| Record no | GENE NAME | SNP ID | CHANGES | ANCESTRAL ALLELES | FUNCTIONAL CONSEQUENCES | DISEASE | POPULATION | Pubmed ID | Comments |
|---|
| 1 | ACE | rs4291 | A/T | A | Upstream variant 2KB (in promoter region of ACE) | Aspirin-intolerant asthma (AIA) | Korean cohort of population | 18727619 | The rare allele is significantly associated with aspirin intolerance in asthmatics.The rare allele decreases promoter activity of ACE gene and thus induces accumulation of inflammatory mediators in lungs. |
|---|
| 2 | ADAM33 | rs2280091 | A/G | A | Missense Variant | Bronchial Asthma | Han ethnic group and Mongolian ethnic group living in the Inner Mongolia region of China | 30591802 | A correlation was observed between the AA genotype and higher asthma risk in both ethnic groups living in Inner Mongolia, with alleles G and A as the protective and susceptibility genes respectively. |
|---|
| 3 | ADAM33 | rs2787094 | C/G | C | Non Coding Transcript Variant | Bronchial Asthma | Mongolian ethnic group living in the Inner Mongolia region of China | 30591802 | In the Mongolian population, a significant difference was seen in the prevalence of the GC and GG genotypes between the asthmatics and healthy individuals. Allele G is a likely asthma risk factor, while allele C is protective against asthma in the Mongolian population. |
|---|
| 4 | ADRB2 | rs1042714 | G/C | G | Coding region | Asthma | African Americans and European Americans | 30334910 | Individuals homozygous for Gln27 (CC) were found to be disproportionately more likely to experience exacerbations versus those who were heterozygous (GC) or Glu27 (GG) homozygous. |
|---|
| 5 | ARG1 | rs2781666 | G/T | T | 2KB Upstream Variant | Asthma | Indian population | 30381539 | rs2781666 gene polymorphism was found to be significantly associated with asthma. Allelic associations study indicated high frequency of G allele in healthy controls compared to T allele in asthmatics. |
|---|
| 6 | ARG1 | rs60389358 | C/T | C | 2KB Upstream Variant | Asthma | Indian population | 30381539 | Significant allele association was observed where C allele was associated with asthmatics compared to healthy controls in whom T allele was predominant. |
|---|
| 7 | ADRB2 | rs1042711 | A/C/T | C | 5' UTR Variant | Pediatric Asthma | Han population | 26633084 | Variations of ADRB2 at base positions −47(C>T) (rs1042711) may contribute to susceptibility to childhood asthma in Chinese Han population. |
|---|
| 8 | ADRB2 | rs1042714 | C/G/T | G | Stop Gained | Pediatric Asthma | Han population | 26633084 | Variations of ADRB2 at base positions 79 (G>C) (rs1042714) may contribute to susceptibility to childhood asthma in Chinese Han population. |
|---|
| 9 | ADRB2 | Haplotype III | - | - | - | Pediatric Asthma | Han population | 26633084 | The frequency of haplotype III was significantly lower in the asthma group than in the control group. Haplotype III was associated with a reduced risk of asthma. |
|---|
| 10 | ADAM33 | rs528557 | A/C/G | C | Synonymous Variant | Asthma | Punjabi population of Pakistan | 26666372 | rs528557 showed significant association with asthma. The genetic variants of ADAM33 gene may play important roles in asthma susceptibility in the Punjabi population of Pakistan. |
|---|
| 11 | ADAM33 | Haplotype III | - | - | - | Asthma | Punjabi population of Pakistan | 26666372 | The significantly higher frequency of haplotype "AAGTCG" of ADAM33 in healthy controls suggests a protective effect against asthma risk in the studied population. |
|---|
| 12 | ADAM33 | rs2280091 | A/G | A | Missense Variant | Asthma | Pakistani population | 29588858 | The minor allele G of rs2280091 in ADAM33 gene showed association with protection from asthma. GG homozygotes were more observed in controls as compared to asthmatics. |
|---|
| 13 | ADAMTS9 | rs9866261 | A/G | A | Intron Variant | Asthma | Spanish population | 26620591 | The minor allele (G allele) of rs9866261 is associated with risk for asthma both in the discovery and replication studies. |
