Browse Result
Total number of records for Asthma in Bronchial Biopsy of Human in DAAB (Version-2) database: 145
| Record no | Disease | Organism | Sample | Gene Name | Techniques | Omics | Study | Comments | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Asthma and effect of glucocorticoid treatment. | Human | Bronchial Biopsy | ANXA5 | iTRAQ labelling followed by nano LC-MS/MS. | Proteomics | High Throughput | This protein is involved in fibrosis and inflammation. | 21939520 |
| 2 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | A2M | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | It is a type of cytokione present in extracellular space. | 21939520 |
| 3 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | ALDOA | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | This gene shows down regulation of protein expression after budesonide treatment on asthmatics. | 21939520 |
| 4 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | ATP5B | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | This gene shows down regulation of protein expression after budesonide treatment on asthmatics. | 21939520 |
| 5 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | DPYSL5 | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | It plays a role in growth and guidance. It is upregulated after budesonide treatment. | 21939520 |
| 6 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | RPS20 | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | It is upregulated after budesonide treatment. It is located in cytoplasm. | 21939520 |
| 7 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | SERPINB3 | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | It is upregulated after budesonide treatment. It is located in extracellular space. | 21939520 |
| 8 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | VIM | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | It is a mesenchymal marker protein. It mediates reduced remodelling in response to budesonide as epithelial to mesenchymal transition has been seen to contribute to remodelling. | 21939520 |
| 9 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | DPT | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | This protein is involved in collagen fibrillogenesis. | 21939520 |
| 10 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | HIST1H2AH | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | It is downregulated in untreated asthma patients. | 21939520 |
| 11 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | LMNA | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | This protein is involved in fibrosis. It is downregulated in untreated asthma patients. | 21939520 |
| 12 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | PPIA | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | This protein is involved in chemotaxix. | 21939520 |
| 13 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | RPL7 | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | This protein is involved in translational protein elongation. | 21939520 |
| 14 | Asthma and effect of glucocorticoid treatment | Human | Bronchial Biopsy | RPL8 | iTRAQ labelling followed by nano LC-MS/MS | Proteomics | High Throughput | This protein is involved in protein synthesis. | 21939520 |
| 15 | Asthma | Human | Tissue from Bronchial Biopsy | ALOX15 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | It s new potential candidate of asthma pathogenesis. | 15038835 |
| 16 | Asthma | Human | Tissue from Bronchial Biopsy | NOS2A | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | NOS2A was increased in pre ICS asthma group as compared to control group and post ICS asthma group. | 15038835 |
| 17 | Asthma | Human | Tissue from Bronchial Biopsy | IL2RB | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | It is an immune signalling molecule. (data collected from supplementary table) | 15038835 |
| 18 | Asthma | Human | Tissue from Bronchial Biopsy | COL11A1 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | It is an extracellular protein involved in remodelling. | 15038835 |
| 19 | Asthma | Human | Tissue from Bronchial Biopsy | MUC5AC | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | Mucus production and goblet cell hyperplasia (data collected from supplementary table) | 15038835 |
| 20 | Asthma | Human | Tissue from Bronchial Biopsy | MUC2 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | Mucus production and goblet cell hyperplasia (data collected from supplementary table) | 15038835 |
