Browse Result
Total number of records for Asthma in Serum of Human in DAAB (Version-2) database: 492
| Record no | Disease | Organism | Sample | Gene Name | Techniques | Omics | Study | Comments | Pubmed ID |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | Treatment with an anti-IL13 monoclonal antibody Lebrikizumab significantly improves prebronchodilator forced expiratory volume in 1 s (FEV(1)) in a subset of subjects with uncontrolled asthma. | 24131304 |
| 2 | Asthma | Human | Serum | IGHE | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 3 | Asthma | Human | Serum | CRP | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 4 | Asthma | Human | Serum | IL6 | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 5 | Asthma | Human | Serum | CXCL8 | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 6 | Asthma | Human | Serum | IL17A | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 7 | Asthma | Human | Serum | TNF | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 8 | Asthma | Human | Serum | RNASE3 | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 9 | Asthma | Human | Serum | MMP25 | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 10 | Asthma | Human | Serum | CHI3L1 | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 11 | Asthma | Human | Serum | CD86 | In silico Pubmed database seraching and analysis | Others | Low Throughput | This serum biomarker is capable of supporting a diagnosis of asthma in order to counter mistreatment and misdiagnosis with other obstructive airways disease. | 23952480 |
| 12 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | It is a candidate for the predictive marker of asthma. | 23943655 |
| 13 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum periostin appears to be a useful biomarker for the development of airflow limitation in asthmatic patients on inhaled corticosteroids. | 23791506 |
| 14 | Asthma | Human | Serum | CHI3L1 | ELISA and SNP typing of the gene promoter | Others, Genomics | Low Throughput | YKL-40 levels are increased in children with severe and therapy-resistant asthma compared to healthy children. | 23628340 |
| 15 | Asthma | Human | Serum | ICAM1 | ELISA | Others | Low Throughput | Patients with shortness in breath can be treated effectively with fluticasone effectively. The effectiveness of treatment can be monitered by significant changes in this biomarker level in serum. | 23606983 |
| 16 | Asthma | Human | Serum | RNASE3 | ELISA | Others | Low Throughput | This protein together with peripheral eosinophil leve is found to be sensitive markers for asthma severity. Patients with shortness in breath can be treated effectively with fluticasone effectively. The effectiveness of treatment can be monitered by significant changes in this biomarker level in serum. | 23606983 |
| 17 | Asthma | Human | Genomic DNA and Serum | SERPINA1 | Genotyping and ELISA | Genomics, Others | Low Throughput | The SNP Glu363Lys in this gene was identified as important genetic markers for use in better management of the disease. Significantly low level of Îħ(1)AT in the serum of asthmatics as compared to controls was found. | 23226977 |
| 18 | Asthma | Human | Genomic DNA and Serum | TIMP1 | Genotyping and ELISA | Genomics, Others | Low Throughput | G3774A and Phe124Phe of TIMP-1 in this gene was identified as important genetic markers for use in better management of the disease. | 23226977 |
| 19 | Asthma | Human | Serum | POSTN | Immunoassay | Others | Low Throughput | Periostin is a systemic biomarker of airway eosinophilia in asthmatic patients and has potential utility in patient selection for emerging asthma therapeutics targeting TH2 inflammation. | 22857879 |
| 20 | Asthma | Human | Serum | NOS2 | Immunoassay | Others | Low Throughput | Bronchial epithelial expression levels of this gene correlated with bronchial IL-13 and IL-5 expression. We observed relatively strong positive correlations between bronchial or systemic eosinophilia and serum periostin levels. | 22857879 |
| 21 | Asthma | Human | Serum | MIR1248 | real time PCR | Genomics | Low Throughput | miR-1248 is predicted to regulate IL5 post-transcriptionally. It physically interacts with the IL-5 transcript in the 3' untranslated region and serves as a positive regulator to increase IL-5 expression. | 23885321 |
| 22 | Asthma | Human | Serum | MIRLET7D | real time PCR | Genomics | Low Throughput | It is downregulated in asthma. It regulated the expression of IL-13. | 23885321 |
| 23 | Asthma | Human | Serum | MIR26A1 | real time PCR | Genomics | Low Throughput | It is downregulated in asthma. It regulated the expression of TGF-β receptor. | 23885321 |
| 24 | Asthma | Human | Serum | MIRLET7A1 | real time PCR | Genomics | Low Throughput | It is downregulated in asthma. It regulated the expression of IL-13. | 23885321 |
| 25 | Asthma and effect of toluene diisocyanate (TDI) | Human | Serum | ALB | Multiplexed tandem mass spectrometry and western blot | Proteomics | Low Throughput | Albumin has been identified as a major reaction target for TDI in vivo and TDI albumin reaction products have been proposed to serve as exposure biomarkers and to act as asthmagens. Vapor phase TDI was found to react with human albumin in a dose-dependent manner with up to 18 potential sites of conjugation, the most susceptible being Lys351 and the dilysine site Lys413-414. | 22206939 |
| 26 | Asthma and obesity | Human | Serum | ADIPOQ | Immunoassay | Others | Low Throughput | The adipocytes are the most important source of adiponectin ans its serum levels are markedly decreased in individuals with visceral obesity. Interdisciplinary therapy resulted in increase from 4 to 5.1. | 22170805 |
| 27 | Asthma and obesity | Human | Serum | CRP | Immunoassay | Others | Low Throughput | The higher CRP levels was correlated with severe asthma. CRP concentrations reduced after 1 year of interdisciplinary treatment from 2,073 to 1,538. | 22170805 |
| 28 | Asthma and obesity | Human | Serum | LEP | Immunoassay | Others | Low Throughput | The higher leptin levels was correlated with severe asthma. CRP concentrations reduced after 1 year of interdisciplinary treatment from 59 to 33. | 22170805 |
| 29 | Asthma | Human | Serum | C3 | Immunodiffusion assay | Others | Low Throughput | Increase in the serum levels of the C3 components of the complement system in the majority of the patients with intermittent atopic asthma was observed. | 22065014 |
| 30 | Asthma | Human | Serum | C4A | Immunodiffusion assay | Others | Low Throughput | Increase in the serum levels of the C4 components of the complement system in the majority of the patients with intermittent atopic asthma was observed. | 22065014 |
| 31 | Atopic Asthma and obesity related Asthma | Human | Fasting Serum | TNF | Immunoassay | Others | Low Throughput | This is a Th1 specific biomarker can distinguish obesity asthma from atopic asthma. | 21980061 |
| 32 | Atopic Asthma and obesity related Asthma | Human | Fasting Serum | IL6 | Immunoassay | Others | Low Throughput | This is a Th1 specific biomarker can distinguish obesity asthma from atopic asthma. | 21980061 |
| 33 | Atopic Asthma and obesity related Asthma | Human | Fasting Serum | IFNG | Immunoassay | Others | Low Throughput | This is a Th1 specific biomarker can distinguish obesity asthma from atopic asthma. | 21980061 |
| 34 | Atopic Asthma and obesity related Asthma | Human | Fasting Serum | CXCL10 | Immunoassay | Others | Low Throughput | This is a Th1 specific biomarker can distinguish obesity asthma from atopic asthma. | 21980061 |
| 35 | Atopic Asthma and obesity related Asthma | Human | Fasting Serum | IL4 | Immunoassay | Others | Low Throughput | This is a Th2 specific biomarker can distinguish obesity asthma from atopic asthma. | 21980061 |
| 36 | Atopic Asthma and obesity related Asthma | Human | Fasting Serum | IL5 | Immunoassay | Others | Low Throughput | This is a Th2 specific biomarker can distinguish obesity asthma from atopic asthma. | 21980061 |
| 37 | Atopic Asthma and obesity related Asthma | Human | Fasting Serum | IL13 | Immunoassay | Others | Low Throughput | This is a Th2 specific biomarker can distinguish obesity asthma from atopic asthma. | 21980061 |
| 38 | Asthma | Human | Serum | CHI3L1 | Immunoassay | Others | Low Throughput | YKL-40 seems to be a good marker of asthma.But its level may not correlate with clinical outcome. | 21899483 |
| 39 | Severe and mild Asthma | Human | Serum | IL6 | ELISA | Others | Low Throughput | This study suggests that there is not any difference between severe and mild asthma in serum IL-8 and IL-6. Thus level of serum cytokines may not predict severity of asthma. | 24024021 |
| 40 | Severe and mild Asthma | Human | Serum | CXCL8 | ELISA | Others | Low Throughput | This study suggests that there is not any difference between severe and mild asthma in serum IL-8 and IL-6. Thus level of serum cytokines may not predict severity of asthma. | 24024021 |
| 41 | Asthma. | Human | Serum | ECP | ELISA | Others | Low Throughput | Elevated in asthmatic patients. | 18504410 |
| 42 | Asthma( grass pollen sensitization). | Human | Serum | ECP | CAP FEIA Pharmacia-Upjohn Uppsala, Sweden | Others | Low Throughput | Upregulated in grass pollen season. | 11097312 |
| 43 | Asthma (unresponsiveness and responsiveness to glucocorticoids) | Human | Serum | IL8 | ELISA | Others | Low Throughput | The serum IL-8 level in uncontrolled asthma patients was significantly higher than that of the healthy controls. There was a significant relationship between serum IL-8 level and blood neutrophil count, neutrophil percentage, serum TNF-α protein, FEV1/FVC ratio and rate of FEV1 change after bronchodilation. Significant reduction of serum IL-8 level was noted in uncontrolled asthmatics with good glucocorticosteroid responsiveness. | 29849682 |
| 44 | Allergic Inflammation (Allergic Rhinitis, Bronchial Asthma, Chronic Spontaneous Urticaria) | Human | Serum | CD93 | ELISA | Others | Low Throughput | Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including Chronic Spontaneous Urticaria, Allergic Rhinitis and Asthma. Serum sCD93 levels were higher in patients with exacerbated allergic diseases than in those with stable diseases or without diseases. ICS use significantly diminished serum sCD93 levels in steroid-naive patients with Bronchial Asthma. | 28332366 |
| 45 | Asthma (Childhood asthma) | Human | Serum | IL-23 | ELISA, RT-PCR | Others, Genomics | Low Throughput | Serum level of IL-23 was significantly higher in patients with persistent asthma as compared to control subjects. A significant difference between IL-23 gene expression in patients with mild and severe persistent asthma was noted compared to control group. The median of IL-23 gene expression in patients with severe persistent asthma was greater than in mild persistent asthmatics, but, there was no significant difference in IL-23 expression level between the two groups. | 28341820 |
| 46 | Asthma (Pediatric Asthma) | Human | Serum | POSTN | ELISA | Others | Low Throughput | Children with asthma had significantly higher serum periostin level than control group. Periostin was slightly correlated with eosinophil count and house dust mite specific IgE Count in asthmatic children. | 27062336 |
| 47 | Asthma (Severe/refractory and Non severe Asthma) | Human | Serum | VEGF | ELISA | Others | Low Throughput | The mean serum level of VEGF was significantly higher in asthmatics (both severe/refractory and non severe) as compared to healthy subjects. Within the Severe/Refractory Asthma group, the mean VEGF serum level was significantly higher in patients with aspirin hypersensitivity as compared to aspirin tolerant individuals. | 26937244 |
| 48 | Asthma (Severe/refractory and Non severe Asthma) | Human | Serum | SPP1 | ELISA | Others | Low Throughput | The mean serum osteopontin level was significantly lower in asthmatics as compared to controls. | 26937244 |
| 49 | Asthma (Severe/refractory and Non severe Asthma) | Human | Serum | ANGPT1 | ELISA | Others | Low Throughput | The mean serum level of Angiopoietin-1 was significantly higher in asthmatics (both severe/refractory and non-severe) as compared to healthy subjects. | 26937244 |
| 50 | Asthma (Severe/refractory and Non severe Asthma) | Human | Serum | ANGPT2 | ELISA | Others | Low Throughput | The mean serum level of Angiopoietin-2 was significantly higher in asthmatics (both severe/refractory and non-severe) as compared to healthy subjects. The mean serum level of Angiopoietin-2 was found to be significantly higher in patients with severe/refractory asthma as compared to non-severe asthma. | 26937244 |
| 51 | Severe Asthma with Fungal Sensitization | Human | Serum | IL33 | ELISA | Others | Low Throughput | Severe asthma patients with fungal sensitization had significantly higher serum level of IL-33 than those without fungal sensitization. | 28801088 |
| 52 | Asthma | Human | Serum | YKL40 | ELISA | Others | Low Throughput | YKL-40 was increased in asthma and more so, in COPD as compared to healthy control subjects. YKL-40 also showed a weak yet significant association with BMI in asthmatic patients only. The increased level correlated with reduced lung function and were relatively steroid-insenstive. | 26372680 |
| 53 | Asthma | Human | Serum | CHIT1 | Chitotriosidase flurimetric assay | Others | Low Throughput | Chitotriosidase was increased in asthma and more so, in COPD as compared to healthy control subjects. The increased level correlated with reduced lung function and were relatively steroid-insenstive. | 26372680 |
| 54 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum periostin was found to be elevated in asthma patients compared to healthy subjects. There exists a positive correlation with the severity of airflow obstruction, as the FEV1 value reduces there is a significant increase in serum periostin levels. Serum periostin serves as an ideal blood biomarker of Th2 high asthma and had higher sensitivity when compared to blood AEC and sputum eosinophils. | 27054127 |
| 55 | Asthma | Human | Serum | IL33 | ELISA | Others | Low Throughput | The level of IL33 was significantly higher in patients with allergic asthma and eosinophilic asthma when compared to healthy subjects. IL33 may play an important role in asthma pathogenesis, especially as a marker for allergic asthma. | 30303258 |
| 56 | Bronchial asthma (mild to moderate severity) | Human | Serum | POSTN | ELISA | Others | Low Throughput | The serum periostin level, a marker of allergic inflammation and remodeling, was increased in bronchial asthma and was reduced with ICS therapy. | 30582493 |
| 57 | Toluene Diisocyanate Induced Occupational Asthma | Human | Serum, Cell culture supernatants | POSTN | ELISA | Others | Low Throughput | A high serum periostin level is a potential serologic marker of the phenotype of Toluene Diisocyanate Induced Occupational Asthma. Increased release of Periostin was noted from primary small airway epithelial cells (SAECs) when exposed to Toluene Diisocyanate and neutrophils isolated from adult asthmatics. | 30450856 |
| 58 | Bronchial Asthma (BA), Atopic Dermatitis (AD), Allergic Rhinitis (AR), Mixed Atopic Patients | Human | Serum | FLG | ELISA | Others | Low Throughput | A significant increase in serum filaggrin levels was observed in patirnts with different atopic disorders as compared with healthy controls of the same age group.Besides, filaggrin levels were significantly increased in AD patients as compared with AR or BA patients, whereas patients with multiple atopic disorders had almost similar levels of filaggrin as AD patients. Filaggrin might be useful in the diagnosis of BA, AD and AR. | 30560019 |
| 59 | Bronchial Asthma (BA), Atopic Dermatitis (AD), Allergic Rhinitis (AR), Mixed Atopic Patients | Human | Serum | MBP | ELISA | Others | Low Throughput | The serum levels of MBP in patients with different atopic disorders were found to be significantly higher as compared with healthy controls. MBP levels were significantly increased in AR patients as compared with AD, BA, or mixed atopic patients. Results also indicated that serum MBP levels were not increased in AD patients as compared with that in controls. MBP might be useful in the diagnosis of BA, AD and AR. | 30560019 |
| 60 | Bronchial Asthma (BA), Atopic Dermatitis (AD), Allergic Rhinitis (AR), Mixed Atopic Patients | Human | Serum | LTB4 | ELISA | Others | Low Throughput | LTB4 levels were almost similar in all tested atopic patients groups including AD, AR, BA and also mixed atopic patients, but were significantly lower as compared with their respective controls (p < 0.05). LTB4 might play a role in the pathogenesis of BA, AD and AR. LTB4 might be useful in the diagnosis of BA, AD and AR. | 30560019 |
| 61 | Asthma | Human | Serum | TNC | ELISA | Others | Low Throughput | Serum TNC levels were significantly higher in patients with severe asthma and high serum total IgE levels. Serum TNC levels in asthmatic patients are associated with clinical features of asthma and that the combination of serum TNC and periostin levels or combination of serum TNC and total IgE levels were more useful for asthma than each single marker, suggesting that serum TNC can serve as a novel biomarker for asthma. | 30473714 |
| 62 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum periostin levels were significantly higher in patients with mild to moderate asthma, Th2-high, high peripheral blood eosinophil counts and high FeNO levels. | 30473714 |
| 63 | Bronchial Asthma | Human | Serum | TNFalpha | Immunoturbidimetry | Others | Low Throughput | The level of TNFalpha in peripheral serum of asthmatic children were significantly higher than those in the control group. | 30401793 |
| 64 | Bronchial Asthma | Human | Serum | IL6 | Immunoturbidimetry | Others | Low Throughput | The level of IL6 in peripheral serum of asthmatic children were significantly higher than those in the control group. | 30401793 |