|---|
| 14 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Childhood Asthma | Chinese Han population | 26613553 | Individuals homozygous for the risk alleles (AA) for rs1042713 are at a higher risk for developing asthma compared with those without any risk homozygotes. IL13 rs20541 (G allele), IL4 rs2243250 (T allele), ADRB2 rs1042713 (A allele), and FCER1B rs569108 (G allele), four SNPs with significant sole effect on asthma, interact to confer a higher risk for the disease in Chinese Han children. |
|---|
| 15 | ADAM33 | rs511898 | C/T | T | Intron Variant | Childhood Asthma | Egyptian Population | 26553447 | The homozygous mutant genotype (AA) of rs511898 was significantly associated with asthma risk and severity in moderate and severe subgroups. |
|---|
| 16 | ADAM33 | rs44707 | A/C/G | C | Intron Variant | Childhood Asthma | Egyptian Population | 26553447 | The heterozygous (AC) and homozygous mutant genotype (AA) of rs44707 was significantly associated with asthma risk and severity in moderate and severe subgroups. |
|---|
| 17 | ADAM12 | rs3740199 | A/C/G | G | Missense Variant | Childhood Asthma | Egyptian Population | 26553447 | Patients with the ADAM12 (rs3740199) CC genotype were at increased risk for moderate and severe asthma. The ADAM12 expression was significantly higher in homozygous CC (variant type) compared with homozygous GG (wild type) of ADAM12 rs3740199. |
|---|
| 18 | ABCC4 | rs868853 | A/G | A | 2KB Upstream Variant | Asthma | Korean population | 28659663 | Asthma patients carrying the G allele at -1508A>G had significantly higher serum levels of periostin, myeloperoxidase, and urinary levels of 15-hydroxyeicosatetraenoic acid and sphingosine-1-phosphate compared with noncarrier asthma patients. |
|---|
| 19 | ADAM33 | rs2280091 | A/G | A | Missense Variant | Childhood Asthma | - | 28876365 | ADAM33 polymorphisms rs2280091 was significantly associated with a high risk of childhood asthma. |
|---|
| 20 | ADAM33 | rs2280090 | A/G | G | Missense Variant | Childhood Asthma | - | 28876365 | ADAM33 polymorphisms rs2280090 was significantly associated with a high risk of childhood asthma. |
|---|
| 21 | ADAM33 | rs2787094 | C/G | C | Non Coding Transcript Variant | Childhood Asthma | - | 28876365 | ADAM33 polymorphisms rs2787094 was significantly associated with a high risk of childhood asthma. |
|---|
| 22 | ADAM33 | rs44707 | A/C/G | C | Intron Variant | Childhood Asthma | - | 28876365 | ADAM33 polymorphisms rs44707 was significantly associated with a high risk of childhood asthma. |
|---|
| 23 | ADAM33 | rs528557 | A/C/G | C | Synonymous Variant | Childhood Asthma | - | 28876365 | ADAM33 polymorphisms rs528557 was significantly associated with a high risk of childhood asthma. |
|---|
| 24 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Childhood Asthma | Serbian population | 30425908 | Polymorphism ADRB2 +46A>G (rs1042713) may be a determinant of asthma severity and response to salbutamol in children with asthma. |
|---|
| 25 | ADRB2 | rs1042714 | C/G/T | G | Stop Gained | Asthma | African American and European American population | 30334910 | The Glu27 variant in the ADRB2 gene is associated with increased frequencies of asthma exacerbations. |
|---|
| 26 | ALCAM | rs1044240 | A/G/T | A | Missense Variant | Asthma | Korean population | 29394080 | The p.N258S variant conferred protection against allergic asthma. |
|---|
| 27 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Severe Allergic Asthma | Italian population | 27421901 | The polymorphism of Arg16Gly beta2-adrenergic receptor gene in Arg/Arg homozygous fashion is associated with the occurrence of severe allergic asthma. |
|---|
| 28 | APOBEC3B, APOBEC3C | rs5995653 | A/G | A | - | Asthma | Admixed population, European population | 30697902 | rs5995653 in the intergenic region of APOBEC3B and APOBEC3C was suggestively associated with asthma exacerbations in admixed populations and showed evidence of replication in Europeans. |