| 21 | Asthma | Human | Tissue from Bronchial Biopsy | AATF | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | Downregulated in allergic asthma | 15038835 |
| 22 | Asthma | Human | Tissue from Bronchial Biopsy | IGKC | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | Downregulated in allergic asthma (data collected from supplementary table) | 15038835 |
| 23 | Asthma | Human | Tissue from Bronchial Biopsy | IGLJ3 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | Downregulated in allergic asthma (data collected from supplementary table) | 15038835 |
| 24 | Asthma | Human | Tissue from Bronchial Biopsy | GNB2 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | Intracellular signaling molecule (data collected from supplementary table) | 15038835 |
| 25 | Asthma | Human | Tissue from Bronchial Biopsy | TYROBP | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | It is involved in inflammatory signaling and found to be down regulated in this study. | 15038835 |
| 26 | Asthma | Human | Tissue from Bronchial Biopsy | CPA3 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | It encodes for a proteolytic enzyme from mast cell and upregulated in asthma (data collected from supplementary table). | 15038835 |
| 27 | Asthma | Human | Tissue from Bronchial Biopsy | NKG7 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | Modulates natural killer cell for development of eosinophilia (data collected from supplementary table) | 15038835 |
| 28 | Asthma | Human | Tissue from Bronchial Biopsy | CYBB | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | Biomarker of allergic inflammation (data collected from supplementary table). | 15038835 |
| 29 | Asthma | Human | Tissue from Bronchial Biopsy | TCF21 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | It is involved in immune signaling. | 15038835 |
| 30 | Asthma | Human | Tissue from Bronchial Biopsy | GAS1 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | GAS1 was reduced in asthma as compared to that in normal condition. | 15038835 |
| 31 | Asthma | Human | Tissue from Bronchial Biopsy | RBP4 | microarray-Affymetrix HG-U95Av2 GeneChips | Genomics | High Throughput | RBP4 was reduced in asthma as compared to that in normal condition. | 15038835 |
| 32 | Allergic Asthma | Human | Bronchial Biopsy | ALOX15 | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. | 19842841 |
| 33 | Allergic Asthma | Human | Bronchial Biopsy | CX3CR1 | Microarray | Genomics | High Throughput | Downregulated in allergic asthma. | 19842841 |
| 34 | Allergic Asthma | Human | Bronchial Biopsy | NOS2A | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. It is an immune signalling molecule. | 19842841 |
| 35 | Allergic Asthma | Human | Bronchial Biopsy | MUC2 | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. Involved in mucus production. | 19842841 |
| 36 | Allergic Asthma | Human | Bronchial Biopsy | MUC5AC | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. Involved in mucus production. | 19842841 |
| 37 | Allergic Asthma | Human | Bronchial Biopsy | CEACAM5 | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. | 19842841 |
| 38 | Allergic Asthma | Human | Bronchial Biopsy | IGHG1 | Microarray | Genomics | High Throughput | Downregulated in allergic asthma. | 19842841 |
| 39 | Allergic Asthma | Human | Bronchial Biopsy | IGKC | Microarray | Genomics | High Throughput | Downregulated in allergic asthma. | 19842841 |
| 40 | Allergic Asthma | Human | Bronchial Biopsy | CTSC | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. It is a proteolytic enzyme. | 19842841 |
| 41 | Allergic Asthma | Human | Bronchial Biopsy | SERPINB2 | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. It is a proteolytic enzyme. | 19842841 |
| 42 | Allergic Asthma | Human | Bronchial Biopsy | SERPINB4 | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. It is a proteolytic enzyme. | 19842841 |
| 43 | Allergic Asthma | Human | Bronchial Biopsy | LGALS7 | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. | 19842841 |
| 44 | Allergic Asthma | Human | Bronchial Biopsy | NQO1 | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. | 19842841 |
| 45 | Allergic Asthma | Human | Bronchial Biopsy | TCF21 | Microarray | Genomics | High Throughput | Downregulated in allergic asthma. | 19842841 |