| 65 | Bronchial Asthma | Human | Serum | CRP | Immunoturbidimetry | Others | Low Throughput | The level of CRP in peripheral serum of asthmatic children were significantly higher than those in the control group. CRP was positively correlated with GSRS (Gastrointestinal symptom rating scale) scores and the total load of intestinal bacteria. | 30401793 |
| 66 | Asthma | Human | Serum | Biopterin | HPLC | Others | Low Throughput | Serum biopterin correlated to the state of the following period's asthma control in children with stable asthma. Therefore, biopterin has a potential to serve as a predictive biomarker for asthma control, especially in children who have difficulty in measuring FeNO. | 30297096 |
| 67 | Allergic Rhinitis, Allergic Asthma | Human | Serum | IL31 | ELISA | Others | Low Throughput | The serum level of IL31 was significantly up regulated in both Allergic Rhinitis and Allergic Asthma patients compared with normal individuals. | 30301503 |
| 68 | Allergic Rhinitis, Allergic Asthma | Human | Serum | IL33 | ELISA | Others | Low Throughput | The serum level of IL33 was significantly up regulated in both Allergic Rhinitis and Allergic Asthma patients compared with normal individuals. | 30301503 |
| 69 | Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group | Human | Serum | IL4 | ELISA | Others | Low Throughput | The serum IL4 level of allergic rhinitis, asthma and complication groups were significantly higher than those of control group. The serum level of IL4 in the combined group was significantly higher than those in the asthma group. Serum IL4 is involved in the pathogenesis of allergic rhinitis and asthma, which can be used to evaluate the degrees of respiratory allergic diseases. | 30344593 |
| 70 | Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group | Human | Serum | IL5 | ELISA | Others | Low Throughput | Serum IL5 level of allergic rhinitis, asthma and complication groups were significantly higher than those of control group. The serum level of IL5 in the combined group was significantly higher than those in the asthma group and allergic rhinitis group. Serum IL5 is involved in the pathogenesis of allergic rhinitis and asthma, which can be used to evaluate the degrees of respiratory allergic diseases. | 30344593 |
| 71 | Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group | Human | Serum | IL10 | ELISA | Others | Low Throughput | Serum IL10 level of allergic rhinitis, asthma and complication groups were significantly higher than those of control group. The serum level of IL10 in the combined group was significantly higher than those in the asthma group and allergic rhinitis group. Serum IL10 is involved in the pathogenesis of allergic rhinitis and asthma, which can be used to evaluate the degrees of respiratory allergic diseases. | 30344593 |
| 72 | Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group | Human | Serum | sICAM1 | ELISA | Others | Low Throughput | sICAM1 level of allergic rhinitis, asthma and complication groups were significantly higher than those of control group. sICAM1 in the combined group was significantly higher than those in the asthma group and allergic rhinitis group. sICAM1 is involved in the pathogenesis of allergic rhinitis and asthma, which can be used to evaluate the degrees of respiratory allergic diseases. | 30344593 |
| 73 | Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group | Human | Serum | sVCAM1 | ELISA | Others | Low Throughput | sVCAM1 level of allergic rhinitis, asthma and complication groups were significantly higher than those of control group. sVCAM1 in the combined group was significantly higher than those in the asthma group and allergic rhinitis group. sVCAM1 is involved in the pathogenesis of allergic rhinitis and asthma, which can be used to evaluate the degrees of respiratory allergic diseases. | 30344593 |
| 74 | Allergic Rhinitis, Asthma and Allergic Rhinitis combined with Asthma group | Human | Serum | sE-selectin | ELISA | Others | Low Throughput | sE-selectin level of allergic rhinitis, asthma and complication groups were significantly higher than those of control group. sE-selectin in the combined group was significantly higher than those in the asthma group and allergic rhinitis group. sE-selectin is involved in the pathogenesis of allergic rhinitis and asthma, which can be used to evaluate the degrees of respiratory allergic diseases. | 30344593 |
| 75 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | The serum level of periostin was significantly higher in asthmatic patients than normal controls. | 30479079 |
| 76 | Asthma | Human | Serum | IL31 | ELISA | Others | Low Throughput | The serum level of IL31 was significantly higher in asthmatic patients than normal controls. IL31 level was significantly lower in elderly asthmatics. | 30479079 |
| 77 | Asthma | Human | Serum | IL33 | ELISA | Others | Low Throughput | The serum level of IL33 was significantly higher in asthmatic patients than normal controls. IL33 level was significantly lower in elderly asthmatics. | 30479079 |
| 78 | Asthma | Human | Serum | TGFB1 | ELISA | Others | Low Throughput | The serum level of TGF-beta 1 was significantly higher in asthmatic patients than normal controls. TGF-beta 1 level was significantly higher in severe elderly asthmatics as compared to non-severe elderly asthmatics. TGF-beta 1 may contribute to disease severity. | 30479079 |
| 79 | Asthma | Human | Serum | CCL24 | ELISA | Others | Low Throughput | The serum level of Eotaxin 2 was significantly higher in asthmatic patients than normal controls. Eotaxin 2 level was significantly higher in severe elderly asthmatics as compared to non-severe elderly asthmatics. Eotaxin 2 may contribute to disease severity. | 30479079 |
| 80 | Asthma (Allergic and Non Allergic asthma) | Human | Serum | sCD48 | ELISA | Others | Low Throughput | sCD48 levels were significantly elevated in patients with nonallergic asthma compared to control and to the allergic asthma cohort. sCD48 has a low to moderate predictive value for the diagnosis of nonallergic asthma. | 30306094 |
| 81 | Asthma (Allergic and Non Allergic asthma) | Human | Serum | IL5 | ELISA | Others | Low Throughput | IL5 levels were elevated only in patients with allergic asthma when compared to control. | 30306094 |
| 82 | Asthma (Allergic and Non Allergic asthma) | Human | Serum | IL33 | ELISA | Others | Low Throughput | IL33 levels were significantly elevated in allergic and nonallergic asthmatics when compared to control. | 30306094 |
| 83 | Asthma (Allergic and Non Allergic asthma) | Human | Serum | IFNG | ELISA | Others | Low Throughput | IFNγ levels were significantly elevated in allergic and nonallergic asthmatics when compared to control. | 30306094 |
| 84 | Asthma (Allergic and Non Allergic asthma) | Human | Serum | IL17A | ELISA | Others | Low Throughput | IL17A levels were significantly elevated in allergic and nonallergic asthmatics when compared to control. | 30306094 |
| 85 | Asthma | Human | Serum | ARG1 | QuantiChrom Arginase Assay | Others | Low Throughput | There was a significant two-fold elevation in the arginase activity in asthmatics as compared to healthy controls which correlated with disease severity. Non-atopic asthmatics showed elevated activity of arginase compared to atopics, indicating its possible role in intrinsic asthma. | 30381539 |
| 86 | Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | Level of serum IL4 was significantly high in asthma group as compared to healthy control group. The IL4 level in the serum correlated with disease severity. IL4 level was high in atopic asthmatics when compared to non-atopics. | 30381539 |
| 87 | Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | Level of serum IL13 was significantly high in asthma group as compared to healthy control group. The IL13 level in the serum correlated with disease severity. | 30381539 |
| 88 | Asthma COPD Overlap (ACO) | Human | Serum | CC16 | ELISA | Others | Low Throughput | Serum CC-16 levels were the lowest in patients with ACO as compared to asthmatics, COPD patients and control. FEV1 and serum CC-16 levels were significantly lower in patients with frequent exacerbations. Serum CC-16 has the potential to be a biomarker for ACO diagnosis. | 30425470 |
| 89 | Geriatric Asthma | Human | Serum | IL17A | ELISA | Others | Low Throughput | Serum IL17A level in geriatric patients with moderate or severe asthma was significantly higher than those in young patients with moderate asthma and in the normal population. | 30304965 |
| 90 | Geriatric Asthma | Human | Serum | IL17F | ELISA | Others | Low Throughput | Serum IL17F level in geriatric patients with moderate or severe asthma was significantly higher than those in young patients with moderate asthma and in the normal population. | 30304965 |
| 91 | Geriatric Asthma | Human | Serum | GRβ | ELISA | Others | Low Throughput | Serum GRβ level in geriatric patients with moderate or severe asthma was significantly higher than those in young patients with moderate asthma and in the normal population. | 30304965 |
| 92 | Asthma | Human | Serum, Induced Sputum, Induced Sputum Cells | IL37 | ELISA, qRT-PCR | Others, Genomics | Low Throughput | The expression of IL37 mRNA in asthmatic patients was significantly lower than that observedin healthy controls. IL37 mRNA expression depended on asthma severity. Serum and Induced Sputum IL37levels were significantly lower in asthma patients compared to healthy controls. Theincreased pro-inflammatory cytokines production from asthma Induced Sputum cells was abrogated by the addition of rIL37. IL37 could be an important cytokine in the control of asthma by suppressing the production ofinflammatory cytokines. | 26454413 |
| 93 | Asthma | Human | Serum | ESM1 | ELISA | Others | Low Throughput | A high significant increase in serum level of Endocan was found in all asthmatic children compared with the controls. There was significant positive correlation between serum level of Endocan and PBE count and negative correlation with FEV1 and PEF. High Endocan level is associated with poor lung functions and severity of asthma. | 30243005 |
| 94 | Asthma | Human | Serum, Peripheral blood mononuclear cells (PBMN) | IL17 | ELISA, qRT-PCR | Others, Genomics | Low Throughput | Significant higher serum IL-17 levels were found in patients with uncontrolled asthma compared to patients with controlled asthma and healthy control group. IL-17 mRNA gene expression levels were also significantly elevated in uncontrolled asthma compared to patients with controlled asthma and healthy control group. | 30243007 |
| 95 | Allergic Asthma | Human | Serum | miR-1165-3p | qRT-PCR | Genomics | Low Throughput | Serum miRNA-1165-3p levels were significantly elevated in asthmatics when compared to the healthy controls. Serum miR-1165-3p can potentially be utilized as a noninvasive biomarker that is able to aid in the diagnosis and characterization of allergic asthma. | 30015513 |
| 96 | T2 High and T2 Low Asthma | Human | Serum | IL1A | ELISA | Others | Low Throughput | Serum IL1A level was increased in T2-high as compared to T2-Low asthmatic patients. | 30578390 |
| 97 | T2 High and T2 Low Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | Serum IL13 level was increased in T2-high as compared to T2-Low asthmatic patients. | 30578390 |
| 98 | T2 High and T2 Low Asthma | Human | Serum | CCL18 | ELISA | Others | Low Throughput | Serum CCL18 level was increased in T2-high as compared to T2-Low asthmatic patients. | 30578390 |
| 99 | Asthma | Human | Serum | IL10 | Bio-Plex Pro human inflammation cytokine 9-plex assay, Principal Componenet Analysis (PCA) | Others | High Throughput | Serum cytokine profile with high level of IL10 was associated with lower subsequent risks of worsening asthma control and attacks in adults. | 28340863 |
| 100 | Asthma | Human | Serum | IL1Ra | Bio-Plex Pro human inflammation cytokine 9-plex assay, Principal Componenet Analysis (PCA) | Others | High Throughput | Serum cytokine profile with high level of IL1Ra was associated with lower subsequent risks of worsening asthma control and attacks in adults. | 28340863 |
| 101 | Bronchial Asthma | Human | Exhaled Breath Condensate (EBC), Serum | EZR | ELISA, qRT-PCR | Others, Genomics | Low Throughput | Ezrin concentrations in EBC and serum were significantly reduced in asthma patients as compared to normal subjects. Levels were much lower in uncontrolled and partly controlled patients compared with well-controlled subjects. EBC and serum ezrin levels correlated with lung function in patients with asthma and serum ezrin levels were negatively correlated with serum IL-13 and periostin. Ezrin might serve as a potential biomarker of asthma control. | 30290132 |
| 102 | Bronchial Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | IL13 was increased in asthma patients compared with healthy controls. | 30290132 |
| 103 | Bronchial Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Periostin was increased in asthma patients compared with healthy controls. | 30290132 |
| 104 | Asthma | Human | Serum | GRN | ELISA | Others | Low Throughput | Serum progranulin levels were significantly lower in the asthma group than in healthy group and were positively correlated with prebronchodilator forced expiratory volume in 1 second predicted within patients with asthma. A negative correlation was noted between serum progranulin levels and blood neutrophil counts. Higher serum progranulin levels were associated with a lower risk of severe asthma. Serum progranulin may be an indicator of severe asthma with airflow limitation. | 28073702 |
| 105 | Asthma | Human | Broncho Alveolar Lavage Fluid (BALF), Serum | MCP1 | ELISA | Others | Low Throughput | The serum and BALF level of MCP1 were significantly elevated in asthmatics as compared to healthy controls. | 29755573 |
| 106 | Asthma | Human | Broncho Alveolar Lavage Fluid (BALF), Serum | IL6 | ELISA | Others | Low Throughput | The serum and BALF level of IL6 were elevated in asthmatics as compared to healthy controls. Serum IL6 showed a negative correlation with Der p1 specific IgE (class) in the total asthmatic group based on Pearson’s correlation coefficients. | 29755573 |
| 107 | Asthma | Human | Broncho Alveolar Lavage Fluid (BALF), Serum | IL8 | ELISA | Others | Low Throughput | The serum and BALF level of IL8 were elevated in asthmatics as compared to healthy controls. | 29755573 |
| 108 | Asthma | Human | Broncho Alveolar Lavage Fluid (BALF), Serum | RANTES | ELISA | Others | Low Throughput | The serum and BALF level of RANTES were significantly elevated in asthmatics as compared to healthy controls. | 29755573 |
| 109 | Asthma | Human | Broncho Alveolar Lavage Fluid (BALF), Serum | MIP-1alpha | ELISA | Others | Low Throughput | Serum MIP-1alpha was significantly lower in asthmatic group as compared to normal controls. BALF level of MIP-1alpha was significantly raised in asthmatic group as compared to normal control group. | 29755573 |
| 110 | Asthma | Human | Broncho Alveolar Lavage Fluid (BALF), Serum | TARC | ELISA | Others | Low Throughput | Serum TARC level was lowered while TARC level in BALF was raised in asthmatics as compared to normal controls. TARC levels in serum were strongly elevated in the elderly adult group relative to the young adults and the middle aged adult groups. TARC in serum was related to total IgE in serum in the elderly adult group. | 29755573 |
| 111 | Asthma | Human | Broncho Alveolar Lavage Fluid (BALF), Serum | IL4 | ELISA | Others | Low Throughput | The serum and BALF level of IL4 were elevated in asthmatics as compared to healthy controls. | 29755573 |
| 112 | Asthma | Human | Serum | IL5 | ELISA | Others | Low Throughput | Serum level of IL5 was slightly elevated in asthmatics as compared to healthy controls. | 29755573 |
| 113 | Asthma | Human | Serum | IL10 | ELISA | Others | Low Throughput | Serum level of IL10 was slightly reduced in asthmatics as compared to healthy controls. | 29755573 |
| 114 | Asthma | Human | Broncho Alveolar Lavage Fluid (BALF), Serum | IFNG | ELISA | Others | Low Throughput | Serum and BALF level of IFNG were slightly increased in asthmatics as compared to healthy controls. | 29755573 |
| 115 | Asthma | Human | Serum | TNF alpha | ELISA | Others | Low Throughput | Serum level of TNF alpha was significantly reduced in asthmatics as compared to healthy controls. | 29755573 |
| 116 | Asthma | Human | Serum | POSTN | Immunoassay | Others | Low Throughput | Serum periostin levels are stable within an individual with wellcontrolled asthma and have little seasonal variation. Periostin levels are modestly reduced by systemic corticosteroid treatment of a severe asthma exacerbation, but the effect lies within the level of variation expected in otherwise stable adults with asthma. Serum periostin has the desirable characteristics to be used as a biomarker in asthma. | 28093216 |
| 117 | Atopic Asthma | Human | Serum | CRP | Biochemical Test | Others | Low Throughput | Serum CRP level was increased in atopic asthmatics as compared to atopic non asthmatics and non atopic non asthmatics. | 28655726 |
| 118 | Atopic Asthma | Human | Serum | HDL | NMR Spectroscopy | Others | Low Throughput | Serum levels of HDL and triglycerides are correlated with both systemic type 2 inflammation and airflow obstruction in atopic asthma. | 28655726 |
| 119 | Childhood Asthma | Human | Serum | sST2 | ELISA | Others | Low Throughput | sST2 serum levels at age 2-3yrs inversely correlate with FeNO levels in asthmatic children at 6yrs. Serum levels of sST2 at preschool age predict increased FeNO levels as a marker of eosinophilic airway inflammation in those children who will develop asthma. sST2 might play a protective role in the development of eosinophilic airway inflammation in children who experience asthma at school age. | 28440062 |
