Browse Result

Total number of records for in M of in DAAB (Version-2) database: 45

Record no	GENE NAME	SNP ID	CHANGES	ANCESTRAL ALLELES	FUNCTIONAL CONSEQUENCES	DISEASE	POPULATION	Pubmed ID	Comments
1	MX1	rs469390	A/G	G	Missense Variant	Viral Respiratory Illness, Asthma	European or American European	26399222	rs469390, which encodes a missense mutation (G/A; Val379Ile) in exon 15 of the MX1 protein, was significantly associated with viral asthma burden in RhinoGen study and asthma exacerbations in COPSAC (Copenhagen Prospective Study on Asthma in Childhood) study. The allele (G) associated with increased viral asthma burden in the RhinoGen children, was associated with fewer asthma exacerbations in COPSAC children.
2	MX1	rs2070229	C/T	T	Synonymous Variant	Viral Respiratory Illness, Asthma	European or American European	26399222	rs2070229 was significantly associated with viral asthma burden and weeks infected in RhinoGen study, with Rhinoviral wheezing in COAST (Childhood Origins of Asthma) study and with asthma exacerbations in COPSAC (Copenhagen Prospective Study on Asthma in Childhood) study.
3	MX1	rs467593	A/G	G	Intron Variant	Viral Respiratory Illness, Asthma	European or American European	26399222	rs467593 was in linkage disequilibrium with rs2070229 and shows the same opposite pattern of association in RhinoGen study as compared to COPSAC (Copenhagen Prospective Study on Asthma in Childhood) study and COAST (Childhood Origins of Asthma) study.
4	MRPP3	rs12436663	A/G	G	Intron Variant	Asthma	-	26031901	rs12436663 in MRPP3 was associated with worsening response to zileuton in asthmatics. Homozygous rs12436663 carriers showed a significant reduction in mean ΔFEV1 following zileuton treatment.
5	miR-196a2	rs11614913	C/T	C	Non Coding Transcript Variant	Asthma	Korean population	28527151	The CT/CC genotype of miR-196a2 rs11614913 was associated with eosinophilic asthma and a higher sputum eosinophil count compared with the TT genotype.
6	miR-146a	rs2910164	C/G	G	Non Coding Transcript Variant	Asthma	Korean population	28527151	The CG/GG genotype of miR-146a rs2910164 was associated with higher bronchial hyperresponsiveness to methacholine compared with the CC genotype in asthmatic patients.
7	miR-499	rs3746444	C/T	T	Non Coding Transcript Variant	Asthma	Korean population	28527151	The AG/GG genotype of miR-499 rs3746444 was associated with higher predicted values of forced expiratory volume in 1 s (%FEV1) compared with the AA genotype in asthmatic patients.
8	miR499	rs3746444	G/A	A	Non Coding Transcript Variant	Bronchial Asthma	Egyptian children and adolescents	28886711	miR499 rs3746444 (A > G) polymorphism was associated with asthma susceptibility and bronchodilator response in Egyptian children and adolescents. The G variant was associated with high risk of developing asthma under all genetic association models.
9	MMP9	rs20544	C/T	C	3 Prime UTR Variant	Childhood Asthma	Slovenian population	29600353	There exists an association of MMP9 genotype rs20544 TT with better asthma control and indirectly better response to treatment.
10	MMP9	rs13925	A/G	G	Synonymous Variant	Childhood Asthma	Slovenian population	29600353	There exists an association of MMP9 genotypes rs13925 AA and AG with better asthma control and indirectly better response to treatment.
11	MUC22	rs2523924	A/G	A	Intron Variant	Childhood Asthma	Chinese population	28262390	Compared with the controls, patients were found to have significantly lower frequencies of genotype AA of rs2523924.
12	MMP12	rs2276109	A/G (REV)	A	2KB Upstream Variant	Bronchial Asthma	Bulgarian population	29390099	The variant G allele of the MMP12 -82 A>G promoter polymorphism (rs2276109) might be considered protective for development of Bronchial Asthma in ethnic Bulgarian adults residing in central Bulgaria.