| 46 | Allergic Asthma | Human | Bronchial Biopsy | S100P | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. | 19842841 |
| 47 | Allergic Asthma | Human | Bronchial Biopsy | POSTN | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. | 19842841 |
| 48 | Allergic Asthma | Human | Bronchial Biopsy | C7 | Microarray | Genomics | High Throughput | Upregulated in allergic asthma. | 19842841 |
| 49 | Asthma | Human | Bronchial Biopsy, Airway Smooth Muscle (ASM) Cells | PAR-2 | Immunohistochemistry | Others | Low Throughput | The proportion of ASM area stained for PAR-2 was greater in patients with severe asthma compared with that in patients with mild-to-moderate asthma and control subjects.Higher degrees of PAR-2 expression in the ASM of patients with severe compared with those with mild-to-moderate asthma and control subjects. Aberrant PAR-2 expression and activation represent an important physiopathologic mechanism involved in the excessive and irreversible ASM expansion in patients with severe asthma. | 27001157 |
| 50 | Severe Allergic Asthma | Human | Bronchial Biopsy | IL13 | qRT-PCR | Genomics | Low Throughput | IL13 mRNA expression was found to be significantly higher in severe allergic asthmatics who responded to Omalizumab as compared with those of Non-Responders or Mild Asthma. | 30107059 |
| 51 | Severe Allergic Asthma | Human | Bronchial Biopsy | IL9 | qRT-PCR | Genomics | Low Throughput | IL9 mRNA expression was found to be significantly higher in severe allergic asthmatics who responded to Omalizumab as compared with those of Non-Responders or Mild Asthma. | 30107059 |
| 52 | Severe Allergic Asthma | Human | Bronchial Biopsy | IL33 | qRT-PCR, Western Blotting, Immunohistochemistry | Genomics, Proteomics, Others | Low Throughput | Higher IL33 mRNA expression was found in severe allergic asthmatics who responded to Omalizumab as compared with those of Non-Responders or Mild Asthma. Immunohistochemical analysis confirmed the up regulation of IL33 protein in bronchial tissues of Responders compared with those of Non-Responders. Western blot analysis also revealed higher protein level of IL33 in Responders as compared with Non-Responders. | 30107059 |
| 53 | Severe Allergic Asthma | Human | Bronchial Biopsy | IL25 | qRT-PCR, Western Blotting, Immunohistochemistry | Genomics, Proteomics, Others | Low Throughput | Higher IL25 mRNA expression was found in severe allergic asthmatics who responded to Omalizumab as compared with those of Non-Responders or Mild Asthma. Immunohistochemical analysis confirmed the up regulation of IL25 protein in bronchial tissues in Responders compared with those of Non-Responders. Western blot analysis also revealed higher protein level of IL25 in Responders as compared with Non-Responders. | 30107059 |
| 54 | Severe Allergic Asthma | Human | Bronchial Biopsy | TSLP | qRT-PCR, Western Blotting, Immunohistochemistry | Genomics, Proteomics, Others | Low Throughput | Higher TSLP mRNA expression was found in severe allergic asthmatics who responded to Omalizumab as compared with those of Non-Responders or Mild Asthma. Immunohistochemical analysis confirmed the up regulation of TSLP protein in bronchial tissues in Responders compared with those of Non-Responders. Western blot also revealed a similar trend in expression of TSLP in Responders as compared with Non-Responders. | 30107059 |
| 55 | Asthma | Human | Bronchial Biopsy | IL25 | Immunohistochemistry | Others | Low Throughput | Allergen inhalation challenge increased expression of IL25 in the bronchial mucosa in atopic asthmatics to a degree correlating with increase late-phase airway obstruction. | 30185520 |
| 56 | Asthma | Human | Bronchial Biopsy | IL33 | Immunohistochemistry | Others | Low Throughput | Allergen inhalation challenge increased expression of IL33 in the bronchial mucosa in atopic asthmatics to a degree correlating with increase late-phase airway obstruction. | 30185520 |
| 57 | Asthma | Human | Bronchial Biopsy | TSLP | Immunohistochemistry | Others | Low Throughput | Allergen inhalation challenge increased expression of TSLP in the bronchial mucosa in atopic asthmatics to a degree correlating with increase late-phase airway obstruction. | 30185520 |
| 58 | Asthma | Human | Bronchial Biopsy | TSLP | qRT-PCR | Genomics | Low Throughput | The relative expression of TSLP was significantly higher in subjects with asthma compared to healthy controls. Airway hyperresponsiveness to inhaled mannitol is associated with an altered submucosal mast cell profile in asthmatic individuals. This mast cell profile is associated with increased levels of TSLP. | 26252943 |
