Browse Result

Total number of records for in I of in DAAB (Version-2) database: 287

Record no	GENE NAME	SNP ID	CHANGES	ANCESTRAL ALLELES	FUNCTIONAL CONSEQUENCES	DISEASE	POPULATION	Pubmed ID	Comments
1	IL13	rs1881457	A/C	A	5' Upstream variant	Asthma	-	27050946	rs1881457 in IL13 was correlated with the expression levels of IL13 and the expression levels of IL13 was correlated with asthma in BAL and thus, IL13 is more likely to be the functional asthma gene in the region.
2	IL13	rs20541	C/T	C	Coding region	Asthma	-	27050946	rs20541 is associated with asthma.
3	IL17A	rs2275913	A/G	A	2KB Upstream Variant	Asthma	Asians	30393475	The G allele of rs2275913 in IL-17A was significantly associated with a reduced risk of asthma in children and Asians. The G allele of rs2275913 in IL-17A is a protective factor for the development of asthma.
4	IL6R	rs2228145	A/C/T	A	Missense Variant	Asthma	UK Biobank population	28334838	An increased risk of atopic asthma compared to non-atopic asthma per copy of the minor allele of rs2228145. There was a positive association between the Asp358Ala variant and atopic asthma. Enhanced shedding of sIL-6R from neutrophils of Asp358Ala homozygotes and an increase in the MCP1 release from lung endothelial cells provides evidence of a mechanism through which IL-6 trans-signaling may contribute to disease severity in severe, neutrophil-driven, asthma phenotypes.
5	IL33	rs928413	A/C/G	A	2KB Upstream Variant	Asthma	-	30257479	The Risk G Allele of the Single-Nucleotide Polymorphism rs928413 Creates a CREB1-Binding Site That Activates IL33 Promoter in Lung Epithelial Cells. This mechanism may explain the negative effect of the rs928413 minor “G” allele on asthma development.
6	IL33	rs928413	A/C/G	A	2KB Upstream Variant	Asthma	French Canadian population	30468398	Carriers of a mutative allele in a haplotype within the promoter of IL33 had a lower IL33 DNA-methylation level. This haplotype (formed by chr9:6210100, rs928413 and rs7848215 variants) may interact with DNA-methylation at the promoter of IL33 and together modulate the asthma risk.
7	IL33	rs7848215	A/C/G/T	T	2KB Upstream Variant	Asthma	French Canadian population	30468398	Carriers of a mutative allele in a haplotype within the promoter of IL33 had a lower IL33 DNA-methylation level. This haplotype (formed by chr9:6210100, rs928413 and rs7848215 variants) may interact with DNA-methylation at the promoter of IL33 and together modulate the asthma risk.
8	IL33	chr9:6210100	-	-	Promoter Region	Asthma	French Canadian population	30468398	Carriers of a mutative allele in a haplotype within the promoter of IL33 had a lower IL33 DNA-methylation level. This haplotype (formed by chr9:6210100, rs928413 and rs7848215 variants) may interact with DNA-methylation at the promoter of IL33 and together modulate the asthma risk.
9	IL1RL1	rs10197862	A/G	A	Intron Variant	Childhood Asthma	Non-Hispanic white (NHW) population, African American (AA) population	30373671	The variant (rs10197862) showed association with childhood asthma in NHWs and AAs.
10	IL13	rs1295686	A/G/T	A	Intron Variant	Childhood Asthma	Non-Hispanic white (NHW) population, African American (AA) population	30373671	The variant (rs1295686) showed association with childhood asthma in NHWs and AAs.
11	IL1RL1	rs4988958	C/T	T	Synonymous Variant	Childhood Asthma	Non-Hispanic white (NHW) population, African American (AA) population	30373671	The variant (rs4988958) showed association with childhood asthma in NHWs and AAs.
12	IL13	rs20541	G/A	G	Missense Variant	Asthma	Saudi Arabian population	29211635	IL13 minor A allele for rs20541 was associated with significantly higher risk of asthma in the Saudi Arabian population.
13	IL13	rs1295686	A/G/T	A	Intron variant	Asthma	Saudi Arabian population	29211635	IL13 minor T allele for rs1295686 was associated with significantly higher risk of asthma in the Saudi Arabian population.
14	IL17A	rs8193036	C/T	T	2KB Upstream Variant	Childhood Asthma	-	27974119	Polymorphisms at position -692C/T in IL-17A gene promoter is associated with the susceptibility to childhood asthma. Asthma group had significantly higher frequencies of TT genotype. Children with -692T allele are more susceptible to childhood asthma.
15	IL10	rs1800896	A/G	A	2KB Upstream Variant	Pediatric Asthma	Asian population, Non Asian population	27323141	IL10 -1082G/A polymorphism might be a risk factor for asthma in children. A significant association between this polymorphism in Asian populations and pediatric asthma in a dominant model and non-Asian populations and pediatric asthma in a recessive model. -1082G/A polymorphism was significantly associated with non-atopic asthma in children in the additive and allelic models and with atopic asthma in children in the recessive model.
16	IL13	rs20541	C/T	C	Coding region	Childhood Asthma	Chinese Han population	26613553	Individuals homozygous for the risk alleles (GG) for rs20541 are at a higher risk for developing asthma compared with those without any risk homozygotes. IL13 rs20541 (G allele), IL4 rs2243250 (T allele), ADRB2 rs1042713 (A allele), and FCER1B rs569108 (G allele), four SNPs with significant sole effect on asthma, interact to confer a higher risk for the disease in Chinese Han children.
17	IL4	rs2243250	C/T	C	2KB Upstream Variant	Childhood Asthma	Chinese Han population	26613553	Individuals homozygous for the risk alleles (TT) for rs2243250 are at a higher risk for developing asthma compared with those without any risk homozygotes. IL13 rs20541 (G allele), IL4 rs2243250 (T allele), ADRB2 rs1042713 (A allele), and FCER1B rs569108 (G allele), four SNPs with significant sole effect on asthma, interact to confer a higher risk for the disease in Chinese Han children.
18	IL13	rs1295686	A/G/T	A	Intron Variant	Asthma	Chinese population	26534891	IL13 rs1295686 was associated with all asthma and early-onset asthma in adults. Moreover, SLC22A5, IL13, SMAD3, and GSDMB interact to modulate spirometric indices.
19	IL13	rs20541	C/T	C	Coding region	Pediatric Asthma	Polish population	26426602	Significant correlation was found between rs20541 in IL13 gene and the positive skin prick test results.
20	IL4R	rs1805011	A/C/G/T	A	Missense Variant	Pediatric Asthma, Atopic Dermatitis	Polish population	26426602	rs1805011 polymorphism of IL4Rα gene seems to influence allergy risk, especially mild asthma and atopic dermatitis predisposition in Polish children.
21	IL4	rs2227284	A/C/G	A	Intron Variant	Pediatric Asthma	Polish population	26426602	rs2227284 was associated with total IgE levels.
22	IL4	rs2243250	C/T	C	2KB Upstream Variant	Pediatric Asthma, Clinical Atopy	Polish population	26426602	rs2243250 polymorphism was associated with clinical atopy.
23	IL17A	rs2275913	A/G	A	2KB Upstream Variant	Allergic Asthma	Finnish population	28647382	The variant genotype of IL17A rs2275913 polymorphism GA or AA was a significant protective factor for asthma in school children from the age 7 to 13 years.
24	IL1R1	rs949963	A/G	G	Intron Variant	Childhood Asthma	Chinese population	26975823	The GG genotype and alleles of IL1R1 SNP rs949963 is associated with the susceptibility to asthma in children from Central China and may increase the serum expression of IL1R1.
25	IL17A	rs8193036	C/T	T	2KB Upstream Variant	Asthma	Asian population	27007832	The IL17A -737C/T polymorphism was found to have a significantly protective effect on asthma in the allele model, dominant model and heterozygous model in the overall analysis. Stratified by ethnicity and age, the effects were also significant in the Asian population and in children.
26	IL1RL1	rs3771180	A/C/T	C	Intron Variant	Childhood Asthma, Hay fever	Swedish population	26786172	rs3771180 in IL1RL1 is associated with childhood asthma and hay fever.
27	IKZF3	rs9303277	C/T	T	Intron Variant	Asthma	American Indian population	28668238	One SNP at 17q21 (rs9303277) was associated with case control status considering the major allele in a dominant model. This SNP was associated with asthma.
28	IL5RA	rs71058675	-/T	T	-	Childhood Asthma	Puerto Rican children	28574721	rs71058675 in IL5RA was associated with asthma, intermediate phenotypes, gene expression and cytokine levels.