13	MAP4K4	rs12468899	A/G/T	G	Intron Variant	Asthma	European Ancestry	27130862	rs12468899 in 2q11-q12 loci was associated with time to asthma onse (TAO) at suggestive significance levels.
14	MED24	rs2302777	A/G	G	Synonymous Variant	Asthma	Slovenian population	27163155	rs2302777 was highly associated with asthma.
15	MMP2	rs9302671	G/T	G	Intron Variant	Asthma	European population	27334786	rs9302671 SNP in the MMP2 gene was associated with asthma.
16	MMP2	rs17301608	A/C/G/T	C	Intron Variant	Asthma	European population	27334786	rs17301608 SNP in the MMP2 gene was associated with asthma.
17	MMP9	rs17577	A/C/G	G	Missense Variant	Asthma	-	30931075	MMP-9 Arg668Gln, rs17577 polymorphism may be the risk factor for asthma susceptibility.
18	MMP9	rs17576	A/G	A	Missense Variant	Asthma	-	30931075	For the Gln279Arg, rs17576 polymorphism, there seems to be a significant association with asthma susceptibility in the allelic genetic model.
19	MYH15	rs9288876	A/T	A	Intron Variant	Asthma	Chinese Han population	30906771	MYH15 polymorphism of rs9288876 altered transcriptional regulation of MYH15 and may be functional variant conferring susceptibility to asthma.
20	MYH15	rs7635009	A/G	A	Intron Variant	Asthma	Chinese Han population	30906771	MYH15 polymorphism of rs7635009 altered transcriptional regulation of MYH15 and may be functional variant conferring susceptibility to asthma.
21	MYH15	rs1454197	G/T	G	Intron Variant	Asthma	Chinese Han population	30906771	MYH15 polymorphism of rs1454197 altered transcriptional regulation of MYH15 and may be functional variant conferring susceptibility to asthma.
22	miR-196a2	rs11614913	C/T	C	Non Coding Transcript Variant	Asthma	Egyptian population	27487239	microRNA-196a2 rs11614913 polymorphism might be associated with asthma severity.
23	miR-152	rs1707	C/T	-	-	Asthma	Chinese Han population	27383317	Pre-miR-152 rs1707 may contribute to the risk of asthma in a Chinese Han population.
24	miR-133a1	rs8089787	C/T	T	2KB Upstream Variant	Asthma	Chinese Han population	27383317	The CT and CT+TT genotypes in the miR-133a1 rs8089787 were significantly associated with a decreased risk for asthma in sample of the Chinese Han population, compared with CC genotype.
25	miR-133a1	rs9948906	A/C/T	T	2KB Upstream Variant	Asthma	Chinese Han population	27383317	The CT and CT+TT genotypes in the miR-133a1 rs9948906 were associated with a decreased risk of asthma.
26	MAML3	rs345983	C/T	T	3 Prime UTR Variant	Asthma	Dutch population	27709636	Minor allele of rs345983 was associated with less severe BHR and higher lung tissue gene expression. MAML3 was associated with BHR severity in adult asthma.
27	miR-149	rs2292832	A/C/T	C	Non Coding Transcript Variant	Allergic Rhinitis with Comorbid Asthma (In Children)	Chinese population	28181414	miR-149 rs2292832 variant is not only strongly associated with Allergic Rhinitis and Allergic Rhinitis with Asthma, but it may lead to an increase in the susceptibility to allergies following the stimulation with an allergen, through the changes in miR-149 expression.
28	MRPL44	rs76568361	G/T	T	-	Asthma and Allergy Traits	Saguenay Lac Saint Jean Population	30206357	rs76568361 was found to be associated with eosinophil percentage.
29	MIF	rs755622	C/G (REV)	G	2KB Upstream Variant	Childhood Asthma	Egyptian population	27833444	MIF-173G/C (rs755622) polymorphism confers an increased risk of susceptibility to the development of childhood asthma in Egyptian population.