| 59 | Asthma | Human | Bronchial Biopsy | CPA3 | qRT-PCR | Genomics | Low Throughput | Airway hyperresponsiveness to inhaled mannitol is associated with an altered submucosal mast cell profile in asthmatic individuals. This mast cell profile is associated with increased levels of CPA3. | 26252943 |
| 60 | Asthma | Human | Bronchial Biopsy, Fibroblasts | B2R | Immunohistochemistry, Western Blotting | Others, Proteomics | Low Throughput | Bronchial B2R expression is constitutively elevated in allergic asthma and is further increased after allergen exposure. Constitutive B2R protein expression was higher in human asthmatic fibroblasts than in human normal fibroblasts. | 26588817 |
| 61 | Asthma | Human | Bronchial Biopsy | NFKB | Immunohistochemistry | Others | Low Throughput | Nuclear NFKB expression was higher in asthmatics after allergen challenge than in controls. | 26588817 |
| 62 | Severe Asthma | Human | Serum, Broncho Alveolar Lavage Fluid (BALF), Bronchial Biopsy | INHBA | ELISA, Immunofluorescence | Others | Low Throughput | Activin-A expression was significantly elevated in serum, BALF and bronchial tissue of the asthmatics as compared to healthy subjects. Activin-A has anti-angiogenic effects in vitro that are not propagated in vivo, where reduced basal expression of its receptors is observed particularly in severe asthma. | 26869672 |
| 63 | Severe Asthma | Human | Bronchial Biopsy | ALK4 | Immunofluorescence | Others | Low Throughput | ALK4 expression was significantly reduced in epithelial and sub epithelial cells only in severe asthma compared to healthy controls. ALK4 inversely correlated with angiogenesis. | 26869672 |
| 64 | Severe Asthma | Human | Bronchial Biopsy | Act-RIIA | Immunofluorescence | Others | Low Throughput | The median number of cells expressing Act-RIIA immunoreactivity was significantly reduced in the bronchial epithelium and lamina propria in mild to moderate asthmatics and severely asthmatic subjects compared to healthy controls. Act-RIIA inversely correlated with angiogenesis. | 26869672 |
| 65 | Asthma | Human | Bronchial Biopsy | p22-PHOX | Immunohistochemistry, Immunofluorescence Staining | Others | Low Throughput | Increased expression and localisation of p22‐PHOX was observed in biopsies of asthmatic patients. p22-PHOX might serve as a promising therapeutic target for the management of asthma. | 28510479 |
| 66 | Asthma | Human | Bronchial Biopsy | IL1B | qRT-PCR | Genomics | Low Throughput | Compared with subjects without asthma, the patients with asthma significantly emerged IL1B up-regulation in mRNA levels. IL1B expression was higher in severe asthma group than that in control and moderate asthma group. IL1B upregulates MUC5AC expression via NFKB-induced HIF-1A in asthma. | 29031476 |
| 67 | Asthma | Human | Bronchial Biopsy, Broncho Alveolar Lavage Fluid (BALF) | MUC5AC | qRT-PCR, ELISA | Genomics, Others | Low Throughput | Hypersecretion and overexpression of MUC5AC were detected in all patients with asthma compared with control group. | 29031476 |
| 68 | Asthma | Human | Bronchial Biopsy | IL33 | qRT-PCR, Immunohistochemistry | Genomics, Others | Low Throughput | In mild untreated asthma, the expression of IL33 in bronchial mucosa is related to innate immune activation and allergic sensitization to HDM and correlates with FeNO. | 26748611 |
| 69 | Asthma | Human | Bronchial Biopsy | SOCS1 | Microarray, qRT-PCR, Immunohistochemistry | Genomics, Others | High Throughput, Low Throughput | SOCS1 gene expression was significantly lower in the airways of severe asthmatics compared with mild/moderate asthmatics and healthy controls. SOCS1 mRNA level was inversely associated with airway eosinophilia and other measures of T-helper type 2 (Th2) inflammation. | 27338192 |
| 70 | Asthma | Human | Bronchial Biopsy, Serum | uPAR | Immunohistochemistry, ELISA | Others | Low Throughput | Elevated airway and blood serum uPAR is a feature of asthma and that blood serum uPAR is particularly related to severe, nonatopic asthma. | 27624865 |
| 71 | Mild to Moderate Asthma, Severe Asthma | Human | Endobronchial Biopsy | pIgR | Immunohistochemistry | Others | Low Throughput | Down regulation of pIgR protein was observed in the bronchial epithelium from patients with asthma as compared to that in healthy controls. | 29652177 |