29	IL5RA	rs1153462	A/G/T	G	-	Childhood Asthma	Puerto Rican children	28574721	rs1153462 in IL5RA was associated with asthma and intermediate phenotypes.
30	IL5RA	rs6773701	A/C	A	2KB Upstream Variant	Childhood Asthma	Puerto Rican children	28574721	IL5RA SNP rs6773701 was associated with eosinophil counts.
31	IL4R	rs1801275	A/G	G	Missense Variant	Asthma	-	28943468	High endotoxin exposure in the presence of the Q/Q genotype for IL4R Q576R was associated with a protective effect against asthma symptoms. IL4R Q versus R variants influence the outcome of endotoxin exposure on asthma.
32	IL8	rs4073	A/T	A	2KB Upstream Variant	Childhood Asthma	Tunisian population	28993876	rs4073 was significantly associated with an increased risk of asthma. The rs4073 T allele was a risk factor for asthma development. The rs4073 T allele is represented as a risk factor for asthma severity in Tunisian children.
33	IL8	rs2227306	C/T	C	Intron Variant	Childhood Asthma	Tunisian population	28993876	rs2227306 was significantly associated with an increased risk of asthma. The rs2227306 C allele was a risk factor for asthma development.
34	IL6	rs1800797	A/G	G	Intron Variant	Asthma	Finnish population	28987812	The GG genotype of rs1800797 is associated with increased risk of asthma among those who had some tobacco smoke exposure. This GG genotype may increase susceptibility to the adverse effects of smoking on the risk of asthma.
35	IL6	rs1800795	C/G	G	Intron Variant	Asthma	Finnish population	28987812	The GG genotype of rs1800795 is associated with increased risk of asthma among those who had some tobacco smoke exposure. This GG genotype may increase susceptibility to the adverse effects of smoking on the risk of asthma.
36	IFNG4	rs368234815	-	-	-	Asthma	Polish population	28874741	IFNG4 generating ΔG allele protected a subpopulation of asthmatic patients, specifically older women, from allergic sensitization.
37	IL1A	rs17561	C/A	C	Missense Variant	Paediatric Asthma	Brazilian population	29154202	Gain-of-function IL1A rs17561 resulted significantly associated with a reduced pulmonary capacity in asthmatic children.
38	IL18	rs5744256	G/A	A	Intron Variant	Paediatric Asthma	Brazilian population	29154202	IL18 rs5744256 which lead to lower serum level of IL-18 appeared to be associated to a worse response to bronchodilators.
39	IL1RL1	rs17026974	A/G	A	Intron Variant	Asthma	Japanese population	29153414	Patients with minor allele in rs17026974 had high FeNO, blood eosinophil differentials and reversibility of FEV1, but low levels of serum sST2 and FEV1. Minor allele of rs17026974 was associated with high blood eosinophil differentials and FeNO, respectively.
40	IL1RL1	rs1420101	T/C	T	Non Coding Transcript Variant	Asthma	Japanese population	29153414	Patients with minor allele in rs1420101 had high FeNO, blood eosinophil differentials and reversibility of FEV1, but low levels of serum sST2 and FEV1. The minor allele of rs1420101 additively contributed to the FeNO, blood eosinophil differentials and reversibility of FEV1.
41	IL1RL1	rs1921622	A/G	G	Intron Variant	Asthma	Japanese population	29153414	Patients with minor allele in rs1921622 had high FeNO, blood eosinophil differentials and reversibility of FEV1, but low levels of serum sST2 and FEV1. Minor allele of rs1921622 was associated with high blood eosinophil differentials and FeNO, respectively.
42	IL33	rs146597587	C/G	G	Splice Acceptor Variant	Asthma	Icelandic population	28273074	rs146597587-C is a loss of function mutation that reduces blood eosinophil counts and protects from Asthma.
43	IL33	rs12551256	A/G	A	Intron Variant	Asthma, Atopy	Brazilian population	28266165	The G allele of IL33 SNP rs12551256 was negatively associated with asthma.
44	IL1RL1	rs1041973	A/C	A	Missense Variant	Asthma, Atopy	Brazilian population	28266165	The A allele of IL1RL1 rs1041973 was positively associated with IL5 production, sIgE levels and positive SPT for Blomia tropicalis mite. The same allele, in atopic subjects, was associated with decreased production of soluble ST2 (sST2).
45	IL1RL1	rs873022	G/T	G	Intron Variant	Asthma, Atopy	Brazilian population	28266165	The T allele of rs873022 was associated with a lower production of sST2 in plasma of Brazilians
46	IL33	rs16924161	C/T	T	Intron Variant	Asthma, Atopy	Brazilian population	28266165	rs16924161 demonstrated a higher risk for SPT positivity against Blomia tropicalis.
47	IL13	rs20541	G/A	G	Missense Variant	Asthma	Asian population	29390465	The IL13 +2044G/A polymorphism is a risk factor for asthma, especially among Asians.
48	IL13	rs1295686	C/T	T	Intron Variant	Asthma	Asian population	29390465	The IL13 +1923C/T polymorphism is a risk factor for asthma, especially among Asians.
49	IRAKM	rs1624395	A/G	G	Intron Variant	Adult onset Asthma	Chinese Han population	30617222	rs1624395 was significantly associated with adult-onset asthma. rs1624395 influenced the mRNA expression of the IRAK-M transcript variant 1 in peripheral monocytes from asthma patients.
50	IRAKM	rs1370128	A/C/T	T	Intron Variant	Adult onset Asthma	Chinese Han population	30617222	rs1370128 was significantly associated with adult-onset asthma.
51	IL1B	rs1143634	C/T (REV)	C	Synonymous Variant	Pediatric Asthma	Polish population (Caucasian origin)	29034996	IL1B polymorphisms rs1143634 was associated with allergic asthma risk.
52	IL1B	rs1143633	A/C/G (REV)	G	Intron Variant	Pediatric Asthma	Polish population (Caucasian origin)	29034996	IL1B polymorphisms rs1143633 was associated with allergic asthma risk.
53	IL1B	rs1143643	A/G (REV)	G	Intron Variant	Pediatric Asthma	Polish population (Caucasian origin)	29034996	IL1B polymorphisms rs1143643 was associated with allergic asthma risk.
54	IL33	rs1342326	G/T (REV)	T	-	Childhood Asthma	Tunisian population	28985997	The CC and AC genotypes as well as the C allele were associated significantly with a decreased asthma risk. The C allele was more frequent in severe asthma patients than in milder ones. Increased serum IL33 was associated with the presence of rs1342326 C allele. The IL33 rs1342326 polymorphism was associated with a lower childhood asthma risk in the Tunisian population and a higher IL33 protein expression.
55	IL1RL1	rs10208293	A/G	A	Intron Variant	Asthma	European Ancestry	27130862	rs10208293 in 2q12 loci was found to be associated with time to asthma onse (TAO) at genome-wide significance levels.
56	IL33	rs928413	A/C/G	A	2KB Upstream Variant	Asthma	European Ancestry	27130862	rs928413 in 9p24 loci was found to be associated with time to asthma onse (TAO) at genome-wide significance levels.
57	IL4R	rs1805013	C/T	C	Missense Variant	Asthma	European Ancestry	27130862	rs1805013 in 16p12-p11 loci was associated with time to asthma onse (TAO) at suggestive significance levels.
58	IL33	rs413382	A/C	C	-	Asthma	European Ancestry	27130862	Secondary signals were associated with time to asthma onset (TAO) after stepwise conditional analysis in rs413382 in 9p24 region.
59	IRF1	rs10035166	A/C/T	T	Intron Variant	Childhood Allergic Asthma		29047170	Carrying the risk allele of IRF1 in rs10035166 was associated with increased risk for Allergic Asthma. NOD2 expression was decreased in Atopic Asthmatics with risk alleles in rs10035166 and with risk-haplotype.
60	IRF1	rs2706384	G/T	G	2KB Upstream Variant	Childhood Allergic Asthma		29047170	Carrying the risk allele of IRF1 in rs2706384 was associated with increased risk for Allergic Asthma. NOD2 expression was decreased in Atopic Asthmatics with risk alleles in rs2706384 and with risk-haplotype.
61	IRF1	rs2070721	A/C (REV)	C	Intron Variant	Childhood Allergic Asthma		29047170	Carrying the risk allele of IRF1 in rs2070721 was associated with increased risk for Allergic Asthma.
62	IRF1	rs17622656	A/G/T	G	Intron Variant	Childhood Allergic Asthma		29047170	Carrying the non risk allele in rs17622656 was associated with lower risk for allergic asthma, but not non allergic asthma.
