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Total number of records for Asthma in Lung Tissue of Rat in DAAB (Version-2) database: 166

 

Record noDiseaseOrganismSampleGene NameTechniquesOmicsStudyCommentsPubmed ID
1Early airway response (EAR) phase of AsthmaRatLung TissueS100a9Serial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt is highly expressed in neutrophils and monocytes. It is present at high levels in the extracellular milieu during inflammatory conditions but its extracellular function remains unclear. Inhibition of the S100A8 and S100A9 proteins prior to intranasal allergen challenge in mice resulted in preservation of all the characteristics of the asthma phenotype but there was a significant reduction in the number of eosinophils in BAL fluid.18922145
2Early airway response (EAR) phase of AsthmaRatLung TissueJunSerial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt is involved in T-cell receptor signalling pathway.18922145
3Early airway response (EAR) phase of AsthmaRatLung TissueLamb2Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputThis protein is involved in focal adhesion and ECM receptor interaction and cell communication.18922145
4Early airway response (EAR) phase of AsthmaRatLung TissueCol4a1Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputThis protein is involved in ECM receptor interaction and cell communication.18922145
5Early airway response (EAR) phase of AsthmaRatLung TissueCcnd1Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputThis protein is involved in focal adhesion and WNT signalling pathway.18922145
6Early airway response (EAR) phase of AsthmaRatLung TissueRrasSerial analysis of gene expression (SAGE)GenomicsHigh ThroughputThis protein is involved in regulation of actin cytoskeleton and IgE receptor signalling pathway.18922145
7Early airway response (EAR) phase of AsthmaRatLung TissueMapk9Serial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt is a component of MAPK signalling pathway and Toll-like receptor signalling pathway. It is also involved in IgE receptor signalling pathway and controls focal adhesion.18922145
8Early airway response (EAR) phase of AsthmaRatLung TissueRac2Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt is a major component of several signal transduction pathways such as MAPK signalling pathway and IgE receptor signalling pathway.18922145
9Early airway response (EAR) phase of AsthmaRatLung TissueCav1Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputWhen the MaxiK channel was activated by Ca2+ spikes or an increase in cAMP then it forms complexes with the caveolin. These mixed signals resulted in cascade-like activation of the MAPK and focal adhesion pathways. It plays a crucial role in processing and integrating extracellular signals leading to airway inflammation and remodelling.18922145
10Early airway response (EAR) phase of AsthmaRatLung TissueVclSerial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt is involved in focal adhesion and leucocyte transendothelial migration. It also controls actin cytoskeleton and adherens junction.18922145
11Early airway response (EAR) phase of AsthmaRatLung TissueCol6a2Serial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputThis gene is downregulated with expression being decreased over 10-fold. These changes in gene expression may affect the immune response or other biological processes relevant to asthma.18922145
12Early airway response (EAR) phase of AsthmaRatLung TissueDusp1Serial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt was significantly elevated in this study which is demonstrating that Dusp1 may function as a negative regulator to alleviate and counteract the OVA challenge signals transmitted by the MAPK pathway. The Dusp1 gene is therefore a potential target for the development of novel anti-inflammatory drugs.18922145
13Early airway response (EAR) phase of AsthmaRatLung TissueFosSerial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt is involved in B-cell receptor and Toll-like receptor signalling pathway.18922145
14Early airway response (EAR) phase of AsthmaRatLung TissueHspa8Serial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt is involved in Antigen processing and presentation.18922145
15Early airway response (EAR) phase of AsthmaRatLung TissueTgfbr2Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt is involved in MAPK signalling pathway and controls adherens junction.18922145
16Early airway response (EAR) phase of AsthmaRatLung TissueNr4a1Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt s a component of MAPK signalling pathway.18922145
17Early airway response (EAR) phase of AsthmaRatLung TissueAgrnSerial analysis of gene expression (SAGE)GenomicsHigh ThroughputThe expression of agrin was decreased in the SAGE library from asthmatic lung. This suggests that agrin may disperse the aggregation of molecules in the immunological synapse including the T-cell receptor and IgE receptor.18922145
18Early airway response (EAR) phase of AsthmaRatLung TissueLmnaSerial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt participates in cell communication.18922145