| 72 | Asthma | Human | Epithelial Brushings, Endobronchial Biopsy | PLA2R1 | Microarray, qRT-PCR, Immunohistochemistry | Genomics, Others | High Throughput, Low Throughput | PLA2R1 is the most differentially expressed in epithelial brushings of children with and without Asthma. PLA2R1 is increased in the airway epithelium in asthma and serves as a regulator of airway hyperresponsiveness, airway permeability, antigen sensitization and airway inflammation. | 27448109 |
| 73 | Asthma (Comparison between Smokers and Non Smokers) | Human | Endobronchial Biopsy | IL17A | Immunohistochemistry | Others | Low Throughput | Expression of IL17A was significantly elevated in the bronchial mucosa of the asthmatic smokers compared to the non-smokers. | 28211191 |
| 74 | Asthma (Comparison between Smokers and Non Smokers) | Human | Endobronchial Biopsy | IL8 | Immunohistochemistry | Others | Low Throughput | Expression of IL8 was significantly elevated in the bronchial mucosa of the asthmatic smokers compared to the non-smokers. | 28211191 |
| 75 | Asthma (Comparison between Smokers and Non Smokers) | Human | Endobronchial Biopsy | IL6 | Immunohistochemistry | Others | Low Throughput | Expression of IL6 was significantly elevated in the bronchial mucosa of the asthmatic smokers compared to the non-smokers. | 28211191 |
| 76 | Asthma | Human | Bronchial Biopsy | MMP10 | Microarray, Immunohistochemistry | Transcriptomics, Others | High Throughput, Low Throughput | MMP10 was significantly overexpressed in biopsies with high mucosal eosinophils (HE) compared to low mucosal eosinophil (LE) numbers. Immunohistochemical analysis confirmed increased expression of MMP10 in bronchial epithelial cells and in subepithelial inflammatory and resident cells in asthmatic biopsies. | 30667542 |
| 77 | Asthma | Human | Bronchial Biopsy | MET | Microarray, Immunohistochemistry | Transcriptomics, Others | High Throughput, Low Throughput | MET was significantly overexpressed in biopsies with high mucosal eosinophils (HE) compared to low mucosal eosinophil (LE) numbers. Immunohistochemical analysis confirmed increased expression of MET in bronchial epithelial cells and in subepithelial inflammatory and resident cells in asthmatic biopsies. | 30667542 |
| 78 | Asthma, COPD | Human | Exhaled Breath Condensate (EBC), Bronchial Biopsy | POSTN | ELISA, Immunostaining | Others | Low Throughput | EBC periostin levels and tissue periostin expression are higher in patients with asthma than in those with COPD. EBC periostin levels may serve as a potential surrogate marker for tissue periostin expression. | 26895432 |
| 79 | Asthma | Human | Bronchial Biopsy | IL31RA | Immunohistochemistry | Others | Low Throughput | IL31RA was significantly elevated in patients with asthma compared with controls. | 26956917 |
| 80 | Asthma | Human | Bronchial Biopsy | OSMR | Immunohistochemistry | Others | Low Throughput | OSMR was significantly elevated in patients with asthma compared with controls. | 26956917 |
| 81 | Poorly Controlled Asthma | Human | Bronchial Biopsy | CSF3 | qRT-PCR | Genomics | Low Throughput | CSF3 expression was significantly increased in poorly controlled neutrophilic asthma as compared to poorly controlled non neutrophilic asthma. | 30312710 |
| 82 | Poorly Controlled Asthma | Human | Bronchial Biopsy | CSF3R | qRT-PCR | Genomics | Low Throughput | CSF3R expression was significantly increased in poorly controlled neutrophilic asthma as compared to poorly controlled non neutrophilic asthma. | 30312710 |
| 83 | Atopic Asthma (Rhinovirus Induced Asthma Exacerbations) | Human | Bronchial Biopsy | IFNA | Immunohistochemistry | Others | Low Throughput | Bronchial epithelial IFNA protein expression is deficient in asthma patients and is related to Rhinovirus induced clinical illness severity. | 29698627 |
| 84 | Atopic Asthma (Rhinovirus Induced Asthma Exacerbations) | Human | Bronchial Biopsy | IFNB | Immunohistochemistry | Others | Low Throughput | Bronchial epithelial IFNB protein expression is deficient in asthma patients and is related to Rhinovirus induced clinical illness severity. | 29698627 |
| 85 | Atopic Asthma (Rhinovirus Induced Asthma Exacerbations) | Human | Bronchial Biopsy | TLR3 | Immunohistochemistry | Others | Low Throughput | TLR3 staining intensity at baseline was not different in asthma as compared with controls. Rhinoviral infection induced TLR3 in vivo. | 29698627 |
