Browse Result

Total number of records for Asthma in Blood Plasma of Human in DAAB (Version-2) database: 183

Record no	Disease	Organism	Sample	Gene Name	Techniques	Omics	Study	Comments	Pubmed ID
1	Asthma	Human	Blood Plasma	CP	MALDI Tof	Proteomics	High Throughput and Low Throughput	Copper protein synthesized by the liver and activated by macrophages. Plays a role in iron metabolism and upregulated in adults suffering from asthma.	21471098
2	Asthma	Human	Blood Plasma	HP	MALDI Tof	Proteomics	High Throughput and Low Throughput	Expressed by eosinophils.Involved in tissue remodelling and fibrosis. Upregulated in asthma.	21471098
3	Asthma	Human	Blood Plasma	HPX	MALDI Tof	Proteomics	High Throughput and Low Throughput	Acute phase protein which is synthesized by the liver and have important antiinflammatory properties through inhibition of oxidative stress.	21471098
4	Asthma	Human	Blood Plasma	F2	MALDI Tof	Proteomics	High Throughput and Low Throughput	Decreased in asthamtics	21471098
5	Asthma	Human	Blood Plasma	FGG	MALDI Tof	Proteomics	High Throughput and Low Throughput	Involved in coagulation cascade	21471098
6	Asthma	Human	Blood Plasma	SERPIND1	MALDI Tof	Proteomics	High Throughput	Involved in coagulation cascade	21471098
7	Asthma	Human	Blood Plasma	PROS1	MALDI Tof	Proteomics	High Throughput	Involved in coagulation cascade	21471098
8	Asthma	Human	Blood Plasma	ITIH4	MALDI Tof	Proteomics	High Throughput	Involved in coagulation cascade	21471098
9	Asthma	Human	Blood Plasma	SERPINF2	MALDI Tof	Proteomics	High Throughput	Involved in coagulation cascade	21471098
10	Asthma	Human	Blood Plasma	HRG	MALDI Tof	Proteomics	High Throughput	Involved in coagulation cascade	21471098
11	Asthma	Human	Blood Plasma	SERPINC1	MALDI Tof	Proteomics	High Throughput and Low Throughput	Significantly increased in asthma patients	21471098
12	Asthma	Human	Blood Plasma	GSN	MALDI Tof	Proteomics	High Throughput	Involved in coagulation cascade	21471098
13	Asthma	Human	Blood Plasma	CFH	MALDI Tof	Proteomics	High Throughput and Low Throughput	Involved in complement pathways	21471098
14	Asthma	Human	Blood Plasma	CFB	MALDI Tof	Proteomics	High Throughput	Involved in complement pathways	21471098
15	Asthma	Human	Blood Plasma	C3	MALDI Tof	Proteomics	High Throughput	Involved in complement pathways	21471098
16	Asthma	Human	Blood Plasma	C4A	MALDI Tof	Proteomics	High Throughput	Involved in complement pathways	21471098
17	Asthma	Human	Blood Plasma	IGHA1	MALDI Tof	Proteomics	High Throughput and Low Throughput	IGHA1 was over expressed in asthma and COPD patients as compared to healthy controls.	21471098
18	Asthma	Human	Blood Plasma	IGHM	MALDI Tof	Proteomics	High Throughput	IGHM was differentially expressed in asthma and COPD patients as compared to healthy subjects.	21471098
19	Asthma	Human	Blood Plasma	A2M	MALDI Tof	Proteomics	High Throughput and Low Throughput	Interacts and captures any proteinases which are encountered as foreign proteins thus providing a humoral defense barrier against pathogens.	21471098
20	Asthma challenged with inhaled allergens	Human	Blood Plasma	FGG	2D gel and MALDI TOF and Western blot	Proteomics	High Throughput and Low Throughput	Participates in inflammation by binding to leukocyte integrin aMb2 (CD11b/CD18,Mac-1, CR3)	19076930
21	Asthma challenged with inhaled allergens	Human	Blood Plasma	C3	2D gel and MALDI TOF	Proteomics	High Throughput	Downregulated in immediate phase reaction of allergic patients	19076930
22	Asthma challenged with inhaled allergens	Human	Blood Plasma	C4A	2D gel and MALDI TOF	Proteomics	High Throughput	Upregulated in immediate phase reaction of allergic patients	19076930
23	Asthma challenged with inhaled allergens	Human	Blood Plasma	C3D	2D gel and MALDI TOF	Proteomics	High Throughput	Upregulated in immediate phase reaction of allergic patients	19076930
24	Asthma challenged with inhaled allergens	Human	Blood Plasma	TTR	2D gel and MALDI TOF	Proteomics	High Throughput	Upregulated in immediate phase reaction of allergic patients	19076930
25	Asthma challenged with inhaled allergens	Human	Blood Plasma	ALB	2D gel and MALDI TOF	Proteomics	High Throughput	Serum albumin was significantly higher in the IPR positive asthmatic group than in the IPR negative group.	19076930
26	Asthma challenged with inhaled allergens	Human	Blood Plasma	APOE	2D gel and MALDI TOF	Proteomics	High Throughput	Upregulated in immediate phase reaction of allergic patients	19076930
27	Asthma and aspirin tolerance	Human	Blood Plasma	FGA	2DE and MALDI-TOF/TOF	Proteomics	High Throughput	Expression of this protein is decreased in Aspirin-exacerbated respiratory disease (AERD) as compared to aspirin-tolerant asthma (ATA).	24120690
28	Asthma and aspirin tolerance	Human	Blood Plasma	APOH	2DE and MALDI-TOF/TOF and ELISA	Proteomics, Others	High Throughput and Low Throughput	Expression of this protein is decreased in Aspirin-exacerbated respiratory disease (AERD) as compared to aspirin-tolerant asthma (ATA).	24120690
29	Asthma and aspirin tolerance	Human	Blood Plasma	C3	2DE and MALDI-TOF/TOF	Proteomics	High Throughput	Expression of this protein is increased in Aspirin-exacerbated respiratory disease (AERD) as compared to aspirin-tolerant asthma (ATA).	24120690
30	Asthma and aspirin tolerance	Human	Blood Plasma	C4A	2DE and MALDI-TOF/TOF	Proteomics	High Throughput	Expression of this protein is increased in Aspirin-exacerbated respiratory disease (AERD) as compared to aspirin-tolerant asthma (ATA).	24120690
31	Asthma and aspirin tolerance	Human	Blood Plasma	KNG1	2DE and MALDI-TOF/TOF	Proteomics	High Throughput	Expression of this protein is increased in Aspirin-exacerbated respiratory disease (AERD) as compared to aspirin-tolerant asthma (ATA).	24120690