63	IL1R1	rs3732131	C/T (REV)	T	3 Prime UTR Variant	Asthma	European population	27334786	The IL1R1 rs3732131 SNP was associated with asthma in both studies with a significant association after statistical correction in the EGEA study.
64	IL1R1	rs10208708	C/G/T	G	Intron Variant	Atopy	European population	27334786	The interaction between IL1R1rs10208708 and IL1RAPrs2241343 was associated with atopy.
65	IL1RAP	rs2241343	C/G/T	G	Intron Variant	Atopy	European population	27334786	The interaction between IL1R1rs10208708 and IL1RAPrs2241343 was associated with atopy.
66	IL1RAP	rs997534	A/G (REV)	A	Intron Variant	Asthma	European population	27334786	The interaction between BACE1rs551662 and IL1RAPrs997534 was associated with asthma.
67	IL1RAP	rs3773976	A/C/T (REV)	A	Intron Variant	Asthma	European population	27334786	The interaction between BACE1rs676134 and IL1RAPrs3773976 was associated with allergic asthma.
68	IL33	rs2381413	C/G/T	C	-	Asthma	African American population	27177148	rs2381413 located upstream of IL33 was significantly associated with asthma.
69	IL33	rs7037276	C/G/T	T	Intron Variant	Moderate-To-Severe Asthma Exacerbations (In Children)	Caucasian population	30644648	rs7037276 in IL33 was significantly associated with decreased odds of Emergency department management failure in case of moderate to severe ssthma exacerbations in children.
70	IL33	rs1342326	G/T (REV)	T	-	Moderate-To-Severe Asthma Exacerbations (In Children)	Caucasian population	30644648	rs1342326 in IL33 was significantly associated with decreased odds of Emergency department management failure in case of moderate to severe ssthma exacerbations in children.
71	IL17A	rs3748067	A/G (REV)	G	3 Prime UTR Variant	Asthma	Chinese Han population	30036556	The frequencies of A allele, GA and (GA + AA) genotype of rs3748067 were significantly higher in asthma patients. The level of serum total IgE in mutant group (GA + AA) of rs3748067 was significantly higher than the wild genotype (GG) group and control group.
72	IL17F	rs763780	C/T	T	Missense Variant	Asthma	Chinese Han population	30036556	As for rs763780, the C allele in patients was more frequent than healthy controls. C carriers (CT + CC) were significantly higher in asthma patients.
73	IL6	rs1800795	C/G	G	Intron Variant	Occupational Bronchial Asthma	-	30351648	Polymorphism of C174G gene of interleukin-6 (IL6) are associated with higher activity of inflammation and therefore with increased risk of occupational bronchial asthma associated with metabolic syndrome and diabetess mellitus 2 type.
74	IL4R	rs1801275	A/G	G	Missense Variant	Asthma, Rhino Conjunctivitis	Sicilian children	30646946	Current Asthma was modestly associated with rs1801275.
75	IL17	rs7741835	C/T	T	-	Asthma, Rhino Conjunctivitis	Sicilian children	30646946	Rhino Conjunctivitis was modestly associated with rs7741835. rs7741835 showed high frequencies of heterozygote genotypes in Rhino Conjunctivitis patients as compared with control subjects, which are frequently homozygous.
76	IL13	rs20541	C/T (REV)	C	Missense Variant	Bronchial Asthma	Japanese population	26765219	IL13 AA of rs20541 is a potential genomic biomarkers for predicting lower pulmonary function. The administration of high-dose ICSs to asthmatic patients with genetic variants of IL13 AA may inhibit the advancement of airway remodelling.
77	IL6R	rs2228145	A/C/T	A	Missense Variant	Asthma	Chinese population	26997259	rs2228145 C is associated with poor lung function in patients with asthma. The rs2228145 A-C variant is associated with levels of sIL-6R and IgE.
78	IL6R	rs12083537	A/G	G	Intron Variant	Asthma	Chinese population	26997259	rs12083537 G is associated with poor lung function in patients with asthma.
79	IL10	rs1800871	C/T (REV)	C	2KB Upstream Variant	Allergy	Finnish population, European population	27228545	IL10 polymorphism at rs1800871 seem to be associated with elevated allergies and/or recurrent wheezing risk in later childhood, after early-life bronchiolitis.
80	IL10	rs1800872	A/C (REV)	C	2KB Upstream Variant	Allergy	Finnish population, European population	27228545	IL10 polymorphism at rs1800872 seem to be associated with elevated allergies and/or recurrent wheezing risk in later childhood, after early-life bronchiolitis.
81	IL10	rs1800890	A/T (REV)	T	Intron Variant	Allergy	Finnish population, European population	27228545	IL10 polymorphism at rs1800890 seem to be associated with elevated allergies and/or recurrent wheezing risk in later childhood, after early-life bronchiolitis.
82	IL10	rs1800896	A/G (REV)	A	2KB Upstream Variant	Allergy	Finnish population, European population	27228545	IL10 polymorphism at rs1800896 seem to be associated with elevated allergies and/or recurrent wheezing risk in later childhood, after early-life bronchiolitis.
83	IL6	rs1800795	C/G	G	Intron Variant	Childhood Bronchial Asthma	Spanish population	28185773	A significant association was noted between IL6 polymorphism at -174G/C (rs1800795) and bronchial asthma. Higher associations between polymorphism at IL-6 -174G/C and bronchial asthma were observed in atopic patients.
84	IL1RAPL1	rs12007907	A/C	A	Intron Variant	Childhood Asthma	Latin American population	28120837	The rs12007907 variant in IL1RAPL gene was negatively associated with asthma and IL13 production.
85	IL4R	rs3024608	C/G	C	Intron Variant	Asthma	Chinese population	28123702	The SNP of rs3024608 is associated with asthma and the positive palm pattern.
86	IL4R	rs1805012	C/T	T	Missense Variant	Asthma	Chinese population	28123702	rs1805012 was associated with asthma.
87	IL4R	rs1805010	A/C/G/T	G	Missense Variant	Allergy (Positive Palm Pattern)	Chinese population	28123702	rs1805010 was associated with the positive palm pattern
88	IL13	rs20541	C/T (REV)	C	Missense Variant	Asthma (with Allergic Rhinitis, Allergic Conjunctivitis)	Finnish population	28273659	Adult Allergic Rhinitis/Allergic Conjunctivitis asthma could putatively be a phenotype, characterized by the presence of atopic and/or eosinophilic factors and a high prevalence of the IL13 rs20541 A allele.
89	IL4	rs2243250	C/T	C	2KB Upstream Variant	Asthma	Iraqi population	28386156	The increasing risk of asthma was associated with C allele and the CC genotype of IL4 -590C>T.
90	IL12A	rs568408	A/G	G	3 Prime UTR Variant	Asthma	Taiwanese population	28600552	IL12A rs568408 may contribute to the etiology and symptoms severity of asthma, indicating its usefulness as a predictive and diagnostic biomarker of asthma.
91	IL7	rs766736182	C/T	-	Missense Variant	Childhood Asthma	Chinese Han population	30239047	SNP rs766736182 of interleukin-7 is the risk factor for children asthma.
92	IL13	rs20541	C/T	C	Coding region	Asthma	Portuguese population	27561723	IL13 rs20541 GG genotype was associated with less susceptibility to asthma.
93	IL17A	rs2275913	A/G	A	2KB Upstream Variant	Asthma, Allergic Rhinitis	Portuguese population	27561723	Among patients, IL17A rs2275913 AA genotype was less associated with asthma than with rhinitis.
94	IL4	rs2243250	C/T	C	2KB Upstream Variant	Childhood Asthma	Xinjiang Uighur population	27525870	The IL4 -590C>T polymorphism is related to bronchial asthma in Uighur children and the T allele may constitute a susceptibility factor in this group.
95	IL4R	rs1801275	A/G	G	Missense Variant	Childhood Asthma	Han Chinese population	27819719	The IL-4R rs1801275 (576 Q/R) polymorphism is associated with childhood asthma and the RR genotype confers a high risk of developing this condition.
96	IL13	rs20541	C/T	C	Coding region	Asthma, Atopy	Chinese Han population	29761786	IL13 rs20541 was associated with the Asthma Predictive Index (API) and atopy.
97	IL4	rs2243250	C/T	C	2KB Upstream Variant	Asthma, Atopy	Chinese Han population	29761786	IL4 rs2243250 was associated with the Asthma Predictive Index (API) and atopy.
98	IL6	rs1800797	A/G	G	Intron Variant	Asthma	Finnish population	26938664	IL6 SNP rs1800797 is associated with the risk of adult-onset asthma.