| 86 | Atopic Asthma (Rhinovirus Induced Asthma Exacerbations) | Human | Bronchial Biopsy | MDA5 | Immunohistochemistry | Others | Low Throughput | MDA5 staining intensity at baseline was not different in asthma as compared with controls. Rhinoviral infection induced MDA5 in vivo. | 29698627 |
| 87 | Atopic Asthma (Rhinovirus Induced Asthma Exacerbations) | Human | Bronchial Biopsy | PRR | Immunohistochemistry | Others | Low Throughput | PRR expression was not deficient in asthmatics. Rhinoviral infection induced PRR in vivo. | 29698627 |
| 88 | Atopic Asthma (Rhinovirus Induced Asthma Exacerbations) | Human | Bronchial Biopsy | RIG-I | Immunohistochemistry | Others | Low Throughput | RIG-I staining intensity at baseline was not different in asthma as compared with controls. Rhinoviral infection induced RIG-I in vitro. | 29698627 |
| 89 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings | CYP1B1 | Microarray | Transcriptomics | High Throughput | CYP1B1 was over-expressed in bronchial brushings of current smoker severe asthmatics compared to other groups. | 29650557 |
| 90 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings | ALDH3A1 | Microarray | Transcriptomics | High Throughput | ALDH3A1 was over-expressed in bronchial brushings of current smoker severe asthmatics compared to other groups. | 29650557 |
| 91 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings | NQO1 | Microarray | Transcriptomics | High Throughput | NQO1 was over-expressed in bronchial brushings of current smoker severe asthmatics compared to other groups. | 29650557 |
| 92 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings | AKR1C1 | Microarray | Transcriptomics | High Throughput | AKR1C1 was over-expressed in bronchial brushings of current smoker severe asthmatics compared to other groups. | 29650557 |
| 93 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings | HSPA5 | Microarray | Transcriptomics | High Throughput | HSPA5 was significantly upregulated in current smoker severe asthmatics compared to non smoker severe asthmatics in bronchial brushings and biopsies. | 29650557 |
| 94 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | CPA3 | Microarray | Transcriptomics | High Throughput | CPA3 was differentially expressed in ex smoker severe asthmatics compared to non smoker severe asthmatics. | 29650557 |
| 95 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | CST1 | Microarray | Transcriptomics | High Throughput | CST1 was differentially expressed in ex smoker severe asthmatics compared to non smoker severe asthmatics. | 29650557 |
| 96 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | IGKC | Microarray | Transcriptomics | High Throughput | IGKC was differentially expressed in ex smoker severe asthmatics compared to non smoker severe asthmatics. | 29650557 |
| 97 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | MUC2 | Microarray | Transcriptomics | High Throughput | MUC2 was differentially expressed in ex smoker severe asthmatics compared to non smoker severe asthmatics. | 29650557 |
| 98 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | TPSAB1 | Microarray | Transcriptomics | High Throughput | TPSAB1 was differentially expressed in ex smoker severe asthmatics compared to non smoker severe asthmatics. | 29650557 |
| 99 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | FDCSP | Microarray | Transcriptomics | High Throughput | FDCSP was significantly up regulated in ex smoker severe asthmatics. | 29650557 |
| 100 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | PPBP | Transcriptomics | High Throughput | PPBP was significantly up regulated in ex smoker severe asthmatics. | 29650557 | |
| 101 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | POSTN | Transcriptomics | High Throughput | POSTN was significantly down regulated in ex smoker severe asthmatics. | 29650557 | |
| 102 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | IGLC1 | Transcriptomics | High Throughput | IGLC1 was significantly down regulated in ex smoker severe asthmatics. | 29650557 | |
| 103 | Severe Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum | IGLV | Transcriptomics | High Throughput | IGLV was significantly down regulated in ex smoker severe asthmatics. | 29650557 | |
| 104 | Atopic Asthma (Following Allergen Challenge) | Human | Bronchial Biopsy | p38 | Immunohistochemistry | Others | Low Throughput | Biopsies collected post-allergen had an increased percentage of epithelial cells expressing phospho-p38. | 29651336 |