32	Asthma	Human	Blood Plasma	CRP	ELISA	Others	Low Throughput	It is one of the most characteristic surrogate markers of systemic inflammation. Significantly higher plasma CRP levels was found at acute exacerbation and remained elevated during remission compared with healthy controls. This reflects chronic systemic inflammation in asthma.	24073339
33	Asthma	Human	Blood Plasma	MMP9	ELISA and zymography	Others	Low Throughput	Level of this marker was significantly higher in acute exacerbation and decreased in remission but remained significantly higher compared to healthy controls.	24073339
34	Asthma and aspirin tolerance	Human	Blood Plasma	RNASE2	ELISA	Others	Low Throughput	This protein is present in higher levels in subjects with aspirin exacerbated respiratory disease (AERD) as compared with aspirin tolerant asthma (ATA )subjects.	23805255
35	Asthma.	Human	Blood Plasma	ELANE	ELISA	Others	Low Throughput	Elevated in asthmatic patients.	18504410
36	Asthma, Rhinoconjunctivitis and Atopic Eczema.	Human	EDTA added Blood Plasma	LEP	ELISA	Others	Low Throughput	High leptin were associated with increased persistence of asthma.	18331416
37	Asthma, Rhinoconjunctivitis and Atopic Eczema.	Human	EDTA added Blood Plasma	ADIPOQ	ELISA	Others	Low Throughput	Low adiponectin is associated with rhinoconjunctivitis and hay fever in girls and higher prevalence of asthma in general.	18331416
38	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-1	RT-PCR Array	Genomics	High Throughput	Blood plasma level of miR-1 was found to decrease in both allergic rhinitis and asthma patients as compared to healthy subjects.	27025347
39	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-125b	RT-PCR Array	Genomics	High Throughput	Blood plasma level of miR-125b was found to increase in both allergic rhinitis and asthma patients as compared to healthy subjects.	27025347
40	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR126	RT-PCR Array	Genomics	High Throughput	Increased blood plasma level of miR-126 was found in both allergic rhinitis and asthma patients as compared to healthy subjects.	27025347
41	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR21	RT-PCR Array	Genomics	High Throughput	Increased blood plasma level of miR-21 was found in both allergic rhinitis and asthma patients as compared to healthy subjects.	27025347
42	Asthma and Allergic Rhinitis	Human	Blood Plasma	let-7b	RT-PCR Array	Genomics	High Throughput	Increased blood plasma level of let-7b was found in both allergic rhinitis and asthma patients as compared to healthy subjects.	27025347
43	Asthma and Allergic Rhinitis	Human	Blood Plasma	let-7c	RT-PCR Array	Genomics	High Throughput	Increased blood plasma level of let-7c was found in both allergic rhinitis and asthma patients as compared to healthy subjects.	27025347
44	Asthma and Allergic Rhinitis	Human	Blood Plasma	let-7e	RT-PCR Array	Genomics	High Throughput	Increased blood plasma level of let-7e was found in both allergic rhinitis and asthma patients as compared to healthy subjects.	27025347
45	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-16	RT-PCR Array	Genomics	High Throughput	miR-16 was up regulated in asthmatics as compared to allergic rhinitis patients and healthy subjects.	27025347
46	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR223	RT-PCR Array	Genomics	High Throughput	miR-223 was up regulated in asthmatics as compared to allergic rhinitis patients and healthy subjects.	27025347
47	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR148A	RT-PCR Array	Genomics	High Throughput	miR-148a was up regulated in asthmatics as compared to allergic rhinitis patients and healthy subjects.	27025347
48	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR146A	RT-PCR Array	Genomics	High Throughput	miR-146a was up regulated in asthmatics as compared to allergic rhinitis patients and healthy subjects.	27025347
49	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-299-5p	RT-PCR Array	Genomics	High Throughput	miR-299-5p was down regulated in asthmatics as compared to allergic rhinitis patients and healthy subjects.	27025347
50	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR570	RT-PCR Array	Genomics	High Throughput	miR-570 was down regulated in asthmatics as compared to allergic rhinitis patients and healthy subjects.	27025347
51	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR150	RT-PCR Array	Genomics	High Throughput	miR-150 was down regulated in asthmatics as compared to allergic rhinitis patients and healthy subjects.	27025347
52	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR106A	RT-PCR Array	Genomics	High Throughput	miR-106a was significantly down regulated in patients with allergic rhinitis and asthmatic patients compared with that in healthy subjects, however, their down regulation was more exaggerated among allergic rhinitis patients as compared to asthmatics.	27025347
53	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR155	RT-PCR Array	Genomics	High Throughput	miR-155 was significantly down regulated in patients with allergic rhinitis and asthmatic patients compared with that in healthy subjects, however, their down regulation was more exaggerated among allergic rhinitis patients as compared to asthmatics.	27025347
54	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR145	RT-PCR Array	Genomics	High Throughput	miR-145 exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit increased plasma levels as compared to healthy controls.	27025347
55	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-422	RT-PCR Array	Genomics	High Throughput	miR-422 exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit increased plasma levels as compared to healthy controls.	27025347
56	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR133B	RT-PCR Array	Genomics	High Throughput	miR-133b exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit decreased plasma levels as compared to healthy controls.	27025347