99	IL17	rs763780	C/T	T	Missense Variant	Asthma	Asian population	26954344	IL17 SNP rs763780 may be associated with asthma susceptibility in Asians.
100	IL17	rs2275913	A/G	A	2KB Upstream Variant	Asthma	Asian population	26954344	IL17 rs2275913 SNP may be associated with asthma susceptibility and GA genotype in rs2275913 may contribute to increased risk of asthma in Asians.
101	IL17	rs8193036	C/T	T	2KB Upstream Variant	Asthma	Asian population	26954344	IL17 rs8193036 SNP may be associated with asthma susceptibility and TT genotype in rs8193036 of IL17 may contribute to increased risk of asthma in Asians.
102	IL10	rs1800871	C/T (REV)	C	2KB Upstream Variant	Atopic Dermatitis	Caucasian population	30932690	The IL-10-819G/A polymorphism seems to be associated with increased risk of Atopic Dermatitis among Caucasian populations.
103	IL10	rs1800896	A/G	A	2KB Upstream Variant	Atopic Dermatitis	Asian population	30932690	The IL10-1082G/A polymorphism (rs1800896) seems to be correlated with Atopic Dermatitis among Asian populations.
104	IL4	rs2243250	C/T	C	2KB Upstream Variant	Childhood Bronchial Asthma	Uygur population	30680016	The IL4 -590C/T (rs2243250) gene polymorphism is associated with the asthma susceptibility and increased serum total IgE in Uygur children in Xinjiang. T allele frequency of C-590T gene in IL4 in the asthma group was significantly higher than those in the control group.
105	IL13	rs20541	C/T	C	Coding region	Childhood Bronchial Asthma	Uygur population	30680016	IL13 Arg130Gln (rs20541) gene polymorphisms is associated with the asthma susceptibility and increased serum total IgE in Uygur children in Xinjiang. The A/A genotype frequency and A allele frequency of Arg130Gln locus in IL13 in the asthma group were obviously higher than those in the control group.
106	IL13	rs848	G/T (REV)	T	3 Prime UTR Variant	Asthma	Italian population	26986948	rs848 in the IL13 gene region is significantly associated with a continuous measure of symptom severity in adult subjects with ever asthma.
107	IL1RL1	rs1420101	A/G (REV)	A	Non Coding Transcript Variant	Asthma	-	27699235	rs1420101 marks eQTL in airway epithelial cells. This risk variant defines a population of asthmatics at risk of IL33 driven type 2 inflammation.
108	IL1RL1	rs11685480	A/G	G	2KB Upstream Variant	Asthma	-	27699235	rs11685480 marks eQTL in distal lung parenchyma. This risk variant defines a population of asthmatics at risk of IL33 driven type 2 inflammation.
109	IL13	-	A/G	-	-	Asthma	Indian population	28083766	IL13 cytokine serum levels were significantly high in atopic and non-atopic asthma patients compared to healthy controls. The GG genotype of IL13 130A/G cytokine gene might be involved in the induced production of total IgE and IL13 cytokine serum levels suggesting IL13 may be important in the signalling of asthma.
110	IL13	rs1295686	A/G/T	A	Intron variant	Asthma	Asian population, Caucasian population	28057889	IL13 +1923C/T (rs1295686) polymorphism was a risk factor for asthma susceptibility, especially in Asians and Caucasians.
111	IL4	rs2227284	A/C/G (REV)	A	Intron Variant	Childhood Allergic Rhinitis	Chinese Han population	30170133	The rs2227284-TG genotype at the IL4 locus was significantly associated with a 0.65-fold decreased risk of Allergic Rhinitis (AR) compared to the TT genotype. The protective effect of the rs2227284-G allele was also found in different severity of AR. A protective effect on Childhood Allergic Rhinitis was associated with the haplotype C-G-C (rs2243250-rs2227284-rs2243290).
112	IL4	rs2243250	C/T	C	2KB Upstream Variant	Childhood Allergic Rhinitis	Chinese Han population	30170133	A protective effect on Childhood Allergic Rhinitis was associated with the haplotype C-G-C (rs2243250-rs2227284-rs2243290).
113	IL4	rs2243290	A/C	C	Intron Variant	Childhood Allergic Rhinitis	Chinese Han population	30170133	A protective effect on Childhood Allergic Rhinitis was associated with the haplotype C-G-C (rs2243250-rs2227284-rs2243290).
114	IL12B	rs3212227	A/C (REV)	A	3 Prime UTR Variant	Bronchial Asthma	East Asian population	28287286	IL12B -1188 C allele may be a protective factor against asthma in East Asian. Promoter MM genotype may be a risk factor for asthma in East Asian and allergic people.
115	IL4RA	rs8832	A/G	A	3 Prime UTR Variant	Asthma	-	28326636	GG genotype of IL4RA rs8832 was associated with type-2 endotype. GG genotype of IL4RA rs8832 may serve as risk marker of asthma exacerbations in type-2 inflammatory endotype.
116	IKZF3	rs907092	A/G	G	Synonymous Variant	Asthma	Puerto Rican population	28461288	rs907092 on IKZF3 showed the most significant association with asthma.
117	IL1RL1	rs10173081	C/T	T	Intron Variant	Asthma	Puerto Rican population	28461288	rs10173081 was found to be associated with asthma.
118	IL33	rs2381416	A/C	A	-	Asthma	Dutch population	27439200	The risk allele C of rs2381416 was significantly associated with asthma.
119	IL33	rs1342326	G/T (REV)	T	-	Asthma	Dutch population	27439200	The risk allele C of rs1342326 was significantly associated with asthma.
120	IL2RB	rs2284033	A/G	G	Intron Variant	Asthma	Dutch population	27439200	The risk allele G of rs2284033 was significantly associated with asthma.
121	IKZF3	rs9303277	C/T	T	Intron Variant	Asthma	Dutch population	27439200	rs9303277 was significantly associated with asthma.
122	IL1RL1	rs1420101	A/G (REV)	A	Non Coding Transcript Variant	Asthma Remission	-	29786918	rs1420101 was associated with complete remission of asthma. rs1420101 was associated with IL1RL1 and IL18R1 expression. rs1420101 was a trans eQTL for IL13 expression.
123	IL1RL1	rs72823641	A/C/T	T	Intron Variant	Asthma, Allergic Diseases	European population	29785011	rs72823641 was associated with asthma and allergic diseases.
124	IL7R	rs6881270	C/T	C	Non Coding Transcript Variant	Asthma, Allergic Diseases	European population	29785011	rs6881270 was associated with asthma and allergic diseases.
125	IKZF4	rs10876864	A/G	G	2KB Upstream Variant	Asthma, Allergic Diseases	European population	29785011	rs10876864 was associated with asthma and allergic diseases.
126	IL2RA	rs61839660	C/T	C	Intron Variant	Asthma, Allergic Diseases	European population	29785011	rs61839660 was associated with asthma and allergic diseases.
127	ITGB8	rs6461503	C/G/T	C	-	Asthma, Allergic Diseases	European population	29785011	rs6461503 was associated with asthma and allergic diseases.
128	IVL, LCE1A, LCE1B, LCE1C, LCE1D, LCE6A, SMCP, SPRR1A, SPRR1B, SPRR2A, SPRR2B, SPRR2D, SPRR2E, SPRR2F	rs61815704	C/G	C	-	Asthma, Allergic Diseases	European population	29785011	rs61815704 was associated with asthma and allergic diseases.
129	IL13	rs20541	C/T	C	Coding region	Allergic Bronchopulmonary Aspergillosis (ABPA)	Caucasian population	27708669	Compared to atopic asthmatics, ABPA patients were more likely to be carriers of the rare A allele of the exonic missense mutation in IL13 (rs20541).
130	IL4R	rs3024656	A/G	G	Intron Variant	Allergic Bronchopulmonary Aspergillosis (ABPA)	Caucasian population	27708669	Compared to atopic asthmatics, ABPA patients were more likely to be carriers of the common G allele and common GG genotype of the intronic SNP in IL4R (rs3024656).
131	IL4R	rs1029489	C/T (REV)	T	500B Downstream Variant	Allergic Bronchopulmonary Aspergillosis (ABPA)	Caucasian population	27708669	rs1029489 was associated with ABPA on the ABPA versus Atopic asthma model and on the ABPA versus Healthy model.
132	IL13	rs1800925	C/G/T	T	Intron Variant	Allergic Bronchopulmonary Aspergillosis (ABPA)	Caucasian population	27708669	rs1800925 was associated with ABPA on the ABPA versus Atopic asthma model and on the ABPA versus Healthy model.