| 120 | Occupational Asthma (Coir Workers) | Human | Serum | sIgE | ELISA | Others | Low Throughput | The serum IgE levels were found to be higher in coir workers with asthmatic symptoms and hence it is reasonable to believe that coir workers asthma is of largely immunological in origin. | 30477054 |
| 121 | Moderate Allergic Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Baseline serum levels of periostin were significantly higher in subjects who experienced one or more exacerbations during the one year period of follow-up, compared with subjects with no exacerbations. Periostin could be envision as a novel biomarker to better characterize asthmatic subjects with higher risk of exacerbations. | 27965769 |
| 122 | Asthma-COPD overlap (ACO), Asthma, COPD | Human | Serum | YKL40 | ELISA | Others | Low Throughput | Serum YKL40 was high in both COPD and ACO, but not in asthma. YKL40 was comparable between ACO and COPD. | 29981861 |
| 123 | Asthma-COPD overlap (ACO), Asthma, COPD | Human | Serum | POSTN | Elecsys Periostin assay | Others | Low Throughput | Serum periostin levels, a marker of type 2 inflammation, were comparable between patients with asthma and ACO, but higher than in patients with COPD, suggesting that serum periostin may be used as a type 2 biomarker also in patients with ACO. | 29981861 |
| 124 | Allergic Asthma (AA), Non Allergic Asthma (NA) | Human | Serum | IL8 | ELISA | Others | Low Throughput | Serum IL8 level was elevated in both allergic and non allergic asthmatics as compared to healthy controls. The highest serum IL8 level was noted in case of non allergic asthma. | 28011367 |
| 125 | Obese Asthma | Human | Serum | LEP | ELISA | Others | Low Throughput | Obese asthmatic subjects had significantly higher leptin levels in the serum compared with lean asthmatic subjects. | 30306746 |
| 126 | Obese Asthma | Human | Serum | ADIPOQ | ELISA | Others | Low Throughput | Obese asthmatic subjects had significantly lower adiponectin levels in the serum compared with lean asthmatic subjects. | 30306746 |
| 127 | Asthma (In Children) | Human | Induced Sputum, Sputum Cells, Serum | TSLP | ELISA, qRT-PCR | Others, Genomics | Low Throughput | Serum and Induced sputum fluid TSLP levels was significantly higher in asthmatic patients compared to healthy controls and their levels correlate with asthma severity. The expression of TSLP mRNA in sputum cells of asthmatic patients was significantly higher than that observed in healthy controls | 27528425 |
| 128 | Bronchial Asthma, COPD | Human | Serum | hsa-miRNA-224 | qRT-PCR (TaqMan Human MicroRNA Array A plates) | Genomics | High Throughput | hsa-miRNA-224 was differentially expressed in Asthma and COPD patients as compared to healthy subjects. In asthma, the expression of hsa-miRNA-224 was 5 fold higher than in COPD. | 27605898 |
| 129 | Bronchial Asthma, COPD | Human | Serum | hsa-miRNA-339-5p | qRT-PCR (TaqMan Human MicroRNA Array A plates) | Genomics | High Throughput | hsa-miRNA-339-5p was differentially expressed in Asthma and COPD patients as compared to healthy subjects. In asthma, the expression of hsa-miRNA-339-5p was 5 fold higher than in COPD. | 27605898 |
| 130 | Bronchial Asthma, COPD | Human | Serum | hsa-miRNA-382 | qRT-PCR (TaqMan Human MicroRNA Array A plates) | Genomics | High Throughput | hsa-miRNA-382 was differentially expressed in Asthma and COPD patients as compared to healthy subjects. In asthma, the expression of hsa-miRNA-382 was 5 fold higher than in COPD. | 27605898 |
| 131 | Asthma | Human | Serum, Broncho Alveolar Lavage Fluid (BALF) | SP-D | ELISA, Western Blotting | Others, Proteomics | Low Throughput | SP-D concentrations in BAL samples declined and serum concentrations increased in patients with treatment-resistant severe asthma. Because reduced BAL concentrations of SP-D are reflected by elevated serum SP-D concentrations, measures of serum SP-D may serve as a potential biomarker of airway events underlying treatment-resistant asthma. The structural integrity of SP-D in the BAL and serum samples of patients with severe asthma was found to be compromised. | 26836907 |
| 132 | Asthma (Aspirin exacerbated respiratory disease (AERD)) | Human | Serum | POSTN | ELISA | Others | Low Throughput | The levels of periostin was significantly higher in patients with eosinophilic asthma than those with non-eosinophilic asthma. These findings suggest that periostin may contribute to develop airway obstruction and severe asthma in adult asthmatics. | 30076619 |
| 133 | Asthma (Aspirin exacerbated respiratory disease (AERD)) | Human | Serum | TGFB1 | ELISA | Others | Low Throughput | The levels of TGFB1 was significantly higher in patients with eosinophilic asthma than those with non-eosinophilic asthma. TGFB1 may contribute to develop airway obstruction and severe asthma in adult asthmatics. | 30076619 |
| 134 | Asthma | Human | Serum | CAT | Biochemical Test | Others | Low Throughput | Catalase activity in serum was markedly lower in the asthmatics as compared to healthy individuals. | 28356865 |
| 135 | Childhood Asthma with Rhinoviral Infection | Human | Serum | IL5 | Bio-Plex Multiplex System | Others | High Throughput | The concentration of IL5 in asthmatic children with Rhino Virus infection was significantly higher than that in asthmatic children without Rhino Virus infection and in control subjects. | 30210646 |
| 136 | Childhood Asthma with Rhinoviral Infection | Human | Serum | IL13 | Bio-Plex Multiplex System | Others | High Throughput | The concentration of IL13 in asthmatic children with Rhino Virus infection was significantly higher than that in asthmatic children without Rhino Virus infection and in control subjects. | 30210646 |
| 137 | Childhood Asthma with Rhinoviral Infection | Human | Serum | TNFalpha | Bio-Plex Multiplex System | Others | High Throughput | The concentration of TNFalpha in asthmatic children with or without Rhino Viral infection was higher than that in control subjects. | 30210646 |
| 138 | Childhood Asthma with Rhinoviral Infection | Human | Serum | IL2 | Bio-Plex Multiplex System | Others | High Throughput | The concentration of IL2 in asthmatic children with and without Rhino Virus infection was significantly lower than that in control subjects. There was no significant difference in IL2 level among asthmatic children with or without Rhino Virus infection. | 30210646 |
| 139 | Childhood Asthma with Rhinoviral Infection | Human | Serum | IL10 | Bio-Plex Multiplex System | Others | High Throughput | The concentration of IL10 in asthmatic children without Rhino Virus infection was significantly higher than that in asthmatic children with Rhino Virus infection and in control subjects. | 30210646 |
| 140 | Childhood Asthma with Rhinoviral Infection | Human | Serum | IL4 | Bio-Plex Multiplex System | Others | High Throughput | The concentration of IL4 in asthmatic children with and without Rhino Virus infection was significantly higher than that in control subjects. there was no significant difference in IL4 level among asthmatic children with or without Rhino Virus infection. | 30210646 |
| 141 | Occupational Bronchial Asthma | Human | Serum | IL1B | ELISA | Others | Low Throughput | Hyperproduction of IL1B is a characteristic of occupational bronchial asthma. While for persons with non-professional asthma, a decrease in IL1B is the characteristic feature. | 30135286 |
| 142 | Occupational Bronchial Asthma | Human | Serum | IL8 | ELISA | Others | Low Throughput | Patients with occupational bronchial asthma were characterized by hyperproduction of IL-8. | 30135286 |
| 143 | Occupational Bronchial Asthma | Human | Serum | IL5 | ELISA | Others | Low Throughput | Patients with non-professional asthma exhibited a characteristic decrease in serum IL5 level. | 30135286 |
| 144 | Occupational Bronchial Asthma | Human | Serum | IL10 | ELISA | Others | Low Throughput | Patients with non-professional asthma exhibited a characteristic decrease in serum IL10 level. | 30135286 |
| 145 | Occupational Bronchial Asthma | Human | Serum | TNFalpha | ELISA | Others | Low Throughput | A decrease in serum concentrations of TNFalpha was observed in both occupational bronchial asthma patients and non-professional asthmatics. | 30135286 |
| 146 | Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | The serum levels of IL4 in patients with asthma was significantly higher than healthy subjects. | 30116273 |
| 147 | Asthma | Human | Serum | TGFB | ELISA | Others | Low Throughput | Serum levels of TGFB in asthmatics was significantly higher than in healthy subjects. The serum TGFB levels in severe asthma were significantly higher than moderate asthma. | 30116273 |
| 148 | Asthma | Human | Serum | ADIPOQ | ELISA | Others | Low Throughput | Asthma is linked with obesity and there is an association between asthma severity and BMI with leptin/adiponectin levels. | 28411906 |
| 149 | Asthma | Human | Serum | LEP | ELISA | Others | Low Throughput | Asthma is linked with obesity and there is an association between asthma severity and BMI with serum leptin and leptin/adiponectin levels. | 28411906 |
| 150 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum periostin concentrations were significantly higher in patients with asthma than in controls. Serum periostin levels respond partially to ICS and may reflect a reduction in airway inflammation and wall thickening in asthma. | 26607392 |
| 151 | Severe Asthma | Human | Serum | POSTN | Electrochemiluminescence Immunoassay | Others | Low Throughput | Higher serum periostin levels were associated with increased blood eosinophils, FENO and type 2 immunity composite score in all asthma and severe asthma. | 27061252 |
| 152 | Asthma | Human | Serum | IFNG | ELISA | Others | Low Throughput | IFNG level was significantly reduced in asthmatic children as compared to the non asthmatic controls. Serum Perfluoroalkyl acids (PFAAs) were associated inversely with TH1 cytokines among male asthmatics. | 27060656 |
| 153 | Asthma | Human | Serum | IL2 | ELISA | Others | Low Throughput | IL2 level was significantly reduced in asthmatic children as compared to the non asthmatic controls. Serum Perfluoroalkyl acids (PFAAs) were associated inversely with TH1 cytokines among male asthmatics. | 27060656 |
| 154 | Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | IL4 level was significantly elevated in asthmatic children as compared to the non asthmatic controls. Serum Perfluoroalkyl acids (PFAAs) were associated positively with TH2 cytokines among male asthmatics. | 27060656 |
| 155 | Asthma | Human | Serum | IL5 | ELISA | Others | Low Throughput | IL5 level was significantly elevated in asthmatic children as compared to the non asthmatic controls. Serum Perfluoroalkyl acids (PFAAs) were associated positively with TH2 cytokines among male asthmatics. | 27060656 |
| 156 | Asthma | Human | Serum | IL5 | Immunoassay | Others | Low Throughput | Serum IL5 is a reliable biomarker for the blood eosinophilia asthma phenotype. | 27060452 |
| 157 | Asthma | Human | Serum | IL13 | Immunoassay | Others | Low Throughput | Serum IL13 is a reliable biomarker for the blood eosinophilia asthma phenotype. | 27060452 |
| 158 | Asthma | Human | Serum | IL8 | Immunoassay | Others | Low Throughput | Association with increased serum levels MCP1 increases asthma severity. | 27060452 |
| 159 | Asthma | Human | Serum | MCP1 | Immunoassay | Others | Low Throughput | Association with increased serum levels IL8 increases asthma severity. | 27060452 |
| 160 | Asthma | Human | Serum | IL6 | ELISA | Others | Low Throughput | Visceral obesity was negatively associated with asthma control and lung function; and positively associated with increased levels of IL6 in women. | 27036303 |
| 161 | Atopic Asthma | Human | Serum | IL17F | qRT-PCR, ELISA | Genomics, Others | Low Throughput | mRNA levels of IL17F and sIL17F has significantly correlation in atopic asthmatic patients. The levels of mRNA IL17F and sIL17F might be useful parameters for the diagnosis of atopic asthma patients. | 28606156 |
| 162 | Steroid Naïve Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum periostin levels were significantly elevated in patients with steroid-naive asthma compared with the controls and patients with asthma who were treated with steroids. Serum periostin may be a candidate for a novel biomarker for not only eosinophilic inflammation but as a marker for airway remodeling in asthma. | 27178891 |
| 163 | Poorly Controlled Asthma | Human | Serum, Sputum | POSTN | ElectroChemiLuminescence Immunoassay (ECLIA), ELISA | Others | Low Throughput | Serum and sputum periostin were significantly higher in patients with eosinophilic asthma as compared with non-eosinophilic asthma. In poorly-controlled asthma, sputum and serum periostin levels are significantly related to sputum eosinophil proportions while their ability to predict the presence of eosinophilic asthma is modest. | 27130294 |
| 164 | Severe Allergic Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Baseline serum periostin levels and serum free IgE levels during treatment follow-up may be useful in evaluating responses to omalizumab treatment. | 27113353 |
| 165 | Atopic Bronchial Asthma | Human | Peripheral Blood Mononuclear Cells (PBMCs), Serum | IL31 | qRT-PCR, ELISA | Genomics, Others | Low Throughput | The levels of IL31 mRNAs in atopic asthmatics were significantly higher than those in controls and nonatopic asthmatics. Serum IL31 level was significantly higher in atopic asthmatics as compared to healthy subjects. There was a strong significant direct correlation between IL31 and SCF and IgE in asthmatics. | 26853551 |
| 166 | Atopic Bronchial Asthma | Human | Peripheral Blood Mononuclear Cells (PBMCs), Serum | SCP | qRT-PCR, ELISA | Genomics, Others | Low Throughput | The levels of SCF mRNAs in atopic asthmatic patients' PBMCs were significantly higher than those in controls and nonatopic asthmatics. Serum SCP level was significantly higher in atopic asthmatics as compared to healthy subjects. There was a strong significant direct correlation between SCF and IL31 and IgE in asthmatics. | 26853551 |
| 167 | Asthma | Human | Serum | IL6 | - | Others | Low Throughput | Aerobic exercise training reduces bronchial hyperresponsiveness and serum level of IL-6 in asthmatics. | 26794246 |
| 168 | Asthma | Human | Serum | MCP1 | - | Others | Low Throughput | Aerobic exercise training reduces bronchial hyperresponsiveness and serum level of MCP-1 in asthmatics. | 26794246 |
| 169 | Childhood Asthma | Human | Serum | IL17 | ELISA | Others | Low Throughput | Serum IL17 is up regulated in childhood asthma. A positive correlation was found between serum IL17 and serum total IgE and a negative correlation exists between IL17 and IL35. | 28554228 |
| 170 | Childhood Asthma | Human | Serum | IL35 | ELISA | Others | Low Throughput | Serum IL35 is down regulated in childhood asthma. A strong negative correlation was found between serum IL35 and both serum IgE and IL17 level. | 28554228 |
| 171 | Severe Asthma | Human | Serum, Broncho Alveolar Lavage Fluid (BALF), Bronchial Biopsy | INHBA | ELISA, Immunofluorescence | Others | Low Throughput | Activin-A expression was significantly elevated in serum, BALF and bronchial tissue of the asthmatics as compared to healthy subjects. Activin-A has anti-angiogenic effects in vitro that are not propagated in vivo, where reduced basal expression of its receptors is observed particularly in severe asthma. | 26869672 |
| 172 | Atopic Asthma | Human | Peripheral Blood Lymphocytes, Serum | IL4 | qRT-PCR, ELISA | Genomics, Others | Low Throughput | Expression level of IL4 mRNA and protein was higher in asthmatics as compared to controls. IL4 expression was higher in uncontrolled asthma as compared to controlled asthma. | 26781462 |
| 173 | Atopic Asthma | Human | Peripheral Blood Lymphocytes, Serum | IL13 | qRT-PCR, ELISA | Genomics, Others | Low Throughput | Expression level of IL13 mRNA and protein was significantly higher in asthmatics as compared to controls. IL13 expression was higher in uncontrolled asthma as compared to controlled asthma. Positive correlation was observed between IL13 level and serum IgE. | 26781462 |
| 174 | Atopic Asthma | Human | Peripheral Blood Lymphocytes, Serum | STAT6 | qRT-PCR, ELISA | Genomics, Others | Low Throughput | Expression level of STAT6 mRNA and protein was higher in asthmatics as compared to controls. STAT6 expression was higher in uncontrolled asthma as compared to controlled asthma. Positive correlation was observed between STAT6 level and serum IgE. | 26781462 |
| 175 | Asthma | Human | Serum | CCL18 | ELISA | Others | Low Throughput | There was a negative correlation between CCL18 and age in patients with asthma. | 27104648 |
| 176 | Asthma, COPD, Asthma COPD Overlap Syndrome (ACOS) | Human | Sputum, Serum | miR145 | qRT-PCR | Genomics | Low Throughput | The expression of miR145 in sputum was higher in asthmatic and COPD patients than in controls. The expression of miR145 in ACOS patients was intermediate between two other groups. No difference was found in the expression of miR145 in the serum among the three groups. | 28694694 |
| 177 | Asthma, COPD, Asthma COPD Overlap Syndrome (ACOS) | Human | Sputum, Serum | miR338 | qRT-PCR | Genomics | Low Throughput | The expression level of miR338 in the sputum was higher in all patient groups compared to controls. Asthmatics showed a significantly higher miR338 expression compared to COPD patients. The serum of ACOS, COPD patients and asthmatics showed a lower level of miR338 expression as compared to controls. | 28694694 |
| 178 | Childhood Asthma | Human | Serum | hsa-miR-16-5p | TaqMan miRNA array | Genomics | High Throughput | In childhood asthma, circulating hsa-miR-16-5p was significantly associated with methacholine PC20, a quantitative marker of airway responsiveness. miR-16-5p regulate airway smooth muscle phenotypes critically involved in asthma pathogenesis. | 28749975 |