57	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-133a	RT-PCR Array	Genomics	High Throughput	miR-133a exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit decreased plasma levels as compared to healthy controls.	27025347
58	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR26B	RT-PCR Array	Genomics	High Throughput	miR-26b exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit decreased plasma levels as compared to healthy controls.	27025347
59	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-330-5p	RT-PCR Array	Genomics	High Throughput	miR-330-5p exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit decreased plasma levels as compared to healthy controls.	27025347
60	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-29	RT-PCR Array	Genomics	High Throughput	miR-29 exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit decreased plasma levels as compared to healthy controls.	27025347
61	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR1291	RT-PCR Array	Genomics	High Throughput	miR-1291 exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit decreased plasma levels as compared to healthy controls.	27025347
62	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR144	RT-PCR Array	Genomics	High Throughput	miR-144 exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit decreased plasma levels as compared to healthy controls.	27025347
63	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR206	RT-PCR Array	Genomics	High Throughput	miR-206 showed similar expression levels between the healthy and asthmatic cohorts. miR-206 was up regulated in allergic rhinitis patients as compared to asthmatics and healthy individuals.	27025347
64	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR328	RT-PCR Array	Genomics	High Throughput	miR-328 showed similar expression levels between the healthy and asthmatic cohorts. miR-328 was up regulated in allergic rhinitis patients as compared to asthmatics and healthy individuals.	27025347
65	Asthma and Allergic Rhinitis	Human	Blood Plasma	miR-338-3p	RT-PCR Array	Genomics	High Throughput	miR-338-3p showed similar expression levels between the healthy and asthmatic cohorts. miR-338-3p was down regulated in allergic rhinitis patients as compared to asthmatics and healthy individuals.	27025347
66	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR26A1	RT-PCR Array	Genomics	High Throughput	miR-26a showed similar expression levels between the healthy and asthmatic cohorts. miR-26a was down regulated in allergic rhinitis patients as compared to asthmatics and healthy individuals.	27025347
67	Asthma and Allergic Rhinitis	Human	Blood Plasma	MIR1248	RT-PCR Array	Genomics	High Throughput	miR-1248 exhibited similar expression trend between allergic rhinitis patients and asthmatics but was found to exhibit decreased plasma levels as compared to healthy controls.	27025347
68	Asthma (Children)	Human	Blood Plasma	TSLP	ELISA	Others	Low Throughput	Children with allergy and asthma had higher TSLP than children without allergy and asthma (healthy children), while nonallergic children with asthma had no difference in the level of TSLP when compared to healthy children.	26999524
69	Pediatric asthma	Human	Blood Plasma	IFNG	ELISA	Others	Low Throughput	Significant decrease in plasma γ-IFN was found in pediatric asthma patients as compared to control group.	30406061
70	Pediatric asthma	Human	Blood Plasma	IL12	ELISA	Others	Low Throughput	Significant decrease in plasma IL12 was found in pediatric asthma patients as compared to control group.	30406061
71	Pediatric asthma	Human	Blood Plasma	IL4	ELISA	Others	Low Throughput	Increase in plasma IL4 was found in pediatric asthma patients as compared to control group.	30406061
72	Pediatric asthma	Human	Blood Plasma	IL6	ELISA	Others	Low Throughput	Increase in plasma IL6 was found in pediatric asthma patients as compared to control group.	30406061
73	Pediatric asthma	Human	Blood Plasma	TNFalpha	ELISA	Others	Low Throughput	Increase in plasma TNFalpha was found in pediatric asthma patients as compared to control group.	30406061
74	Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group	Human	Blood Plasma, CD8 T cells, Eosinophils	IFN-λ2	ELISA, Flow Cytometry	Others	Low Throughput	The elevated plasma levels of IFN-λ2 in the patients with allergic rhinitis, asthma and allergic rhinitis combined with asthma as compared to the control, and positive correlations of plasma IFN-λ2 with tryptase in Allergic Rhinits and asthma indicate that IFN-λ2 is likely to contribute to the pathogenesis of allergic airway disorders. Upregulated IFN-λ2 expression was observed in CD8 T cells and eosinophils of allergic airway disorders indicating that they are the potential sources of IFN-λ2.	27057098
75	Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group	Human	Blood Plasma	IL4	ELISA	Others	Low Throughput	The plasma levels of IL4 was increased in the patients with asthma as compared to the control, but not in allergic rhinitis combined with asthma or allergic rhinitis alone.	27057098
76	Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group	Human	Blood Plasma	IL10	ELISA	Others	Low Throughput	The plasma levels of IL10 was decreased in the patients with allergic rhinitis, asthma and allergic rhinitis combined with asthma as compared to the control.	27057098
77	Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group	Human	Blood Plasma	IL12	ELISA	Others	Low Throughput	The plasma levels of IL12 was decreased in the patients with allergic rhinitis, asthma and allergic rhinitis combined with asthma as compared to the control.	27057098