133	IKZF3	rs2952140	A/G (REV)	G	Intron Variant	Asthma	-	27554816	rs2952140 is an eQTL for GSDMB and ORMDL3 gene which are significantly associated with asthma risk.
134	IKZF3	rs9916765	A/C/G/T	T	Intron Variant	Asthma	-	27554816	rs9916765 is an eQTL for ZPBP2 gene which is significantly associated with asthma risk.
135	IL1RL1	rs6751967	C/T	A	Intron Variant	Asthma	-	27554816	rs6751967 is an eQTL for IL18R1 gene which is significantly associated with asthma risk.
136	IL1RL2	rs9646944	C/G	G	-	Asthma	-	27554816	rs9646944 is an eQTL for IL1RL2 gene which is significantly associated with asthma risk.
137	IGSF10	rs9877416	A/G	G	Intron Variant	Asthma	-	27554816	rs9877416 is an eQTL for P2RY13 gene which is significantly associated with asthma risk.
138	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	Egyptian population	21624746	A significant association was observed between the IL10 polymorphism (-1082G/A) and asthma in both atopic and non-atopic asthma groups.
139	IL2RA	rs41295115	C/T	T	-	Asthma with Hay Fever	European population, American population, Australian population	24388013	This single nucleotide polymorphism showed suggestive evidence for association with asthma with hay fever risk.
140	IL1RL1	rs10197862	A/G	A	Intron Variant	Asthma with Hay Fever	European population, American population, Australian population	24388013	The rs10197862:A allele was associated with increased asthma with hay fever risk.
141	IL33	rs72699186	A/T	A	-	Asthma with Hay Fever	European population, American population, Australian population	24388013	The rs72699186:T allele was associated with increased asthma with hay fever risk.
142	IL33	rs343496	A/T	A	-	Asthma with Hay Fever	European population, American population, Australian population	24388013	rs343496 was associated with asthma with hay fever risk at a suggestive significance level.
143	IKZF3	rs12450323	G/T	G	Intron Variant	Asthma with Hay Fever	European population, American population, Australian population	24388013	rs12450323 was associated with asthma with hay fever risk at a suggestive significance level.
144	IL17A	rs8193036	C/T	T	2KB Upstream Variant	Allergic Rhinitis	Han Chinese population	26196693	rs8193036 in IL17A was significantly associated with Allergic Rhinitis.
145	IL12	rs2569254	C/T	C	Intron Variant	Allergic Rhinitis	Han Chinese population	26196693	rs2569254 in IL12 was significantly associated with Allergic Rhinitis.
146	IL2	rs77468365	C/G	G	Intron Variant	Allergic Rhinitis	Chinese population	26791767	rs77468365 showed significant correlation with the efficacy of allergic rhinitis specific immune therapy.
147	IL6	rs1800795	C/G	G	Intron Variant	Allergic Rhinitis	Iranian population	24974143	Patients homozygous for the G allele of rs1800795 in IL6 had a 3.35 fold risk of having Allergic Rhinitis than those with the C allele.
148	IL6	rs1800797	A/G	G	Intron Variant	Allergic Rhinitis	Iranian population	24974143	AA genotype in rs1800797 of IL6 was associated with the increased risk of developing Allergic Rhinitis.
149	IL6	rs1800795	C/G	G	Intron Variant	Allergic Rhinitis	Chinese population	26909898	IL6 rs1800795 polymorphism was associated with an increased risk of allergic rhinitis.
150	IL6	rs1800795	C/G	G	Intron Variant	Asthma	-	26550171	IL6 -174 CC genotype may be a protective factor against asthma in Caucasian and adults.
151	IL10	rs1800896	A/G	A	2KB Upstream Variant	Atopic Dermatitis	Saudi Arabian population	29887728	IL10 rs1800896 (−1082 G/A) polymorphism is associated with the susceptibility and can be a risk factor for Atopic Dermatitis.
152	IL10	rs1800872	A/C (REV)	C	2KB Upstream Variant	Childhood Atopic Dermatitis	Korean population	17188628	Patients with Atopic Dermatitis had a significantly lower frequency of the combined homozygous CC genotype and heterozygous AC genotype group of IL10 rs1800872 (-592A>C) as compared with Non atopic eczema patients.
153	IL10	rs1800871	C/T (REV)	C	2KB Upstream Variant	Childhood Atopic Dermatitis	Korean population	17188628	Patients with Atopic Dermatitis and non atopic eczema had a significantly lower frequency of the combined homozygous TT genotype and heterozygous CT genotype group of IL-10 rs1800871 (-819T>C) as compared with controls.
154	IL10	rs1800896	A/G	A	2KB Upstream Variant	Atopic Dermatitis	Polish population	25624864	Atopic Dermatitis patients carrying G allele in rs1800896 (-1082 G/A) IL10 polymorphism are predisposed to higher serum concentration of IL10.
155	IL13	G4257A	G/A	-	-	Atopic Dermatitis	Japanese population	12413765	IL13 gene polymorphism G4257A is associated with susceptibility to atopic dermatitis in Japanese patients.
156	IL13	rs1800925	C/G/T	T	Intron Variant	Atopic Dermatitis	Polish population	23317483	There is a significant role of -1112 C/T IL13 gene polymorphism in the pathogenesis of Atopic Dermatitis.
157	IL13	rs20541	C/T	C	Coding region	Atopic Dermatitis	Korean population	24848505	The association between cesarean delivery and Atopic Dermatitis was significantly modified by parental history of allergic diseases or risk-associated IL13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL13 (rs20541) and delivery mode with respect to the subsequent risk of Atopic Dermatitis.
158	IL13	rs20541	C/T	C	Coding region	Atopic Dermatitis	White population, Asian population and others	12847555	The IL13 130Gln allele was associated with atopy and with atopic dermatitis. The IL13 Arg130Gln polymorphism and haplotypes consisting of IL13 Arg130Gln and IL4 C-589 T were associated with the development of atopy and atopic dermatitis.
159	IL4	rs2243250	C/T	C	2KB Upstream Variant	Atopic Dermatitis	White population, Asian population and others	12847555	The IL13 Arg130Gln polymorphism and haplotypes consisting of IL13 Arg130Gln and IL4 C-589 T were associated with the development of atopy and atopic dermatitis.
160	IL10	rs1800896	A/G	A	2KB Upstream Variant	Allergic Rhinitis	Iranian population	26316419	A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL10 gene were found with higher frequencies in allergic rhinitis patients than controls.
161	IL10	rs1800872	A/C (REV)	C	2KB Upstream Variant	Allergic Rhinitis	Iranian population	26316419	A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL10 gene were found with higher frequencies in allergic rhinitis patients than controls.
162	IL10	rs1800871	C/T (REV)	C	2KB Upstream Variant	Allergic Rhinitis	Iranian population	26316419	A/C/A, A/T/C and G/C/A haplotypes (rs1800896, rs1800871, rs1800872) in IL10 gene were found with higher frequencies in allergic rhinitis patients than controls. Patients with CC genotype in rs1800871 in IL10 had significantly lower levels of IgE.
163	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	Finnish population	31074014	IL10 rs1800896 gene polymorphism was associated with post-bronchiolitis asthma at 11-13 years of age in children hospitalised for bronchiolitis at less than six months of age.
164	IL13	rs20541	C/T	C	Coding region	Allergic Rhinitis	Iranian population	31832433	IL13 polymorphism (rs20541, Exo 4, G>A, Arg130Gln) and IL4 polymorphism (rs2243250= C-590T, promoter, T>C) are co-associated with Allergic Rhinitis and sensitivity to aeroallergens.
165	IL4	rs2243250	C/T	C	2KB Upstream Variant	Allergic Rhinitis	Iranian population	31832433	IL13 polymorphism (rs20541, Exo 4, G>A, Arg130Gln) and IL4 polymorphism (rs2243250= C-590T, promoter, T>C) are co-associated with Allergic Rhinitis and sensitivity to aeroallergens.
166	IL13	rs1881457	A/C	A	5' Upstream variant	Allergic Rhinitis, Asthma	Pakistani population	23996716	rs1881457 (A-1512C) polymorphism in IL13 is a risk factor for asthma and Allergic rhinitis.
167	IL13	rs20541	C/T	C	Coding region	Allergic Rhinitis	Malaysian population	22852128	Polymorphic variant of IL13 R130Q appears to be associated with increased risk for development of allergic rhinitis in a hospital-based Malaysian population.
168	IL13	rs20541	C/T	C	Coding region	Allergic Rhinitis	Korean population	17091279	The IL13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans.