| 179 | Childhood Asthma | Human | Serum | hsa-miR-138-5p | TaqMan miRNA array | Genomics | High Throughput | In childhood asthma, circulating hsa-miR-138-5p was significantly associated with methacholine PC20, a quantitative marker of airway responsiveness. | 28749975 |
| 180 | Childhood Asthma | Human | Serum | hsa-miR-30d-5p | TaqMan miRNA array | Genomics | High Throughput | In childhood asthma, circulating hsa-miR-30d-5p was significantly associated with methacholine PC20, a quantitative marker of airway responsiveness. miR-30d-5p regulate airway smooth muscle phenotypes critically involved in asthma pathogenesis. | 28749975 |
| 181 | Childhood Asthma | Human | Serum | hsa-miR-203a-3p | TaqMan miRNA array | Genomics | High Throughput | In childhood asthma, circulating hsa-miR-203a-3p was significantly associated with methacholine PC20, a quantitative marker of airway responsiveness. | 28749975 |
| 182 | Childhood Asthma | Human | Serum | hsa-miR-128-3p | TaqMan miRNA array | Genomics | High Throughput | In childhood asthma, circulating hsa-miR-128-3p was significantly associated with methacholine PC20, a quantitative marker of airway responsiveness. | 28749975 |
| 183 | Childhood Asthma | Human | Serum | hsa-miR-296-5p | TaqMan miRNA array | Genomics | High Throughput | In childhood asthma, circulating hsa-miR-296-5p was significantly associated with methacholine PC20, a quantitative marker of airway responsiveness. | 28749975 |
| 184 | Childhood Asthma | Human | Serum | hsa-miR-548b-5p | TaqMan miRNA array | Genomics | High Throughput | In childhood asthma, circulating hsa-miR-548b-5p was significantly associated with methacholine PC20, a quantitative marker of airway responsiveness. | 28749975 |
| 185 | Childhood Asthma | Human | Serum | hsa-miR-1227-3p | TaqMan miRNA array | Genomics | High Throughput | In childhood asthma, circulating hsa-miR-1227-3p was significantly associated with methacholine PC20, a quantitative marker of airway responsiveness. | 28749975 |
| 186 | Perimenstrual Asthma (PMA) | Human | Serum | Testosterone | Electrochemiluminescence immunoassay (ECLIA) | Others | Low Throughput | When compared to non-PMA asthmatics and healthy controls, PMA subjects had decreased serum testosterone levels in both, follicular and luteal phase of the cycle. | 28752719 |
| 187 | Perimenstrual Asthma (PMA) | Human | Serum | β-Estradiol | Electrochemiluminescence immunoassay (ECLIA) | Others | Low Throughput | When compared to non-PMA asthmatics and healthy controls, the luteal phase of the cycle in PMA subjects was associated with increased serum estradiol concentration and increased serum estradiol-to-progesterone ratio. | 28752719 |
| 188 | Severe Uncontrolled Asthma | Human | Serum | IL17A | ELISA | Others | Low Throughput | Uncontrolled asthmatics and steroid resistant asthma patients had higher level of IL17A as compared to controlled asthmatics. The IL17A levels were significantly correlated with those of IL4, IL25, IL10, and IFNG in patients with uncontrolled asthma. IL17A may play important roles in asthmatic exacerbation and its high level, in combination with upregulated Th2 and other cytokines, may indicate the refractory endotype of asthma. | 28840844 |
| 189 | Severe Uncontrolled Asthma | Human | Serum | IL6 | ELISA | Others | Low Throughput | Serum levels of IL6 was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 190 | Severe Uncontrolled Asthma | Human | Serum | IL8 | ELISA | Others | Low Throughput | Serum levels of IL8 was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 191 | Severe Uncontrolled Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | Serum levels of IL13 was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 192 | Severe Uncontrolled Asthma | Human | Serum | IL16 | ELISA | Others | Low Throughput | Serum levels of IL16 was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 193 | Severe Uncontrolled Asthma | Human | Serum | HGF | ELISA | Others | Low Throughput | Serum levels of HGF was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 194 | Severe Uncontrolled Asthma | Human | Serum | TSLP | ELISA | Others | Low Throughput | Serum levels of TSLP was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 195 | Severe Uncontrolled Asthma | Human | Serum | MIF | ELISA | Others | Low Throughput | Serum levels of MIF was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 196 | Severe Uncontrolled Asthma | Human | Serum | IL1RA | ELISA | Others | Low Throughput | Serum levels of IL1RA was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 197 | Severe Uncontrolled Asthma | Human | Serum | MIP-1α | ELISA | Others | Low Throughput | Serum levels of MIP-1α was significantly higher in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 198 | Severe Uncontrolled Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | Serum levels of IL4 was significantly lower in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 199 | Severe Uncontrolled Asthma | Human | Serum | EGF | ELISA | Others | Low Throughput | Serum levels of EGF was significantly lower in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 200 | Severe Uncontrolled Asthma | Human | Serum | SCF | ELISA | Others | Low Throughput | Serum levels of SCF was significantly lower in the asthmatic patient group, as compared to the Healthy Control group. SCF level was significantly different between controlled and uncontrolled asthma. | 28840844 |
| 201 | Severe Uncontrolled Asthma | Human | Serum | ANG2 | ELISA | Others | Low Throughput | Serum levels of ANG2 was significantly lower in the asthmatic patient group, as compared to the Healthy Control group. | 28840844 |
| 202 | Asthma (Steroid Naïve Asthma) | Human | Bronchial Epithelial Cells (BECs), Lung Biopsy, Broncho Alveolar Lavage Fluid (BALF), Serum | ITLN1 | qRT-PCR, Immunohistochemistry, ELISA | Genomics, Others | Low Throughput | ITLN1 mRNA expression in freshly isolated BECs was significantly higher in the Steroid Naive (SN) Asthma group than in Steroid treated asthmatics and healthy controls in both distal and proximal airway samples. ITLN1 mRNA was also positively correlated with iNOS, CCL26, periostin and DPP4 mRNA. ITLN1 protein was increased in goblet cells in SN-Asthmatics and increased in SN-Asthmatic BAL fluid. | 28775743 |
| 203 | Bronchial Asthma | Human | Serum | ECP | Fluoro enzyme immunoassay (FEIA) | Others | Low Throughput | Higher serum ECP levels were associated with higher EOS% in serum and with lower pulmonary function indices (FEVl%pred and FEV1/FVC). Measuring serum ECP levels is helpful for assessing the efficacy of ICS therapy in Bronchial Asthma children. | 28781336 |
| 204 | Bronchial Asthma | Human | Serum | ET1 | Radioimmunoassay | Others | Low Throughput | ET1 level was elevated in pretreated asthmatics as compared to the control group. ET1 level in the ICS and SABA groups were significantly lower than the pre-treatment values but were still higher than that the levels observed in the control group. | 28781336 |
| 205 | Asthma | Human | Serum, Broncho Alveolar Lavage Fluid (BALF) | FSTL1 | ELISA | Others | Low Throughput | Plasma FSTL1 levels were higher in asthmatics than in controls. FSTL1 levels in asthmatics were linked with increased smooth muscle mass and thickened Reticular Basement Membrane. FSTL1 may contribute to airway remodeling in asthmatics. | 28845090 |
| 206 | Asthma | Human | Serum | S1P | ELISA | Others | Low Throughput | During asthma attack, the serum S1P level was gradually increased with the exacerbation of the disease. Serum S1P level has significant evaluative effect on the severity of asthma. There were significant positive correlations between serum S1P level and peripheral blood EOS in patients with mild, moderate and severe asthma and negatively correlations with FEV1 were found. | 28936954 |
| 207 | Asthma, COPD | Human | Serum, Genomic DNA | SP-D | ELISA, Gel permeation chromatography, SNP Genotyping | Others, Genomics | Low Throughput | In a Lebanese population cohort, non-multimerized species of serum surfactant protein D (SP-D) were dominant in Met11/Met11 COPD and asthmatic patients suggesting that degradation of SP-D takes place to a significant degree in pulmonary diseases. | 28960651 |
| 208 | Asthma and Obesity | Human | Exhaled Breath Condensate (EBC), Serum | LEP | ELISA | Others | Low Throughput | EBC and serum leptin levels are significantly higher in the obese subjects and in asthmatic ones compared with healthy subjects. Leptin may therefore represent a non-invasive marker of non-specific airway inflammation in children. A significant correlation between EBC-leptin levels and the serum-leptin levels was noted. | 28952460 |
| 209 | Asthma | Human | Peripheral Blood Mononuclear Cells (PBMCs), Serum | IL8 | qRT-PCR, ELISA | Genomics, Others | Low Throughput | The IL8 expression at both protein and mRNA levels was found to be significantly elevated in asthmatic children compared to healthy subjects. Both IL8 gene and protein expression may play a key role in asthma pathogenesis. | 28993876 |
| 210 | Severe Allergic Asthma | Human | Serum | PAPP-A | ELISA | Others | Low Throughput | Compared to control subjects, serum PAPP-A levels were significantly higher in asthmatic subjects. PAPP-A level may be a useful biomarker for predicting airway remodeling in patients with severe asthma receiving omalizumab, and may also reflect the response to treatment. | 29211611 |
| 211 | Severe Allergic Asthma | Human | Serum | IGFBP-4 | ELISA | Others | Low Throughput | Compared to control subjects, serum IGFB-4 levels were significantly higher in asthmatic subjects. | 29211611 |
| 212 | Asthma | Human | Serum | IGF-I | ELISA | Others | Low Throughput | Serum level of IGF-I was significanlty elevated in the asthma group as compared to the control group. High Serum Levels of IGF-I and IGFBP3 May Increase Comorbidity Risk for Asthmatic Patients. | 29216726 |
| 213 | Asthma | Human | Serum | IGFBP3 | ELISA | Others | Low Throughput | Serum level of IGFBP3 was significanlty elevated in the asthma group as compared to the control group. High Serum Levels of IGF-I and IGFBP3 May Increase Comorbidity Risk for Asthmatic Patients. | 29216726 |
| 214 | Allergic Rhinitis in Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | The presence of Allergic Rhinitis (AR) was associated with an increase in serum periostin levels. BMI was negatively associated with periostin levels in both healthy and asthmatic subjects, while there was a tendency of a positive association with AR in asthmatic subjects. | 29223720 |
| 215 | Asthma, COPD | Human | Serum, Induced Sputum | IL6 | ELISA | Others | Low Throughput | In the COPD group, serum and induced sputum IL6 concentrations were statistically higher than in the asthma group. | 29319364 |
| 216 | Bronchial Asthma | Human | Serum | IL17 | ELISA | Others | Low Throughput | IL17 serum levels were significantly increased in atopic asthmatic cases relative to controls with higher values among severe atopic asthmatics. | 29572197 |
| 217 | Bronchial Asthma | Human | Serum | IL8 | ELISA | Others | Low Throughput | IL8 serum levels were significantly increased in atopic asthmatic cases relative to controls with higher values among severe atopic asthmatics. | 29572197 |
| 218 | Bronchial Asthma | Human | Serum | CHIT1 | Spectrofluorometric Assay | Others | Low Throughput | CHIT1 activity was significantly increased in atopic asthmatic cases relative to controls with higher values among severe atopic asthmatics. | 29572197 |
| 219 | Bronchial Asthma | Human | Peripheral Blood Mononuclear Cells (PBMCs), Serum | TF | Western Blotting, ELISA | Proteomics, Others | Low Throughput | Compared with healthy controls, TF expression was significantly upregulated in PBMCs and serum of bronchial asthma patients. | 29545867 |
| 220 | Bronchial Asthma | Human | Serum | TSP1 | ELISA | Others | Low Throughput | Compared with healthy controls, TSP1 expression was significantly upregulated in serum of bronchial asthma patients. | 29545867 |
| 221 | Asthma | Human | Induced Sputum, Serum | PlGF | ELISA | Others | Low Throughput | Significantly higher serum and sputum PlGF levels were noted in asthma patients, especially asthmatic smokers, than in healthy controls. Serum and sputum PlGF levels correlated negatively with post-bronchodilator forced expiratory volume in 1s (FEV1) and the FEV1/forced vital capacity, but positively with airway-wall thickening. | 28220848 |
| 222 | Asthma | Human | Serum | IL4 | Flow Cytometry | Others | Low Throughput | Serum levels of IL4 were higher in asthmatics compared to controls. IL4 serum levels were found significantly elevated in patients with allergic asthma. IL4 were found significantly higher in patients with eosinophil cut off values above 300 cells/μl. | 31047104 |
| 223 | Asthma | Human | Serum | IL5 | Flow Cytometry | Others | Low Throughput | Serum levels of IL5 were higher in asthmatics compared to controls. IL5 were found significantly higher in patients with eosinophil cut off values above 300 cells/μl. | 31047104 |
| 224 | Asthma | Human | Serum | IL13 | Flow Cytometry | Others | Low Throughput | Serum levels of IL13 were higher in asthmatics compared to controls. IL13 were found significantly higher in patients with eosinophil cut off values above 300 cells/μl. | 31047104 |
| 225 | Asthma | Human | Serum | IL23 | Flow Cytometry | Others | Low Throughput | Serum levels of IL23 were higher in asthmatics compared to controls. IL23 were found significantly higher in patients with eosinophil cut off values above 300 cells/μl. | 31047104 |
| 226 | Asthma | Human | Serum | IL6 | Flow Cytometry | Others | Low Throughput | Serum levels of IL6 were higher in asthmatics compared to controls. | 31047104 |
| 227 | Asthma | Human | Serum | IL17A | Flow Cytometry | Others | Low Throughput | Serum levels of IL17A were higher in asthmatics compared to controls. IL17A serum levels were found significantly elevated in patients with allergic asthma. IL17A levels were positively correlated with FeNO values in severe asthmatics with eosinophils greater than 400 cells/μl. | 31047104 |
| 228 | Asthma, Food Allergy | Human (Asthmatic children with history of worsening symptoms by food allergens) | Serum | IL17 | Cytometric Bead Array, Flow Cytometry | Others | High Throughput | IL17 level was significantly higher in the patient group as compared to the control group. A significant positive correlation of total IgE with IL17 was observed. | 29098994 |
| 229 | Asthma, Food Allergy | Human (Asthmatic children with history of worsening symptoms by food allergens) | Serum | IFNG | Cytometric Bead Array, Flow Cytometry | Others | High Throughput | IFNG level was significantly lower in the patient group as compared to the control group. A significant negative correlation of total IgE and IFNG was noted. | 29098994 |
| 230 | Asthma, Food Allergy | Human (Asthmatic children with history of worsening symptoms by food allergens) | Serum | IL4 | Cytometric Bead Array, Flow Cytometry | Others | High Throughput | A significant positive correlation of total IgE with IL4 was observed in the patient group studied. | 29098994 |
| 231 | Asthma, Food Allergy | Human (Asthmatic children with history of worsening symptoms by food allergens) | Serum | IL13 | Cytometric Bead Array, Flow Cytometry | Others | High Throughput | A significant positive correlation of total IgE with IL13 was observed in the study group. | 29098994 |
| 232 | Asthma, Food Allergy | Human (Asthmatic children with history of worsening symptoms by food allergens) | Serum | IL10 | Cytometric Bead Array, Flow Cytometry | Others | High Throughput | A significant negative correlation of total IgE was IL10 was observed in the study group. | 29098994 |
| 233 | Asthma | Human | Serum | IL33 | ELISA | Others | Low Throughput | Higher levels of IL33 was detected in asthmatic patients as compared with controls. In the asthmatic group, a significant direct association of IL33 with age and with total IgE level were observed. IL33 is suggested as a new inflammatory marker of severe and refractory asthma. | 28966754 |
| 234 | Asthma | Human | Serum | YKL40 | ELISA | Others | Low Throughput | Elevated serum YKL40 levels were associated with two distinct clinical asthma phenotypes: one with irreversible airway obstruction and another with severe exacerbations. The YKL40 clusters are potentially useful for identification of individuals with severe or exacerbation-prone asthma. | 29025889 |
| 235 | Severe Persistent Asthma | Human | Serum | CXCL10 | Bio-Plex Pro Human Cyokine Panel (ELISA) | Others | High Throughput | High baseline serum CXCL10 level may be useful in predicting a good omalizumab response in severe asthmatics. | 29413515 |
| 236 | Severe Persistent Asthma | Human | Serum | IL12 | Bio-Plex Pro Human Cyokine Panel (ELISA) | Others | High Throughput | High baseline serum IL12 level may be useful in predicting a good omalizumab response in severe asthmatics. | 29413515 |
| 237 | Pediatric Asthma | Human | Serum, Sputum | ALCAM | ELISA | Others | Low Throughput | ALCAM levels were higher in children with asthma than in normal control subjects. Serum and sputum ALCAM levels were higher in children with more severe asthma and serum ALCAM levels were inversely correlated with PC20 in asthma patients. ALCAM can be a potential therapeutic target for allergic asthma. | 29394080 |
| 238 | Asthma | Human | Serum | IL5 | ELISA | Others | Low Throughput | Moderate eosinophilic asthma clusters were characterized by high serum IL5 level and blood eosinophilia. | 28987809 |
| 239 | Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | Moderate eosinophilic asthma clusters were characterized by high serum IL13 level and blood eosinophilia. | 28987809 |