78	Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group	Human	Blood Plasma	Tryptase	ELISA	Others	Low Throughput	The plasma levels of tryptase were increased in the patients with allergic rhinitis and asthma as compared to the control, but not in allergic rhinitis combined with asthma.	27057098
79	T2 High and T2 Low Asthma	Human	Blood Plasma	CCL11	ELISA	Others	Low Throughput	Plasma CCL11 level was increased in T2-high as compared to T2-low asthmatic patients.	30578390
80	T2 High and T2 Low Asthma	Human	Blood Plasma	CCL26	ELISA	Others	Low Throughput	Plasma CCL26 level was significantly increased in T2-high as compared to T2-low asthmatic patients. CCL26 expression was highest in patients with high FeNO and blood eosinophils.	30578390
81	Bronchial Asthma	Human	Peripheral Blood Mononuclear Cells (PBMCs), Blood Plasma	TF	Western Blotting, ELISA	Proteomics, Others	Low Throughput	Compared with healthy controls, the levels of TF protein was increased in asthmatic patients.	30293344
82	Asthma	Human	Blood Plasma	TNFalpha	ELISA	Others	Low Throughput	TNFalpha levels were generally higher in atopic compared with non-atopic children. Children with persistent asthma showed significantly higher TNFalpha levels compared with those with no persistent asthma.	27001655
83	Asthma	Human	Blood Plasma	PGE2	ELISA	Others	Low Throughput	The levels of PGE2 in asthma patients group were significantly higher than those in healthy group.	30172255
84	Asthma	Human	Blood Plasma	TXB2	ELISA	Others	Low Throughput	The levels of TXB2 in asthma patients group were significantly higher than those in healthy group.	30172255
85	Asthma	Human	Blood Plasma	PGE1	ELISA	Others	Low Throughput	The levels of PGE1 in asthma patients group were significantly higher than those in healthy group.	30172255
86	Asthma	Human	Blood Plasma	PGF2α	ELISA	Others	Low Throughput	The levels of PGF2α in asthma patients group were significantly lower than those in healthy group.	30172255
87	Asthma	Human	Blood Plasma	6-k-PGF1α	ELISA	Others	Low Throughput	The levels of 6-k-PGF1α in asthma patients group were significantly lower than those in healthy group.	30172255
88	Asthma	Human	Blood Plasma	TNFalpha	ELISA	Others	Low Throughput	TNFalpha level was higher in asthmatics and associated with the total amount of thrombin. Plasma TNFalpha were higher in persistent and sporadic asthmatics.	28429138
89	Asthma	Human	Blood Plasma	Prothrombin	Biochemical Test	Others	Low Throughput	Enhanced thrombin generation in asthma might be a reason of systemic inflammatory state and is at least partially, driven by inflammatory cytokines such as IL6 and TNFalpha.	28429138
90	Asthma	Human	Blood Plasma	IL6	ELISA	Others	Low Throughput	IL6 level was higher in asthmatics and associated with the total amount of thrombin. Plasma IL6 were higher in persistent and sporadic asthmatics.	28429138
91	Childhood Asthma	Human	Blood Plasma	IL5RA	ELISA	Others	Low Throughput	Children with moderate–severe asthma exacerbations had lower IL5RA levels and children with earlier age of asthma onset had higher IL5RA.	28574721
92	Asthma	Human	Peripheral Blood Monocytes, Neutrophils, B cells, Blood Plasma	IL18	Flow Cytometry, ELISA	Others	Low Throughput	Plasma IL18 level was elevated in asthmatics as compared to healthy subjects. Enhanced expression of IL18 was also noted in asthmatic neutrophils and B cells.	28922563
93	Asthma	Human	Peripheral Blood Monocytes, Neutrophils, B cells, Blood Plasma	IL18BP	Flow Cytometry, ELISA	Others	Low Throughput	Plasma IL18BP level was elevated in asthmatics as compared to healthy subjects. Majority of the peripheral blood monocytes, neutrophils and B cells were found to express IL18BP in aathmatic patients.	28922563
94	Bronchial Asthma	Human	Blood Plasma	CLDN4	ELISA	Others	Low Throughput	Claudin-4 in blood from asthmatic patients was increased compared with that from healthy control subjects. Plasma claudin-4 levels were significantly higher in exacerbated patients than in control patients with bronchial asthma. The plasma claudin-4 level was correlated with eosinophils, total IgE, FEV1% pred, and FEV1/FVC.	29178675
95	Asthma (in pregnant women)	Human	Blood Plasma	OPN	ELISA	Others	Low Throughput	Increase of osteopontin level in pregnancy was independent of concomitant asthma suggesting that it has an important role during gestation.	29200898
96	Asthma (in pregnant women)	Human	Blood Plasma	CLU	ELISA	Others	Low Throughput	Clusterin level decreases in healthy pregnancy but not in asthmatic pregnancy and correlates directly with lung function.	29200898
97	Neutrophilic Asthma	Human	Blood Plasma	sRAGE	ELISA, Sanger Sequencing method	Others, Genomics	Low Throughput	Plasma sRAGE levels were decreased in neutrophilic asthmatics and increased in non-neutrophilic asthmatics as compared with healthy controls. Plasma sRAGE levels were positively correlated with FEV1% predicted (FEV1% Pre) in neutrophilic asthmatics. Plasma sRAGE may be a biomarker of asthma severity and may be associated with G82S gene variants in neutrophilic asthmatics.	29257350
98	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Peripheral Blood Mononuclear Cells (PBMCs), Blood Plasma, Sputum	RIGI	Flow Cytometry	Others	Low Throughput	At exacerbation, the RIGI expression was higher in classical Dendritic Cells and peripheral Dendritic Cells but not in monocytes from asthma patients with viral infection both at steady state and exacerbation (V+V+) than in patients with viral infection at exacerbation only (V+V-).	29137638
99	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Blood Plasma, Sputum	IL5	ELISA	Others	Low Throughput	Virus infected asthma patients had significantly higher IL5 levels in sputum and plasma than in asthma patients without any viral infection. These levels were associated with higher percentages of sputum eosinophils. Sputum IL5 concentrations were lower in asthma patients with viral infection at both steady and exacerbation state (V+V+) than in patients with viral infection at exacerbation only (V+V-) at both periods.	29137638