169	IFITM2	rs3809112	C/T	T	2KB Upstream Variant	Atopic Dermatitis	European population	22445417	In silico analysis of genome wide single nucleotide polymorphism data revealed evidence of an association between Atopic Dermatitis and rs3809112 near IFITM2.
170	IFITM2	rs741738	A/G	G	500B Downstream Variant	Atopic Dermatitis	European population	22445417	In silico analysis of genome wide single nucleotide polymorphism data revealed evidence of an association between Atopic Dermatitis and rs741738 near IFITM2.
171	IFITM3	rs7395116	C/G/T (REV)	C	-	Atopic Dermatitis	European population	22445417	In silico analysis of genome wide single nucleotide polymorphism data revealed evidence of an association between Atopic Dermatitis and rs7395116 near IFITM3.
172	IL13	G4257A	G/A	-	-	Atopic Dermatitis	German population	10887320	An IL13 coding region variant (G4257A) is associated with a high total serum IgE level and Atopic Dermatitis in the German multicenter atopy study.
173	IL1A	rs17561	G/T (REV)	G	Missense Variant	Asthma with Nasal Polyposis	Finnish Caucasian population	12752325	The distribution of the IL1A genotype (G4845T) differed significantly between asthmatics with and without nasal polyposis. The risk of nasal polyposis was markedly increased in allele G homozygous subjects.
174	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	Egyptian population	21624746	Polymorphism of IL10 (-1082G/A) may be useful as a new DNA-based diagnostic biomarker for identifying high-risk children susceptible to asthma.
175	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	Finnish population	24167151	IL10 rs1800896 SNP was significantly associated with preschool asthma after severe lower respiratory tract infection in early infancy.
176	IL10	rs1800871	C/T (REV)	C	2KB Upstream Variant	Asthma	South Indian population	26108303	An association was observed between IL10 rs1800871 and mild asthma.
177	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	South Indian population	26108303	An association was observed between IL10 rs1800896 and mild asthma.
178	IL17F	rs1889570	A/G/T (REV)	G	2KB Upstream Variant	Asthma	South Indian population	26108303	IL17F rs1887570 AA variant was associated with a number of allergens sensitized.
179	IL13	rs20541	C/T	C	Coding region	Allergic Rhinitis	Asian population, Caucasian population	23545317	IL13 SNP rs20541 was associated with Allergic Rhinitis, particularly in Asians.
180	IL13	rs20541	C/T	C	Coding region	Allergic Rhinitis	Asian population	23954258	IL13 SNP rs20541 (Arg > Gln) was significantly associated with Allergic Rhinitis.
181	IFNG	CA repeat polymorphism	-	-	Intron Variant	Childhood Atopic Asthma	Japanese population	11240951	IFNG CA repeat polymorphism confer genetic susceptibility to atopic asthma in Japanese children.
182	IRF1	GT repeat polymorphism	-	-	Intron Variant	Childhood Atopic Asthma	Japanese population	11240951	IRF1 GT repeat polymorphism confer genetic susceptibility to atopic asthma in Japanese children.
183	IL6R	rs2228145	A/C/T	A	Missense Variant	Asthma	European population	22554704	The IL6R coding SNP rs2228145 (Asp(358)Ala) is a potential modifier of lung function in subjects with asthma and might identify subjects at risk for more severe asthma.
184	IL6R	rs12083537	A/G	G	Intron Variant	Asthma	European population, Australian population	23945879	rs12083537:A allele increased asthma risk by 1.04-fold.
185	IL6R	rs2228145	A/C/T	A	Missense Variant	Persistent Atopic Dermatitis	European population	23582566	A functional amino acid change in the IL-6 receptor (IL-6R Asp358Ala; rs2228145) was significantly associated with Atopic Dermatitis.
186	IFNG	rs2430561	A/T	T	Intron Variant	Asthma	Chinese Han population	24995662	The allelic frequencies of the AA genotypes in IFNG at +874 is associated with an increased risk of asthma in the Chinese Han adult population.
187	IFNG	CA repeat polymorphism	-	-	Intron Variant	Asthma	Japanese population	24995662	CA14 occurrence in the first intron of IFNG can increase the risk of asthma in the Japanese population.
188	IL17RB	rs3733072	A/C/G	G	Intron Variant	Asthma	Korean population	19118269	A rare allele of IL17RB +5661G>A may have a protective role against the development of asthma via regulation at the level of transcription.
189	IFNG	rs1861494	C/T	C	Intron Variant	Asthma	Indian population	18385742	rs1861494 A/G polymorphism was associated with asthma, which may regulate the IFNgamma levels and, hence, modulate asthma pathogenesis.
190	IL13	rs1800925	C/G/T	T	Intron Variant	Asthma	Malaysian population	23865080	The -1111T mutant allele (rs1800925) are associated with asthma.
191	IL13	G4257A	A/G	-	-	Asthma	Malaysian population	23865080	The 4257GA heterozygous and 4257AA homozygous mutant alleles were associated with higher IL-13 production in asthmatics.
192	IL13	rs1295686	A/G/T	A	Intron Variant	Asthma in Children	Mauritian population	26155367	IL13 C1923T (rs1295686) TT has been detected to be the susceptible genotype and may have a significant effect on the pathogenesis of childhood asthma in the Mauritian population.
193	IL3	rs40401	C/T	T	Missense Variant	Asthma	Japanese population	24684517	IL3 SNP rs40401 is significantly associated with the risk of asthma in young adult Japanese women and the combination of ever smoking and having the CC genotype of IL3 SNP rs40401 is significantly positively associated with asthma.
194	ITLN1	rs2274907	A/G/T	T	Missense Variant	Asthma	UK population	19000584	A Single-Nucleotide Polymorphism (rs2274907) in Intelectin 1 is associated with increased asthma risk.
195	IL8	rs4073	A/T	A	2KB Upstream Variant	Bronchial Asthma	German population	15356575	IL8 -A251T (rs4073) was associated with asthma, which is the opposite allele as described in association with RSV bronchiolitis.
196	IL8	rs2227306	C/T	C	Intron Variant	Bronchial Asthma	German population	15356575	IL8 C781T (rs2227306) polymorphism was associated with asthma.
197	IL8	C1633T	C/T	-	-	Bronchial Asthma	German population	15356575	IL8 C1633T polymorphism was associated with asthma.
198	IL8	A2767T	A/T	-	-	Bronchial Asthma	German population	15356575	IL8 A2767T polymorphism was associated with asthma.
199	IL8	rs2227306	C/T	C	Intron Variant	Asthma	German population	16503988	The IL8 polymorphism -781C/T as well as IL8 haplotypes were associated with asthma.
200	IL13	rs848	G/T (REV)	T	3 Prime UTR Variant	Asthma	Italian population	26986948	SNP rs848 in the IL13 gene region (IL5/RAD50/IL13/IL4) was associated with symptom and treatment score (STS) in asthmatics.
201	IL4	rs2243250	C/T	C	2KB Upstream Variant	Asthma	-	31522432	Polymorphism rs2243250 of IL4 was associated with asthma.
202	IL4	rs2070874	C/T	T	5 Prime UTR Variant	Asthma	-	31522432	Polymorphism rs2070874 of IL4 was associated with asthma.
203	IL4R	rs1801275	A/G	G	Missense Variant	Asthma	-	31522432	Polymorphism rs1801275 of IL4R was associated with asthma.
204	IL4R	rs1805011	A/C/G/T	A	Missense Variant	Asthma	-	31522432	Polymorphism rs2070874 of IL4R was associated with asthma.
205	IL23R	rs11209026	A/G	G	Missense Variant	Asthma	Iranian population	26547706	R381Q polymorphism (rs11209026) in IL-23 receptor may be a predisposing allele for asthma.
206	IL33	rs1342326	G/T (REV)	T	-	Asthma	Iranian population	31820077	The rs1342326 was associated with atopic, mild and adult-onset asthma and a higher level of eosinophils in peripheral blood.
207	IL33	rs3939286	A/G/T (REV)	G	-	Asthma	Iranian population	31820077	rs3939286 was more frequent in moderate and severe asthma. rs3939286 was associated with non-atopic and childhood-onset asthma.
208	IL17F	rs763780	C/T	T	Missense Variant	Asthma	Japanese population	16630936	IL17F H161R variant (rs763780) influences the risk of asthma.
209	IL13	rs20541	C/T	C	Coding region	Asthma	Japanese population	23978640	The SNP rs20541 in IL13 was associated with airway hyperresponsiveness in Japanese adult asthmatics.