| 105 | Atopic Asthma (Following Allergen Challenge) | Human | Bronchial Biopsy | STAT5 | Immunohistochemistry | Others | Low Throughput | Biopsies collected post-allergen had increased numbers of sub-epithelial cells expressing phospho-STAT5. | 29651336 |
| 106 | Atopic Asthma (Following Allergen Challenge) | Human | Bronchial Biopsy | RPS6 | Immunohistochemistry | Others | Low Throughput | Biopsies collected post-allergen had increased numbers of sub-epithelial cells expressing phospho-RPS6. | 29651336 |
| 107 | Asthma | Human | Bronchial Biopsy | miR-142-3p | qRT-PCR | Genomics | Low Throughput | miR-142-3p was significantly increased in early onset asthma patients as compared to late onset asthma patients. miR-142-3p was significantly decreased in severe asthma patients as compared to mild asthma patients. | 29722559 |
| 108 | Asthma | Human | Bronchial Biopsy | DKK1 | qRT-PCR | Genomics | Low Throughput | DKK1 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 109 | Asthma | Human | Bronchial Biopsy | DVL1 | qRT-PCR | Genomics | Low Throughput | DVL1 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 110 | Asthma | Human | Bronchial Biopsy | FBXW4 | qRT-PCR | Genomics | Low Throughput | FBXW4 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 111 | Asthma | Human | Bronchial Biopsy | FZD8 | qRT-PCR | Genomics | Low Throughput | FZD8 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 112 | Asthma | Human | Bronchial Biopsy | JUN | qRT-PCR | Genomics | Low Throughput | JUN was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 113 | Asthma | Human | Bronchial Biopsy | MMP7 | qRT-PCR | Genomics | Low Throughput | MMP7 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 114 | Asthma | Human | Bronchial Biopsy | MYC | qRT-PCR | Genomics | Low Throughput | MYC was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 115 | Asthma | Human | Bronchial Biopsy | RHOU | qRT-PCR | Genomics | Low Throughput | RHOU was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 116 | Asthma | Human | Bronchial Biopsy | WIF1 | qRT-PCR | Genomics | Low Throughput | WIF1 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 117 | Asthma | Human | Bronchial Biopsy | WNT16 | qRT-PCR | Genomics | Low Throughput | WNT16 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 118 | Asthma | Human | Bronchial Biopsy | WNT3 | qRT-PCR | Genomics | Low Throughput | WNT3 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 119 | Asthma | Human | Bronchial Biopsy | WNT5A | qRT-PCR | Genomics | Low Throughput | WNT5A was significantly reduced in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 120 | Asthma | Human | Bronchial Biopsy | WNT6 | qRT-PCR | Genomics | Low Throughput | WNT6 was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 121 | Asthma | Human | Bronchial Biopsy | WNT9A | qRT-PCR | Genomics | Low Throughput | WNT9A was significantly elevated in late onset asthma patients as compared to early onset asthma patients. | 29722559 |
| 122 | Asthma | Human | Bronchial Biopsy | NOS2 | Microarray Data Analysis | Bioinformatics | High Throughput | NOS2 was upregulated in asthmatics as compared to healthy subjects. NOS2 may serve as a potential target for asthma diagnosis and treatment. | 30186379 |
| 123 | Asthma | Human | Bronchial Biopsy | CXCL9 | Microarray Data Analysis | Bioinformatics | High Throughput | CXCL9 was down regulated in asthmatics as compared to healthy subjects. CXCL9 may serve as a potential target for asthma diagnosis and treatment. | 30186379 |
| 124 | Asthma | Human | Bronchial Biopsy | CCL21 | Microarray Data Analysis | Bioinformatics | High Throughput | CCL21 was down regulated in asthmatics as compared to healthy subjects. CCL21 may serve as a potential target for asthma diagnosis and treatment. | 30186379 |
| 125 | Asthma | Human | Bronchial Biopsy | PTPRC | Microarray Data Analysis | Bioinformatics | High Throughput | PTPRC was down regulated in asthmatics as compared to healthy subjects. PTPRC may serve as a potential target for asthma diagnosis and treatment. | 30186379 |
| 126 | Asthma | Human | Bronchial Biopsy | FN1 | Microarray Data Analysis | Bioinformatics | High Throughput | FN1 was down regulated in asthmatics as compared to healthy subjects. | 30186379 |
| 127 | Asthma | Human | Bronchial Biopsy | CD8A | Microarray Data Analysis | Bioinformatics | High Throughput | CD8A is an important hub in protein protein interaction network for asthma. | 30186379 |