100	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Blood Plasma, Sputum	CXCL8	ELISA	Others	Low Throughput	Compared to steady state, CXCL8 level in the sputum of virus infected asthmatic patients were significantly higher during exacerbation.	29137638
101	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Peripheral Blood Mononuclear Cells (PBMCs), Blood Plasma, Sputum	TLR3	Flow Cytometry	Others	Low Throughput	At exacerbation and steady state, classical Dendritic Cells and monocytes in asthma patients with viral infection both at steady state and exacerbation (V+V+), expressed significantly more TLR3 than that in patients with viral infection at exacerbation only (V+V-).	29137638
102	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Blood Plasma, Sputum	IL22	ELISA	Others	Low Throughput	Plasma IL22 levels were significantly lower in virus infected asthma patients at steady state. Higher IL22 levels were detected in sputum of asthma patients with viral infection both at steady state and exacerbation (V+V+) at steady state.	29137638
103	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Peripheral Blood Mononuclear Cells (PBMCs), Blood Plasma, Sputum	IL1B	ELISA	Others	Low Throughput	Compared to Virus uninfected asthma patients, IL1B was increased in unstimulated PBMC of Virus infected asthma patients. During exacerbation and at steady state, sputum concentrations of IL1B were higher in asthma patients with viral infection at both steady and exacerbation state (V+V+) than in patients with viral infection at exacerbation only (V+V-).	29137638
104	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Blood Plasma, Sputum	IFNG	ELISA	Others	Low Throughput	Compared to asthma patients with viral infection at exacerbation only (V+V-), sputum IFNG levels at exacerbation were lower in asthma patients with viral infection both at steady state and exacerbation (V+V+). In plasma, IFNG levels were lower in V+V+.	29137638
105	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Blood Plasma, Sputum	IL6	ELISA	Others	Low Throughput	Compared to steady state, IL6 level in the sputum of virus infected asthmatic patients were significantly higher during exacerbation. Plasma IL6 concentrations were greater in asthma patients with viral infection both at steady state and exacerbation (V+V+) than in patients with viral infection at exacerbation only (V+V-) during exacerbation.	29137638
106	Allergic Asthma (Virus triggered exacerbation in allergic asthma children)	Human	Blood Plasma, Sputum	IL29	ELISA	Others	Low Throughput	In plasma, IL29 levels were greater in asthma patients with viral infection both at steady state and exacerbation (V+V+).	29137638
107	Asthma	Human	Blood Plasma	IL17A	Human Cytokine Antibody Array, ELISA	Others	High Throughput, Low Throughput	Plasma IL17A level was signifcantly increased in asthmatics when compared with controls.	29138487
108	Asthma	Human	Blood Plasma	IL9	Human Cytokine Antibody Array, ELISA	Others	High Throughput, Low Throughput	Plasma IL9 level was signifcantly increased in asthmatics when compared with controls.	29138487
109	Asthma	Human	Blood Plasma	CCL11	Human Cytokine Antibody Array, ELISA	Others	High Throughput, Low Throughput	The plasma expressions of CCL11 in asthmatics was signifcantly lower than that in healthy controls.	29138487
110	Asthma	Human	Blood Plasma	CFD	Human Cytokine Antibody Array, ELISA	Others	High Throughput, Low Throughput	The plasma expressions of adipsin in asthmatics was signifcantly lower than that in healthy controls.	29138487
111	Asthma	Human	Blood Plasma	YKL40	ELISA	Others	Low Throughput	YKL40 could be used in identifying clinical phenotypes associated with poor prognosis in adult-onset asthma.	30954645
112	Asthma	Human	Blood Plasma	IL6	ELISA	Others	Low Throughput	IL6 was significantly up regulated in obese asthmatics as compared to the other categories of asthma patients.	30954645
113	Childhood Asthma	Human	Blood Plasma	miR-21	qRT-PCR	Genomics	Low Throughput	miR-21 was upregulated in asthmatic children. miR-21 plays a role in eosinophilic endotypic classification of asthma. miR-21 levels positively correlated with IL-13 levels and eosinophil percentage.	29635981
114	Childhood Asthma	Human	Blood Plasma	miR-146a	qRT-PCR	Genomics	Low Throughput	miR-146a was upregulated in asthmatic children. miR-146a plays a role in eosinophilic endotypic classification of asthma. miR-146a only correlated to eosinophil percentage.	29635981
115	Childhood Asthma	Human	Blood Plasma	IL13	ELISA	Others	Low Throughput	IL13 level was significantly up regulated in asthmatic children as compared to healthy controls.	29635981
116	Asthma-COPD Overlap Syndrome (ACOS), Asthma, COPD	Human	Blood Plasma	YKL40	ELISA	Others	Low Throughput	Compared with the plasma YKL40 levels in healthy control subjects, levels were significantly elevated in patients with asthma and those with features of ACO and were highest in patients with COPD. There was no significant difference in the levels between the asthma and ACO groups. Plasma YKL40 was negatively correlated with lung function and with the bronchodilator response.	29580282
117	Asthma-COPD Overlap Syndrome (ACOS), Asthma, COPD	Human	Blood Plasma	NGAL	ELISA	Others	Low Throughput	NGAL may be a valuable biomarker for differentiating between patients with features of ACO and asthma patients. Plasma NGAL was positively correlated with the extent of emphysema.	29580282