| 240 | Asthma | Human | Serum | EDN | ELISA | Others | Low Throughput | Moderate eosinophilic asthma clusters were characterized by high serum EDN level and blood eosinophilia. | 28987809 |
| 241 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Moderate eosinophilic asthma clusters were characterized by high serum POSTN level and blood eosinophilia. | 28987809 |
| 242 | Asthma | Human | Serum | CCL11 | ELISA | Others | Low Throughput | Severe asthma (noneosinophilic cluster) with a mixed endotype was characterized by increased serum eotaxin. | 28987809 |
| 243 | Asthma | Human | Serum | IL8 | ELISA | Others | Low Throughput | Severe asthma (noneosinophilic cluster) with a mixed endotype was characterized by increased serum IL8. | 28987809 |
| 244 | Asthma | Human | Serum | DPP4 | ELISA | Others | Low Throughput | Low eosinophilic cluster of severe asthmatics were characterized by low DPP4 levels, increased exacerbation rates and late onset asthma. Low serum DPP4 levels could be a new biomarker for low eosinophilic non–type 2 severe asthma. | 28987809 |
| 245 | Pediatric Asthma | Human | Serum | IL1B | ELISA | Others | Low Throughput | Asthmatic children showed significantly higher IL1B levels in the serum than healthy controls. | 29034996 |
| 246 | Bronchial Asthma | Human | Serum, Tregs | SEMA3A | ELISA, Flow Cytometry | Others | Low Throughput | SEMA3A serum levels and the expression of SEMA3A on Tregs were significantly lower in patients with moderate to severe asthma when compared to healthy individuals. SEMA3A is a potent immuneregulator of inflammation including that of asthma. | 28502680 |
| 247 | Asthma (Crop and Dairy Farmers with Asthma) | Human | Serum | ECP | Chemiluminescent Immunoassay | Others | Low Throughput | s-ECP level was elevated in asthmatics as compared to control group. s-ECP is an important biomarker in means of reflecting disease severity and prognosis among exposed workers. | 29610600 |
| 248 | Bronchial Asthma | Human | Serum | IL8 | ELISA | Others | Low Throughput | IL8 exhibited high levels in patients with Bronchial Asthma and glucocorticoid treatment notably decreased the levels. The IL8 levels were positively correlated with the clinical stages and severity of Bronchial Asthma and negatively correlated with lung function. IL8 can be used as a serum marker to predict the efficacy of glucocorticoids in the treatment of Bronchial Asthma. | 29908291 |
| 249 | Bronchial Asthma | Human | Serum | ECP | ELISA | Others | Low Throughput | ECP exhibited high levels in patients with Bronchial Asthma and glucocorticoid treatment notably decreased the levels. ECP levels were positively correlated with the clinical stages and severity of Bronchial Asthma and negatively correlated with lung function. ECP can be used as a serum marker to predict the efficacy of glucocorticoids in the treatment of Bronchial Asthma. | 29908291 |
| 250 | Bronchial Asthma | Human | Serum | TNFalpha | ELISA | Others | Low Throughput | TNFalpha exhibited high levels in patients with Bronchial Asthma and glucocorticoid treatment notably decreased the levels. TNFalpha levels were positively correlated with the clinical stages and severity of Bronchial Asthma and negatively correlated with lung function. TNFalpha can be used as a serum marker to predict the efficacy of glucocorticoids in the treatment of Bronchial Asthma. | 29908291 |
| 251 | Childhood Asthma | Human | Serum | IL33 | ELISA | Others | Low Throughput | The level of IL33 in sera was significantly increased in asthmatic children as compared to healthy controls. | 28985997 |
| 252 | Atopic Asthma, Non atopic Asthma, COPD | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum periostin and IgE concentrations were increased in patients with atopic-asthma compared with those with non-atopic asthma and COPD. Serum periostin concentrations could be biomarker for atopic asthma. | 29035604 |
| 253 | Childhood Asthma | Human | Serum | OPN | ELISA | Others | Low Throughput | The serum level of OPN in the asthma group was significantly higher than in the control group. Both the atopic and non atopic subgroups showed increased serum levels of OPN compared with the control group. | 27097577 |
| 254 | Childhood Asthma | Human | Serum | TGFB1 | ELISA | Others | Low Throughput | The serum level of TGFB1 in the atopic asthma group was significantly higher than in the control group. | 27097577 |
| 255 | Childhood Asthma | Human | Serum | NE | ELISA | Others | Low Throughput | Both the acute and non-acute exacerbation groups had higher serum levels of NE than the control group. The acute exacerbation group had significantly higher serum levels of NE than the non-acute exacerbation group. | 27165586 |
| 256 | Childhood Asthma | Human | Serum | IL8 | ELISA | Others | Low Throughput | Both the acute and non-acute exacerbation groups had higher serum levels of IL8 than the control group. The acute exacerbation group had significantly higher serum levels of IL8 than the non-acute exacerbation group. | 27165586 |
| 257 | Asthma | Human | Serum, Broncho Alveolar Lavage Fluid (BALF) | CC16 | ELISA | Others | Low Throughput | CC16 level was reduced in serum and BALF of asthmatics as compared to healthy subjects. | 27315766 |
| 258 | Childhood Asthma | Human | Serum | IP10 | Cytometric Bead Array | Others | High Throughput | The IP10 concentration was similar between the whole asthma group and healthy controls, while significantly increased levels of this chemokine in acute asthma have been observed when compared to stable asthma. A negative correlation between the IP10 and eosinophil count and a negative correlation between FEV1 and IP10 were found. | 27279817 |
| 259 | Childhood Asthma | Human | Serum | MIG | Cytometric Bead Array | Others | High Throughput | MIG level was lower in all children with asthma as compared to their control counterparts. Decreased MIG levels were observed in patients with stable asthma when compared with children in the control group. | 27279817 |
| 260 | Childhood Asthma | Human | Serum | CCL5 | Cytometric Bead Array | Others | High Throughput | The concentration of RANTES (CCL5) was significantly higher in all children with asthma as compared to their control counterparts. Increased RANTES levels were noted in patients with stable asthma when compared with children in the control group. An increased serum RANTES level in children with asthma may result in enhancement of Th2 lymphocyte recruitment into the airway. | 27279817 |
| 261 | Childhood Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | The serum level of IL13 was significantly higher in asthmatic children when compared to its level in control group. | 30981701 |
| 262 | Childhood Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum levels of periostin in asthmatic children with both positive exercise and mannitol bronchial provocation test (BPT were significantly greater than those in asthmatic children with both negative exercise and mannitol BPT and also greater than in healthy controls. | 30937129 |
| 263 | Asthma | Human (Poorly controlled severe oral corticosteroid (OCS) dependent asthmatics) | Serum | POSTN | ELISA | Others | Low Throughput | High dose Oral Corticosteroid reduced median serum periostin in poorly controlled severe oral corticosteroid (OCS) dependent asthmatics. Following rescue steroids, 1 month is a sufficient time period before using type-2 biomarkers to guide long-term treatment decisions. | 30940770 |
| 264 | Asthma | Human (Poorly controlled severe oral corticosteroid (OCS) dependent asthmatics) | Serum | IL5 | ELISA | Others | Low Throughput | High dose Oral Corticosteroid reduced median serum IL5 in poorly controlled severe oral corticosteroid (OCS) dependent asthmatics. Following rescue steroids, 1 month is a sufficient time period before using type-2 biomarkers to guide long-term treatment decisions. | 30940770 |
| 265 | Asthma | Human (Poorly controlled severe oral corticosteroid (OCS) dependent asthmatics) | Serum | IL13 | ELISA | Others | Low Throughput | High dose Oral Corticosteroid reduced median serum IL13 in poorly controlled severe oral corticosteroid (OCS) dependent asthmatics. Following rescue steroids, 1 month is a sufficient time period before using type-2 biomarkers to guide long-term treatment decisions. | 30940770 |
| 266 | Asthma | Human | Serum | miR-16 | qRT-PCR | Genomics | Low Throughput | Serum miR-16 level may function as a biomarker to predict the response to salmeterol therapy and was robust in distinguishing between patients with asthma who were sensitive or resistant to salmeterol. Upregulation of microRNA‑16 alters the response to inhaled β‑agonists in patients with asthma though modulating expression of ADRB2. miR‑16 expression displayed a significant negative correlation with FEV1. | 30942450 |
| 267 | Asthma, COPD | Human | Primary Bronchial Epithelial Cells (BECs), Serum | miR-10a-5p | Next Generation Sequencing, qRT-PCR, Microarray Data Analysis | Genomics, Bioinformatics | High Throughput, Low Throughput, High Throughput | Increased miR-10a-5p level was noted in primary bronchial epithelial cells and serum of patients with asthma and COPD as compared with normal control subjects. | 30696075 |
| 268 | Asthma, COPD | Human | Primary Bronchial Epithelial Cells (BECs), Serum | miR-146a-5p | Next Generation Sequencing, qRT-PCR, Microarray Data Analysis | Genomics, Bioinformatics | High Throughput, Low Throughput, High Throughput | Increased miR-146a-5p level was noted in primary bronchial epithelial cells and serum of patients with asthma and COPD as compared with normal control subjects. | 30696075 |
| 269 | Asthma | Human | Serum | VEGF | ELISA | Others | Low Throughput | Increased VEGF serum concentration is characteristic of patients with asthma, especially those with irreversible bronchoconstriction. | 30740942 |
| 270 | Childhood Asthma | Human | Serum | D-Dimer | Immunoassay | Others | Low Throughput | Serum D-Dimer level was significantly increased in asthmatics as compared to healthy controls. D-Dimer could be considered useful to demonstrate the presence of a low grade inflammatory status and a low grade fibrinolytic activity in children with asthma. | 30723958 |
| 271 | Childhood Bronchial Asthma | Human | Serum | NRF2 | ELISA | Others | Low Throughput | The pathogenesis of childhood bronchial asthma may be associated with low serum NRF2 which may be a strong predictor of the disease severity. | 30729848 |
| 272 | Childhood Bronchial Asthma | Human | Serum | GPX | Biochemical Test | Others | Low Throughput | Serum GPX was significantly lower in asthmatic group than controls group. In severe bronchial asthma, mean serum GPX was significantly lower than in mild and moderate asthma. | 30729848 |
| 273 | Asthma, COPD | Human | Serum | PAMP | ELISA | Others | Low Throughput | Serum Pro AM and PAMP levels were significantly elevated in asthmatics and COPD patients as compared to healthy subjects. | 30690080 |
| 274 | Asthma, Multiple Sclerosis | Human | Serum | IL33 | ELISA | Others | Low Throughput | The level of IL33 was significantly higher in asthma and multiple sclerosis patients compared to the control group. | 30950351 |
| 275 | Childhood Asthma | Human | Serum | IL1B | ELISA | Others | Low Throughput | Serum IFNB levels were significantly lower in Asthmatic children than those in the controls. Low levels of IFNB may be related to the susceptibility to severe asthma. IFNB may play a role in the pathogenesis of asthma. | 30950247 |
| 276 | Severe Childhood Asthma | Human | Serum | TGFB | ELISA | Others | Low Throughput | Serum TGFB level was negatively correlated with asthma severity. Serum TGFB level was decreased with increasing severity of asthma. | 30670774 |
| 277 | Severe Childhood Asthma | Human | Serum | IL17A | ELISA | Others | Low Throughput | Serum IL17A level was positively correlated with asthma severity. Serum IL17A level was increased with increasing severity of asthma. | 30670774 |
| 278 | Severe Childhood Asthma | Human | Serum | IL23 | ELISA | Others | Low Throughput | Serum IL23 level was positively correlated with asthma severity. Serum IL23 level was increased with increasing severity of asthma. | 30670774 |
| 279 | Severe Childhood Asthma | Human | Serum | FOXP3 | ELISA | Others | Low Throughput | Serum FOXP3 level was negatively correlated with asthma severity. Serum FOXP3 level was decreased with increasing severity of asthma. | 30670774 |
| 280 | Pediatric Asthma | Human | Serum | OX40L | ELISA | Others | Low Throughput | The serum OX40L level in asthmatic patients was significantly higher than that of the healthy controls and significantly higher in Steroid Resistant Asthma group than in Steroid Sensitive Asthma group. High serum OX40L can be used as a biomarker to identify asthmatic patients with corticosteroid resistance, and the change in OX40L level also reflects the response to ICS treatment. | 30890137 |
| 281 | Asthma, COPD | Human | Serum, Sputum | IL4 | ELISA | Others | Low Throughput | Serum and sputum levels of IL4 was significantly increased in the COPD patient group as compared to asthma group. | 30908476 |
| 282 | Asthma, COPD | Human | Serum, Sputum | IL5 | ELISA | Others | Low Throughput | Serum and sputum levels of IL5 was significantly increased in the COPD patient group as compared to asthma group. | 30908476 |
| 283 | Asthma, COPD | Human | Serum, Sputum | IL9 | ELISA | Others | Low Throughput | Serum and sputum levels of IL9 was significantly increased in the COPD patient group as compared to asthma group. | 30908476 |
| 284 | Asthma, COPD | Human | Serum, Sputum | IL13 | ELISA | Others | Low Throughput | Serum and sputum levels of IL13 was significantly increased in the COPD patient group as compared to asthma group. | 30908476 |
| 285 | Asthma, COPD | Human | Serum, Sputum | IL6 | ELISA | Others | Low Throughput | Serum and sputum levels of IL6 was significantly increased in the bronchial asthma patient group as compared to COPD subjects. | 30908476 |
| 286 | Asthma, COPD | Human | Serum, Sputum | IL1B | ELISA | Others | Low Throughput | Serum and sputum levels of IL1B was significantly increased in the bronchial asthma patient group as compared to COPD subjects. | 30908476 |
| 287 | Asthma, COPD | Human | Serum, Sputum | TNFalpha | ELISA | Others | Low Throughput | Serum and sputum levels of TNFalpha was significantly increased in the bronchial asthma patient group as compared to COPD subjects. | 30908476 |
| 288 | Severe Asthma | Human | Serum | EDN | ELISA | Others | Low Throughput | The serum levels of EDN was significantly higher in severe asthmatics than in nonsevere asthmatics and in healthy controls. The serum EDN level may be a useful biomarker for assessing asthma severity in adult asthmatics. | 30912328 |
| 289 | Severe Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | The serum levels of POSTN was significantly higher in severe asthmatics than in nonsevere asthmatics and in healthy controls. | 30912328 |
| 290 | Bronchial Asthma | Human (Children) | Serum | miR-98-5p | qRT-PCR | Genomics | Low Throughput | The current study showed that the relative expression level of miR-98-5p in the asthmatic remission group and asthmatic acute group was significantly lower than that in the healthy control group, and the relative expression level of miR-98-5p in the asthmatic acute group was significantly lower than that in the asthmatic remission group. The current study suggests that miR-98-5p may affect the occurrence and development of bronchial asthma in children via affecting the expression of IL13. | 30868866 |
| 291 | Bronchial Asthma | Human (Children) | Serum | IL13 | - | - | Low Throughput | The serum IL13 levels in the asthma remission group and acute asthma group were significantly higher than those in the healthy control group and the serum IL13 levels in acute asthma group were significantly higher than those in asthma remission group. | 30868866 |
| 292 | Childhood Asthma | Human | Peripheral Blood Mononuclear Cells (PBMCs), Serum | NOD1 | qRT-PCR, ELISA | Genomics, Others | Low Throughput | NOD1 expression at mRNA and protein levels was significantly increased in asthma patients as compared to healthy subjects. | 30874883 |
| 293 | Atopic Asthma | Human | Serum | IL17F | ELISA, qRT-PCR | Others, Genomics | Low Throughput | There is a strong and significant positive correlation was noted between IL17F expression and Nathan's Asthma Control Test (ACT) score. IL17F plays an important role in asthma control. | 29968887 |
| 294 | Severe Childhood Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | POSTN was significantly higher during acute asthma exacerbations. A highly significant relation was noted between serum levels of POSTN and asthma severity. POSTN can serve as serum biomarker for assessment of asthma severity and acute asthma exacerbations in children with asthma. | 29970479 |
| 295 | Severe Childhood Asthma | Human | Serum | YKL40 | ELISA | Others | Low Throughput | YKL40 was significantly higher during acute asthma exacerbations. A highly significant relation was noted between serum levels of YKL40 and asthma severity. YKL40 can serve as serum biomarker for assessment of asthma severity and acute asthma exacerbations in children with asthma. | 29970479 |
| 296 | Asthma | Human | Peripheral Eosinophils, Serum | miR-1246 | Next Generation Sequencing, qRT-PCR | Genomics | High Throughput, Low Throughput | miR-1246 was significantly up regulated in asthmatics as compared to healthy subjects. | 30040124 |
| 297 | Asthma | Human | Peripheral Eosinophils, Serum | miR-144-5p | Next Generation Sequencing, qRT-PCR | Genomics | High Throughput, Low Throughput | miR-144-5p was significantly down regulated in peripheral eosinophils of asthmatics as compared to healthy subjects. However, serum miR-144-5p was significantly up regulated in asthmatics as compared to healthy subjects. | 30040124 |