210	ILVBL	rs2240299	C/T	T	Intron Variant	Aspirin exacerbated respiratory disease (AERD) in Asthma	Korean population	29246216	rs2240299 showed significant association with the risk for AERD.
211	ILVBL	rs7507755	A/G	G	Intron Variant	Aspirin exacerbated respiratory disease (AERD) in Asthma	Korean population	29246216	rs7507755 showed significant association with the risk for AERD.
212	ILVBL	rs1468198	A/C/T	T	Intron Variant	Aspirin exacerbated respiratory disease (AERD) in Asthma	Korean population	29246216	rs1468198 showed significant association with the risk for AERD.
213	ILVBL	rs2074261	A/C	C	Intron Variant	Aspirin exacerbated respiratory disease (AERD) in Asthma	Korean population	29246216	rs2074261 showed significant association with the risk for AERD.
214	ILVBL	rs13301	C/T	T	500B Downstream Variant	Aspirin exacerbated respiratory disease (AERD) in Asthma	Korean population	29246216	rs13301 showed significant association with the risk for AERD.
215	IL10RA	rs3135932	A/G	A	Missense Variant	Atopic Diseases (Atopic Asthma, Allergic Rhinitis, Atopic Dermatitis)	Egyptian population	20232770	The IL10RA gene SNP S138G (rs3135932) may contribute to susceptibility to atopic diseases.
216	IL6	rs1800795	C/G	G	Intron Variant	Asthma	Egyptian population	18810365	IL6 (rs1800795) polymorphisms can be considered as genetic marker for bronchial asthma susceptibility and severity among Egyptian children.
217	IL4	rs2243250	C/T	C	2KB Upstream Variant	Atopic Allergy	Filipino population	21537454	The -590C/T IL4 polymorphism is a potential risk factor to and correlates with atopic allergy.
218	IL18	rs795467	A/C/G/T	G	Intron Variant	Atopic Dermatitis	Korean population	17517100	The rs795467 SNP and haplotype T-T-C were significantly associated with Atopic Dermatitis.
219	IL18	rs187238	C/G/T (REV)	G	2KB Upstream Variant	Atopic Dermatitis	Polish population	19453784	G/G genotype and –137G allele of rs187238 in IL18 gene were prevalent in the atopic dermatitis patients group.
220	IL4	rs2243250	C/T	C	2KB Upstream Variant	Atopic Dermatitis	Swedish population	12190659	A linkage to the - 590C/T (rs2243250) polymorphism in the promoter of the IL4 gene was reported for the semiquantitative trait severity score of Atopic Dermatitis.
221	IL12B	rs3212227	A/C (REV)	A	3 Prime UTR Variant	Allergic Rhinitis	Chinese Han population	26663019	The frequencies of the rs3212227 genotype with the CC and C alleles were higher in patients with Allergic Rhinitis.
222	IL12RB1	rs438421	A/G/T	G	Intron Variant	Allergic Rhinitis	Chinese Han population	25082175	A strong association between rs438421 in a single nucleotide polymorphism of IL-12RB1 and Allergic Rhinitis was identified.
223	IL27	rs153109	C/T	C	Intron Variant	Allergic Rhinitis	Chinese Han population	29771013	IL-27 p28 polymorphism rs153109 is likely to be involved in Allergic Rhinitis susceptibility.
224	IL27	rs17855750	A/G/T (REV)	T	Missense Variant	Allergic Rhinitis	Chinese Han population	29771013	IL-27 p28 polymorphism rs17855750 is likely to be involved in Allergic Rhinitis susceptibility.
225	IL13	rs20541	C/T	C	Coding region	Allergic Rhinitis	-	21309855	There is evidence for an overall association between IL13 SNP rs20541 and increased risk of Allergic Rhinitis.
226	IL3	rs40401	C/T	T	Missense Variant	Allergic Rhinoconjunctivitis	Japanese population	23953855	A significant positive association between IL3 SNP rs40401 variant and the risk of rhinoconjunctivitis.
227	ICAM1	rs5498	A/G	A	Missense Variant	Childhood Asthma	European population	24393359	The ICAM1 rs5498 A allele was positively associated with asthma development and ICAM1 gene expression.
228	IL17	rs2275913	A/G	A	2KB Upstream Variant	Childhood Asthma	Chinese population	20437253	IL17 SNP rs2275913 was associated with several asthma-related traits and confers genetic susceptibility to childhood asthma.
229	IL28B	rs12979860	C/T	T	Intron Variant	Allergic Diseases	Australian population	22295096	The association between rs12979860 genotype and allergic disease is enhanced in girls.
230	IL4RA	rs1801275	A/G	G	Missense Variant	Childhood Asthma	Chinese Han population	19657898	IL4RA Q551R and TGF-beta1 C-509T are single nucleotide polymorphism loci with significant association to childhood asthma, but they do not have synergistic effects.
231	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Asthma	-	23922687	The IL4RA I50V polymorphism may be risk factor for developing asthma.
232	IL4RA	rs1801275	A/G	G	Missense Variant	Asthma	-	23922687	The IL4RA Q551R polymorphism may be risk factor for developing asthma.
233	IL13	rs1800925	C/G/T	T	Intron Variant	Allergy (Olive Pollen Allergy)	Spanish population	18849614	IL13 C-1112T polymorphism is a protective factor.
234	IL13	rs20541	C/T	C	Coding region	Allergy (Olive Pollen Allergy)	Spanish population	18849614	IL13 R130Q polymorphism is a risk factor.
235	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Asthma	Spanish population	18849614	The interaction between IL4RA I50V (rs1805010)/Q551R (rs1801275) was strongly associated with the asthma phenotype.
236	IL4RA	rs1801275	A/G	G	Missense Variant	Asthma	Spanish population	18849614	The interaction between IL4RA I50V (rs1805010)/Q551R (rs1801275) was strongly associated with the asthma phenotype.
237	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Diisocyanate Asthma (DA)	Canadian population	17201240	A significant association was found between IL4RA (I50V) II (rs1805010) and DA among individuals exposed to hexamethylene diisocyanate (HDI). Similarly, the IL4RA (I50V) II and IL-13 (R110Q) RR combination was significantly associated with DA in HDI-exposed workers, as was the IL4RA (I50V) II and CD14 (C159T) CT genotype combination and the triple genotype combination IL4RA (I50V) II, IL-13 (R110Q) RR and CD14 (C159T) CT.
238	IL13	rs20541	C/T	C	Coding region	Allergy (Beta Lactam Allergy)	Italian population	17001290	IL13 R130Q (rs20541) polymorphism with any of the predominant homozygous genotypes of the three polymorphisms (I50V, S478P, and Q551R variants) of IL4RA was more significantly associated with the risk of betalactam allergy.
239	IL13	rs1800925	C/G/T	T	Intron Variant	Allergy (Beta Lactam Allergy)	Italian population	17001290	IL13 -1055 C>T polymorphism (rs1800925) with any of the predominant homozygous genotypes of the three polymorphisms (I50V, S478P, and Q551R variants) of IL4RA was more significantly associated with the risk of betalactam allergy.
240	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Allergy (Beta Lactam Allergy)	Italian population	17001290	IL13 -1055 C>T or R130Q polymorphism with the predominant homozygous genotype of I50V (rs1805010) polymorphism of IL4RA was more significantly associated with the risk of betalactam allergy.
241	IL4RA	rs1801275	A/G	G	Missense Variant	Allergy (Beta Lactam Allergy)	Italian population	17001290	IL13 -1055 C>T or R130Q polymorphism with the predominant homozygous genotype of Q551R (rs1801275) polymorphism of IL4RA was more significantly associated with the risk of betalactam allergy.
242	IL4RA	rs1805015	C/T	T	Missense Variant	Allergy (Beta Lactam Allergy)	Italian population	17001290	IL13 -1055 C>T or R130Q polymorphism with the predominant homozygous genotype of S478P (rs1805015) polymorphism of IL4RA was more significantly associated with the risk of betalactam allergy.
243	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Allergy (Beta Lactam Allergy)	Algerian population	30525746	IL4RA (I50V) was associated with beta-lactam allergy.
244	IL13	rs20541	C/T	C	Coding region	Allergy (Beta Lactam Allergy)	Algerian population	30525746	IL13 (R130Q) was associated with beta-lactam allergy.
245	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Allergy (Beta Lactam Allergy)	Spanish population	22764749	IL4RA I50V was associated with IgE against prevalent allergens and was also predictor of Beta Lactam allergy.
246	IL4RA	rs1801275	A/G	G	Missense Variant	Allergy (Beta Lactam Allergy)	Spanish population	22764749	IL4RA Q551R was associated with total IgE and was also predictors of Beta Lactam allergy.