118	Asthma	Human	Bronchial Brushings, Induced Sputum, Blood Plasma	miR-221-3p	qRT-PCR	Genomics	Low Throughput	Epithelial, sputum, and plasma miR-221-3p expression was significantly decreased in subjects with asthma. Decreased epithelial miR-221-3p may protect against airway eosinophilic inflammation by upregulating anti-inflammatory chemokine CXCL17.	29644894
119	Asthma (in pregnant women)	Human	Blood Plasma	POSTN	ELISA	Others	Low Throughput	Periostin levels of the asthmatic and healthy pregnant groups were similar and were higher than asthmatic and healthy non pregnants. In Asthmatic Pregnant women, periostin correlated negatively with FEV1 and airway resistance. Although periostin correlates with lung function in asthmatic pregnancy, periostin as a biomarker has to be handled with caution in pregnant patients due to the influence of pregnancy on its plasma level.	27340880
120	Childhood Asthma	Human	Blood Plasma	CCL5	Antibody Suspension Bead Array, ELISA	Proteomics, Others	High Throughput, Low Throughput	Significantly lower levels of both CCL5 was found in children with persistent asthma.	27145233
121	Childhood Asthma	Human	Blood Plasma	HPGDS	Antibody Suspension Bead Array	Proteomics	Low Throughput	Significantly lower levels of both HPGDS was found in children with persistent asthma.	27145233
122	Childhood Asthma	Human	Blood Plasma	NPSR1	Antibody Suspension Bead Array	Proteomics	Low Throughput	NPSR1 was found at higher levels in children with mild intermittent asthma compared to healthy controls.	27145233
123	Asthma	Human	Epithelial Brushings, Blood Plasma	miR-181b-5p	Microarray, qRT-PCR	Genomics	High Throughput, Low Throughput	Epithelial miR-181b-5p expression was decreased in subjects with asthma. Epithelial miR-181b-5p levels were inversely correlated with sputum and bronchial submucosal eosinophilia. Plasma miR-181b-5p was decreased and correlated with epithelial miR-181b-5p in subjects with asthma. Epithelial and plasma miR-181b-5p are potential biomarkers for airway eosinophilia in asthma.	27192552
124	Atopic Asthma	Human	Blood Plasma	IL18	ELISA	Others	Low Throughput	IL18 levels in the plasma of moderate and severe but not mild asthma were elevated in comparison with healthy control subjects.	27069315
125	Atopic Asthma	Human	Blood Plasma	TPSAB1	ELISA	Others	Low Throughput	Tryptase levels in the plasma of moderate and severe asthma were higher than that of Healthy control subjects.	27069315
126	Childhood Asthma	Human	Blood Plasma	miR-155	qRT-PCR	Genomics	Low Throughput	miR-155 expression was significantly increased in the plasma of asthmatic children than in control children. The relative level of miR-155 was associated with degree of asthma severity. Plasma miRNA-155 was correlated positively with IL13 levels and correlated negatively with FEV1and FVC. miR-155 could be used as a serological non-invasive biomarker for diagnosis of asthma and degree of severity.	30981701
127	Childhood Asthma	Human	Blood Plasma	Let-7a	qRT-PCR	Genomics	Low Throughput	Let-7a expression was significantly lower in asthmatics than in control children. The relative level of Let-7a was associated with degree of asthma severity. Let-7a was correlated negatively with IL13 and correlated positively with FEV1 and FVC. Let-7a could be used as a serological non-invasive biomarker for diagnosis of asthma and degree of severity.	30981701
128	Pediatric Asthma (HDM Induced Asthma)	Human	Blood Plasma	IFNG	ELISA	Others	Low Throughput	IFNG was significantly reduced in blood plasma of asthmatic subjects as compared to control subjects.	27277384
129	Pediatric Asthma (HDM Induced Asthma)	Human	Blood Plasma	IL12	ELISA	Others	Low Throughput	IL12 was significantly reduced in blood plasma of asthmatic subjects as compared to control subjects.	27277384
130	Pediatric Asthma (HDM Induced Asthma)	Human	Blood Plasma	IL10	ELISA	Others	Low Throughput	IL10 was significantly reduced in blood plasma of asthmatic subjects as compared to control subjects.	27277384
131	Pediatric Asthma (HDM Induced Asthma)	Human	Blood Plasma	TNFalpha	ELISA	Others	Low Throughput	TNFalpha was significantly reduced in blood plasma of asthmatic subjects as compared to control subjects.	27277384
132	Childhood Asthma	Human	Blood Plasma	PTX3	Immunoassay	Others	Low Throughput	Plasma PTX3 level was significantly increased in asthmatics as compared to healthy controls. PTX3 could be considered useful to demonstrate the presence of a low grade inflammatory status and a low grade fibrinolytic activity in children with asthma.	30723958
133	Asthma	Human	Blood Plasma	sCD14	ELISA	Others	Low Throughput	sCD14 level is negatively associated with asthma severity, suggesting a protective role for sCD14 in the development of asthma in adults. Plasma sCD14 level might be a potential biomarker in prediction of asthma severity in adults.	30691461
134	Allergic Asthma	Human	Blood Plasma	FGF21	Proximity Ligation Assay panels	Proteomics	High Throughput	FGF‐21 levels correlate positively with the frequency of circulating mast cell progenitors in allergic asthmatic patients.	30892731
135	Chronic Persistent Asthma	Human	Blood Plasma	TGFB	ELISA	Others	Low Throughput	TGFB level was significantly decreased in patients with asthma compared with the controls.	27216911
136	Chronic Persistent Asthma	Human	Blood Plasma	IL17	ELISA	Others	Low Throughput	IL17 level was highly elevated in patients with asthma compared with the controls.	27216911
137	Childhood Acute Stage Asthma	Human	Blood Plasma	IL4	ELISA	Others	Low Throughput	The expression levels of IL4 was significantly higher in asthmatic children as compared to the control group.	30046607
138	Childhood Acute Stage Asthma	Human	Blood Plasma	IL5	ELISA	Others	Low Throughput	The expression levels of IL5 was significantly higher in asthmatic children as compared to the control group.	30046607
