues, Sputum | HMGB1 | qRT-PCR, Immunofluorescence, Flow cytometry, Immunohistochemistry, ELISA, Nonreducing electrophoresis, Western Blotting | Genomics, Others, Proteomics | Low Throughput | Sputum HMGB1 concentration was increased in those with severe asthma but not in those with mild to moderate asthma versus healthy controls. HMGB1 protein expression was significantly reduced in ASMCs from those with asthma versus controls. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. | 28259445 |
| 54 | Asthma | Human | Airway smooth muscle cells (ASMCs) (Stimulated with IL1B), Bronchial Biopsy | CCL20 | Microarray, ELISA | Transcriptomics, Others | High Throughput, Low Throughput | IL1B induced increased CCL20 expression and protein release in ASMCs from moderate asthmatics as compared to mild asthmatics and healthy controls. Elevated CCL20 production by ASMCs, possibly resulting from dysregulated expression of the anti-inflammatory miR-146a-5p, may contribute to enhanced mucus production in asthma. | 29946002 |
| 55 | Asthma | Human | Airway smooth muscle cells (ASMCs) (Stimulated with IL1B) | miR-146a | Microarray | Transcriptomics | High Throughput | IL1B induced lower miR-146a expression in asthma-derived ASMCs compared to controls. Decreased miR-146a expression was validated in-vivo in bronchial biopsies from asthmatics and healthy controls. | 29946002 |