| 298 | Asthma | Human | Peripheral Eosinophils, Serum | miR-320a | Next Generation Sequencing, qRT-PCR | Genomics | High Throughput, Low Throughput | miR-320a was significantly up regulated in asthmatics as compared to healthy subjects. | 30040124 |
| 299 | Asthma | Human | Peripheral Eosinophils, Serum | miR-185-5p | Next Generation Sequencing, qRT-PCR | Genomics | High Throughput, Low Throughput | miR-185-5p was significantly up regulated in asthmatics as compared to healthy subjects. The expression of miR-185-5p may be related to disease severity. | 30040124 |
| 300 | Asthma | Human | Peripheral Eosinophils, Serum | miR-21-5p | Next Generation Sequencing, qRT-PCR | Genomics | High Throughput, Low Throughput | miR-21-5p was significantly up regulated in asthmatics as compared to healthy subjects. | 30040124 |
| 301 | Allergy/Asthma | Human | Serum | IgA | Nephelometry | Others | Low Throughput | Sensitization to HDM and methacholine airway hyper responsiveness were significantly associated with serum IgA levels in suspected asthmatics, even when those levels were normal. | 27586868 |
| 302 | Asthma | Human | Bronchial Biopsy, Serum | uPAR | Immunohistochemistry, ELISA | Others | Low Throughput | Elevated airway and blood serum uPAR is a feature of asthma and that blood serum uPAR is particularly related to severe, nonatopic asthma. | 27624865 |
| 303 | Acute Childhood Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | The relative circulating IL4 levels in the peripheral blood serum of children in the acute asthma group were significantly higher than those in the control group. Along with the aggravation of the disease, the relative levels of IL4 increased gradually. The relative level of IL4 was positively correlated with the severity of the asthma. | 29809062 |
| 304 | Acute Childhood Asthma | Human | Serum | IFNG | ELISA | Others | Low Throughput | The relative circulating IFNG levels in the peripheral blood serum of children in the acute asthma group were significantly lower than those in the control group. Along with the aggravation of the disease, the relative levels of IFNG decreased gradually. The relative level of IFNG was negatively correlated with the severity of the asthma. | 29809062 |
| 305 | Childhood Asthma | Human | Cord Blood, Serum | CCL22 | Multiplex Luminex Assay | Others | High Throughput | Mothers of children with higher CCL22 chemokine levels at birth were signifcantly more likely to display Dermatophagoides pteronyssinus sensitization. A lower CCL22 level at birth with a slight rise during infancy was associated with higher prevalence of mite sensitization and a higher risk of asthma at 3 years-of-age. Low mother to-child Th2-associated chemokine CCL22 levels appear to be inversely related to mite sensitization and the risk of asthma development in early childhood. | 29662241 |
| 306 | Childhood Asthma | Human | Serum | TPSAB1 | Fluoroenzymeimmunoassay | Others | Low Throughput | Children with mild and moderate to severe persistent asthma had significantly increased serum baseline Tryptase (sBT) levels as compared to those with mild intermittent asthma and healthy controls. sBT levels were significantly correlated with a variety of key markers that reflect the disease severity of asthma. | 28049209 |
| 307 | Pediatric Bronchial Asthma, Pediatric Atopic Dermatitis, Pediatric Allergic Rhinitis | Human | Serum | FLG | ELISA | Others | Low Throughput | Serum analysis showed that filaggrin levels were remarkably high in pediatric patients with Atopic Dermatitis, followed by Bronchial Asthma and Allergic Rhinitis, whereas its levels were low in non-atopic pediatric controls. Filaggrin levels were statistically significantly higher among those atopic patients whose disease activity scores were higher as compared with atopic patients with lower disease activity scores. | 30473631 |
| 308 | Pediatric Bronchial Asthma, Pediatric Atopic Dermatitis, Pediatric Allergic Rhinitis | Human | Serum | MBP | ELISA | Others | Low Throughput | MBP levels in sera of atopic patients were significantly high as compared with their respective controls, but its levels were highest in Allergic Rhinitis patients, followed by Atopic Dermatitis and Bronchial Asthma patients. Eosinophil MBP levels were statistically significantly higher among those atopic patients whose disease activity scores were higher as compared with atopic patients with lower disease activity scores. | 30473631 |
| 309 | Asthma, COPD, Asthma COPD Overlap (ACO) | Human | Serum | YKL40 | ELISA | Others | Low Throughput | Serum YKL40 level was significantly reduced in bronchial asthmatics as compared to COPD and ACO patients. | 28285848 |
| 310 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | There is day-time variation of serum periostin in adults with asthma receiving maintenance ICS and LABA therapy, with higher levels in the morning. Periostin values are higher in the morning compared with the afternoon in asthmatic and non-asthmatic adults. | 28194189 |
| 311 | Severe Acute Bronchial Asthma Deaths | Human | Serum | TPSAB1 | Fluoroenzyme Immunoassay | Others | Low Throughput | Postmortem serum mast cell tryptase levels are increased in asthmatic deaths. | 27888720 |
| 312 | Childhood Asthma | Human | Serum | CRP | Biochemical Test | Others | Low Throughput | CRP showed significant correlation with FEF₂₅₋₇₅, resistance and reactance at 5Hz. It can reflect small airway obstruction in childhood asthma, and it is more prominent in neutrophil dominant inflammation. | 26996570 |
| 313 | Allergic Asthma | Human | Serum, Peripheral Blood Mononuclear Cells (PBMCs) | IL9 | ELISA, qRT-PCR | Others, Genomics | Low Throughput | IL9 protein and mRNA levels were increased in allergic asthmatics as compared with healthy controls. | 28105134 |
| 314 | Asthma | Human | Exhaled Breath Condensate (EBC), Serum | POSTN | ELISA | Others | Low Throughput | EBC periostin levels seem to reflect intensity of upper airway disease in asthmatics, while serum levels of periostin are associated with asthma activity (exacerbations or FeNO) or NSAID-Exacerbated Respiratory Disease (NERD) subphenotypes. | 28102057 |
| 315 | Childhood Asthma | Human | Serum | BDNF | ELISA | Others | Low Throughput | The asthmatic children at the acute exacerbation and remission stages had significantly higher serum BDNF levels than healthy controls. The serum BDNF level was significantly reduced in the remission stage compared with that in the acute exacerbation stage in asthmatic children. BDNF may play an important role in the pathogenesis of childhood asthma and is related to the severity of the disease. | 28202114 |
| 316 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | An associations between periostin and markers of type 2 inflammation, as well as lung function was observed. | 28398635 |
| 317 | Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES), Asthma | Human | Serum | MDC | Human Plex Cytokine/Chemokine Panel Assay | Others | High Throughput | Serum MDC levels were lower in EGPA patients as compared to healthy controls. Serum MDC level in EGPA patients was significantly different from that of HES and asthmatic patients as well. | 30652675 |
| 318 | Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES), Asthma | Human | Serum | IL8 | Human Plex Cytokine/Chemokine Panel Assay | Others | High Throughput | Serum IL8 levels were lower in EGPA patients as compared to healthy controls. Serum IL8 level in EGPA patients was significantly different from that of HES and asthmatic patients as well. | 30652675 |
| 319 | Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES), Asthma | Human | Serum | MIP-1a | Human Plex Cytokine/Chemokine Panel Assay | Others | High Throughput | Serum MIP-1a levels were lower in EGPA patients as compared to healthy controls. Serum MIP-1a level in EGPA patients was significantly different from that of HES and asthmatic patients as well. | 30652675 |
| 320 | Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES), Asthma | Human | Serum | MIP1B | Human Plex Cytokine/Chemokine Panel Assay | Others | High Throughput | Serum MIP-1b levels were lower in EGPA patients as compared to healthy controls. Serum MIP-1b level in EGPA patients was significantly different from that of HES and asthmatic patients as well. | 30652675 |
| 321 | Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES), Asthma | Human | Serum | TNFalpha | Human Plex Cytokine/Chemokine Panel Assay | Others | High Throughput | Serum TNFalpha levels were lower in EGPA patients as compared to healthy controls. Serum TNFalpha level in EGPA patients was significantly different from that of HES and asthmatic patients as well. | 30652675 |
| 322 | Asthma | Human | Serum | miR-21 | qRT-PCR | Genomics | Low Throughput | The expression levels of miRNA-21 were significantly higher in the asthmatic children than in control group; with significantly higher levels in asthmatic patients without ICS or in steroid resistant patients compared to steroid sensitive children. Serum miRNA-21 is stable and detectable in serum of asthmatic children, which could promise potential biomarker in diagnosis as well as in response to therapy of asthma. | 26874829 |
| 323 | Asthma | Human | Serum | IL12p35 | ELISA | Others | Low Throughput | Serum IL12p35 levels were significantly decreased in asthmatic patients without ICS therapy or in steroid resistant asthma patients as compared to steroid sensitive patients. | 26874829 |
| 324 | Viral Induced Acute Asthma | Human | Serum | IP10 | ELISA | Others | Low Throughput | Serum IP10 levels of acute asthma group were significantly higher than controlled asthma group. Serum IP10 showed a significant positive correlation with parameters of asthma attack severity in acute asthma group. | 27955890 |
| 325 | Viral Induced Acute Asthma | Human | Serum | CAMP | ELISA | Others | Low Throughput | Serum cathelicidin levels of acute asthma group were significantly higher than controlled asthma group. | 27955890 |
| 326 | Viral Induced Acute Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | Serum IL4 levels of acute asthmatics were significantly lower than the controlled asthma group. | 27955890 |
| 327 | Viral Induced Acute Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | Serum IL13 levels of acute asthmatics were significantly lower than the controlled asthma group. | 27955890 |
| 328 | Asthma | Human | Serum | IL17A | ELISA | Others | Low Throughput | Fungal exposure is associated with increased IL17A serum levels and asthma severity. | 27221135 |
| 329 | Asthma | Human | Serum | TNFalpha | ELISA | Others | Low Throughput | TNFalpha are highly expressed in asthmatic patients. | 30299194 |
| 330 | Asthma | Human | Serum | IFNG | ELISA | Others | Low Throughput | IFNG are highly expressed in asthmatic patients. | 30299194 |
| 331 | Asthma | Human | Serum | YKL40 | Real time Surface Plasmon Resonance (SPR) | Others | Low Throughput | Serum YKL40 may be used as a protein marker in classifying asthma severity by applying SPR technology as a reliable, label-free, highly sensitive, and cost-effective tool. | 27616735 |
| 332 | Asthma | Human | Serum | ANP | ELISA | Others | Low Throughput | Levels of ANP signaling in serum were significantly increased with the severity of allergic asthma, suggesting a close relation with the pathogenesis of asthma; ANP signaling may play a role in the pathogenesis of allergic asthma through inducing the Th2-type immune response. | 27592571 |
| 333 | Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | IL4 level in the serum of asthmatics was significantly elevated as compared to healthy controls. | 27592571 |
| 334 | Asthma | Human | Serum | IFNG | ELISA | Others | Low Throughput | IFNG level in the serum of asthmatics was significantly reduced as compared to healthy controls. | 27592571 |
| 335 | Asthma | Human | Serum | ECP | Enzyme Radioimmunoassay | Others | Low Throughput | Subjects with simultaneously elevated serum ECP and FeNO had a higher prevalence of asthma attacks in the preceding 3 months than subjects with normal serum ECP and FeNO. FeNO and serum ECP are markers for inflammation in asthma. | 27513280 |
| 336 | Childhood Asthma | Human | Serum | IL38 | ELISA | Others | Low Throughput | Serum IL38 concentration was significantly higher in asthmatic patients with or without steroid treatment than those in controls. The overexpression of circulating IL38 may play a role in the immunopathogenesis in asthma. | 27438823 |
| 337 | Childhood Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum POSTN concentration was significantly higher in asthmatic patients with or without steroid treatment than those in controls. | 27438823 |
| 338 | Childhood Asthma | Human | Serum | IL5 | Bioplex 200 Suspension Array | Others | High Throughput | Serum IL5 concentration was significantly higher in asthmatic patients with or without steroid treatment than those in controls. | 27438823 |
| 339 | Childhood Asthma | Human | Serum | IL6 | Bioplex 200 Suspension Array | Others | High Throughput | Serum IL6 concentration was significantly higher in asthmatic patients with or without steroid treatment than those in controls. | 27438823 |
| 340 | Childhood Asthma | Human | Serum, Peripheral Blood Mononuclear Cells (PBMCs) | IL13 | Bioplex 200 Suspension Array, qRT-PCR | Others, Genomics | High Throughput, Low Throughput | Serum IL13 concentration was significantly higher in asthmatic patients with or without steroid treatment than those in controls. IL13 mRNA expression in PBMCs of steroid treated asthmatics were significantly higher that than controls. | 27438823 |
| 341 | Childhood Asthma | Human | Serum | IL17 | Bioplex 200 Suspension Array | Others | High Throughput | Serum IL17 concentration was significantly higher in asthmatic patients with or without steroid treatment than those in controls. | 27438823 |
| 342 | Childhood Asthma | Human | Serum | IL1B | Bioplex 200 Suspension Array | Others | High Throughput | Serum IL1B concentration was significantly higher in asthmatic patients with or without steroid treatment than those in controls. | 27438823 |
| 343 | Childhood Asthma | Human | Serum | IFNG | Bioplex 200 Suspension Array | Others | High Throughput | Serum IFNG concentration was significantly higher in asthmatic patients with or without steroid treatment than those in controls. | 27438823 |
| 344 | Asthma with Allergic Rhinitis | Human | Serum | IL17 | ELISA | Others | Low Throughput | Serum IL17 level was significantly elevated in patients during asthma attack and remission compared with healthy control subjects. These levels in patients during asthma attack were much higher than those during remission. Serum IL17 level was negatively correlated with pulmonary function in asthmatic patients with allergic rhinitis. | 27375717 |
| 345 | Asthma with Allergic Rhinitis | Human | Serum | CCL11 | ELISA | Others | Low Throughput | Serum eotaxin level was significantly elevated in patients during asthma attack and remission compared with healthy control subjects. These levels in patients during asthma attack were much higher than those during remission. Serum eotaxin level was negatively correlated with pulmonary function in asthmatic patients with allergic rhinitis. | 27375717 |
| 346 | Asthma, COPD | Human | Serum | CRP | ELISA | Others | Low Throughput | Concentration of CRP protein in serum of patients with occupational COPD in comparison with the asthmatic subjects was significantly higher. | 27265531 |
| 347 | Asthma | Human | Serum | ARG1 | ELISA | Others | Low Throughput | Arginase I was significantly lower in the inhalation steroid therapy group than in the no steroid therapy group. Serum arginase I might influence serum levels of l-arginine in asthmatics. | 27328636 |
| 348 | Asthma | Human | Serum | hsCRP | Highly sensitive CRP assay | Others | Low Throughput | High-sensitivity-C-reactive protein (hs-CRP) was significantly lower in the inhalation steroid therapy group than in the no steroid therapy group. | 27328636 |
| 349 | Childhood Asthma | Human | Serum | ANG1 | ELISA | Others | Low Throughput | ANG1 levels and the ANG1/ANG2 ratio were significantly lower in children with asthma compared with healthy controls. | 25584916 |
| 350 | Asthma | Human | Serum | IL6 | ELISA | Others | Low Throughput | Higher level of IL6 was observed in asthmatics as compared to controls and in severe persistent asthma as compared to moderate persistent asthma. | 27780376 |
| 351 | Asthma | Human | Serum | MMP9 | ELISA | Others | Low Throughput | Higher level of MMP9 was observed in asthmatics as compared to controls and in severe persistent asthma as compared to moderate persistent asthma. Higher levels of MMP9 was associated with lower lung functions. | 27780376 |
| 352 | Childhood Allergic Asthma | Human | Serum | IL17 | ELISA | Others | Low Throughput | IL17 was significantly elevated in asthmatic children as compared to healthy controls. | 28463581 |
| 353 | Allergic Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | Serum IL4 level was significantly elevated in asthmatic patients as compared to healthy controls. | 28760845 |
| 354 | Allergic Asthma | Human | Serum | IL5 | ELISA | Others | Low Throughput | Serum IL5 level was significantly elevated in asthmatic patients as compared to healthy controls. | 28760845 |
| 355 | Allergic Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | Serum IL13 level was significantly elevated in asthmatic patients as compared to healthy controls. | 28760845 |
| 356 | Allergic Asthma | Human | T Lymphocytes, Serum | CD26 | Flow Cytometry, ELISA | Others | Low Throughput | CD26 expression on lymphocytes was higher in asthmatics, while serum sCD26 was lower in women and patients. | 29297467 |
| 357 | Toluene Diisocyanate Induced Occupational Asthma | Human | Serum | CLU | ELISA | Others | Low Throughput | Serum CLU levels were significantly lower in the Toluene diisocyanate Induced Occupational Asthma group than in the Asymptomatic Exposed COntrol and Unexposed Healthy Normal Control groups. | 29717106 |