|---|
| 29 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Asthma | Arabian population | 30774389 | rs1042713 SNP in the ADRB2 gene and its related haplotype were nominally significantly associated with level of asthma control in Jordanian Arab asthmatic patients. |
|---|
| 30 | ADRB2 | rs1042714 | G/C | G | Coding region | Asthma | Arabian population | 30774389 | rs1042714 SNP in the ADRB2 gene and its related haplotype were nominally significantly associated with level of asthma control in Jordanian Arab asthmatic patients. |
|---|
| 31 | ADRB2 | rs1800888 | C/T | C | Missense Variant | Asthma | European population | 30682460 | The ADRB2 p.Thr164Ile variant was associated with hospitalization for asthma-related exacerbations. |
|---|
| 32 | ADAM33 | rs612709 | A/G | G | Intron Variant | Asthma | Asian population | 30791911 | Q1 polymorphism (rs612709) of ADAM33 gene might contribute to asthma risk. |
|---|
| 33 | ADAM33 | rs2280090 | A/G | G | Missense Variant | Asthma | Asian population | 30791911 | T2 polymorphism (rs2280090) of ADAM33 gene might contribute to asthma risk. |
|---|
| 34 | ADAM33 | rs511898 | C/T | T | Intron Variant | Asthma | Asian population | 30791911 | F + 1 polymorphism (rs511898) of ADAM33 gene might contribute to asthma risk. |
|---|
| 35 | ADAM33 | rs2787094 | C/G | C | Non Coding Transcript Variant | Asthma | Caucasian population | 30791911 | V4 polymorphism was associated with asthma among Caucasian populations. |
|---|
| 36 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Pediatric Asthma | - | 30855197 | Presence of Arg/Gly or Gly/Gly genotypes in position 16 of ADRB2 was significantly associated to lower basal FEV1 and to a worse bronchodilation response. |
|---|
| 37 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Childhood Bronchial Asthma | Egyptian Population | 30468638 | The risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in ADRB2 gene. |
|---|
| 38 | ADRB2 | rs1042714 | G/C | G | Coding region | Childhood Bronchial Asthma | Egyptian Population | 30468638 | The risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in ADRB2 gene. |
|---|
| 39 | ATF3 | rs72756369 | A/T | T | Intron Variant | Diisocyanate Induced Asthma | European population | 29969634 | rs72756369, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. |
|---|
| 40 | ATF3 | rs11571537 | C/T | T | Intron Variant | Diisocyanate Induced Asthma | European population | 29969634 | rs11571537, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. |
|---|
| 41 | ATF3 | rs11571559 | A/C/T | C | 500B Downstream Variant | Diisocyanate Induced Asthma | European population | 29969634 | rs11571559, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. |
|---|
| 42 | ATF3, FAM71A | rs11571563 | A/G/T | G | Intergenic Variant | Diisocyanate Induced Asthma | European population | 29969634 | rs11571563, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. |
|---|
| 43 | ATF3, FAM71A | rs74138575 | A/G | A | Intergenic Variant | Diisocyanate Induced Asthma | European population | 29969634 | rs74138575, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. |
|---|
| 44 | ATF3, FAM71A | rs75465959 | A/G | G | Intergenic Variant | Diisocyanate Induced Asthma | European population | 29969634 | rs75465959, associated with Diisocyanate Induced Asthma is considered most likely to function by altering gene regulatory mechanism in disease relevant cells. |
|---|
| 45 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Childhood Asthma Exacerbations | Northern European population, Latino population | 26774659 | The use of a LABA as an "add-on controller" is associated with increased risk of asthma exacerbation in children carrying 1 or 2 A alleles at rs1042713. |
|---|