| 128 | Asthma | Human | Bronchial Biopsy | CCL19 | Microarray Data Analysis | Bioinformatics | High Throughput | CCL19 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 129 | Asthma | Human | Bronchial Biopsy | CCL5 | Microarray Data Analysis | Bioinformatics | High Throughput | CCL5 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 130 | Asthma | Human | Bronchial Biopsy | CXCR4 | Microarray Data Analysis | Bioinformatics | High Throughput | CXCR4 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 131 | Asthma | Human | Bronchial Biopsy | CXCR6 | Microarray Data Analysis | Bioinformatics | High Throughput | CXCR6 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 132 | Asthma | Human | Bronchial Biopsy | CXCL6 | Microarray Data Analysis | Bioinformatics | High Throughput | CXCL6 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 133 | Asthma | Human | Bronchial Biopsy | CD2 | Microarray Data Analysis | Bioinformatics | High Throughput | CD2 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 134 | Asthma | Human | Bronchial Biopsy | ITK | Microarray Data Analysis | Bioinformatics | High Throughput | ITK is an important hub in protein protein interaction network for asthma. | 30186379 |
| 135 | Asthma | Human | Bronchial Biopsy | ADCY7 | Microarray Data Analysis | Bioinformatics | High Throughput | ADCY7 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 136 | Asthma | Human | Bronchial Biopsy | COL3A1 | Microarray Data Analysis | Bioinformatics | High Throughput | COL3A1 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 137 | Asthma | Human | Bronchial Biopsy | CD247 | Microarray Data Analysis | Bioinformatics | High Throughput | CD247 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 138 | Asthma | Human | Bronchial Biopsy | PENK | Microarray Data Analysis | Bioinformatics | High Throughput | PENK is an important hub in protein protein interaction network for asthma. | 30186379 |
| 139 | Asthma | Human | Bronchial Biopsy | H2AFV | Microarray Data Analysis | Bioinformatics | High Throughput | H2AFV is an important hub in protein protein interaction network for asthma. | 30186379 |
| 140 | Asthma | Human | Bronchial Biopsy | POSTN | Microarray Data Analysis | Bioinformatics | High Throughput | POSTN is an important hub in protein protein interaction network for asthma. | 30186379 |
| 141 | Asthma | Human | Bronchial Biopsy | KLRB1 | Microarray Data Analysis | Bioinformatics | High Throughput | KLRB1 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 142 | Asthma | Human | Bronchial Biopsy | SERPING1 | Microarray Data Analysis | Bioinformatics | High Throughput | SERPING1 is an important hub in protein protein interaction network for asthma. | 30186379 |
| 143 | Asthma | Human | Bronchial Biopsy, Bronchial Brushings, Sputum, Blood Plasma | ITLN1 | Immunohistochemistry, qRT-PCR, ELISA | Others, Genomics, Others | Low Throughput | The expression of ITLN1 is increased in the airway and plasma of subjects with asthma and is correlated with induced sputum eosinophils. | 28224996 |
| 144 | Severe Asthma | Human | Bronchial Biopsy | CEACAM6 | Immunohistochemistry, Microarray | Others, Transcriptomics | Low Throughput, High Throughput | CEACAM6 protein expression in bronchial biopsies was increased in airway epithelial cells and lamina propria inflammatory cells in severe asthma compared with healthy control subjects. CEACAM6 in the lamina propria was localized to neutrophils predominantly. The percentage of neutrophils expressing CEACAM6 was significantly increased in severe asthma, suggesting the presence of an altered neutrophil phenotype. CEACAM6 expression is increased in severe asthma and primarily associated with airway epithelial cells and tissue neutrophils. CEACAM6 may contribute to the pathology of treatment-resist | 28275137 |
| 145 | Asthma | Human | Airway smooth muscle cells (ASMCs) (Stimulated with IL1B), Bronchial Biopsy | CCL20 | Microarray, ELISA | Transcriptomics, Others | High Throughput, Low Throughput | IL1B induced increased CCL20 expression and protein release in ASMCs from moderate asthmatics as compared to mild asthmatics and healthy controls. Elevated CCL20 production by ASMCs, possibly resulting from dysregulated expression of the anti-inflammatory miR-146a-5p, may contribute to enhanced mucus production in asthma. | 29946002 |