| 358 | Toluene Diisocyanate Induced Occupational Asthma | Human | Serum | PGRN | ELISA | Others | Low Throughput | Serum PGRN levels were significantly lower in the Toluene diisocyanate Induced Occupational Asthma group than in the Asymptomatic Exposed COntrol and Unexposed Healthy Normal Control groups. | 29717106 |
| 359 | Asthma, COPD, Asthma-COPD Overlap Syndrome (ACOS) | Human | Serum | IL5 | Cytokine Magnetic Bead Panel Assay | Others | High Throughput | Serum levels of IL5 were higher in asthma patients than in COPD patients. Their values in ACO were intermediate between those in asthma and in COPD. | 29483774 |
| 360 | Asthma, COPD, Asthma-COPD Overlap Syndrome (ACOS) | Human | Serum | IL6 | Cytokine Magnetic Bead Panel Assay | Others | High Throughput | Serum levels of IL6 were higher in asthma patients than in COPD patients. Their values in ACO were intermediate between those in asthma and in COPD. | 29483774 |
| 361 | Asthma, COPD, Asthma-COPD Overlap Syndrome (ACOS) | Human | Serum | IL8 | Cytokine Magnetic Bead Panel Assay | Others | High Throughput | Serum levels of IL8 were higher in COPD patients than in asthma patients. Their values in ACO were intermediate between those in asthma and in COPD. | 29483774 |
| 362 | Asthma, COPD, Asthma-COPD Overlap Syndrome (ACOS) | Human | Serum | IL13 | Cytokine Magnetic Bead Panel Assay | Others | High Throughput | Principal component and network analysis showed a mixed inflammatory pattern in ACO in between asthma and COPD. IL13 was the most connected node in the network. IL13 could be central to the regulation of inflammation in these conditions. | 29483774 |
| 363 | Asthma | Human | Serum | CRP | ELISA | Others | Low Throughput | Serum high sensitive C-reactive protein (hs-CRP) in asthma is higher than healthy control and increases with severity of asthma. Serum hs-CRP measurement can be helpful in predicting asthma control and treatment response. | 26958331 |
| 364 | Asthma (With and Without Psychological Symptoms) | Human | Serum | IFNG | Luminex Based assay | Others | Low Throughput | Significant elevation of serum IFNG was found in patients with asthma and with psychological symptoms than in healthy subjects. | 26932172 |
| 365 | Asthma (With and Without Psychological Symptoms) | Human | Serum | IL17A | Luminex Based assay | Others | Low Throughput | Significant elevation of serum IL17A was found in patients with asthma and with psychological symptoms than in healthy subjects. | 26932172 |
| 366 | Asthma (With and Without Psychological Symptoms) | Human | Serum | TNFalpha | Luminex Based assay | Others | Low Throughput | Significant elevation of serum TNFalpha was found in patients with asthma and with psychological symptoms than in healthy subjects. | 26932172 |
| 367 | Severe Asthma | Human | Serum | SIGLEC8 | ELISA | Others | Low Throughput | Serum Levels of Soluble Siglec-8 May Predict Responsiveness of Severe Eosinophilic Asthma to Mepolizumab. | 29703694 |
| 368 | Asthma with Depression | Human | Serum, Sputum | IL1B | ELISA, Human Cytokine/Chemokine Bead Panel | Others | Low Throughput, High Throughput | Level of IL1B in the serum and sputum were elevated in the depressive asthmatics compared to those in the non‐depressive group. | 30675924 |
| 369 | Asthma with Depression | Human | Serum, Sputum | IFNG | ELISA, Human Cytokine/Chemokine Bead Panel | Others | Low Throughput, High Throughput | Level of IFNG in the serum and sputum were elevated in the depressive asthmatics compared to those in the non‐depressive group. | 30675924 |
| 370 | Asthma with Depression | Human | Serum | CCL17 | ELISA | Others | Low Throughput | Level of CCL17 in the serum was elevated in the depressive asthmatics compared to those in the non‐depressive group. | 30675924 |
| 371 | Asthma with Depression | Human | Serum | TNFalpha | ELISA | Others | Low Throughput | Level of TNFalpha in the serum was elevated in the depressive asthmatics compared to those in the non‐depressive group. | 30675924 |
| 372 | Asthma | Human | Serum | IL5 | ELISA | Others | Low Throughput | Serum IL5 level was significantly elevated in patients with asthma compared with controls. | 26956917 |
| 373 | Asthma | Human | Serum, Broncho Alveolar Lavage Fluid (BALF), Bronchial Tissue | IL31 | ELISA, Immunohistochemistry | Others | Low Throughput | Serum and BALF IL31 levels were significantly elevated in patients with asthma compared with controls. Expression of IL31 was more prominent in the bronchial tissue in severe compared to mild asthma and controls. | 26956917 |
| 374 | Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | Serum IL13 level was significantly elevated in patients with asthma compared with controls. | 26956917 |
| 375 | Asthma | Human | Serum | TSLP | ELISA | Others | Low Throughput | Serum TSLP level was significantly elevated in patients with asthma compared with controls. | 26956917 |
| 376 | Chronic Bronchial Asthma | Human | Exhaled Breath Condensate (EBC), Serum | IL33 | ELISA | Others | Low Throughput | EBC and serum levels of IL33 were statistically higher in patients with asthma than in controls. | 26953567 |
| 377 | Steroid Resistant Asthma (SRA) | Human | Serum | VDBP | Fluorescence based Difference Gel Electrophoresis (DIGE), Mass spectrometry, Western Blotting, ELISA | Proteomics, Others | High Throughput, Low Throughput | Serum VDBP was significantly up-regulated in Steroid Resistant Asthma group compared with Steroid Sensitive Asthma group. Serum VDBP may serve as a useful biomarker for predicting Steroid Resistance in asthma patients. | 27109820 |
| 378 | Steroid Resistant Asthma (SRA) | Human | Serum | ALB | Mass spectrometry | Proteomics | High Throughput | Serum ALB was significantly down regulated in Steroid Resistant Asthma group compared with Steroid Sensitive Asthma group. | 27109820 |
| 379 | Steroid Resistant Asthma (SRA) | Human | Serum | MASP2 | Mass spectrometry | Proteomics | High Throughput | Serum MASP2 was significantly down regulated in Steroid Resistant Asthma group compared with Steroid Sensitive Asthma group. | 27109820 |
| 380 | Steroid Resistant Asthma (SRA) | Human | Serum | HP | Mass spectrometry | Proteomics | High Throughput | Serum HP was significantly up regulated in Steroid Resistant Asthma group compared with Steroid Sensitive Asthma group. | 27109820 |
| 381 | Steroid Resistant Asthma (SRA) | Human | Serum | MTMR9 | Mass spectrometry | Proteomics | High Throughput | Serum MTMR9 was significantly up regulated in Steroid Resistant Asthma group compared with Steroid Sensitive Asthma group. | 27109820 |
| 382 | Steroid Resistant Asthma (SRA) | Human | Serum | C4a | Mass spectrometry | Proteomics | High Throughput | Serum C4a was significantly up regulated in Steroid Resistant Asthma group compared with Steroid Sensitive Asthma group. | 27109820 |
| 383 | Steroid Resistant Asthma (SRA) | Human | Serum | APOA1 | Mass spectrometry | Proteomics | High Throughput | Serum APOA1 was significantly down regulated in Steroid Resistant Asthma group compared with Steroid Sensitive Asthma group. | 27109820 |
| 384 | Asthma with Rhinoviral infection | Human | Serum | IFNG | ELISA | Others | Low Throughput | A significant increase of IFNG protein was noted in serum obtained from children with asthma and with Rhinovirus detected in their nasopharyngeal tract as compared with Rhinovirus negative asthmatic children at baseline. | 27836955 |
| 385 | Asthma | Human | Serum | IL13 | ELISA | Others | Low Throughput | IL13 cytokine serum levels were significantly high in atopic and non-atopic asthma patients compared to healthy controls. | 28083766 |
| 386 | Asthma | Human | Serum, CD4 T cells, Tregs | IL17A | ELISA, Flow Cytometry | Others | Low Throughput | IL17A was significantly elevated in mild, moderate and severe asthmatics as compared to healthy controls. | 30261984 |
| 387 | Asthma | Human | Serum | IL5 | ELISA | Others | Low Throughput | IL5 was significantly elevated in mild, moderate and severe asthmatics as compared to healthy controls. | 30261984 |
| 388 | Asthma | Human | Serum, CD4 T cells, Tregs | IFNG | ELISA, Flow Cytometry | Others | Low Throughput | IFNG was significantly elevated in mild, moderate and severe asthmatics as compared to healthy controls. | 30261984 |
| 389 | Asthma | Human | Serum | TGFB1 | ELISA | Others | Low Throughput | TGFB1 was significantly elevated in mild, moderate and severe asthmatics as compared to healthy controls. | 30261984 |
| 390 | Uncontrolled Childhood Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | 38% of children with poorly controlled asthma have Uncontrolled Severe Asthma, which is associated with higher levels of total serum IgE and lower levels of serum periostin. | 28128098 |
| 391 | Virus Induced Acute Childhood Asthma | Human | Serum | ECP | Fluoroenzyme Immunoassay kit | Others | Low Throughput | ECP level was significantly elevated in sensitized asthmatic patients compared with nonsensitized asthmatic patients. | 27988920 |
| 392 | Virus Induced Acute Childhood Asthma | Human | Serum | IL5 | BioPlex Luminex Multi Cytokine Detection Kit | Others | High Throughput | IL5 level was significantly elevated in sensitized asthmatic patients compared with nonsensitized asthmatic patients. | 27988920 |
| 393 | Virus Induced Acute Childhood Asthma | Human | Serum | IP10 | BioPlex Luminex Multi Cytokine Detection Kit | Others | High Throughput | IP10 level was significantly higher in nonsensitized asthmatic patients compared with sensitized asthmatic patients. | 27988920 |
| 394 | Bronchial Asthma | Human | Serum | IL8 | ELISA | Others | Low Throughput | Serum IL8 level in the asthmatic patients with acute attack was significantly higher than those in the control group and the asthma group of clinical remission. | 28399677 |
| 395 | Bronchial Asthma | Human | Serum | TNFalpha | ELISA | Others | Low Throughput | Serum TNFalpha level in the asthmatic patients with acute attack was significantly higher than those in the control group and the asthma group of clinical remission. | 28399677 |
| 396 | Bronchial Asthma | Human | Serum | ECP | ELISA | Others | Low Throughput | Serum ECP level in the asthmatic patients with acute attack was significantly higher than those in the control group and the asthma group of clinical remission. | 28399677 |
| 397 | Asthma | Human | Serum | mTOR | ELISA | Others | Low Throughput | The level of mTOR in the serum of patients in the asthma attack group was significantly higher than that in the pneumonia and control groups, whereas such elevation was not observed in patients of the asthma remission group. | 28674387 |
| 398 | Asthma | Human | Serum | IL17 | ELISA | Others | Low Throughput | The level of IL17 in the serum of patients in the asthma attack group was significantly higher than that in the pneumonia and control groups, whereas such elevation was not observed in patients of the asthma remission group. | 28674387 |
| 399 | Asthma | Human | Serum | TGFB | ELISA | Others | Low Throughput | The level of TGFB in the serum of patients in the asthma attack group was significantly lower than that in the pneumonia and control groups, whereas such reduction was not observed in patients in asthma remission group. | 28674387 |
| 400 | Asthma | Human | Serum | IL10 | ELISA | Others | Low Throughput | The level of IL10 in the serum of patients in the asthma attack group was significantly lower than that in the pneumonia and control groups, whereas such reduction was not observed in patients in asthma remission group. | 28674387 |
| 401 | Asthma | Human | Serum | IL4 | ELISA | Others | Low Throughput | The level of IL4 in the serum of patients in the asthma attack group was significantly higher than that in the pneumonia and control groups, whereas such elevation was not observed in patients of the asthma remission group. | 28674387 |
| 402 | Asthma | Human | Serum | IFNG | ELISA | Others | Low Throughput | The level of IFNG in the serum of patients in the asthma attack group was significantly lower than that in the pneumonia and control groups, whereas such reduction was not observed in patients in asthma remission group. | 28674387 |
| 403 | Asthma (In Children and Adolescents) | Human | Serum | IL17 | ELISA | Others | Low Throughput | Serum IL17 level was significantly elevated in asthmatics as compared to healthy controls. | 29980401 |
| 404 | Childhood Asthma | Human | Serum | miR-155 | qRT-PCR | Genomics | Low Throughput | Serum level of miR-155 was higher in the children with asthma caused by air pollution than the healthy control group. Indoor air pollution aggravates the asthma in Chinese children and induces the changes in the serum level of miR-155. | 30084260 |
| 405 | Childhood Asthma | Human | Serum | IL6 | ELISA | Others | Low Throughput | IL6 level in the asthma group was higher than those in the normal control group. The content of serum IL6 in the high 25-(OH)D group was lower than those in the low 25-(OH)D group 3 days after treatment. IL6 was negatively associated with pulmonary function indexes. The serum 25-(OH)D level in asthmatic children was negatively associated with the IL6 level. | 29904394 |
| 406 | Childhood Asthma | Human | Serum | TNFalpha | ELISA | Others | Low Throughput | TNFalpha level in the asthma group was higher than those in the normal control group. The content of serum TNFalpha in the high 25-(OH)D group was lower than those in the low 25-(OH)D group 3 days after treatment. TNFalpha was negatively associated with pulmonary function indexes. The serum 25-(OH)D level in asthmatic children was negatively associated with the TNFalpha level. | 29904394 |
| 407 | Asthma | Human | Lung Lysate, Broncho Alveolar Lavage fluid (BALF), Serum | INPP4A | Western Blotting, ELISA | Proteomics, Others | Low Throughput | INPP4A expression was significantly reduced in lung lysate, BALF and serum of asthma patients as compared to that from healthy controls. | 30335467 |
| 408 | Asthma | Human | Sputum, Serum, Peripheral Blood Mononuclear Cells (PBMCs) | CD163 | ELISA, Flow Cytometry | Others | Low Throughput | Sputum sCD163 level significantly increased in asthma, unlike healthy controls. Sputum sCD163 and serum sCD163 levels were significantly higher in patients with severe asthma compared to those with mild/moderate asthma. Increased sCD163 levels in sputum are associated with the impairment of lung function. Percentage of CD163+ monocytes in patients with asthma was significantly lower than the controls. | 30246699 |
| 409 | Asthma | Human | Serum | IL6 | ELISA | Others | Low Throughput | Serum IL6 level was significantly higher in patients with severe asthma compared to patients with mild/moderate asthma. | 30246699 |
| 410 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | CCL19 | Olink proximity extension analysis | Proteomics | High Throughput | Serum CCL19 level efficiently distinguished controlled and poorly controlled asthmatics. CCL19 level was significantly elevated in poorly controlled asthmatics as compared to well controlled asthmatics. | 29665127 |
| 411 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | CCL25 | Olink proximity extension analysis | Proteomics | High Throughput | Serum CCL25 level efficiently distinguished controlled and poorly controlled asthmatics. | 29665127 |
| 412 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | CDCP1 | Olink proximity extension analysis | Proteomics | High Throughput | Serum CDCP1 level efficiently distinguished controlled and poorly controlled asthmatics. CDCP1 level was significantly elevated in poorly controlled asthmatics as compared to well controlled asthmatics. | 29665127 |
| 413 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | CCL11 | Olink proximity extension analysis | Proteomics | High Throughput | Serum CCL11 level efficiently distinguished controlled and poorly controlled asthmatics. | 29665127 |
| 414 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | FGF21 | Olink proximity extension analysis | Proteomics | High Throughput | Serum FGF21 level efficiently distinguished controlled and poorly controlled asthmatics. FGF21 level was significantly elevated in poorly controlled asthmatics as compared to well controlled asthmatics. | 29665127 |
| 415 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | FGF23 | Olink proximity extension analysis | Proteomics | High Throughput | Serum FGF23 level efficiently distinguished controlled and poorly controlled asthmatics. | 29665127 |
| 416 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | FLT3L | Olink proximity extension analysis | Proteomics | High Throughput | Serum Flt3L level efficiently distinguished controlled and poorly controlled asthmatics. | 29665127 |
| 417 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | IL10RB | Olink proximity extension analysis | Proteomics | High Throughput | Serum IL10RB level efficiently distinguished controlled and poorly controlled asthmatics. | 29665127 |
| 418 | Asthma (Controlled versus poorly controlled asthma) | Human | Serum | IL6 | Olink proximity extension analysis | Proteomics | High Throughput | Serum IL6 level efficiently distinguished controlled and poorly controlled asthmatics. IL6 level was significantly elevated in poorly controlled asthmatics as compared to well controlled asthmatics. | 29665127 |
| 419 | Childhood Asthma | Human | Serum | miR-206 | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-206 showed highest association with exacerbation for pediatric asthma. miR-206 was found to be associated with baseline FEV1/FVC in asthmatics. | 29940952 |
| 420 | Childhood Asthma | Human | Serum | miR-146-5p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-146-5p was associated with exacerbation for pediatric asthma. miR-146-5p was found to be associated with baseline FEV1/FVC in asthmatics. | 29940952 |