| 46 | ATG5 | rs510432 | A/G (REV) | G | 2KB Upstream Variant | Neutrophilic Asthma | Korean population | 26701229 | In the asthma group, GA/AA genotypes at ATG5 -335G>A were associated with higher neutrophil counts in sputum. |
|---|
| 47 | ATG5 | rs573775 | C/T (REV) | T | Intron Variant | Neutrophilic Asthma | Korean population | 26701229 | In the asthma group, CC/TT genotype at ATG5 8830C>T associated with lower FEV1% predicted value. |
|---|
| 48 | ATG7 | rs2594971 | C/T (REV) | C | 2KB Upstream Variant | Neutrophilic Asthma | Korean population | 26701229 | GG genotype at ATG7 -100A>G was significantly associated with high serum levels of IL8. |
|---|
| 49 | ATG7 | rs1375206 | C/G (REV) | G | Intron Variant | Neutrophilic Asthma | Korean population | 26701229 | CC genotype at ATG7 25108G>C was significantly associated with high serum levels of IL8. |
|---|
| 50 | ADCY9 | rs2601796 | C/T (REV) | T | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2601796 was positively associated with asthma. rs2601796 was significantly associated with skin prick test for Dermatophagoides pteronyssinus. |
|---|
| 51 | ADCY9 | rs2601814 | A/C/G (REV) | C | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2601814 was positively associated with asthma. rs2601814 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus or atleast one of the allergen tested. |
|---|
| 52 | ADCY9 | rs2283497 | C/G/T | T | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2283497 was negatively associated with allergy in asthmatic patients. rs2283497 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus or atleast one of the allergen tested. rs2283497 was significantly associated with sIgE for Blomia tropicalis and Dermatophagoides pteronyssinus. |
|---|
| 53 | ADCY9 | rs8061182 | C/T | T | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs8061182 was positively associated with allergy in asthmatic patients. rs8061182 was significantly associated with skin prick test for Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested. |
|---|
| 54 | ADCY9 | rs4785947 | A/C/G | G | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs4785947 was positively associated with allergy in asthmatic patients. rs4785947 was significantly associated with sIgE for Blomia tropicalis. |
|---|
| 55 | ADCY9 | kgp12201986 | A/G | - | - | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | kgp12201986 was positively associated with allergy in asthmatic patients. kgp12201986 was significantly associated with skin prick test for Periplaneta americana, Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested. kgp12201986 was also significantly associated sIgE for Blomia tropicalis or atleast one of the allergen tested. |
|---|
| 56 | ADCY9 | rs432166 | G/T (REV) | T | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs432166 was significantly associated with sIgE for Blomia tropicalis or atleast one of the allergen tested. |
|---|
| 57 | ADCY9 | rs2601777 | A/G | G | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2601777 was significantly associated with sIgE for Blomia tropicalis or atleast one of the allergen tested. |
|---|
| 58 | ADCY9 | rs6500567 | A/G | G | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs6500567 was significantly associated with skin prick test for Periplaneta americana or atleast one of the allergen tested. rs6500567 was significantly associated with sTgE for Dermatophagoides pteronyssinus. |
|---|
| 59 | ADCY9 | rs4785953 | A/G | A | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs4785953 was significantly associated with sIgE for Blomia tropicalis and Dermatophagoides pteronyssinus. |
|---|
| 60 | ADCY9 | rs2444217 | C/T (REV) | C | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2444217 was significantly associated with sIgE for Blomia tropicalis. rs2444217 was significantly associated with skin prick test for Dermatophagoides pteronyssinus or atleast one of the allergen tested. |
|---|