139	Childhood Acute Stage Asthma	Human	Blood Plasma	IL8	ELISA	Others	Low Throughput	The expression levels of IL8 was significantly higher in asthmatic children as compared to the control group.	30046607
140	Childhood Acute Stage Asthma	Human	Blood Plasma	TNFalpha	ELISA	Others	Low Throughput	The expression levels of TNFalpha was significantly higher in asthmatic children as compared to the control group.	30046607
141	Childhood Acute Stage Asthma	Human	Blood Plasma	IFNG	ELISA	Others	Low Throughput	The expression levels of IFNG was significantly lower in asthmatic children as compared to the control group.	30046607
142	Asthma	Human	Blood Plasma	IL4	ELISA	Others	Low Throughput	IL4 expression was significantly increased in the mild asthma and severe asthma groups when compared to normal control. Highest expression of IL4 was noted in severe asthmatics.	30088373
143	Asthma	Human	Blood Plasma	IL5	ELISA	Others	Low Throughput	IL5 expression was significantly increased in the mild asthma and severe asthma groups when compared to normal control. Highest expression of IL4 was noted in severe asthmatics.	30088373
144	Asthma	Human	Blood Plasma	IL13	ELISA	Others	Low Throughput	IL13 expression was significantly increased in the mild asthma and severe asthma groups when compared to normal controls. Highest expression of IL4 was noted in severe asthmatics.	30088373
145	Asthma	Human	Blood Plasma, CD4 T cells	IL17A	ELISA, qRT-PCR	Others, Genomics	Low Throughput	Increased expression of IL17A was noted in asthma patients as compared to control group.	30088373
146	Asthma	Human	Blood Plasma, CD4 T cells	TGFB1	ELISA, qRT-PCR	Others, Genomics	Low Throughput	Increased expression of TGFB1 was noted in asthma patients as compared to control group.	30088373
147	Childhood Allergic Asthma	Human	Blood Plasma	B7-H3	ELISA	Others	Low Throughput	Children with asthma exacerbation had significantly higher level of plasma B7-H3 compared to controls.	30075787
148	Asthma	Human	Blood Plasma, Induced Sputum	miR-199a-5p	qRT-PCR	Genomics	Low Throughput	The miRNA-199a-5p levels in plasma and sputum were increased significantly in patients with neutrophilic asthma compared to healthy subjects. Plasma miR-199a-5p was negatively correlated with pulmonary function.	29505605
149	Bronchial Asthma	Human	Blood Plasma	ANG1	ELISA	Others	Low Throughput	Expression of ANG1 was elevated in asthmatic patients as compared to control group. Plasma ANG1 concentrations were correlated with the ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC).	26776887
150	Bronchial Asthma	Human	Blood Plasma	ANG2	ELISA	Others	Low Throughput	Expression of ANG2 was significantly reduced in asthmatic patients as compared to control group. Plasma ANG2 levels were correlated with FEV1 percentage of predicted, FEV1/FVC, and total immunoglobulin E values.	26776887
151	Obese Asthma	Human	Blood Plasma, Induced Sputum	IL17	ELISA	Others	Low Throughput	Obesity promotes increased sputum and plasma IL17 expression in stable asthma patients. IL17 contributes to worse disease control in obese asthma through enhancing airway neutrophilia and depression and may implicate in asthma exacerbations.	27888992
152	Severe Allergic Asthma	Human	Blood Plasma	CCL27	ELISA	Others	Low Throughput	CCL27 plasma concentrations were higher in allergic patients with severe asthma, when compared to healthy individuals.	30475388
153	Atopic Asthma (Controlled crossover allergen challenge)	Human	Blood Plasma	IL25	ELISA	Others	Low Throughput	IL25 plasma levels was increased significantly in response to the allergen but not the diluent challenge.	27685606
154	Asthma	Human	Blood Plasma	RETN	ELISA	Others	Low Throughput	Plasma resistin and resistin:adiponectin ratio were higher in asthma compared to controls and were higher again in subjects with a severe versus mild-to-moderate asthma pattern. Resistin is a predictor of asthma risk and resistin:adiponectin is a predictor of FEV1 in asthma.	27079485
155	Asthma, Allergic Rhinitis	Human	Blood Plasma	LRG1	Flow Cytometry, ELISA	Others	Low Throughput	LRG1 expression in plasma of patients with Allergic Rhinitis and Asthma were markedly lower than that of healthy control subjects. LRG1 may be a key regulatory factor of allergic responses.	27378305
156	Asthma, Allergic Rhinitis	Human	Blood Plasma	TGFBR2	Flow Cytometry, ELISA	Others	Low Throughput	Soluble TGFBR2 expression in plasma of patients with Allergic Rhinitis and Asthma were markedly lower than that of healthy control subjects.	27378305
157	Asthma, Allergic Rhinitis	Human	Blood Plasma	TPSAB1	ELISA	Others	Low Throughput	Soluble tryptase expression in plasma of patients with Allergic Rhinitis and Asthma were markedly elevated than that of healthy control subjects.	27378305
158	Asthma	Human	Blood Plasma	IL6	ELISA	Others	Low Throughput	Plasma IL6 is increased in a subset of asthmatics characterized by obesity, metabolic dysfunction and severe asthma.	27283230
159	Asthma	Human	Blood Plasma	CD93	ELISA	Others	Low Throughput	sCD93 level was significantly elevated in asthmatic group as compared to control group. The serum level of soluble CD93 is increased in patients with asthma exacerbation. It showed that serum levels of sCD93 decreased with treatment of asthma attack.	27334785
160	Asthma	Human	Blood Plasma	ANXA1	ELISA	Others	Low Throughput	Plasma ANXA1 levels in asthmatic patients were higher than those in healthy control subjects. Plasma ANXA1 levels were significantly lower in exacerbated patients compared with stable asthma patients. ANXA1 may be a potential marker and therapeutic target for asthma.	29301525
161	Childhood Asthma	Human	CD4 T cells, Blood Plasma	miR-192	qRT-PCR	Genomics	Low Throughput	miR-192 expression was down regulated in childhood asthmatics as compared to healthy controls.	29490514