| 421 | Childhood Asthma | Human | Serum | miR-222-3p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-222-3p was associated with exacerbation for pediatric asthma. | 29940952 |
| 422 | Childhood Asthma | Human | Serum | miR-409-3p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-409-3p was associated with exacerbation for pediatric asthma. miR-409-3p was found to be associated with baseline FEV1/FVC in asthmatics. | 29940952 |
| 423 | Childhood Asthma | Human | Serum | miR-223-5p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-223-5p was associated with exacerbation for pediatric asthma. miR-223-5p was found to be associated with baseline FVC % in asthmatics. | 29940952 |
| 424 | Childhood Asthma | Human | Serum | miR-126-5p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-126-5p was associated with exacerbation for pediatric asthma. | 29940952 |
| 425 | Childhood Asthma | Human | Serum | miR-339-3p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-339-3p was associated with exacerbation for pediatric asthma. miR-339-3p was found to be associated with baseline FVC % in asthmatics. | 29940952 |
| 426 | Childhood Asthma | Human | Serum | miR-30e-3p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-30e-3p was associated with exacerbation for pediatric asthma. | 29940952 |
| 427 | Childhood Asthma | Human | Serum | miR-126-3p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-126-3p was associated with exacerbation for pediatric asthma. miR-126-3p was found to be associated with baseline FEV1/FVC in asthmatics. | 29940952 |
| 428 | Childhood Asthma | Human | Serum | miR-342-3p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-342-3p was associated with exacerbation for pediatric asthma. miR-342-3p was found to be associated with baseline FEV1/FVC in asthmatics. | 29940952 |
| 429 | Childhood Asthma | Human | Serum | miR-454-3p | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-454-3p was associated with exacerbation for pediatric asthma. miR-454-3p was found to be associated with baseline FEV1/FVC and baseline FVC % in asthmatics. | 29940952 |
| 430 | Childhood Asthma | Human | Serum | miR-720 | miRNA quantitative PCR array | Transcriptomics | High Throughput | miR-720 was associated with exacerbation for pediatric asthma. | 29940952 |
| 431 | Asthma | Human | Serum | miR-146a | qRT-PCR | Genomics | Low Throughput | Circulating plasma concentrations of miR-146a were significantly elevated in asthmatic individuals compared to healthy controls. miR-146a levels were higher in asthmatics with worse disease control. Elevated blood miR-146a levels in asthmatics were associated with need for higher doses of ICS. | 30300399 |
| 432 | Asthma (Severe Asthma Exacerbations) | Human | Serum | ST2 | ELISA | Others | Low Throughput | Serum sST2 levels predict severe exacerbation of asthma. High serum sST2 levels predicted exacerbation within the general asthmatic population and, when combined with blood neutrophil levels, provided an exacerbation risk score that was an accurate predictor of exacerbation occurring within 3 months. | 30176857 |
| 433 | Adult Onset Asthma | Human | Serum | IL6 | ELISA | Others | Low Throughput | Serum IL6 level showed weak negative correlation to pre- and post-bronchodilator FEV1 (% predicted) and positive correlation to ICS dose in asthmatics. Elevated serum IL6 level was associated with use of high dose ICS in asthmatics. | 27540019 |
| 434 | Asthma | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics on Inhaled Corticosteroid (ICS) treatment. | 29648484 |
| 435 | Asthma | Human | Serum | VEGF | Human Cytokine Antibody Array | Others | High Throughput | Increased VEGF expression was associated with a more severe asthma endotype with systemic inflammation characterized by poor lung function, more severe asthma symptoms and increased circulatory neutrophil levels. | 27336865 |
| 436 | Asthma | Human | Serum | sRAGE | Human Cytokine Antibody Array | Others | High Throughput | Decreased sRAGE expression was associated with a more severe asthma endotype with systemic inflammation characterized by poor lung function, more severe asthma symptoms and increased circulatory neutrophil levels. | 27336865 |
| 437 | Asthma | Human | Serum | LEP | Human Cytokine Antibody Array | Others | High Throughput | Increased LEP expression was associated with a more severe asthma endotype with systemic inflammation characterized by poor lung function, more severe asthma symptoms and increased circulatory neutrophil levels. | 27336865 |
| 438 | Asthma | Human | Serum | IFNG | Human Cytokine Antibody Array | Others | High Throughput | Increased IFNG expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 439 | Asthma | Human | Serum | IL4 | Human Cytokine Antibody Array | Others | High Throughput | Increased IL4 expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 440 | Asthma | Human | Serum | IL5 | Human Cytokine Antibody Array | Others | High Throughput | Increased IL5 expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 441 | Asthma | Human | Serum | IL6 | Human Cytokine Antibody Array | Others | High Throughput | Increased IL6 expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 442 | Asthma | Human | Serum | IL9 | Human Cytokine Antibody Array | Others | High Throughput | Increased IL9 expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 443 | Asthma | Human | Serum | IL17 | Human Cytokine Antibody Array | Others | High Throughput | Increased L17 expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 444 | Asthma | Human | Serum | IL23 | Human Cytokine Antibody Array | Others | High Throughput | Increased IL23 expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 445 | Asthma | Human | Serum | EGF | Human Cytokine Antibody Array | Others | High Throughput | Increased EGF expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 446 | Asthma | Human | Serum | GMCSF | Human Cytokine Antibody Array | Others | High Throughput | Increased GMCSF expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 447 | Asthma | Human | Serum | TNFalpha | Human Cytokine Antibody Array | Others | High Throughput | Increased TNFalpha expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 448 | Asthma | Human | Serum | IL10 | Human Cytokine Antibody Array | Others | High Throughput | Increased IL10 expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 449 | Asthma | Human | Serum | TGFB | Human Cytokine Antibody Array | Others | High Throughput | Increased TGFB expression was associated with an asthma endotype characterized by low basophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 450 | Asthma | Human | Serum | IL8 | Human Cytokine Antibody Array | Others | High Throughput | Decreased IL8 expression was associated with an asthma endotype characterized by high basophil levels, high neutrophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 451 | Asthma | Human | Serum | IL13 | Human Cytokine Antibody Array | Others | High Throughput | Decreased IL13 expression was associated with an asthma endotype characterized by high basophil levels, high neutrophil levels, high FVC and FEV1 and low ACQ-5. | 27336865 |
| 452 | Childhood Asthma | Human | Serum | hsa-miR-126-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-126-3p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 453 | Childhood Asthma | Human | Serum | hsa-miR-1290 | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-1290 was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 454 | Childhood Asthma | Human | Serum | hsa-miR-139-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-139-5p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 455 | Childhood Asthma | Human | Serum | hsa-miR-142-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-142-3p was significantly associated with FEV1/FVC in childhood asthmatics. Circulating hsa-miR-142-3p was associated with FEV1%. | 27362794 |
| 456 | Childhood Asthma | Human | Serum | hsa-miR-146b-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-146b-5p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 457 | Childhood Asthma | Human | Serum | hsa-miR-15b-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-15b-5p was significantly associated with FEV1/FVC in childhood asthmatics. Circulating hsa-miR-15b-5p was associated with FVC%. | 27362794 |
| 458 | Childhood Asthma | Human | Serum | hsa-miR-16-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-16-5p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 459 | Childhood Asthma | Human | Serum | hsa-miR-186-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-186-5p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 460 | Childhood Asthma | Human | Serum | hsa-miR-191-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-191-5p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 461 | Childhood Asthma | Human | Serum | hsa-miR-203a-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-203a-3p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 462 | Childhood Asthma | Human | Serum | hsa-miR-206 | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-206 was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 463 | Childhood Asthma | Human | Serum | hsa-miR-26a-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-26a-5p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 464 | Childhood Asthma | Human | Serum | hsa-miR-301a-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-301a-3p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 465 | Childhood Asthma | Human | Serum | hsa-miR-30b-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-30b-5p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 466 | Childhood Asthma | Human | Serum | hsa-miR-331-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-331-3p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 467 | Childhood Asthma | Human | Serum | hsa-miR-342-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-342-3p was significantly associated with FEV1/FVC in childhood asthmatics. miR-342-3p was associated with the male sex-specific FEV1/FVC analysis. | 27362794 |
| 468 | Childhood Asthma | Human | Serum | hsa-miR-374a-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-374a-5p was significantly associated with FEV1/FVC in childhood asthmatics. Circulating hsa-miR-374a-5p was associated with FEV1%. | 27362794 |
| 469 | Childhood Asthma | Human | Serum | hsa-miR-409-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-409-3p was significantly associated with FEV1/FVC in childhood asthmatics. miR-409-3p was associated with the male sex-specific FEV1/FVC analysis. | 27362794 |
| 470 | Childhood Asthma | Human | Serum | hsa-miR-454-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-454-3p was significantly associated with FEV1/FVC in childhood asthmatics. Circulating hsa-miR-454-3p was associated with FEV1%. | 27362794 |
| 471 | Childhood Asthma | Human | Serum | hsa-miR-484 | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-484 was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 472 | Childhood Asthma | Human | Serum | hsa-miR-660-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-660-5p was significantly associated with FEV1/FVC in childhood asthmatics. | 27362794 |
| 473 | Childhood Asthma | Human | Serum | hsa-miR-942-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | hsa-miR-942-5p was significantly associated with FEV1/FVC in childhood asthmatics. miR-942-5p was associated with the male sex-specific FEV1/FVC analysis. | 27362794 |
| 474 | Childhood Asthma | Human | Serum | hsa-miR-27b-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | Circulating hsa-miR-27b-3p was associated with FEV1% in childhood asthmatics. | 27362794 |
| 475 | Childhood Asthma | Human | Serum | hsa-miR-106b-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | Circulating hsa-miR-106b-5p was associated with FVC% in childhood asthmatics. | 27362794 |
| 476 | Childhood Asthma | Human | Serum | hsa-miR-223-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | Circulating hsa-miR-223-5p was associated with FVC% in childhood asthmatics. | 27362794 |
| 477 | Childhood Asthma | Human | Serum | hsa-miR-320a | Taqman MicroRNA Array | Transcriptomics | High Throughput | Circulating hsa-miR-320a was associated with FVC% in childhood asthmatics. | 27362794 |
| 478 | Childhood Asthma | Human | Serum | hsa-miR-339-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | Circulating hsa-miR-339-3p was associated with FVC% in childhood asthmatics. | 27362794 |
| 479 | Childhood Asthma | Human | Serum | hsa-miR-340-5p | Taqman MicroRNA Array | Transcriptomics | High Throughput | Circulating hsa-miR-340-5p was associated with FVC% in childhood asthmatics. | 27362794 |
| 480 | Childhood Asthma | Human | Serum | hsa-miR-376c-3p | Taqman MicroRNA Array | Transcriptomics | High Throughput | Circulating hsa-miR-376c-3p was associated with FVC% in childhood asthmatics. | 27362794 |
| 481 | Childhood Asthma | Human | Serum | hsa-miR-645 | Taqman MicroRNA Array | Transcriptomics | High Throughput | Circulating hsa-miR-645 was associated with FVC% in childhood asthmatics. | 27362794 |
| 482 | Asthma (Sensitization to Staphylococcus aureus enterotoxin (SE)) | Human | Serum | POSTN | ELISA | Others | Low Throughput | Among patients with nonatopic asthma or late-onset asthma, those sensitized to Staphylococcus aureus enterotoxin (SE) had significantly higher serum periostin levels than those not sensitized to SE. | 28034578 |
| 483 | Asthma with Chronic Rhinosinusitis | Human | Serum | POSTN | ELISA | Others | Low Throughput | Serum periostin levels were higher in patients with asthma who had chronic rhinosinusitis than in those without upper airway disease. Serum periostin levels in patients with asthma who had chronic rhinosinusitis and nasal polyps were significantly higher than in those without nasal polyps. Serum periostin is useful for detecting chronic rhinosinusitis with nasal polyps and predicting radiological chronic rhinosinusitis severity in patients with asthma. | 28248547 |
| 484 | Bronchial Asthma | Human | Serum | IL33 | ELISA | Others | Low Throughput | IL33 expression was significantly increased in serum of asthmatics as compared to healthy subjects. Inverse relationship was noted between reduced miR-200 levels and increased IL33 production in Asthmatic patients. | 29778524 |
| 485 | Asthma, Allergic Rhinitis | Human | Serum | IL4 | ELISA, qRT-PCR | Others, Genomics | Low Throughput | Level of IL4 in asthma and rhinitis patients and in those complicated with allergic rhinitis was significantly increased as compared with the control group. IL4 may be involved in the pathogenesis of asthma and rhinitis. Dust mite and mugwort allergy could increase its level significantly. | 28303765 |
| 486 | Asthma, Allergic Rhinitis | Human | Serum | IL31 | ELISA, qRT-PCR | Others, Genomics | Low Throughput | Level of IL31 in asthma and rhinitis patients and in those complicated with allergic rhinitis was significantly increased as compared with the control group. IL31 may be involved in the pathogenesis of asthma and rhinitis. Dust mite and mugwort allergy could increase its level significantly. | 28303765 |
| 487 | Asthma, Allergic Rhinitis | Human | Serum | IL33 | ELISA, qRT-PCR | Others, Genomics | Low Throughput | Level of IL33 in asthma and rhinitis patients and in those complicated with allergic rhinitis was significantly increased as compared with the control group. IL33 may be involved in the pathogenesis of asthma and rhinitis. Dust mite and mugwort allergy could increase its level significantly. | 28303765 |
| 488 | Asthma, Allergic Rhinitis | Human | Serum | TSLP | ELISA, qRT-PCR | Others, Genomics | Low Throughput | Level of TSLP in asthma and rhinitis patients and in those complicated with allergic rhinitis was significantly increased as compared with the control group. TSLP may be involved in the pathogenesis of asthma and rhinitis. Dust mite and mugwort allergy could increase its level significantly. | 28303765 |
| 489 | Paediatric Asthma | Human | Serum, Nasopharyngeal Fluid (NPF), Whole Blood, Peripheral Blood Mononuclear Cells (PBMCs) | ST2 | ELISA, qRT-PCR, Gene Array | Others, Genomics | Low Throughput | ST2 was found up regulated in the blood cells of asthmatic children with low serum levels of 25(OH)-VitD3 in the absence of Rhinovirus (RV) in their airways. Asthmatic children with low 25(OH)-VitD3 in serum and with RV in vivo in their airways at the time of the analysis had the lowest sST2 protein levels in the peripheral blood compared to control children without RV and high levels of 25(OH)-VitD3. sST2, in serum correlated directly with interleukin (IL)-33 in the airways of asthmatic children. Furthermore, RV colonization in the airways and low serum levels of 25(OH)-VitD3 were found to be | 29645082 |
| 490 | Paediatric Asthma | Human | Serum | IFNB | ELISA | Others | Low Throughput | Reduced IFNB levels in serum of preschool children with asthma was noted as compared to control preschool children. | 29645082 |
| 491 | Asthma | Human | Serum | LEP | ELISA | Others | Low Throughput | Serum leptin levels were not different between asthmatic patients and health controls. Female asthmatic patients had significantly higher serum leptin levels than males. Asthmatic patients with obesity had significantly higher serum leptin levels than asthmatic patients with overweight, with normal BMI, with underweight and healthy controls. Serum leptin level was positively related to percentage of induced sputum eosinophil in female asthmatic patients. | 27760633 |
| 492 | Allergy (Allergic Rhinitis, Asthma) | Human | Serum | CXCL8 | ELISA | Others | Low Throughput | CXCL8 level was slightly elevated in allergic rhinitis patients and was highly elevated in patients with allergic rhinitis and severe asthma as compared to healthy controls. | 24986253 |