| 61 | ADCY9 | rs8045426 | A/C/T | C | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs8045426 was significantly associated with sIgE for Blomia tropicalis. rs8045426 was significantly associated with unstimulated IL5 and IL13 production. |
|---|
| 62 | ADCY9 | rs7196832 | A/G | A | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs7196832 was significantly associated with skin prick test for cat epithelium. rs7196832 was significantly associated with unstimulated IL5 production. |
|---|
| 63 | ADCY9 | rs2108987 | A/C/G (REV) | A | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2108987 was significantly associated with skin prick test for dog epithelium and Blatella germanica. rs2108987 was significantly associated with unstimulated IL5 production. |
|---|
| 64 | ADCY9 | rs2239313 | A/C/G | G | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2239313 was significantly associated with skin prick test for Periplaneta americana, Blomia tropicalis, Dermatophagoides pteronyssinus, dog epithelium or atleast one of the allergen tested. |
|---|
| 65 | ADCY9 | rs4785951 | A/C/T | T | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs4785951 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus, dog epithelium or atleast one of the allergen tested. |
|---|
| 66 | ADCY9 | rs2601798 | A/C/G (REV) | C | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2601798 was significantly associated with skin prick test for Blatella germanica. rs2601798 was significantly associated with unstimulated IL5 production. |
|---|
| 67 | ADCY9 | rs13337675 | A/G | A | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs13337675 was significantly associated with skin prick test for Blatella germanica. rs13337675 was significantly associated with unstimulated IL5 production. |
|---|
| 68 | ADCY9 | rs2601807 | A/G (REV) | G | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2601807 was significantly associated with skin prick test for Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested. |
|---|
| 69 | ADCY9 | rs61042195 | A/C/G/T | C | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs61042195 was significantly associated with skin prick test for Blomia tropicalis and Dermatophagoides pteronyssinus. |
|---|
| 70 | ADCY9 | rs2531995 | A/G (REV) | G | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2531995 was significantly associated with skin prick test for Periplaneta americana, Blomia tropicalis, Dermatophagoides pteronyssinus or atleast one of the allergen tested. rs2531995 was significantly associated with unstimulated IL13 production. |
|---|
| 71 | ADCY9 | rs409963 | A/C/G (REV) | A | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs409963 was significantly associated with skin prick test for Periplaneta americana or atleast one of the allergen tested. |
|---|
| 72 | ADCY9 | rs2532019 | A/C (REV) | C | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2532019 was significantly associated with skin prick test for Periplaneta americana and Dermatophagoides pteronyssinus. |
|---|
| 73 | ADCY9 | rs9922384 | A/G | G | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs9922384 was significantly associated with skin prick test for Periplaneta americana and Dermatophagoides pteronyssinus. |
|---|
| 74 | ADCY9 | rs2058166 | A/G/T (REV) | G | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2058166 was significantly associated with skin prick test for Periplaneta americana, Dermatophagoides pteronyssinus or atleast one of the allergen tested. |
|---|
| 75 | ADCY9 | rs2601831 | A/C/G (REV) | A | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs2601831 was significantly associated with skin prick test for Dermatophagoides pteronyssinus or atleast one of the allergen tested. |
|---|
| 76 | ADCY9 | rs79964474 | C/G/T | C | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs79964474 was significantly associated with skin prick test for Dermatophagoides pteronyssinus or atleast one of the allergen tested. |
|---|