247	IL13	rs1800925	C/G/T	T	Intron Variant	Asthma	Chinese Han population	19862939	IL13 C-1112T makes little contribution to the development of asthma in children of Chinese Han nationality.
248	IL13	rs1295686	A/G/T	A	Intron Variant	Asthma	Chinese Han population	19862939	IL13 C1923T makes little contribution to the development of asthma in children of Chinese Han nationality.
249	IL4	rs2243250	C/T	C	2KB Upstream Variant	Asthma	Chinese Han population	19862939	IL4 C-590T makes little contribution to the development of asthma in children of Chinese Han nationality.
250	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Asthma	Chinese Han population	19862939	IL4RA 175V makes little contribution to the development of asthma in children of Chinese Han nationality.
251	IL10	rs1800896	A/G	A	2KB Upstream Variant	Aspirin-Intolerant Asthma (AIA) and Rhinosinusitis	Korean population	19222424	AG or GG genotype of IL-10-1082A/G was significantly higher in the patients with AIA.
252	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	North Indian population	16008678	A suggestive evidence of association was obtained for -1082 A/G polymorphism at the level of alleles and genotypes with asthma.
253	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	-	24162871	IL10 promoter -1028A/G (rs1800896), -592A/C (rs1800872) polymorphisms and their haplotypes correlate with asthma susceptibility.
254	IL10	rs1800872	A/C (REV)	C	2KB Upstream Variant	Asthma	-	24162871	IL10 promoter -1028A/G (rs1800896), -592A/C (rs1800872) polymorphisms and their haplotypes correlate with asthma susceptibility.
255	IL10	rs1800896	A/G	A	2KB Upstream Variant	Childhood Asthma	Korean population	21779975	The -1082A>G polymorphism and ATA haplotype in the IL-10 promoter gene were associated with airway hyper responsiveness (AHR) in asthmatics.
256	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Asthma	Malay population	16757160	Ile50Val heterozygote is less frequent in asthmatics than in controls in Malay population.
257	IL10	rs1800896	A/G	A	2KB Upstream Variant	Food Allergy	Taiwanese population	23265747	The SNP at -1082A/G was associated with Food Allergy in Taiwanese population.
258	IL10	rs1800872	A/C (REV)	C	2KB Upstream Variant	Food Allergy	Taiwanese population	23265747	The SNP at -592A/C was associated with Food Allergy in Taiwanese population.
259	IL10	rs1800871	C/T (REV)	C	2KB Upstream Variant	Allergy (Beta Lactam Allergy)	French population	16867043	Significant associations between immediate beta-lactam allergy in women and two linked IL-10 promoter gene polymorphisms, -819C>T (rs1800871) and -592 C>A (rs1800872) were noted.
260	IL10	rs1800872	A/C (REV)	C	2KB Upstream Variant	Allergy (Beta Lactam Allergy)	French population	16867043	Significant associations between immediate beta-lactam allergy in women and two linked IL-10 promoter gene polymorphisms, -819C>T (rs1800871) and -592 C>A (rs1800872) were noted.
261	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Allergy (Beta Lactam Allergy)	French population	16867043	A significant association between immediate beta-lactam allergy in women and the Ile75Val (rs1805010) variant of IL-4Ralpha gene was noted.
262	IL13	rs1295686	A/G/T	A	Intron Variant	Asthma	Mauritian Indian population	24838642	The IL13 C1923T locus predisposed to asthma in Mauritian Indian children.
263	IL4RA	rs1805010	A/C/G/T	G	Missense Variant	Asthma	Caucasian population	19796199	One SNP in IL4RA1 [rs1805010(I75V)] was associated with asthma severity.
264	IL13	rs1881457	A/C	A	5' Upstream variant	Asthma, Atopy	Caucasian population	19796199	IL13 SNP rs1881457(-1512) was associated with atopy risk. rs1881457(-1512) was associated with better FEV(1) and FEV(1)/FVC in asthmatics.
265	IL13	rs20541	C/T	C	Coding region	Atopy	Caucasian population	19796199	rs20541(R130Q) was associated with atopy risk.
266	IL13	rs1800925	C/G/T	T	Intron Variant	Asthma, Atopy	Caucasian population	19796199	IL13 SNP rs1800925 was associated with atopy risk. rs1800925 was associated with better FEV(1) and FEV(1)/FVC in asthmatics.
267	IL13	rs20541	C/T	C	Coding region	Asthma, Atopy	British population	19254294	IL13 rs20541 was significantly associated with self-reported asthma and allergy.
268	IL13	rs1800925	C/G/T	T	Intron Variant	Asthma, Atopy	British population	19254294	IL13 rs1800925 was significantly associated with self-reported asthma and allergy.
269	IL4	rs2243250	C/T	C	2KB Upstream Variant	Asthma	Italian Caucasian population	23527710	IL-4 -590T/C heterozygous condition was significantly associated with asthma.
270	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	Italian Caucasian population	23527710	IL-10 -1082G/A heterozygous condition was significantly associated with asthma.
271	IL4RA	rs1801275	A/G	G	Missense Variant	Asthma	Italian Caucasian population	23527710	IL-4Ralpha +1902A/A homozygous condition was significantly associated with asthma.
272	IL1A	rs1800587	A/C/G	A	5 Prime UTR Variant	Asthma	Italian Caucasian population	23527710	IL-1alpha -889C/C homozygous condition was significantly associated with asthma.
273	IL33	rs1342326	G/T (REV)	T	-	Hay fever	German population	27171815	rs1342326 was positively associated with hay fever.
274	IL33	rs928413	A/C/G	A	2KB Upstream Variant	Hay fever	German population	27171815	rs928413 was positively associated with hay fever.
275	IRAK4	rs3794262	A/C/T	-	Intron Variant	Allergic Rhinitis	Chinese population	22932140	The potential genetic contribution of the IRAK4 (rs3794262) gene to AR demonstrated an allergen-dependant association pattern in Chinese population.
276	IRAK4	rs4251481	A/G	-	Intron Variant	Allergic Rhinitis	Chinese population	22932140	The potential genetic contribution of the IRAK4 gene (rs4251481) to AR demonstrated an allergen-dependant association pattern in Chinese population.
277	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma	-	23017230	Significant association between -1082A/G polymorphism and asthma was observed.
278	IL10	rs1800896	A/G	A	2KB Upstream Variant	Occupational Allergic Dermatoses	Russian population	26515179	The presence of homozygous variant IL10 G1082A--AA in 80% cases characterizes early disease development, i.e. within 3 years after the first exposure to the occupational factor.
279	IL10	rs1800871	C/T (REV)	C	2KB Upstream Variant	Asthma	Taiwanese population	26546526	The CC genotype of IL10 T-819C compared to the TT genotype may have a protective effect on asthma risk in younger adults (25-40 years old), and males in Taiwan.
280	IL4	rs2243250	C/T	C	2KB Upstream Variant	Asthma, Allergy	Xhosa population	29314322	IL4 -589C>T showed multiple associations with allergic sensitization and asthma phenotypes.
281	IL10	rs1800872	A/C (REV)	C	2KB Upstream Variant	Asthma, Allergy	Xhosa population	29314322	IL10 -592A>C showed multiple associations with allergic sensitization and asthma phenotypes.
282	IL10	rs1800896	A/G	A	2KB Upstream Variant	Asthma, Allergy	Xhosa population	29314322	IL10 -1082A>G showed multiple associations with allergic sensitization and asthma phenotypes.
283	IL10	rs1800896	A/G	A	2KB Upstream Variant	Allergy (Allergic Reaction to Efavirenz)	Brazilian population	22715992	The polymorphism in the interleukin-10 gene promoter -1082G/A can be related to the development of allergic reactions to efavirenz.
284	IL4	rs2070874	C/T	T	5 Prime UTR Variant	Allergic Rhinitis	Iranian population	24075353	CC genotype in rs2070874 significantly was correlated with Allergic Rhinitis.
285	IL4	rs2243250	C/T	C	2KB Upstream Variant	Allergic Rhinitis	Iranian population	24075353	Homozygosity for the C allele of rs2243250 in IL4 was significantly overrepresented in the Allergic Rhinitis patient group.
286	IL10	rs1800896	A/G	A	2KB Upstream Variant	Allergy (Cow Milk Allergy)		23917667	Homozygosis for the G allele at the IL10 -1082G/A (rs1800896) polymorphism is associated with the persistent form of cow's milk allergy.
287	IL10	rs1800872	A/C (REV)	C	2KB Upstream Variant	Asthma	-	23017230	Significant association between -592A/C polymorphism and asthma was observed.