19Early airway response (EAR) phase of AsthmaRatLung TissueCldn18Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt is involved in leucocyte transendothelial migration and tight junction.18922145
20Early airway response (EAR) phase of AsthmaRatLung TissueTmsb4xSerial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt participates in the regulation of actin cytoskeleton.18922145
21Early airway response (EAR) phase of AsthmaRatLung TissueMt2ASerial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt may play a protective role in the early respone phase of asthma and may be a potential candidate antioxidant drug for asthma and inflammation.18922145
22Early airway response (EAR) phase of AsthmaRatLung TissueElnSerial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt is a major component of the extracellular matrix in the airways and is disrupted by the high levels of active elastase produced in the asthmatic lung. The simultaneous decrease in the expression of this gene may reduce the cohesiveness of the connective tissue and permeabilize the walls of vessels and facilitate the migration of inflammatory cells in the early response phase of asthma.18922145
23Early airway response (EAR) phase of AsthmaRatLung TissueRab7aSerial analysis of gene expression (SAGE) and qRT-PCRGenomicsHigh Throughput and Low ThroughputIt is downregulated in asthmatic lung.18922145
24Early airway response (EAR) phase of AsthmaRatLung TissueGnai2Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt is involved in the regulation of tight junction.18922145
25Early airway response (EAR) phase of AsthmaRatLung TissueSptan1Serial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt is involved in the regulation of tight junction.18922145
26Early airway response (EAR) phase of AsthmaRatLung TissueB2mSerial analysis of gene expression (SAGE)GenomicsHigh ThroughputIt participates in antigen processing and presentation18922145
27AsthmaRatLung TissueParp1Ferric Reducing Ability Assay and Poly(ADP-ribosyl)ation and immunoblotOthersLow ThroughputMinocycline-treated/ovalbumin-challenged mice showed reduction in poly(ADP-ribose) immunoreactivity in lung and it correlates with decreased oxidative DNA damage. However the drug can not block direct PARP activation in lungs of N-methyl-N -nitro-N-nitroso-guanidine-treated mice or H2O2-treated cells.23184953
28Asthma (Asthmatics exposed to cigarette smoke)Rat (Male Wistar rats)Lung TissuesCCR7Immunohistochemistry, Western BlotOthers, ProteomicsLow ThroughputTissue CCR7 expression was significantly higher in the asthma with smoke exposure group than the asthma group and the control group. Cigarette smoking may aggravate asthma symptoms by attenuating immunity, possibly through CCR7-mediated Dendritic Cells aggregation in lung tissue.30416795
29Asthma (Neonatal Asthma)Rat (Male Sprague–Dawley neonatal rats)Lung TissueCasp3Real time PCR, ImmunohistochemistryGenomics, OthersLow ThroughputThe mRNA expression levels of caspase-3 was increased by 1.3 fold in asthmatic rats. Caspase-3 protein expression increased dramatically (1.1-fold) in asthmatic rats as compared sham rats.30382409
30Asthma (Neonatal Asthma)Rat (Male Sprague–Dawley neonatal rats)Lung Tissuep53Real time PCRGenomicsLow ThroughputThe mRNA expression levels of p53 was increased by 1.4 fold in asthmatic rats as compared sham rats.30382409
31Asthma (Neonatal Asthma)Rat (Male Sprague–Dawley neonatal rats)Lung TissueBaxReal time PCRGenomicsLow ThroughputThe mRNA expression levels of Bax was increased by 0.9 fold in asthmatic rats as compared sham rats.30382409
32Asthma (Neonatal Asthma)Rat (Male Sprague–Dawley neonatal rats)Lung TissueProNgfReal time PCRGenomicsLow ThroughputThe mRNA expression levels of proNGF was increased by 1.1 fold in asthmatic rats as compared sham rats.30382409
33Asthma (Neonatal Asthma)Rat (Male Sprague–Dawley neonatal rats)Lung TissueBcl2Real time PCRGenomicsLow ThroughputBcl-2 expression was reduced by 0.78-fold in asthmatic rats as compared to sham rats.30382409
34Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung Tissues, Broncho Alveolar Lavage Fluid (BALF), SerumAlbAlbumin KitOthersLow ThroughputThe albumin level was elevated in OVA treated rats as compared to control rats.30541359
35Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung Tissue SupernatantSodBiochemical TestsOthersLow ThroughputSod level was reduced in OVA treated rats as compared to control rats.30541359
36Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung TissuesNrf2qRT-PCRGenomicsLow ThroughputThere was significant down-regulation in lung Nrf2 mRNA expression in OVA treated rat as compared to normal rat.30541359
37Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung TissuesHo-1qRT-PCRGenomicsLow ThroughputThere was significant up-regulation in lung Ho-1 mRNA expression in OVA treated rat as compared to normal rat.30541359
38Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung TissuesiNosqRT-PCRGenomicsLow ThroughputThere was significant up-regulation in lung iNos mRNA expression in OVA treated rat as compared to normal rat.30541359
39Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung TissuesTgfbqRT-PCRGenomicsLow ThroughputThere was significant up-regulation in lung Tgfb mRNA expression in OVA treated rat as compared to normal rat.30541359
40Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung TissuesTnf alphaqRT-PCRGenomicsLow ThroughputThere was significant up-regulation in lung Tnf alpha mRNA expression in OVA treated rat as compared to normal rat.30541359
41Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung TissuesIl1bqRT-PCRGenomicsLow ThroughputThere was significant up-regulation in lung Il1b mRNA expression in OVA treated rat as compared to normal rat.30541359
42Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung TissuesIl4qRT-PCRGenomicsLow ThroughputThere was significant up-regulation in lung Il4 mRNA expression in OVA treated rat as compared to normal rat.30541359
43Asthma (OVA Induced Asthma)Rat (Male Sprague-Dawley rats)Lung TissuesIl6qRT-PCRGenomicsLow ThroughputThere was significant up-regulation in lung Il6 mRNA expression in OVA treated rat as compared to normal rat.30541359
44Asthma (OVA Induced Asthma)Rat (Sprague Dawley Rats)Lung TissuesIcam-1Western BlottingProteomicsLow ThroughputWestern blot analysis showed that the expression of Icam1 was dramatically enhanced in OVA‐treated rats when compared with the control group.30520122
45Asthma (OVA Induced Asthma)Rat (Sprague Dawley Rats)Lung Tissuesp-p65Western BlottingProteomicsLow ThroughputExpression of phospho-p65 was increased in OVA‐treated rats when compared with the control group.30520122
46Asthma (OVA Induced Asthma)Rat (Sprague Dawley Rats)Lung TissuesMmp9Immunohistochemistry, Western BlottingOthers, ProteomicsLow ThroughputIncreased expression of Mmp9 was observed in the OVA group when compared with the control group.30520122
47Asthma (OVA Induced Asthma)Rat (Sprague Dawley Rats)Lung TissuesTimp1Immunohistochemistry, Western BlottingOthers, ProteomicsLow ThroughputIncreased expression of Timp1 was observed in the OVA group when compared with the control group.30520122
48Asthma (OVA Induced Asthma)RatLung Tissue Sectionsα-SmaImmunohistochemistryOthersLow Throughputα-Sma level was elevated significantly in OVA induced asthmatic rats as compared to control rats. This indicates that OVA sensitization and challenge increases airway smooth muscle deposition.26242865
49Asthma (OVA Induced Asthma)RatLung Tissues, Lung Tissue SectionsWisp1qRT-PCR, ImmunohistochemistryGenomics, OthersLow ThroughputOVA Challenge induces Wisp1 transcription and expression in lung tissues of rat models of asthma. Wisp1 may be a potential inducer of ASM proliferation and hypertrophy in asthma. The pro-remodeling effect of Wisp1 is likely due to be involved in PI3K-GSK3β-dependent noncanonical TGF-β signaling.26242865
50Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley Rat)Lung Tissues, Lung Homogenate Il1bWestern Blotting, ELISAProteomics, OthersLow ThroughputOVA induced rats displayed significantly elevated protein expression of Il1b in lung lavage as compared to normal rats.28850927
51Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley Rat)Lung Tissues, Lung Homogenate Tgfb1Western Blotting, ELISAProteomics, OthersLow ThroughputTgfb1 was up regulated in the lung from the rats of OVA stimulated group as compared to normal rats.28850927
52Asthma (OVA Induced Asthma)RatLung TissuesJnk1/2Western BlottingProteomicsLow ThroughputThe expressions of Jnk 1/2 was increased in the lung tissues of cigarette smoke control group, asthma model group and cigarette smoke-exposed asthma group as compared to normal control group. The mechanism of the inflammation may be related to Jnk1/2 signaling pathway.28871941
53Asthma (OVA Induced Asthma)RatLung TissuesEt2Western Blotting, ImmunohistochemistryProteomics, OthersLow ThroughputThe expressions of Et2 was increased in the lung tissues of cigarette smoke control group, asthma model group and cigarette smoke-exposed asthma group as compared to normal control group. The mechanism of the inflammation may be related to Et2 signaling pathway.28871941
54AsthmaRat (Male Sprague Dawley Rats)Lung Tissues, Broncho Alveolar Lavage Fluid (BALF), SerumTgfb1Immunohistochemistry, Immunofluorescence Staining, ELISAOthersLow ThroughputTgfb1 expression in the asthma model group was increased as compared with that in the blank group.29231548
55Asthma (OVA Induced Asthma)RatLung Tissues, Peripheral Blood, LymphNotch1qRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputNotch1 was significantly increased in asthmatic rats as compared to control groups.29363718
56Asthma (OVA Induced Asthma)RatLung Tissues, Peripheral Blood, LymphNotch2qRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputNotch2 was significantly increased in asthmatic rats as compared to control groups.29363718
57Asthma (OVA Induced Asthma)RatLung Tissues, Peripheral Blood, LymphNotch3qRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputNotch3 was significantly decreased in asthmatic rats as compared to control groups.29363718
58Asthma (OVA Induced Asthma)RatLung Tissues, Peripheral Blood, LymphJagged1qRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputJagged1 was significantly increased in asthmatic rats as compared to control groups.29363718