| 77 | ADCY9 | rs73490519 | A/G | A | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs73490519 was significantly associated with skin prick test for Dermatophagoides pteronyssinus or atleast one of the allergen tested. |
|---|
| 78 | ADCY9 | rs1045476 | C/T (REV) | C | Intron Variant | Asthma, Allergy | Brazilian population (African or mixed descent) | 28076799 | rs1045476 was significantly associated with skin prick test for Dermatophagoides pteronyssinus and unstimulated IL13 production. |
|---|
| 79 | ACE | rs4646994 | - | - | Insertion/Deletion polymorphism | Asthma | Pakistani population | 27581935 | Homozygous insertion genotype II and insertion allele (I) was significantly more frequent in Pakistani asthmatics than in healthy controls. There is an involvement of ACE I/D polymorphism in asthma risk in the Pakistani population. |
|---|
| 80 | ACE | - | - | - | Insertion/Deletion polymorphism | Childhood Asthma | East Asian population | 27645324 | The deletion genotype D/D in ACE may increase the risk of childhood asthma from East Asia. |
|---|
| 81 | ADRB2 | rs1800888 | C/T | C | Missense Variant | Severe Asthma | South Indian population | 27450915 | The ADRB2 Thr164Ile polymorphism was not associated with disease susceptibility however, this polymorphism was significantly associated with non-responding patients with severe asthma. |
|---|
| 82 | ADAM33 | rs2280091 | A/G | A | Missense Variant | Bronchial Asthma | Mongolian population | 27686544 | T1 (rs2280091) locus polymorphism of ADAM33 gene may play a role in the Mongolian asthma population. |
|---|
| 83 | ADAM33 | rs528557 | A/C/G | C | Synonymous Variant | Bronchial Asthma | Mongolian population | 27686544 | S2 (rs528557) locus polymorphism of ADAM33 gene may play a role in the Mongolian asthma population. |
|---|
| 84 | ADAM33 | rs2787094 | C/G | C | Non Coding Transcript Variant | Bronchial Asthma | Mongolian population | 27686544 | V4 locus polymorphism (rs2787094) of ADAM33 gene may play a role in the Mongolian asthma population. The genotype polymorphism of V4 sites may be associated with asthma severity. |
|---|
| 85 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Asthma, Atopy | Chinese Han population | 29761786 | ADRB2 rs1042713 was associated with the Asthma Predictive Index (API) and atopy. |
|---|
| 86 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Bronchial Asthma | - | 30178312 | The Arg16Gly polymorphism (rs1042713) in the β2-AR gene (ADRB2 gene) are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future. |
|---|
| 87 | ADRB2 | rs1042714 | G/C | G | Coding region | Bronchial Asthma | - | 30178312 | The Gln27Glu polymorphism (rs1042714) in the β2-AR gene (ADRB2 gene) are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future. |
|---|
| 88 | ADO, EGR2 | rs224108 | A/G (REV) | A | - | Atopic Dermatitis | Chinese Han population | 30915103 | rs224108 on 10q21.2 showed significant association with Atopic Dermatitis. |
|---|
| 89 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Mild Persistant Asthma | Japanese population | 27885204 | Interaction of ADRB2 Gly16Arg (rs1042713) with PTGER4 is important in determining the differential response to salmeterol versus montelukast in patients with chronic adult asthma. |
|---|
| 90 | ABP1 | - | C/T | - | - | Childhood Asthma | African American population | 28101058 | There was association between ABP1 47 C/T and histamine pharmacodynamic response in children with asthma. |
|---|
| 91 | ALOX5 | rs892690 | A/G (REV) | G | Intron Variant | Asthma | Greenlandic population | 28740106 | Homozygous AA genotype of ALOX5 SNP rs892690 had a signifcantly increased risk of ever asthma compared to GG genotype. |
|---|
| 92 | AKR1B1 | rs2229542 | A/G (REV) | A | Missense Variant | Asthma, Allergic Rhinitis | Caucasian population | 29726087 | The rs2229542 variant, introducing the p.Lys90Glu mutation, was significantly more frequent in allergic patients than in healthy subjects. The rs2229542 variant associates with asthma and rhinitis and hampers AKR1B1 protein levels and stability. |