30	mEPHX1	-	-	-	-	Childhood Bronchial Asthma	Pre Carpathian population	28713081	Patients with uncontrolled asthma have genotypes CC and GG much more often. Children with asthma often have high enzymatic activity of a gene mEPHX1 (polymorphic variants of AG and AA-TT-TT). A "slow" functional state of gene mEPHX1 corresponding to homozygotes and heterozygotes for the mutant alleles: СС-АА and ТС-АА is also a frequent phenomenon.
31	MMP9	rs17576	A/G	A	Missense Variant	Childhood Asthma	-	27395373	A direct correlation between MMP9 (Q279R) SNP (rs17576) and MMP9 enzyme activity was found in EBC of asthmatic children.
32	MMP9	rs17577	A/C/G	G	Missense Variant	Childhood Asthma	-	27395373	A direct correlation between MMP9 (R668Q) SNP (rs17577) and MMP9 enzyme activity was found in EBC of asthmatic children.
33	MICA	rs2596560	A/G (REV)	A	2KB Upstream Variant	Asthma	Dutch population	27439200	The risk allele C of rs2596560 on chromosome 6 near MICA, associated with a higher risk of atopy within asthmatics.
34	MIR205HG, MIR205, LAMB3, CAMK1G	rs10746419	C/G/T	T	-	Childhood Asthma	Puerto Rican population, Mexican population, African American population	29509491	The T allele of rs10746419 was significantly associated with bronchodilator drug response (BDR) in asthmatic children.
35	MN1, PITPNB	rs60163793	A/C/G	C	-	Childhood Asthma	Puerto Rican population, Mexican population, African American population	29509491	The G allele of rs60163793 was significantly associated with bronchodilator drug response (BDR) in asthmatic children.
36	MED24	rs7502514	A/G	G	Intron Variant	Asthma	-	27554816	rs7502514 is an eQTL for MED24 gene which is significantly associated with asthma risk.
37	MED12L	rs10513393	A/G	G	Intron Variant	Asthma	-	27554816	rs10513393 is an eQTL for P2RY14 gene which is significantly associated with asthma risk.
38	MICB	rs9268764	C/T	T	-	Asthma	-	27554816	rs9268764 is an eQTL for MICB gene which is significantly associated with asthma risk.
39	miR-146a	rs2910164	C/G	G	Non Coding Transcript Variant	Bronchial hyperresponsiveness (BHR) in patients with basic pulmonary disease (such as Asthma, Emphysema and Bronchitis)	Chinese population	27431205	The miR-146a rs2910164 polymorphism CC genotype was identified to be significantly associated with an increased risk of Bronchial hyperresponsiveness (BHR) in response to intubation in patients exhibiting basic pulmonary disease (such as asthma, emphysema and bronchitis) when compared with the GG or GC genotype.
40	MYLK	rs936170	A/C/G	C	Intron Variant	Asthma	Korean population	19277499	MYLK Polymorphism (+89872C > G) was associated with blood eosinophil level among asthmatic patients in korean population.
41	MYLK	92263T >C	T/C		-	Asthma	Korean population	19277499	MYLK Polymorphism (+92263T >C) was associated with blood eosinophil level among asthmatic patients in korean population.
42	MYLK	rs9840993	A/G	G	Missense Variant	Asthma	-	25271083	MYLK variant rs9840993 regulates asthmatic inflammation via alterations in mRNA secondary structure.
43	MMP2	rs243865	C/T	C	2KB Upstream Variant	Asthma	North Indian population	24843799	The MMP-2 -1306C/T promoter (rs243865) polymorphism confers significant protection from asthma in the studied North Indian population.
44	MMP8	rs17099451	A/C/T	C	2KB Upstream Variant	Bronchial Asthma	Japanese population	24498518	rs17099451 in MMP8 was associated with Bronchial Asthma in a Japanese Population.
45	MS4A2	rs1441586	C/T	C	Intron Variant	Asthma	Chinese Han population	24838642	The MS4A2 C-109T T/T genotype was associated with asthma in the Chinese Han children.