59Asthma (OVA Induced Asthma)RatLung Tissues, Peripheral Blood, Lymph∆4qRT-PCR, Western BlottingGenomics, ProteomicsLow Throughput∆4 was significantly decreased in asthmatic rats as compared to control groups.29363718
60Asthma (OVA Induced Asthma)Rat (Sprague Dawley rats)Lung TissuesRorγtqRT-PCR, Western Blotting, ImmunohistochemistryGenomics, Proteomics, OthersLow ThroughputThe expression levels of Rorγt protein and mRNA in the lung tissues were notably higher in the asthma model group than in the normal control group.29105464
61Neonatal Asthma (OVA Induced Asthma)Rat (Male neonatal Sprague Dawley rats)Lung Tissues, SerumTnfalphaqRT-PCR, ELISAGenomics, OthersLow ThroughputThe mRNA expression levels of Tnfalpha were elevated in asthmatic rats by 1.3 fold as compared to normal control rats. Tnfalpha protein level was increased in the neonatal asthmatic rats. 31065489
62Neonatal Asthma (OVA Induced Asthma)Rat (Male neonatal Sprague Dawley rats)Lung Tissues, SerumIl6qRT-PCR, ELISAGenomics, OthersLow ThroughputThe mRNA expression levels of Il6 were elevated in asthmatic rats by 1.04 fold as compared to normal control rats. Il6 protein level was increased in the neonatal asthmatic rats. 31065489
63Neonatal Asthma (OVA Induced Asthma)Rat (Male neonatal Sprague Dawley rats)Lung TissuesiNosqRT-PCR, ImmunohistochemistryGenomics, OthersLow ThroughputThe mRNA expression levels of iNos were elevated in asthmatic rats by 1.1 fold as compared to normal control rats. Immunohistochemistry showed that iNos protein expression increased by 0.9-fold in the asthmatic rats.31065489
64Asthma (Antigen induced pulmonary inflammation, AIPI) RatLung TissuesmiR-23aqRT-PCRGenomicsLow ThroughputThe expression of miR‐23a was significantly upregulated in rats with acute and chronic AIPI as compared to control rats. miR‐23a contributes to asthma by targeting Bcl2 in airway epithelial cells and Cxcl12 in fibroblasts.31020662
65Asthma (Antigen induced pulmonary inflammation, AIPI) RatLung TissuesBcl2qRT-PCR, Western Blotting, ImmunohistochemistryGenomics, Proteomics, OthersLow ThroughputBcl2 mRNA and protein expression was significantly decreased in both acute and chronic AIPI as compared to control rats.31020662
66Asthma (Antigen induced pulmonary inflammation, AIPI) RatLung TissuesCxcl12qRT-PCR, Western Blotting, ImmunohistochemistryGenomics, Proteomics, OthersLow ThroughputThe protein expression of Cxcl12 was significantly decreased in chronic AIPI, but only slightly in acute AIPI as compared to control rats. Cxcl12 mRNA expression was reduced in AIPI rats as compared to control rats.31020662
67Asthma (OVA/LPS induced asthma)Rat (Male Wistar rats)Lung Tissue HomogenateIl4ELISAOthersLow ThroughputIn the OVA/LPS control rats, significant increase in lung levels of Il4 was noted as compared to control rats.29288381
68Asthma (OVA/LPS induced asthma)Rat (Male Wistar rats)Lung Tissue HomogenateIl13ELISAOthersLow ThroughputIn the OVA/LPS control rats, significant increase in lung levels of Il13 was noted as compared to control rats.29288381
69Asthma (OVA/LPS induced asthma)Rat (Male Wistar rats)Lung Tissue Homogenate, Lung TissuesIl17aELISA, Immunohistochemistry, qRT-PCROthers, GenomicsLow ThroughputIn the OVA/LPS control rats, significant increase in lung levels of Il17 mRNA and protein was noted as compared to control rats.29288381
70Asthma (OVA/LPS induced asthma)Rat (Male Wistar rats)Lung Tissue Homogenate, Lung TissuesIl23ELISA, Immunohistochemistry, qRT-PCROthers, GenomicsLow ThroughputIn the OVA/LPS control rats, significant increase in lung levels of Il23 mRNA and protein was noted as compared to control rats.29288381
71Asthma (OVA/LPS induced asthma)Rat (Male Wistar rats)Lung Tissue HomogenateTnfalphaELISAOthersLow ThroughputIn the OVA/LPS control rats, significant increase in lung levels of Tnfalpha was noted as compared to control rats.29288381
72Asthma (OVA/LPS induced asthma)Rat (Male Wistar rats)Lung Tissue HomogenateTgfb1ELISAOthersLow ThroughputIn the OVA/LPS control rats, significant increase in lung levels of Tgfb1 was noted as compared to control rats.29288381
73Asthma (OVA Induced Asthma)Rat (Female Wistar rats)Lung TissuesIfngELISAOthersLow ThroughputIfng was significantly decreased in asthmatic rats as compared to healthy controls.29576798
74Asthma (OVA Induced Asthma)Rat (Female Wistar rats)Lung TissuesIl4ELISAOthersLow ThroughputIl4 was significantly increased in asthmatic rats as compared to healthy controls.29576798
75Asthma (OVA Induced Asthma)RatLung TissuesCcr7ImmunohistochemistryOthersLow ThroughputIn the lung tissues of the rats from asthma group, smoke exposure group and asthma-smoke exposure group, the average optical density (AOD) of Ccr7 were significantly higher than those in control group. The AOD of Ccr7 of asthma-smoke exposure group was much higher than both that in asthma group and in smoke exposure group.30078283
76Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesIl4ELISAOthersLow ThroughputIl4 level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in the Il4 level in NO2 plus OVA group.28986735
77Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesIl1bqRT-PCRGenomicsLow ThroughputIl1b level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in the Il1b level in NO2 plus OVA group.28986735
78Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesIcam1qRT-PCRGenomicsLow ThroughputIcam1 level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in the Icam1 level in NO2 plus OVA group.28986735
79Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesIl6qRT-PCRGenomicsLow ThroughputIl6 level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in the Il6 level in NO2 plus OVA group.28986735
80Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesIfngqRT-PCRGenomicsLow ThroughputIfng level was significantly decreased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further promoted decrease in Ifng level in NO2 plus OVA group.28986735
81Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesIl4raqRT-PCRGenomicsLow ThroughputIl4ra level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further promoted significant increase in the Il4ra level in NO2 plus OVA group.28986735
82Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesJak1qRT-PCRGenomicsLow ThroughputJak1 level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further promoted significant increase in the Jak1 level in NO2 plus OVA group.28986735
83Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesJak3qRT-PCRGenomicsLow ThroughputJak3 level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further promoted significant increase in the Jak3 level in NO2 plus OVA group.28986735
84Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesMuc5acqRT-PCRGenomicsLow ThroughputMuc5ac level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in the Muc5ac expression in NO2 plus OVA group.28986735
85Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesStat6qRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputStat6 and pStat6 expression were significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further promoted significant increase in the Stat6 and pStat6 expression in NO2 plus OVA group.28986735
86Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesGata3qRT-PCRGenomicsLow ThroughputGata3 level was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in Gata3 expression in NO2 plus OVA group.28986735
87Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesLckWestern BlottingProteomicsLow ThroughputActivation of Lck was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in Lck activation in NO2 plus OVA group.28986735
88Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesErk1/2Western BlottingProteomicsLow ThroughputActivation of Erk1/2 was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in Erk1/2 activation in NO2 plus OVA group.28986735
89Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesNfkbWestern BlottingProteomicsLow ThroughputActivation of Nfkb was significantly increased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further dramatically promoted increase in Nfkb activation in NO2 plus OVA group.28986735
90Asthma (OVA induced asthma, NO2 inhalation)Rat (Male Wistar rats)Lung TissuesTbetqRT-PCRGenomicsLow ThroughputTbet level was significantly decreased in OVA induced asthmatic rats as compared to control rats. NO2 exposure further promoted decrease in Tbet level in NO2 plus OVA group.28986735
91Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung Tissuesα-SmaImmunohistochemistryOthersLow Throughputα-Sma expression in lung tissues was significantly increased in OVA challenged asthmatic rats as compared to control rats.30616171
92Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesWnt5aWestern Blotting, qRT-PCRProteomics, GenomicsLow ThroughputWnt5a expression in lung tissues was significantly increased in OVA challenged asthmatic rats as compared to control rats.30616171
93Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesCtnnb1Western Blotting, qRT-PCRProteomics, GenomicsLow ThroughputBeta catenin expression in lung tissues was significantly increased in OVA challenged asthmatic rats as compared to control rats.30616171
94Asthma (OVA Induced Asthma)Rat (Female Sprague Dawley rats)Broncho Alveolar Lavage Fluid (BALF), Lung TissuesTgfb1ELISA, Immunohistochemistry, qRT-PCR, Western BlottingOthers, Genomics, ProteomicsLow ThroughputTgfb1 level was significantly increased in asthmatic rats as compared to control rats.30681402
95Asthma (OVA Induced Asthma)Rat (Female Sprague Dawley rats)Lung TissuesSmad3Western BlottingProteomicsLow ThroughputPhosphorylation of Smad3 was significantly increased in asthmatic rats as compared to control rats.30681402
96Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesVcam1qRT-PCRGenomicsLow ThroughputThe expression levels of Vcam1 was significantly higher in OVA sensitized group as compared to the control group.30088169
97Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIcam1qRT-PCRGenomicsLow ThroughputThe expression levels of Icam1 was significantly higher in OVA sensitized group as compared to the control group.30088169
98Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIl5qRT-PCRGenomicsLow ThroughputThe expression levels of Il5 was significantly higher in OVA sensitized group as compared to the control group.30088169
99Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIl12qRT-PCRGenomicsLow ThroughputThe expression levels of Il12 was significantly lower in OVA sensitized group as compared to the control group.30088169
100Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIfngqRT-PCRGenomicsLow ThroughputThe expression levels of Ifng was significantly decreased in OVA sensitized group as compared to the control group.30088169
101Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesNfat1Western BlottingProteomicsLow ThroughputNfat1 expression was significantly increased in OVA challenged asthma mice as compared to normal control mice.30806289
102Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuescMycWestern BlottingProteomicsLow ThroughputcMyc expression was significantly increased in OVA challenged asthma mice as compared to normal control mice.30806289
103Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesT2r10qRT-PCRGenomicsLow ThroughputT2r10 expression was significantly decreased in OVA challenged asthma mice as compared to normal control mice.30806289
104Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIp3r1qRT-PCRGenomicsLow ThroughputIp3r1 expression was significantly increased in OVA challenged asthma mice as compared to normal control mice.30806289
105Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesOrai1qRT-PCRGenomicsLow ThroughputOrai1 expression was significantly increased in OVA challenged asthma mice as compared to normal control mice.30806289
106Bronchial Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesSodBiochemical TestOthersLow ThroughputSod activity was significantly reduced in lung tissues of OVA induced asthmatic rats as compared to control rats.30422021
107Bronchial Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesSp-DWestern BlottingProteomicsLow ThroughputSurfactant protein D expression was significantly increased in lung tissues of OVA induced asthmatic rats as compared to control rats.30422021
108Bronchial Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesUcnImmunohistochemistryOthersLow ThroughputOvalbumin challenged group showed a significant increase in Ucn protein expression in lung tissues than the normal control group.30422021
109Asthma (OVA Induced asthma, high fat diet)Rat (Male Wistar rats)Lung TissuesmiR-146aqRT-PCRGenomicsLow ThroughputmiR-146a was significantly elevated in OVA sensitized rats as compared to normal rats. Further, elevation in miR-146a was observed in OVA sensitized high fed diet rats.30521085
110Asthma (OVA Induced asthma, high fat diet)Rat (Male Wistar rats)Lung TissuesIrak1ELISAOthersLow ThroughputIrak1 protein level was significantly elevated in OVA sensitized rats as compared to normal rats. Further, elevation in Irak1 was observed in OVA sensitized high fed diet rats.30521085
111Asthma (OVA Induced asthma, high fat diet)Rat (Male Wistar rats)Lung TissuesNfkbELISAOthersLow ThroughputNfkb protein level was significantly elevated in OVA sensitized rats as compared to normal rats. Further, elevation in Nfkb was observed in OVA sensitized high fed diet rats.30521085
112Asthma (OVA Induced asthma, high fat diet)Rat (Male Wistar rats)Lung TissuesIl1bELISAOthersLow ThroughputIl1b protein level was significantly elevated in OVA sensitized rats as compared to normal rats. Further, elevation in Il1b was observed in OVA sensitized high fed diet rats.30521085
113Asthma (OVA Induced asthma, high fat diet)Rat (Male Wistar rats)Lung TissuesTraf6ELISAOthersLow ThroughputTraf6 protein level was elevated in OVA sensitized rats as compared to normal rats. Significant elevation in Traf6 was observed in OVA sensitized high fed diet rats.30521085
114Obese Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIl1bqRT-PCR, ELISAGenomics, OthersLow ThroughputThe expression levels of Il1b in OVA-sensitized asthma and obese asthma groups showed a significant increase compared with other groups. High fat diet caused overexpression of both Il1b mRNA and protein in an experimental model of asthma. 27424133
115Obese Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIrak1qRT-PCRGenomicsLow ThroughputIn obese asthma group, expression level of Irak1 mRNA was markedly higher than other groups. High fat diet caused overexpression of Irak1 mRNA in an experimental model of asthma. 27424133
116Obese Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesTraf6qRT-PCRGenomicsLow ThroughputIn obese asthma group, expression level of Traf6 mRNA was markedly higher than other groups. High fat diet caused overexpression of Traf6 mRNA in an experimental model of asthma. 27424133
117Asthma (OVA + Aspergillus fumigatus Induced Asthma)Rat (Wistar rats)Lung TissuesGcrqRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputCompared with the normal control group, the expressions of Gcr mRNA and protein in Aspergillus fumigatus group and OVA group were decreased significantly. The expressions of Gcr mRNA and protein in OVA + Aspergillus fumigatus group were further decreased than those in OVA group and Aspergillus fumigatus group.28297812
118Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesFasqRT-PCRGenomicsLow ThroughputFas was significantly reduced in lung tissues of asthmatic mice as compared to control mice.29713367
119Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesFasLqRT-PCRGenomicsLow ThroughputFasL was significantly reduced in lung tissues of asthmatic mice as compared to control mice.29713367
120Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesBcl2qRT-PCRGenomicsLow ThroughputBcl2 was significantly increased in lung tissues of asthmatic mice as compared to control mice.29713367
121Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesCcl11qRT-PCRGenomicsLow ThroughputCcl11 was significantly increased in lung tissues of asthmatic mice as compared to control mice.29713367
122Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesVcam1qRT-PCRGenomicsLow ThroughputVcam1 was significantly up regulated in OVA induced asthmatic rats as compared to control rats.30343002
123Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIcam1qRT-PCRGenomicsLow ThroughputIcam1 was significantly up regulated in OVA induced asthmatic rats as compared to control rats.30343002
124Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIl5qRT-PCRGenomicsLow ThroughputIl5 was significantly up regulated in OVA induced asthmatic rats as compared to control rats.30343002
125Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIl12qRT-PCRGenomicsLow ThroughputIl12 was significantly down regulated in OVA induced asthmatic rats as compared to control rats.30343002
126Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesIfngqRT-PCRGenomicsLow ThroughputIfng was significantly down regulated in OVA induced asthmatic rats as compared to control rats.30343002
127Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Broncho Alveolar Lavage Fluid (BALF), Lung TissuesTnfalphaELISAOthersLow ThroughputTnfalpha expression was significantly elevated in asthmatic rats as compared to control rats.30260006
128Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Broncho Alveolar Lavage Fluid (BALF), Lung TissuesIfngELISAOthersLow ThroughputIfng expression was significantly reduced in asthmatic rats as compared to control rats.30260006
129Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Broncho Alveolar Lavage Fluid (BALF), Lung TissuesIl1bELISAOthersLow ThroughputIl1b expression was significantly elevated in asthmatic rats as compared to control rats.30260006
130Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Broncho Alveolar Lavage Fluid (BALF), Lung TissuesIl6ELISAOthersLow ThroughputIl6 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
131Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesLc3-I/IIImmunohistochemistry, Western BlottingOthers, ProteomicsLow ThroughputLc3 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
132Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesBecn1Western BlottingProteomicsLow ThroughputBecn1 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
133Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesP62Western BlottingProteomicsLow ThroughputP62 expression was significantly reduced in asthmatic rats as compared to control rats.30260006
134Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesAtg3Western BlottingProteomicsLow ThroughputAtg3 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
135Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesAtg5Western BlottingProteomicsLow ThroughputAtg5 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
136Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesAtg7Western BlottingProteomicsLow ThroughputAtg7 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
137Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesTlr4Western BlottingProteomicsLow ThroughputTlr4 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
138Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung Tissuesp65Western BlottingProteomicsLow Throughputp-p65 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
139Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesHmgb1Western BlottingProteomicsLow ThroughputHmgb1 expression was significantly elevated in asthmatic rats as compared to control rats.30260006
140Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesPi3kWestern BlottingProteomicsLow ThroughputPi3k expression was significantly reduced in asthmatic rats as compared to control rats.30260006
141Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesAktWestern BlottingProteomicsLow Throughputp-Akt was significantly reduced in asthmatic rats as compared to control rats.30260006
142Asthma (OVA Induced Asthma)Rat (Male Sprague Dawley rats)Lung TissuesmTorWestern BlottingProteomicsLow Throughputp-mTor was significantly reduced in asthmatic rats as compared to control rats.30260006
143Asthma (Effects of Aspergillus fumigatus on OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesTlr2qRT-PCRGenomicsLow ThroughputAspergillus fumigatus exposed asthmatic rats exhibited significantly elevated expression of Tlr2 as compared to asthmatic rats and control rats.28696809
144Asthma (Effects of Aspergillus fumigatus on OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesGcrqRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputqRT-PCR and Western blot analyses both revealed lower Gcr expression levels in Aspergillus fumigatus exposed asthmatic rats, suggesting that Aspergillus fumigatus exposure to asthmatics may be associated with steroid-resistant asthma by down-regulating the expression of Gcr.28696809
145Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesCdh1ImmunohistochemistryOthersLow ThroughputE-Cadherin expression was significantly lowered in asthmatic model as compared to the control group.30078282
146Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesFnImmunohistochemistryOthersLow ThroughputFibronectin expression was significantly increased in asthmatic model as compared to the control group.30078282
147Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung Tissuesα-SmaImmunohistochemistryOthersLow Throughputα-Sma expression was significantly increased in asthmatic model as compared to the control group.30078282
148Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesTbetqRT-PCRGenomicsLow ThroughputTbet level in the asthmatic rats was significantly lower than those in the normal control group.30268855
149Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesGata3qRT-PCRGenomicsLow ThroughputGata3 level in the asthmatic rats was significantly higher than those in the normal control group.30268855
150Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Serum, Lung TissuesIl4ELISA, qRT-PCROthers, GenomicsLow ThroughputIl4 level in the asthmatic rats was significantly higher than those in the normal control group.30268855
151Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Serum, Lung TissuesIfngELISA, qRT-PCROthers, GenomicsLow ThroughputIfng level in the asthmatic rats was significantly lower than those in the normal control group.30268855
152Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesmiR-142qRT-PCRGenomicsLow ThroughputmiR-142 expression was significantly decreased in asthmatic rats as compared to normal rats.29949788
153Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesEgfrqRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputEgfr expression and phosphorylation was significantly increased in asthmatic rats as compared to normal rats.29949788
154Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesAktqRT-PCR, Western BlottingGenomics, ProteomicsLow ThroughputAkt expression and phosphorylation was significantly increased in asthmatic rats as compared to normal rats.29949788
155Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesTgfbqRT-PCRGenomicsLow ThroughputTgfb expression was significantly increased in asthmatic rats as compared to normal rats.29949788
156Asthma (OVA Induced Asthma)Rat (Sprague Dawley (SD) rats)Lung TissuesIl21Western BlottingProteomicsLow ThroughputIl21 expression was significantly increased in asthmatic rats as compared to normal control rats.29906536
157Asthma (OVA Induced Asthma)Rat (Sprague Dawley (SD) rats)Lung TissuesIl21rWestern BlottingProteomicsLow ThroughputIl21r expression was significantly increased in asthmatic rats as compared to normal control rats.29906536
158Asthma (OVA Induced Asthma)Rat (Sprague Dawley (SD) rats)Lung TissuesStat3Western BlottingProteomicsLow ThroughputStat3 expression and phosphorylation was significantly increased in asthmatic rats as compared to normal control rats.29906536
159Asthma (OVA Induced Asthma)Rat (Sprague Dawley (SD) rats)Lung Tissues, Blood PlasmaTslpImmunohistochemistry, qRT-PCR, ELISAOthers, Genomics, OthersLow ThroughputTslp expression was significantly increased in asthmatic rats as compared to normal control rats.29940571
160Asthma (OVA Induced Asthma)Rat (Sprague Dawley (SD) rats)Lung Tissues, Blood PlasmaOx40lImmunohistochemistry, qRT-PCR, ELISAOthers, Genomics, OthersLow ThroughputOx40l expression was significantly increased in asthmatic rats as compared to normal control rats.29940571
161Asthma (OVA Induced Asthma)Rat (Sprague Dawley (SD) rats)Lung Tissuesα-SmaImmunohistochemistry, qRT-PCROthers, GenomicsLow Throughputα-Sma expression was significantly increased in asthmatic rats as compared to normal control rats.29940571
162Asthma (OVA Induced Asthma)Rat (Sprague Dawley (SD) rats)Lung TissuesCol1a1Immunohistochemistry, qRT-PCROthers, GenomicsLow ThroughputCol1a1 expression was significantly increased in asthmatic rats as compared to normal control rats.29940571
163Allergic Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesChatImmunohistochemistry, qRT-PCR, Western BlottingOthers, Genomics, ProteomicsLow ThroughputChat expression was significantly increased in OVA induced asthmatic rats as compared to control rats.29520557
164Allergic Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesAcheImmunohistochemistry, qRT-PCR, Western BlottingOthers, Genomics, ProteomicsLow ThroughputAche expression was significantly increased in OVA induced asthmatic rats as compared to control rats.29520557
165Allergic Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesAchRM1Immunohistochemistry, qRT-PCR, Western BlottingOthers, Genomics, ProteomicsLow ThroughputAchRM1 expression was significantly increased in OVA induced asthmatic rats as compared to control rats.29520557
166Allergic Asthma (OVA Induced Asthma)Rat (Male Wistar rats)Lung TissuesAchRM2Immunohistochemistry, qRT-PCR, Western BlottingOthers, Genomics, ProteomicsLow ThroughputAchRM2 expression was significantly decreased in OVA induced asthmatic rats as compared to control rats.29520557