|---|
| 93 | ADAM33 | rs2280091 | A/G | A | Missense Variant | Childhood Asthma | Asian population | 28285393 | ADAM33 T1 (rs2280091) polymorphism might be a potential susceptible predictor of asthma for Asian children. |
|---|
| 94 | ADAM33 | rs2280090 | A/G | G | Missense Variant | Asthma | - | 28326636 | A allele of ADAM33 T_2 was associated with mixed type of eosinophilic/type-2 and neutrophilic inflammations. ADAM33 T_2 may serve as risk marker of asthma exacerbations in type-2 inflammatory endotype. |
|---|
| 95 | ADAM33 | rs2787094 | C/G | C | Non Coding Transcript Variant | Asthma, COPD | Venezuelan population | 28429897 | The polymorphism V4 of ADAM33 (rs2787094) is associated with asthma or COPD in Venezuelan patients. |
|---|
| 96 | ADAM33 | rs44707 | A/C/G | C | Intron Variant | Asthma | Chinese Li Population | 28451394 | Significant difference was observed in allele frequencies at the SNP rs44707/T2 between asthma patients and control subjects. The SNP rs44707/T2 was found to be associated with the high severity group. |
|---|
| 97 | ADAM33 | rs2787094 | C/G | C | Non Coding Transcript Variant | Asthma | Chinese Li Population | 28451394 | Significant difference was observed in allele frequencies at the SNP rs2787094/V4 between asthma patients and control subjects. The SNPs rs2787094/V4 was associated with the low severity group. |
|---|
| 98 | ADAM33 | rs2280089 | A/G | G | Intron Variant | Asthma | Asian population | 28451394 | Significant difference was observed in allele frequencies at the SNP rs2280089/T+1 between asthma patients and control subjects. The SNP rs2280089/T+1 has been reported to be associated with asthma in an Asian population. |
|---|
| 99 | ABI3BP | rs13091963 | A/G | A | - | Asthma | Dutch population | 27439200 | The risk allele G of rs13091963 on chromosome 3 near ABI3BP was associated with lower levels of total IgE measured in blood within asthmatics. |
|---|
| 100 | ABI3BP | rs1449302 | A/G (REV) | A | - | Asthma | Dutch population | 27439200 | The risk allele T of rs1449302 on chromosome 3 near ABI3BP was associated with lower levels of total IgE measured in blood within asthmatics. |
|---|
| 101 | ASB7, LINS1, PRKXP1 | rs1565749 | A/G | G | - | Childhood Asthma | Puerto Rican population, Mexican population, African American population | 29509491 | The A allele of rs1565749 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. |
|---|
| 102 | ASB7, LINS1, PRKXP1 | rs57924834 | A/G | G | - | Childhood Asthma | Puerto Rican population, Mexican population, African American population | 29509491 | The A allele of rs57924834 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. |
|---|
| 103 | ASB7, LINS1, PRKXP1 | rs55638658 | A/G | G | - | Childhood Asthma | Puerto Rican population, Mexican population, African American population | 29509491 | The A allele of rs55638658 was significantly associated with bronchodilator drug response (BDR) in asthmatic children. |
|---|
| 104 | ADAD1, IL2, IL21, IL21-AS1, KIAA1109 | rs56267605 | G/T (REV) | T | - | Asthma, Allergic Diseases | European population | 29785011 | rs56267605 was associated with asthma and allergic diseases. |
|---|
| 105 | ALG9, BTG4, C11orf1, C11orf88, FDXACB1, LAYN, MIR34B, MIR34C, PPP2R1B, SIK2 | rs659529 | A/C/T | T | - | Asthma, Allergic Diseases | European population | 29785011 | rs659529 was associated with asthma and allergic diseases. |
|---|
| 106 | AOAH | rs9268853 | C/T | T | - | Asthma | - | 27554816 | rs9268853 is an eQTL for AOAH gene which is significantly associated with asthma risk. |
|---|
| 107 | ACO2 | rs960596 | C/T | C | - | Asthma | - | 27554816 | rs960596 is an eQTL for ACO2 gene which is significantly associated with asthma risk. |
|---|