162	Childhood Asthma	Human	Blood Plasma	IL21	ELISA	Others	Low Throughput	IL21 expression was significantly increased in plasma of asthmatics as compared to that of healthy controls.	29490514
163	Asthma, COPD, Asthma COPD Overlap Syndrome (ACOS)	Human	Blood Plasma	IL4	ELISA	Others	Low Throughput	IL4 level was significantly lower in the COPD group and ACOS group than those in the asthma group.	27501772
164	Asthma, COPD, Asthma COPD Overlap Syndrome (ACOS)	Human	Blood Plasma	IL8	ELISA	Others	Low Throughput	IL8 level was significantly higher in the COPD group and ACOS group than those in the asthma group.	27501772
165	Asthma, COPD, Asthma COPD Overlap Syndrome (ACOS)	Human	Blood Plasma	IL10	ELISA	Others	Low Throughput	IL10 was positively related with FEV1, FEV1%pred, and FEV1/FVC in Asthma, COPD and ACOS patients.	27501772
166	Asthma, COPD, Asthma COPD Overlap Syndrome (ACOS)	Human	Blood Plasma	TNFalpha	ELISA	Others	Low Throughput	TNFalpha level in the asthma group was higher than in the COPD group and ACOS group.	27501772
167	Asthma	Human	Blood Plasma	HBD1	ELISA	Others	Low Throughput	The plasma level of HBD1 was significantly elevated in asthmatic patients as compared to healthy controls.	28437599
168	Asthma	Human	Blood Plasma	HBD2	ELISA	Others	Low Throughput	The plasma level of HBD2 was significantly reduced in asthmatic patients as compared to healthy controls.	28437599
169	Asthma	Human	Blood Plasma	HBD3	ELISA	Others	Low Throughput	The plasma level of HBD3 was significantly elevated in asthmatic patients as compared to healthy controls.	28437599
170	Asthma-COPD Overlap Syndrome (ACOS)	Human	Blood Plasma	NGAL	Enzyme Immunoassay (EIA)	Others	Low Throughput	NGAL levels were significantly higher in ACO compared to non-ACO COPD in female subjects. After adjusting for gender as a confounding factor, the ability to distinguish ACO was better at higher levels of NGAL.	30233879
171	Childhood Asthma	Human	Blood Plasma	miR-146a	qRT-PCR	Genomics	Low Throughput	The expression level of miR-146a was upregulated in the children with asthma as compared with the healthy children.	27446287
172	Asthma	Human	Bronchial Biopsy, Bronchial Brushings, Sputum, Blood Plasma	ITLN1	Immunohistochemistry, qRT-PCR, ELISA	Others, Genomics, Others	Low Throughput	The expression of ITLN1 is increased in the airway and plasma of subjects with asthma and is correlated with induced sputum eosinophils.	28224996
173	Asthma	Human	Blood Plasma	miR-155	qRT-PCR	Genomics	Low Throughput	Plasma miR-155 levels were elevated in severe asthmatics when compared with nonasthmatics or mild-to-moderate asthmatics. These increased plasma miR-155 levels were also observed in asthmatics with cockroach allergy compared with those without cockroach allergy.	29967100
174	Asthma	Human	Blood Plasma	LBP	ELISA	Others	Low Throughput	The level of circulating LBP was significantly higher in asthma patients in phase 1 compared with the control in phase 1. The level of LBP was significantly reduced in the asthma patients in phase 2 compared to that in phase 1. Its level was still significantly higher in asthma patients than that in controls.	28444548
175	Asthma	Human	Blood Plasma	NE	ELISA	Others	Low Throughput	NE levels were significantly higher in asthma patients when compared to that in the controls.	28444548
176	Asthma	Human	Blood Plasma	miR-425-5p	qRT-PCR assay panel	Genomics	High Throughput	Asthma patients receiving antileukotriene therapy showed decreased values for miR-223-3p/miR-425-5p as compared to those not receiving antileukotriene therapy.	28513859
177	Asthma	Human	Blood Plasma	miR-223-3p	qRT-PCR assay panel	Genomics	High Throughput	Asthma patients receiving antileukotriene therapy showed decreased values for miR-223-3p/miR-425-5p as compared to those not receiving antileukotriene therapy.	28513859
178	Asthma	Human	Blood Plasma	miR-15a-5p	qRT-PCR assay panel	Genomics	High Throughput	miR-15a-5p/miR-342-3p was inversely correlated to FVC % predicted in asthmatics. Asthma patients taking oral steroids had significantly lower values for miR-15a-5p/miR-342-3p compared to those not on oral steroids. Asthma patients taking oral steroids had significantly higher values for miR-21-5p/miR-15a-5p, miR-27a-3p/miR-15a-5p and miR-29c-3p/miR-15a-5p compared to those not on oral steroids.	28513859
179	Asthma	Human	Blood Plasma	miR-29c-3p	qRT-PCR assay panel	Genomics	High Throughput	Asthma patients taking oral steroids had significantly higher values for miR-29c-3p/miR-15a-5p compared to those not on oral steroids.	28513859
180	Asthma	Human	Blood Plasma	miR-342-3p	qRT-PCR assay panel	Genomics	High Throughput	miR-15a-5p/miR-342-3p was inversely correlated to FVC % predicted in asthmatics. Asthma patients taking oral steroids had significantly lower values for miR-15a-5p/miR-342-3p compared to those not on oral steroids.	28513859
181	Asthma	Human	Blood Plasma	miR-27a-3p	qRT-PCR assay panel	Genomics	High Throughput	Asthma patients taking oral steroids had significantly higher values for miR-27a-3p/miR-15a-5p compared to those not on oral steroids.	28513859
182	Asthma	Human	Blood Plasma	miR-21-5p	qRT-PCR assay panel	Genomics	High Throughput	Asthma patients taking oral steroids had significantly higher values for miR-21-5p/miR-15a-5p compared to those not on oral steroids.	28513859
183	Asthma (In Type 2 diabetes (T2D))	Human	Blood Plasma	MCP1	Milliplex MAP human Cytokine/Chemokine Magnetic Bead Panel Multiplex Immunoassay	Others	High Throughput	The systemic MCP1 levels were significantly elevated in type-2 diabetes (T2D) patients with asthma as compared with those without asthma and/or diabetes. These changes correlated differentially with important biomarkers of inflammation and airway remodeling (like VEGF, IFNA2, IL10 and fractalkine).	27709105