| Record no | GENE NAME | SNP ID | CHANGES | ANCESTRAL ALLELES | FUNCTIONAL CONSEQUENCES | DISEASE | POPULATION | Pubmed ID | Comments |
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| 1 | BMPR2 | rs17199249 | G/T | G | 3 Prime UTR Variant | Asthma | Spanish population | 26620591 | The minor allele (G allele) of rs17199249 is associated with risk for asthma both in the discovery and replication studies. |
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| 2 | B2AR | rs1042713 | A/G (Arg16Gly) | G | Missense Variant | Severe Asthma | - | 27050801 | Gly/Gly subjects have a borderline significantly higher morning peak expiratory flow rate (AM PEFR) when continued on ICS/LABA compared with ICS alone. Arg/Arg subjects with asthma being treated with ICS/LABA therapy showed no significant difference in AM PEFR compared with those in whom LABA is discontinued. |
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| 3 | BPIFA1 | rs750064 | A/G/T (REV) | G | 2KB Upstream Variant | Asthma | Non Hispanic White population | 30996135 | Less BPIFA1 in asthma patients with the CC allele may predispose them to greater eosinophilic inflammation. |
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| 4 | BDNF | rs6265 | A/G (REV) | G | Missense Variant | Asthma | Han Chinese population | 27176146 | There was an association between BDNF gene polymorphisms and asthmatic patients with depression regardless of gender. An association was noted between BDNF gene polymorphisms and female asthmatic patients with anxiety. The majority of patients with asthma had the A+ allele in the BDNF gene. |
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| 5 | BIRC3 | rs3460 | C/G | G | 3 Prime UTR Variant | Asthma | Caucasian population | 27304223 | The frequency of the minor allele for the BIRC3 SNP rs3460 was significantly lower in asthmatics compared to the control cases. The frequency of a haplotype tagged by rs3460 was reduced in the asthma sub group. |
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| 6 | BIRC3 | rs7928663 | C/T | T | Intron Variant | Asthma | Caucasian population | 27304223 | BIRC3 SNP rs7928663 was associated with a reduction in eosinophil and neutrophil abundance when assessed across the study population. The frequency of a haplotype tagged by rs7928663 was reduced in the asthma sub group, while the presence of the major allele for rs7928663 associated with an increased load of circulating eosinophils and neutrophils. |
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| 7 | BIRC3 | rs7127583 | C/T | C | Intron Variant | Asthma | Caucasian population | 27304223 | BIRC3 SNP rs7127583 was associated with a reduction in eosinophil and neutrophil abundance when assessed across the study population. The frequency of a haplotype tagged by rs7127583 was reduced in the asthma sub group. |
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| 8 | BACE2 | rs9975388 | A/C | A | Intron Variant | Asthma | European population | 27334786 | Statistically significant association between the BACE2 rs9975388 SNP with allergic asthma was observed. |
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| 9 | BACE1 | rs551662 | A/G (REV) | A | Intron Variant | Asthma | European population | 27334786 | The interaction between BACE1*rs551662 and IL1RAP*rs997534 was associated with asthma. |
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| 10 | BACE1 | rs676134 | C/T | T | Intron Variant | Asthma | European population | 27334786 | The interaction between BACE1*rs676134 and IL1RAP*rs3773976 was associated with allergic asthma. |
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| 11 | BTNL2 | rs3806156 | A/G/T | G | Intron Variant | Asthma | - | 27554816 | rs3806156 is an eQTL for HLA-DRB1 gene which is significantly associated with asthma risk. |
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