| 108 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Childhood Bronchial Asthma | Egyptian population | 29658513 | Polymorphism of ADRB2 (Arg16Gly) (rs1042713) correlates with asthma severity and response to treatment in asthmatic children. The presence or absence of Gly16 or Glu27 either homozygous or heterozygous for both correlated with the grade of asthma severity. The presence of heterozygous Arg-Gly gives a better response to drug therapy than the presence of Gly-Gly genotype at codon 16. |
|---|
| 109 | ADRB2 | rs1042714 | G/C | G | Coding region | Childhood Bronchial Asthma | Egyptian population | 29658513 | Polymorphism of ADRB2 (Gln27Gly) (rs1042714) correlates with asthma severity and response to treatment in asthmatic children. The presence or absence of Gly16 or Glu27 either homozygous or heterozygous for both correlated with the grade of asthma severity. The presence of heterozygous Gln-Glu gives a better response to drug therapy than the presence of Glu-Glu genotype at codon 27. |
|---|
| 110 | ATF6B | rs2228628 | C/G (REV) | C | Synonymous Variant | Asthma | Korean population | 24587951 | rs2228628 was significantly associated with % decline of FEV1 by aspirin provocation in asthmatics. |
|---|
| 111 | ATF6B | rs8111 | A/G (REV) | G | 3 Prime UTR Variant | Asthma | Korean population | 24587951 | rs8111 was significantly associated with % decline of FEV1 by aspirin provocation in asthmatics. |
|---|
| 112 | ADM | rs4399321 | A/G/T | A | Non Coding Transcript Variant | Atopic Dermatitis | European population | 22445417 | In silico analysis of genome wide single nucleotide polymorphism data revealed evidence of an association between Atopic Dermatitis and rs4399321 near ADM. |
|---|
| 113 | ADAM33 | rs2787094 | C/G | C | Non Coding Transcript Variant | Asthma | Jordanian population | 25313536 | An association between V4 (rs2787094) SNP and the incidence of childhood asthma was noted. |
|---|
| 114 | ADAM33 | rs528557 | A/C/G | C | Synonymous Variant | Asthma | Jordanian population | 25313536 | An association between S2 SNP and the incidence of adult asthma was observed. |
|---|
| 115 | ADAM33 | rs511898 | C/T | T | Intron Variant | Asthma | Jordanian population | 25313536 | An association between F+1 SNP and the incidence of adult asthma was observed. |
|---|
| 116 | ADAM33 | rs612709 | A/G | G | Intron Variant | Asthma | Jordanian population | 25313536 | An association between Q-1 SNPs and the incidence of adult asthma was observed. |
|---|
| 117 | ADAM33 | rs2787094 | C/G | C | Non Coding Transcript Variant | Asthma | Chinese population | 24944803 | The genetic variants at ADAM33 V4 (rs2787094) had the potential to modify the childhood asthma risk and the association showed no notable difference with the disease severity. |
|---|
| 118 | ALOX5AP | SG13S114 | A/T | - | Intron Variant | Asthma and Allergy | Caucasian population | 18547289 | An association between SNP SG13S114(ALOX5AP) and asthma and/or related phenotypes was observed. |
|---|
| 119 | ALOX5AP | SG13S89 | A/G | - | Intron Variant | Asthma and Allergy | Caucasian population | 18547289 | An association between SNP SG13S89(ALOX5AP) and asthma and/or related phenotypes was observed. |
|---|
| 120 | ALOX5AP | SG13S41 | A/G | - | Intron Variant | Asthma and Allergy | Caucasian population | 18547289 | An association between SNP SG13S41 (ALOX5AP) and asthma and/or related phenotypes was observed. |
|---|
| 121 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Childhood Asthma | Chinese Han population | 19862939 | ADRB2 R16G was significantly associated with childhood asthma. |
|---|
| 122 | ADRB2 | rs1042714 | G/C | G | Coding region | Asthma | Chinese Han population | 19862939 | ADRB2 Q27E makes little contribution to the development of asthma in children of Chinese Han nationality. |
|---|
| 123 | ADRB2 | rs1042713 | A/G | G | Missense Variant | Asthma | Chinese Han population | 24838642 | The ADRB2 R16G A/A genotype was associated with asthma in the Chinese Han children. |
|---|
